American Journal of Kidney Diseases
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American Journal of Kidney Diseases
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AJKD, official journal of @kidney.org, is the leading source of information devoted to clinical nephrology research and practice. AJKD.org | AJKDblog.org | Organizer of #NephMadness @nephmadness.bsky.social
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American Journal of Kidney Diseases @ajkd.bsky.social · 22d
In celebration of #KidneyWk, the entire November issue is FREE to access until November 30, 2025!

Check out the plain-language summaries on what inspired each study, the basic approach taken, what was learned, and why it matters:

bit.ly/3X1XpZj
ajkd.bsky.social
Association of Influenza Vaccination With Acute Kidney Injury: A Prospective Target Trial Emulation Study

bit.ly/43qLk3s #OpenAccess
November 29, 2025 at 11:13 PM
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Quantifying APOL1, Human Leukocyte Antigen, and Other Genetic Contributions to Unexplained Kidney Failure #OpenAccess

bit.ly/4nfGoXe
Breakdown of solved cases by gene category. Breakdown of the solved uKF cases by gene and phenotypic category. All percentages represent a proportion of the total solved cases (n=38). ADTKD, autosomal dominant tubulointerstitial kidney disease; CAKUT, congenital anomalies of the kidneys and urinary tract.
November 29, 2025 at 11:00 PM
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The December 2025 issue is available now! Check out the plain-language summaries on what inspired each study, the basic approach taken, what was learned, and why it matters:

bit.ly/3XUKQPQ
November 29, 2025 at 5:00 PM
ajkd.bsky.social
A 24-year-old female patient with history of epilepsy, depression, and CKD presented to the ED for suicidal ideation and was incidentally found to have a creatinine of 6.24 mg/dL.

How can skin lesions guide the differential diagnosis for the CKD etiology in this patient?

bit.ly/44EZ2jN (FREE)
Raised bumpy skin.
November 29, 2025 at 11:00 AM
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Infectious Tropical Diseases That Acutely Affect the Kidneys: What Physicians and Health Care Workers in Nonendemic Countries Should Know

bit.ly/488LTC0 (FREE)
The geographic distribution of regions endemic for infectious tropical diseases associated with acute kidney injury. (A) Dengue. (B) Yellow fever. (C) Chikungunya. (D) Malaria. (E) Leptospirosis. (F) Scrub typhus.
November 28, 2025 at 11:00 PM
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Corticosteroid, Parathyroid Hormone, and Body Composition Associations With Bone Density and Structure Following Kidney Transplantation

bit.ly/47wHN6h #OpenAccess
November 28, 2025 at 5:00 PM
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Mini-Review by Aleksandra Kukla, Ricardo Cohen, and Allon Friedman:

Metabolic Bariatric Surgery in Kidney Transplant Candidates

bit.ly/3Vzeauk
Suggested weight loss treatment pathways to achieve eligibility for kidney transplantation for patients with advanced kidney disease. aGLP1/GIP RA should be considered in all kidney transplant candidates as either a bridge to MBS, an alternative to MBS, or to enhance the weight loss effect of MBS. bNo rigid upper age limit for bariatric surgery. Frailty, not chronological age, should guide decision making. Abbreviations: BMI, body mass index; eGFR, estimated glomerular filtration rate; GIP, glucose-dependent insulinotropic polypeptide; GLP1 RA, glucagon-like peptide-1 receptor agonist; MBS, metabolic bariatric surgery; T1D, type 1 diabetes; T2D, type 2 diabetes; SPK, simultaneous pancreas and kidney transplant.
November 28, 2025 at 11:00 AM
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Intronic and Coding Genetic Variants in Autosomal Recessive Polycystic Kidney Disease Among Israeli Bedouins of Arabian Peninsula Ancestry

bit.ly/Agam25OI

#ARPKD #VisualAbstract
November 27, 2025 at 11:00 PM
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MINI REVIEW: A Practical Primer on How to Detect and Treat Depression in CKD

bit.ly/4agFzJU (FREE)
Criteria for the diagnosis of a Major Depressive Disorder (MDD). According to the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5), the patient must experience at least 5 of the symptoms depicted over the same 2-week period, and at least one of the symptoms must be either sadness or loss of Interest. Created with BioRender.com.
November 27, 2025 at 5:00 PM
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EDITORIAL: A Novel Founder PKHD1 Disease Causing Variant in Israeli Bedouins With Autosomal Recessive Polycystic Kidney Disease

bit.ly/44ng1He (FREE)
November 26, 2025 at 11:00 PM
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Access to Kidney Transplantation in Adults With Severe Obesity: A Population-Based Retrospective Cohort Study

bit.ly/4pxoRdx (OPEN ACCESS)
Likelihood of graft failure or death at 5 years in transplant cohort using permutations of four characteristics and BMI groups BMI body mass index, DKD diabetic cause of kidney failure, HKD congenital/hereditary or polycystic cause of kidney failure Time to graft failure or death was regressed on age (18-29, 30-49, 50-64, 65-79, ≥80y), cause of kidney failure (diabetic nephropathy, renal vascular disease, glomerulonephritis/autoimmune disease, congenital/hereditary renal disease and polycystic kidney disease, drug induced nephropathy, unknown, and other), smoking at dialysis initiation, the number of comorbidities (0, 1, 2, 3 or more). Risks are presented for 16 selected permutations: age 30-49y vs 65-70y; non-smoker vs smoker at dialysis initiation, congenital/hereditary vs diabetic cause of kidney failure, and 0 vs 3 or more comorbidities) and all five BMI groups.
November 26, 2025 at 5:01 PM
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The December 2025 issue is available now: bit.ly/43SrjDd

