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American Journal of Kidney Diseases @ajkd.bsky.social · 2h

Monoallelic IFT140 Variants Causing Childhood-Onset Autosomal Dominant Polycystic Kidney Disease

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Radiology imaging of pediatric ADPKD-IFT140 cases. (A, B) Case IFT1-IV-2: MRI at 17 years of age showing 12 cysts on the right kidney and 16 on the left. The largest measures 26 mm on the lower pole of the right and 4 cm on the upper pole of the left. The majority are <5 mm in length. A: Coronal T2 image (MRI) with the arrow pointing to the 4 cm cyst with internal septation located at the upper pole of the left kidney. B: Coronal T2 MRI with the arrow pointing at the 26 mm simple cyst on the lower pole of the right kidney. (C, D) Case IFT1-IV-4: Ultrasound imaging at 4 years of age showing 3 cysts on the right kidney and none on the left. All cysts measured 2-5 mm. Longitudinal ultrasound pictures of the right kidney with the arrow pointing at the cysts. (E, F) Case IFT2-III-5: Ultrasound imaging at 9 months old showing multiple cysts on the right kidney with a 3 cm cyst on the upper pole and a 0.7 cm cyst on the left kidney.

American Journal of Kidney Diseases @ajkd.bsky.social · 8h

Core Curriculum by Biff F. Palmer and Deborah J. Clegg:

Mixed Acid-Base Disturbances: Core Curriculum 2025

bit.ly/Palmer25CC (FREE)

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American Journal of Kidney Diseases @ajkd.bsky.social · 20h

NEW Commentary by Matthew A. Sparks and Alessandra Tomasi:

Silencing Primary Hyperoxaluria with Lumasiran: Two Year Follow-up of the Phase 3 ILLUMINATE-C Trial

bit.ly/47crprj

Article by Anne-Laure Sellier-Leclerc et al. bit.ly/3WuEvtO

American Journal of Kidney Diseases @ajkd.bsky.social · 1d

Environmental Impacts of Kidney Replacement Therapies: A Comparative Lifecycle Assessment

bit.ly/3KNKibh #OpenAccess

Lifecycle environmental impacts of kidney replacement therapies (midpoint impact categories) The figure shows the environmental impacts of kidney replacement therapies, measured for different environmental categories in addition to carbon emissions

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American Journal of Kidney Diseases @ajkd.bsky.social · 1d

Review by Michelle A. Baum, Mallory Mandel, and Michael J.G. Somers:

Understanding Rare Kidney Stone Diseases: A Review

bit.ly/3I2RiA6 (FREE)

American Journal of Kidney Diseases @ajkd.bsky.social · 1d

Editorial by Sandipan Shringi, Edward Medeiros, and Ankur D. Shah:

From What to Why: Mechanistic Understandings Behind Sex Differences in Peritoneal Dialysis Discontinuation

bit.ly/4odFXfQ (FREE)

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American Journal of Kidney Diseases @ajkd.bsky.social · 2d

Shared Decision Making in Health Care Visits for CKD: Patients’ Decisional Role Preferences and Experiences

bit.ly/45m2Swf #OpenAccess

#CKD

Survey: patients’ experienced versus preferred decisional role per decision topic: visualization per decision topic of the total number of patients whose preferred decisional role did or did not match their experienced role. In the left column, the decision topic includes the number of patients who indicated having discussed the decision in the previous health care visit. Light grey: number of patients who experienced their decisions as less shared or patient directed than preferred; darker grey: number of patients for whom experienced decisional role matched their preferred role; darkest grey: number of patients who experienced their decisional role as more shared or patient directed than preferred.

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American Journal of Kidney Diseases @ajkd.bsky.social · 2d

#RenalPath: AJKD Atlas of Renal Pathology: Focal Segmental Glomerulosclerosis

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Two small peripheral foci of segmental sclerosis with intracapillary foam cells and prominence of overlying visceral epithelial cells (right glomerulus), with normal left glomerulus by light microscopy, representative of an early segmental sclerosing lesion in focal segmental glomerulosclerosis, not otherwise specified variant (Jones silver stain). Reproduced with permission from AJKD 33(4):e1.

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American Journal of Kidney Diseases @ajkd.bsky.social · 2d

Arterial Stiffness and Subsequent Incidence of CKD and Kidney Function Decline in a Large Longitudinal Community Cohort: The Atherosclerosis in Communities (ARIC) Study

bit.ly/Yao25OI #OpenAccess

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American Journal of Kidney Diseases @ajkd.bsky.social · 3d

NEW Commentary by Matthew A. Sparks and Alessandra Tomasi:

Silencing Primary Hyperoxaluria with Lumasiran: Two Year Follow-up of the Phase 3 ILLUMINATE-C Trial

bit.ly/47crprj

Article by Anne-Laure Sellier-Leclerc et al. bit.ly/3WuEvtO

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American Journal of Kidney Diseases @ajkd.bsky.social · 3d

A Patient With HIV and Nephrotic Range Proteinuria: A Quiz

What are the differences between HIV-associated immune complex kidney disease (HIVICK) and HIV-associated nephropathy (HIVAN)?

bit.ly/4mf9RiC (FREE)

American Journal of Kidney Diseases @ajkd.bsky.social · 3d

Review by Jiawen Peng, Yuemiao Zhang, Jingyu Wang, Hong Zhang, and Georg Schett:

Role of Chimeric Antigen Receptor–Expressing Cell Therapy in Immune-Mediated Kidney Diseases: A Review

bit.ly/4n2RZbA (FREE)

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American Journal of Kidney Diseases @ajkd.bsky.social · 4d

Identifying Adaptation Needs of a Decision Aid for Older Latino Adults With Advanced CKD: A Qualitative Study

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Targeting and tailoring decision aids framework

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American Journal of Kidney Diseases @ajkd.bsky.social · 4d

Trends in Outcomes Among Patients Initiating Peritoneal Dialysis in the United States, 2009-2018

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Trends in 1-year probability of mortality among incident peritoneal dialysis patients by patient age category, race/ethnicity, Social Deprivation Index category, urban/nonurban residence, 2009-2018, unadjusted analysis. Mortality trends evaluated by (A) age group, (B) Social Deprivation Index group (1-100 scale, 1=least deprived), (C) urban or nonurban location of patient residence, and (D) race or ethnicity group. The 1-year cumulative incidence of mortality from peritoneal dialysis initiation at end-stage kidney disease first service date was estimated using the Kaplan-Meier method.

