Robert Screaton
@roblab.bsky.social
scientist. regeneration. mitochondria. diabetes. cancer. views my own.
Reposted by Robert Screaton
How is #insulin production affected in residual beta cells in type 1 #diabetes? Préfontaine et al show unexpectedly that stressed senescent beta cells continue to produce mature insulin in the context of type 1 diabetes #DiabetesResearch #T1D #Islets link.springer.com/article/10.1... 🔓
Insulin production is sustained during DNA damage-mediated senescence in adult human beta cells - Diabetologia
Aims/hypothesis Residual pancreatic beta cells in type 1 diabetes show reduced insulin production but the mechanisms remain unclear. Beta cells undergo stress responses during type 1 diabetes, includi...
link.springer.com
November 26, 2025 at 12:34 PM
How is #insulin production affected in residual beta cells in type 1 #diabetes? Préfontaine et al show unexpectedly that stressed senescent beta cells continue to produce mature insulin in the context of type 1 diabetes #DiabetesResearch #T1D #Islets link.springer.com/article/10.1... 🔓
Islet Biologists in 🇨🇦 🏆 @cirtn.bsky.social
November 26, 2025 at 3:45 AM
Islet Biologists in 🇨🇦 🏆 @cirtn.bsky.social
Reposted by Robert Screaton
Every machine in a Hospital that diagnoses your body without cutting you open is based on a principle of Physics, discovered by a Physicist who had no interest in Medicine.
If you think the world doesn’t need Basic Science, or that somehow Science has failed you, think again.
#sciencematters
If you think the world doesn’t need Basic Science, or that somehow Science has failed you, think again.
#sciencematters
November 25, 2025 at 1:40 AM
Every machine in a Hospital that diagnoses your body without cutting you open is based on a principle of Physics, discovered by a Physicist who had no interest in Medicine.
If you think the world doesn’t need Basic Science, or that somehow Science has failed you, think again.
#sciencematters
If you think the world doesn’t need Basic Science, or that somehow Science has failed you, think again.
#sciencematters
Reposted by Robert Screaton
Bri2 BRICHOS domain inhibits cytotoxic IAPP amyloid formation and improves beta cell function in stem cell-derived islets under metabolic stress. #T1D #SC-islets #CellTherapy
link.springer.com/article/10.1... 🔓
link.springer.com/article/10.1... 🔓
Bri2 BRICHOS domain inhibits IAPP amyloid formation and improves beta cell function in stem cell-derived islets under metabolic stress - Diabetologia
Aims/hypothesis Accumulation of islet amyloid polypeptide (IAPP) and amyloid formation is associated with beta cell dysfunction and cell death in human islets and may also contribute to graft failure ...
link.springer.com
November 21, 2025 at 12:51 PM
Bri2 BRICHOS domain inhibits cytotoxic IAPP amyloid formation and improves beta cell function in stem cell-derived islets under metabolic stress. #T1D #SC-islets #CellTherapy
link.springer.com/article/10.1... 🔓
link.springer.com/article/10.1... 🔓
Reposted by Robert Screaton
🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)
November 11, 2025 at 12:52 PM
🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)
A future star in 🇨🇦 diabetes research
Today is World Diabetes Day! Each year, we mark the day by highlighting BBDC trainees, who represent the future of diabetes research. This year, we asked why diabetes research matters to them. Mithusha Peragerasingam from the lab of Dr. @roblab.bsky.social shares her reflections below.
November 14, 2025 at 5:27 PM
A future star in 🇨🇦 diabetes research
Reposted by Robert Screaton
Diabetologia supports this year’s #WorldDiabetesDay focus on diabetes and well-being. Well-being is key to people’s lived experiences of diabetes around the world, and we were honoured to explore this through the voices of PLWD in our recent special issue link.springer.com/article/10.1...
Diabetes in four dialects: a global call for equity across lived, loved, learned and laboured experiences - Diabetologia
Diabetologia -
link.springer.com
November 14, 2025 at 9:08 AM
Diabetologia supports this year’s #WorldDiabetesDay focus on diabetes and well-being. Well-being is key to people’s lived experiences of diabetes around the world, and we were honoured to explore this through the voices of PLWD in our recent special issue link.springer.com/article/10.1...
