SFB 1453 NephGen
@sfb1453.bsky.social
NephGen brings together scientists who use genetic evidence and innovative transdisciplinary approaches to prevent and treat kidney diseases.
Congratulations to NephGen PIs Melanie Börries and Sven Diederichs and their groups on their practise changing publication in @natgenet.nature.com 👏👏
#MedSky #OncoSky
rdcu.be/eUbf3
#MedSky #OncoSky
rdcu.be/eUbf3
Saturation mutagenesis identifies activating and resistance-inducing FGFR kinase domain mutations
Nature Genetics - Saturation mutagenesis screening examines 11,520 point mutations in the kinase domains of FGFR1, FGFR2, FGFR3 and FGFR4, identifying their activating and resistance properties to...
rdcu.be
December 11, 2025 at 9:05 AM
Congratulations to NephGen PIs Melanie Börries and Sven Diederichs and their groups on their practise changing publication in @natgenet.nature.com 👏👏
#MedSky #OncoSky
rdcu.be/eUbf3
#MedSky #OncoSky
rdcu.be/eUbf3
NephGen speaker Anna Köttgen attendend the first ERA Science Meeting in November to further improve precision medicine in genetic kidney diseases #NephSky #MedSky
See link for more details 👇
www.linkedin.com/posts/europe...
See link for more details 👇
www.linkedin.com/posts/europe...
✨ On November 27–28, the first ERA Science Meeting took place in Barcelona, Spain
🧬 This exclusive, invitation-only event brought together leading experts to shape a roadmap for implementing… | Euro...
✨ On November 27–28, the first ERA Science Meeting took place in Barcelona, Spain
🧬 This exclusive, invitation-only event brought together leading experts to shape a roadmap for implementing precisi...
www.linkedin.com
December 10, 2025 at 2:50 PM
NephGen speaker Anna Köttgen attendend the first ERA Science Meeting in November to further improve precision medicine in genetic kidney diseases #NephSky #MedSky
See link for more details 👇
www.linkedin.com/posts/europe...
See link for more details 👇
www.linkedin.com/posts/europe...
A new exciting and highly collaborative @sfb1453.bsky.social paper by NephGen groups Börries, Schell, and Kühn in @pnas.org
Inhibition of the inflammasome ameliorates orthologous polycystic kidney disease | PNAS www.pnas.org/doi/10.1073/...
Inhibition of the inflammasome ameliorates orthologous polycystic kidney disease | PNAS www.pnas.org/doi/10.1073/...
Inhibition of the inflammasome ameliorates orthologous polycystic kidney disease | PNAS
Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney
disease. Limited treatment options lead to renal failure in ...
www.pnas.org
December 9, 2025 at 12:03 PM
A new exciting and highly collaborative @sfb1453.bsky.social paper by NephGen groups Börries, Schell, and Kühn in @pnas.org
Inhibition of the inflammasome ameliorates orthologous polycystic kidney disease | PNAS www.pnas.org/doi/10.1073/...
Inhibition of the inflammasome ameliorates orthologous polycystic kidney disease | PNAS www.pnas.org/doi/10.1073/...
Reposted by SFB 1453 NephGen
Pascal Schlosser and Matthias Wuttke, our
@sfb1453.bsky.social representation and speakers at this year's #kidneywk
@sfb1453.bsky.social representation and speakers at this year's #kidneywk
November 12, 2025 at 7:10 PM
Pascal Schlosser and Matthias Wuttke, our
@sfb1453.bsky.social representation and speakers at this year's #kidneywk
@sfb1453.bsky.social representation and speakers at this year's #kidneywk
Congratulations to @sfb1453.bsky.social PI Tobias Hermle and his team for their groundbreaking work on slit diaphragm architecture. Go check it out 👇
rdcu.be/eOzXF
rdcu.be/eOzXF
The slit diaphragm in Drosophila exhibits a bilayered, fishnet architecture
Nature Communications - The slit diaphragm is a key component of the glomerular filter. This study reveals that the slit diaphragm of Drosophila nephrocytes exhibits a fishnet architecture,...
rdcu.be
November 6, 2025 at 12:07 PM
Congratulations to @sfb1453.bsky.social PI Tobias Hermle and his team for their groundbreaking work on slit diaphragm architecture. Go check it out 👇
rdcu.be/eOzXF
rdcu.be/eOzXF
Reposted by SFB 1453 NephGen
Our study on the genetic determinants of kidney structure is available online in Kidney International as a pre-proof!