American Journal of Kidney Diseases @ajkd.bsky.social · 4d

Discordances Between Creatinine- and Cystatin C–Based Estimated GFR and Adverse Clinical Outcomes in Routine Clinical Practice

bit.ly/4491HQp #OpenAccess

(A) Univariate correlation between eGFRcys and eGFRcr, and (B) scatterplot of eGFRcr versus eGFRdiff at baseline. Shown are correlations in a random 1% sample of 1,569 observations. The blue line shows the line of identity, and red line marks eGFRdiff higher and lower than 15mL/min/1.73m2. Abbreviations: cr, creatinine; cys, cystatin C; eGFR, estimated glomerular filtration rate.

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American Journal of Kidney Diseases @ajkd.bsky.social · 5d

Mini Review by Kristen L. Nowak and Michel Chonchol:

Targeting Inflammation in CKD

bit.ly/46TMzsY (FREE)

Inflammatory Signaling and Potential Therapeutic Targets in CKD. Sterile inflammation triggered by innate immune system activation is a key driver of both chronic kidney disease (CKD) and associated atherosclerosis and cardiovascular disease (CVD), in part via activation of the NLRP3 inflammasome. Recent and ongoing clinical trials are testing therapeutics targeting the NLRP3 inflammasome, interleukin-1 (IL-1) and its receptor (IL-1R), interleukin-6 (IL-6) and its receptor (IL6R), as represented in this schematic.

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American Journal of Kidney Diseases @ajkd.bsky.social · 5d

NEW Commentary by Matthew A. Sparks and Alessandra Tomasi:

Silencing Primary Hyperoxaluria with Lumasiran: Two Year Follow-up of the Phase 3 ILLUMINATE-C Trial

bit.ly/47crprj

Article by Anne-Laure Sellier-Leclerc et al. bit.ly/3WuEvtO

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American Journal of Kidney Diseases @ajkd.bsky.social · 5d

Editorial by Isabelle Ethier and Caroline Stigant:

Operationalizing Environmental Sustainability in Kidney Care at System and Provider Levels: Knowledge Is the First Step

bit.ly/3VTtHFn (FREE)

American Journal of Kidney Diseases @ajkd.bsky.social · 6d

Association of Sex With All-Cause and Cause-Specific Peritoneal Dialysis Discontinuation

bit.ly/Sabanayagam2...

#VisualAbstract

American Journal of Kidney Diseases @ajkd.bsky.social · 6d

Carbon Emissions From Different Dialysis Modalities: A Life Cycle Assessment

bit.ly/Barraclough2... #OpenAccess

#VisualAbstract

American Journal of Kidney Diseases @ajkd.bsky.social · 6d

Immunofluorescence and Electron Microscopy in Genetically Engineered Pig-to-Human Kidney Xenotransplantation: A Case Report

bit.ly/3VTpKka

Case 1 xenografts. (A) Left preimplantation biopsy shows glomerulus with mild increase in mesangial matrix and segmental increase in mesangial cellularity (periodic acid-Schiff hematoxylin, ×20). (B) Right postimplantation biopsy, postoperative day (POD) 2, shows diffuse tubular epithelial cell necrosis with loss of nuclei and frequent granular casts. The glomerulus shows rare lumina occluded by fibrin thrombi (arrows); the rest of the capillaries are congested (periodic acid-Schiff hematoxylin, ×20). (C) Left preimplantation biopsy; immunofluorescence shows global granular staining for immunoglobulin M (IgM) limited to the mesangium (fluorescein isothiocyanate anti-human IgM). (D) Right preimplantation biopsy shows electron-dense immune complex deposits within the expanded mesangium (uranyl acetate and lead citrate, ×4,000).

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American Journal of Kidney Diseases @ajkd.bsky.social · 7d

Core Curriculum by Kristen Tillquist et al.

The Nephrologist’s Perspective in Evaluation and Management of Localized Renal Masses

bit.ly/4o6z0NG #OpenAccess

Renal Cell Carcinoma Subtypes Based on Histology. (A) Clear cell renal cell carcinoma. (B) Papillary renal cell carcinoma. (C) Chromophobe renal cell carcinoma. (D) Oncocytoma. (E) Medullary renal cell carcinoma.

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American Journal of Kidney Diseases @ajkd.bsky.social · 7d

In the Literature by Momen Abbasi and Anand Srivastava:

Advancing Noninvasive Imaging to Quantify Kidney Fibrosis: Hidden in Plain Sight

bit.ly/46TMIwB (FREE)

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American Journal of Kidney Diseases @ajkd.bsky.social · 7d

The October 2025 issue is available now! Check out the plain-language summaries on what inspired each study, the basic approach taken, what was learned, and why it matters:

bit.ly/4mGAkpD

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American Journal of Kidney Diseases @ajkd.bsky.social · 8d

Prevalence of the M1 Modifier p.N264K in APOL1 Among Individuals With Kidney Disease Undergoing Commercial Genetic Testing in the United States

bit.ly/48PB2xk (FREE)