Reposted by Robert Screaton
🎉Very excited to share our new work on senescence and insulin processing now out in @DiabetologiaJnl link.springer.com/article/10.100…
Fantastic effort by my @dream-diabetes.bsky.social trainees, along with @yichunchen.bsky.social @bruceverchere.bsky.social
@cirtn.bsky.social
Fantastic effort by my @dream-diabetes.bsky.social trainees, along with @yichunchen.bsky.social @bruceverchere.bsky.social
@cirtn.bsky.social
https://link.springer.com/article/10.100…
November 14, 2025 at 3:33 AM
🎉Very excited to share our new work on senescence and insulin processing now out in @DiabetologiaJnl link.springer.com/article/10.100…
Fantastic effort by my @dream-diabetes.bsky.social trainees, along with @yichunchen.bsky.social @bruceverchere.bsky.social
@cirtn.bsky.social
Fantastic effort by my @dream-diabetes.bsky.social trainees, along with @yichunchen.bsky.social @bruceverchere.bsky.social
@cirtn.bsky.social
Reposted by Robert Screaton
During the workday, people living with #diabetes may need time for blood sugar checks, insulin and breaks.
Remember:
💬Ask how you can support.
👂Listen to what they need, or do not need, from you.
🙅♀️Blaming and shaming is never helpful.
Learn more🔗bit.ly/4844grn #WorldDiabetesDay
Remember:
💬Ask how you can support.
👂Listen to what they need, or do not need, from you.
🙅♀️Blaming and shaming is never helpful.
Learn more🔗bit.ly/4844grn #WorldDiabetesDay
November 14, 2025 at 10:20 AM
During the workday, people living with #diabetes may need time for blood sugar checks, insulin and breaks.
Remember:
💬Ask how you can support.
👂Listen to what they need, or do not need, from you.
🙅♀️Blaming and shaming is never helpful.
Learn more🔗bit.ly/4844grn #WorldDiabetesDay
Remember:
💬Ask how you can support.
👂Listen to what they need, or do not need, from you.
🙅♀️Blaming and shaming is never helpful.
Learn more🔗bit.ly/4844grn #WorldDiabetesDay
Reposted by Robert Screaton
Happening TODAY! Join us in 500 JBRC for the 7th Annual DREAM Trainee Lectureship, where Dr. Hertzel Gerstein (@mcmasteruniversity.bsky.social) will present on "Type 2 Diabetes Remission: The Quest" from 12 - 1 p.m. Don't miss this! @chrimanitoba.bsky.social @um-radyfhs.bsky.social
November 14, 2025 at 3:14 PM
Happening TODAY! Join us in 500 JBRC for the 7th Annual DREAM Trainee Lectureship, where Dr. Hertzel Gerstein (@mcmasteruniversity.bsky.social) will present on "Type 2 Diabetes Remission: The Quest" from 12 - 1 p.m. Don't miss this! @chrimanitoba.bsky.social @um-radyfhs.bsky.social
Reposted by Robert Screaton
Can we prevent Type 1 Diabetes in Canada? Join the CanScreen T1D Symposium at @diabetescanada.bsky.social's preconference!
📅 Nov 26, 2025 | 🕒 2:45 - 4:15 PM | 📍 Toronto
✅ Screening, prevention, family insights, and how to get involved
🔗 Register: bit.ly/4nyxy79
#Diabetes #Type1Diabetes #Symposium
📅 Nov 26, 2025 | 🕒 2:45 - 4:15 PM | 📍 Toronto
✅ Screening, prevention, family insights, and how to get involved
🔗 Register: bit.ly/4nyxy79
#Diabetes #Type1Diabetes #Symposium
October 31, 2025 at 5:37 PM
Can we prevent Type 1 Diabetes in Canada? Join the CanScreen T1D Symposium at @diabetescanada.bsky.social's preconference!
📅 Nov 26, 2025 | 🕒 2:45 - 4:15 PM | 📍 Toronto
✅ Screening, prevention, family insights, and how to get involved
🔗 Register: bit.ly/4nyxy79
#Diabetes #Type1Diabetes #Symposium
📅 Nov 26, 2025 | 🕒 2:45 - 4:15 PM | 📍 Toronto
✅ Screening, prevention, family insights, and how to get involved
🔗 Register: bit.ly/4nyxy79
#Diabetes #Type1Diabetes #Symposium
Reposted by Robert Screaton
What a gem from @dudinlab.bsky.social @gautamdey.bsky.social @centriolelab.bsky.social in Cell! Expansion microscopy atlas of >200 eukaryotes comparing cytoskeletal architectures revealing structures not seen before. Stunning visualisation! Exactly the kind of transformative cell biology we need.
October 31, 2025 at 5:45 PM
What a gem from @dudinlab.bsky.social @gautamdey.bsky.social @centriolelab.bsky.social in Cell! Expansion microscopy atlas of >200 eukaryotes comparing cytoskeletal architectures revealing structures not seen before. Stunning visualisation! Exactly the kind of transformative cell biology we need.