We used a CNN to derive kidney sub-volumes from MRIs and performed a GWAS to uncover their genetic determinants.
Thanks to all involved!
#CKD #Imaging #DeepLearning #GWAS
We used a CNN to derive kidney sub-volumes from MRIs and performed a GWAS to uncover their genetic determinants.
Thanks to all involved!
#CKD #Imaging #DeepLearning #GWAS
Genetic screens of imaging-derived kidney volumes identify genes linked to kidney function
doi.org/10.1016/j.kint.2025.08.0
#OpenAccess #MedSky #NephSky #kidneydisease #GWAS @uniklinik-fr.bsky.social @columbiakidney.bsky.social @columbiauniversity.bsky.social @kirylukk.bsky.social
doi.org/10.1016/j.kint.2025.08.0
#OpenAccess #MedSky #NephSky #kidneydisease #GWAS @uniklinik-fr.bsky.social @columbiakidney.bsky.social @columbiauniversity.bsky.social @kirylukk.bsky.social
October 28, 2025 at 10:55 AM
Our study on the genetic determinants of kidney structure is available online in Kidney International as a pre-proof!
We used a CNN to derive kidney sub-volumes from MRIs and performed a GWAS to uncover their genetic determinants.
Thanks to all involved!
#CKD #Imaging #DeepLearning #GWAS
We used a CNN to derive kidney sub-volumes from MRIs and performed a GWAS to uncover their genetic determinants.
Thanks to all involved!
#CKD #Imaging #DeepLearning #GWAS
A massive shoutout to our @sfb1453.bsky.social colleague Nora Scherer from Anna Köttgen's group for receiving the @dgfn.bsky.social Rainer-Greger-Award for her outstanding dissertation! Congratulations and so well deserved!!! 🎉👏
October 27, 2025 at 12:44 PM
A massive shoutout to our @sfb1453.bsky.social colleague Nora Scherer from Anna Köttgen's group for receiving the @dgfn.bsky.social Rainer-Greger-Award for her outstanding dissertation! Congratulations and so well deserved!!! 🎉👏
We are delighted that our external advisory board member @ksusztak.bsky.social will be receiving this year’s Homer Smith Award at Kidney Week 2025. www.kidneynews.org/view/journal...
Congratulations Katalin, so well deserved! 👏👏💐
Congratulations Katalin, so well deserved! 👏👏💐
www.kidneynews.org
October 12, 2025 at 8:31 PM
We are delighted that our external advisory board member @ksusztak.bsky.social will be receiving this year’s Homer Smith Award at Kidney Week 2025. www.kidneynews.org/view/journal...
Congratulations Katalin, so well deserved! 👏👏💐
Congratulations Katalin, so well deserved! 👏👏💐
Brilliant presentations by our NephGen PIs Anna Köttgen, Ulla Schultheiss, Michael Köttgen and Sven Diederichs in the @sfb1453.bsky.social session at this year's Annual Meeting of the @dgfn.bsky.social
#Nephrologie #dgfn
#Nephrologie #dgfn
October 7, 2025 at 3:33 PM
Brilliant presentations by our NephGen PIs Anna Köttgen, Ulla Schultheiss, Michael Köttgen and Sven Diederichs in the @sfb1453.bsky.social session at this year's Annual Meeting of the @dgfn.bsky.social
#Nephrologie #dgfn
#Nephrologie #dgfn
Reposted by SFB 1453 NephGen
Association of Serum Afamin Concentrations With Kidney Failure in Patients With CKD: Findings From the German CKD Cohort Study
bit.ly/4fWGYES #OpenAccess
#VisualAbstract
bit.ly/4fWGYES #OpenAccess
#VisualAbstract
August 30, 2025 at 10:00 PM
Association of Serum Afamin Concentrations With Kidney Failure in Patients With CKD: Findings From the German CKD Cohort Study
bit.ly/4fWGYES #OpenAccess
#VisualAbstract
bit.ly/4fWGYES #OpenAccess
#VisualAbstract
Super cool project! Maybe it's time for a NephGen comic? 🤔
Seeking scientist volunteers for this fall! Want to practice science communication and help author a 🌟comic🌟 about your research? I need collaborators for the next cohort of SciComm & Comics art and design students. All countries and scientific fields eligible.