Highlights:
- Intronic and Coding Genetic Variants in Autosomal Recessive Polycystic Kidney Disease Among Israeli Bedouins of Arabian Peninsula Ancestry
- Nephrologist Perspectives on Using Telemedicine During In-Center Hemodialysis
November 26, 2025 at 11:00 AM
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EDITORIAL by Pascale Khairallah, Elizabeth Lorenz, and Puneet Sood:

Rethinking Transplant Care Through a Sex- and Gender-Based Lens

bit.ly/433XPly (FREE)
November 25, 2025 at 11:00 PM
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Patient and Caregiver Perspectives on Diet and Nutrition for Children With CKD: A Systematic Review of Qualitative Studies

bit.ly/48cuZAX
November 25, 2025 at 5:02 PM
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In the Literature by Stephanie M. Hu:

Understanding Estimated GFR

bit.ly/3JdrUIH (FREE)
November 25, 2025 at 11:01 AM
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NEW on #AJKDBlog:

AJKDBlog’s Interviews Editor, Timothy Yau chatted with Kristen L. Nowak and Michel Chonchol about the complicated interplay between CKD and systemic inflammation, and new targets/pathways that could improve kidney and cardiovascular outcomes.

bit.ly/4o63tv6 (FREE)
November 24, 2025 at 11:00 PM
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Prevalence of the M1 Modifier p.N264K in APOL1 Among Individuals With Kidney Disease Undergoing Commercial Genetic Testing in the United States

bit.ly/48PB2xk (FREE)
November 24, 2025 at 5:01 PM
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Eculizumab Prophylaxis for Systematic Rechallenging Gemcitabine in Gemcitabine-Induced Thrombotic Microangiopathy: A Case Report

bit.ly/3KjdHtJ
Trends in laboratory parameters and treatment timeline. Abbreviations: GITMA, gemcitabine-induced thrombotic microangiopathy; LDH, lactate dehydrogenase; UPCR, urinary protein-creatinine ratio; Scr, serum creatinine; Plt, platelets; FOLFIRINOX, folinic acid, 5-fluorouracil, irinotecan, and oxaliplatin; FOLFIRI, folinic acid, 5-fluorouracil, and irinotecan.
November 24, 2025 at 11:00 AM
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EDITORIAL: Supportive Care for Patients Receiving Maintenance Hemodialysis: Why Nephrologists Should Care and What They Can Do

bit.ly/49lyt6q (FREE)
November 23, 2025 at 11:00 PM
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#RenalPath: C1q nephropathy w. segmental sclerosis w. increased mesangial matrix, obliteration of capillary lumens, adhesion to Bowman capsule (right half of tuft) Open left portion of glomerulus shows mild to moderate increase in mesangial cellularity

bit.ly/3XadOLx
November 23, 2025 at 5:00 PM
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2025 AJKD Editors' Choice Award winning article: Explaining International Trends in Mortality on Hemodialysis Through Changes in Hemodialysis Practices in the Dialysis Outcomes and Practice Patterns Study (DOPPS)

bit.ly/3T0tz5V

@DOPPStudy @MichelJado1204 @brurobinson1 @ArborResHealth @UMichKidney
November 23, 2025 at 11:00 AM
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Environmental Impacts of Kidney Replacement Therapies: A Comparative Lifecycle Assessment

bit.ly/3KNKibh #OpenAccess
November 22, 2025 at 11:07 PM
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Patient and Center Factors in Home Dialysis Therapy Uptake: Analysis of a UK Renal Registry Cohort and a National Dialysis Center Survey

bit.ly/43qyMcf #OpenAccess
November 22, 2025 at 11:00 PM
ajkd.bsky.social
Impact of the Type of Dialysate Acid Concentrate Container on the Environmental Footprint of Hemodialysis Centers

bit.ly/Cadenas25OI #OpenAccess

#VisualAbstract
November 22, 2025 at 11:00 PM
ajkd.bsky.social
NEW on #AJKDBlog:

AJKDBlog’s Interviews Editor, Timothy Yau chatted with Kristen L. Nowak and Michel Chonchol about the complicated interplay between CKD and systemic inflammation, and new targets/pathways that could improve kidney and cardiovascular outcomes.

bit.ly/4o63tv6 (FREE)
November 22, 2025 at 5:00 PM