August 22, 2025 at 10:29 AM
Super cool project! Maybe it's time for a NephGen comic? 🤔
Reposted by SFB 1453 NephGen
Huge congratulations to Dr. Magdalena Brislinger-Engelhardt for defending her PhD thesis today 👏👏👏🥳🥳🥳
May 28, 2025 at 4:05 PM
Huge congratulations to Dr. Magdalena Brislinger-Engelhardt for defending her PhD thesis today 👏👏👏🥳🥳🥳
Registration for this year’s EUKISS summer school in Freiburg, Germany, is now open! Join us in July for two days of discussions around the basis of kidney functions and their relevance for kidney disease!
Registration & program ➡️ www.eukiss.org
Registration & program ➡️ www.eukiss.org
May 28, 2025 at 2:41 PM
Registration for this year’s EUKISS summer school in Freiburg, Germany, is now open! Join us in July for two days of discussions around the basis of kidney functions and their relevance for kidney disease!
Registration & program ➡️ www.eukiss.org
Registration & program ➡️ www.eukiss.org
Reposted by SFB 1453 NephGen
🧬 Looking forward to presenting at the #ESHG2025! Our GWAS & EWAS studies of 10,000+ individuals reveal how genetics & epigenetics regulate trace element metabolism. Visit our poster P18.057.D today at 4pm! Huge thanks to @sfb1453.bsky.social, @zkutalik.bsky.social, and all collaborators involved!
May 26, 2025 at 1:13 PM
🧬 Looking forward to presenting at the #ESHG2025! Our GWAS & EWAS studies of 10,000+ individuals reveal how genetics & epigenetics regulate trace element metabolism. Visit our poster P18.057.D today at 4pm! Huge thanks to @sfb1453.bsky.social, @zkutalik.bsky.social, and all collaborators involved!
Congratulations to the CIBSS team for this outstanding achievement! So well deserved!!! 🎉👏👏
We are thrilled to have just found out: CIBSS has secured continued funding under the #ExcellenceStrategy! This major boost will enable us to accelerate our research into biological signalling and lay the groundwork for next-generation insights from 2026 to 2032!
May 26, 2025 at 12:26 PM
Congratulations to the CIBSS team for this outstanding achievement! So well deserved!!! 🎉👏👏
Reposted by SFB 1453 NephGen
Wondering whether you should read the great kidney disease genetic scorecard paper by @hongbo919.bsky.social @ksusztak.bsky.social on 2.2Mio people?
Here 👇 rdcu.be/eejuB Matthias Wuttke at @sfb1453.bsky.social and I report some highlights for you (and recommend reading the original work) #nephgen
Here 👇 rdcu.be/eejuB Matthias Wuttke at @sfb1453.bsky.social and I report some highlights for you (and recommend reading the original work) #nephgen
March 24, 2025 at 3:22 PM
Wondering whether you should read the great kidney disease genetic scorecard paper by @hongbo919.bsky.social @ksusztak.bsky.social on 2.2Mio people?
Here 👇 rdcu.be/eejuB Matthias Wuttke at @sfb1453.bsky.social and I report some highlights for you (and recommend reading the original work) #nephgen
Here 👇 rdcu.be/eejuB Matthias Wuttke at @sfb1453.bsky.social and I report some highlights for you (and recommend reading the original work) #nephgen
Reposted by SFB 1453 NephGen
please re-post! we are looking for a PhD candidate:
www.uniklinik-freiburg.de/en/career/jo...
www.uniklinik-freiburg.de/en/career/jo...
March 6, 2025 at 9:22 AM
please re-post! we are looking for a PhD candidate:
www.uniklinik-freiburg.de/en/career/jo...
www.uniklinik-freiburg.de/en/career/jo...
March 13, 2025 at 9:36 AM
February 28, 2025 at 2:23 PM
Reposted by SFB 1453 NephGen
🚨2 fully funded postdoc positions for 6 years 🚨
Are you interested in gene regulation, cardiovascular diseases or aging? Join our team in beautiful Graz, Austria!
Postdoc in Bioinformatics 🖥️
tinyurl.com/3ufv767b
Postdoc in functional genomics and models (e.g. organoids) 🧪
tinyurl.com/4ucahvzn
Are you interested in gene regulation, cardiovascular diseases or aging? Join our team in beautiful Graz, Austria!
Postdoc in Bioinformatics 🖥️
tinyurl.com/3ufv767b
Postdoc in functional genomics and models (e.g. organoids) 🧪
tinyurl.com/4ucahvzn
February 25, 2025 at 7:10 AM
🚨2 fully funded postdoc positions for 6 years 🚨
Are you interested in gene regulation, cardiovascular diseases or aging? Join our team in beautiful Graz, Austria!
Postdoc in Bioinformatics 🖥️
tinyurl.com/3ufv767b
Postdoc in functional genomics and models (e.g. organoids) 🧪
tinyurl.com/4ucahvzn
Are you interested in gene regulation, cardiovascular diseases or aging? Join our team in beautiful Graz, Austria!
Postdoc in Bioinformatics 🖥️
tinyurl.com/3ufv767b
Postdoc in functional genomics and models (e.g. organoids) 🧪
tinyurl.com/4ucahvzn
Reposted by SFB 1453 NephGen
Freiburger Forschende zeigen, wie seltene „Nonstop-Mutationen“ die Proteinbildung stören und die Entstehung von #Nierenkrebs fördern können. Erkenntnisse bieten Potenzial für bessere Diagnosen und Therapien.
Link zur Studie: t1p.de/ytfs3
#Medizin #Forschung
Link zur Studie: t1p.de/ytfs3
#Medizin #Forschung
February 14, 2025 at 12:47 PM
Freiburger Forschende zeigen, wie seltene „Nonstop-Mutationen“ die Proteinbildung stören und die Entstehung von #Nierenkrebs fördern können. Erkenntnisse bieten Potenzial für bessere Diagnosen und Therapien.
Link zur Studie: t1p.de/ytfs3
#Medizin #Forschung
Link zur Studie: t1p.de/ytfs3
#Medizin #Forschung
Reposted by SFB 1453 NephGen
This study challenges the idea that KDM5D in male cells functions equivalently to the second KDM5C allele in female cells, implicating an interplay between KDM5C mutation and Y chromosome loss in ccRCC development in men.
@sfb1453.bsky.social
www.nature.com/articles/s42...
@sfb1453.bsky.social
www.nature.com/articles/s42...
KDM5C and KDM5D mutations have different consequences in clear cell renal cell carcinoma cells - Communications Biology
This study challenges the idea that KDM5D in male cells functions equivalently to the second KDM5C allele in female cells and implicates an interplay between KDM5C mutation and Y chromosome loss in cc...
www.nature.com
February 18, 2025 at 10:05 PM
This study challenges the idea that KDM5D in male cells functions equivalently to the second KDM5C allele in female cells, implicating an interplay between KDM5C mutation and Y chromosome loss in ccRCC development in men.
@sfb1453.bsky.social
www.nature.com/articles/s42...
@sfb1453.bsky.social
www.nature.com/articles/s42...
Congratulations to @sfb1453.bsky.social PIs Athina Ganner, Elke Neumann-Haefelin, Ian Frew, and Sven Diedierichs and their teams! 👏👏👏 Nonstop mutations cause loss of renal tumor suppressor proteins VHL and BAP1 and affect multiple stages of protein translation www.science.org/doi/10.1126/...
Nonstop mutations cause loss of renal tumor suppressor proteins VHL and BAP1 and affect multiple stages of protein translation
Extending a protein at its end affects its stability, but also its translation efficiency and even selection of its start.
www.science.org
February 13, 2025 at 8:51 AM
Congratulations to @sfb1453.bsky.social PIs Athina Ganner, Elke Neumann-Haefelin, Ian Frew, and Sven Diedierichs and their teams! 👏👏👏 Nonstop mutations cause loss of renal tumor suppressor proteins VHL and BAP1 and affect multiple stages of protein translation www.science.org/doi/10.1126/...