Reposted by Robert Screaton
Discover MyRoad, a platform supported by CIHR, offering research training & mentorship in #obesity, #diabetes & #cardiometabolic #diseases. New opportunities this fall include cohort training, travel awards & more. 🎓✈️
Learn more: www.myroadplatform.ca/en
Contact: [email protected]
Learn more: www.myroadplatform.ca/en
Contact: [email protected]
September 2, 2025 at 6:46 PM
Discover MyRoad, a platform supported by CIHR, offering research training & mentorship in #obesity, #diabetes & #cardiometabolic #diseases. New opportunities this fall include cohort training, travel awards & more. 🎓✈️
Learn more: www.myroadplatform.ca/en
Contact: [email protected]
Learn more: www.myroadplatform.ca/en
Contact: [email protected]
this is why we put a runner on second
October 28, 2025 at 6:01 AM
this is why we put a runner on second
but the dodgers are better 😛
October 25, 2025 at 5:27 AM
but the dodgers are better 😛
Reposted by Robert Screaton
The Dome is going to collapse.
After Addison Barger hit the first pinch-hit home run in World Series history, Alejandro Kirk just went yard. They’ve scored 9 in the 6th.
It’s 11-2 #BlueJays
After Addison Barger hit the first pinch-hit home run in World Series history, Alejandro Kirk just went yard. They’ve scored 9 in the 6th.
It’s 11-2 #BlueJays
October 25, 2025 at 2:37 AM
The Dome is going to collapse.
After Addison Barger hit the first pinch-hit home run in World Series history, Alejandro Kirk just went yard. They’ve scored 9 in the 6th.
It’s 11-2 #BlueJays
After Addison Barger hit the first pinch-hit home run in World Series history, Alejandro Kirk just went yard. They’ve scored 9 in the 6th.
It’s 11-2 #BlueJays
Reposted by Robert Screaton
Metabolomics study indicates that the microvascular complications neuropathy, nephropathy & retinopathy arise through distinct mechanisms and can occur among individuals who do not yet have a #diabetes diagnosis #DiabetesResearch
Untargeted metabolomics profiling of fasting blood in DPPOS reveals that the microvascular complications neuropathy, nephropathy & retinopathy arise through distinct mechanisms and can occur among individuals who do not yet have a diabetes diagnosis link.springer.com/article/10.1... 🔓
Shared and distinct metabolomics profiles associated with microvascular complications in the Diabetes Prevention Program Outcomes Study - Diabetologia
Aims/hypothesis The aim of this study was to identify shared and distinct metabolite profiles prospectively associated with nephropathy, retinopathy and neuropathy at 15 years’ follow-up among 1947 pa...
link.springer.com
October 20, 2025 at 11:19 AM
Metabolomics study indicates that the microvascular complications neuropathy, nephropathy & retinopathy arise through distinct mechanisms and can occur among individuals who do not yet have a #diabetes diagnosis #DiabetesResearch
Reposted by Robert Screaton
“People with advanced lung or skin cancer who received a COVID-19 mRNA vaccine within 100 days of beginning immunotherapy lived considerably longer than those who did not… .”
www.sciencedaily.com/releases/202...
www.sciencedaily.com/releases/202...
Cancer patients who got a COVID vaccine lived much longer
A groundbreaking study reveals that cancer patients who received a COVID-19 mRNA vaccine within 100 days of starting immunotherapy lived dramatically longer than those who didn’t. Researchers from the...
www.sciencedaily.com
October 19, 2025 at 11:26 PM
“People with advanced lung or skin cancer who received a COVID-19 mRNA vaccine within 100 days of beginning immunotherapy lived considerably longer than those who did not… .”
www.sciencedaily.com/releases/202...
www.sciencedaily.com/releases/202...
Reposted by Robert Screaton
New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org.
rdcu.be/eKKz1 🇨🇦
rdcu.be/eKKz1 🇨🇦
October 14, 2025 at 11:50 AM
New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org.
rdcu.be/eKKz1 🇨🇦
rdcu.be/eKKz1 🇨🇦
Reposted by Robert Screaton
Reposted by Robert Screaton
Exciting study from @frisophagy.bsky.social in @chinnery in the Chinnery lab @mrc-mbu.bsky.social. Congratulations to all authors involved in the study! #mitochondria
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations | Science
www.science.org/doi/10.1126/...
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations | Science
www.science.org/doi/10.1126/...
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations
Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...
www.science.org
October 9, 2025 at 9:43 PM
Exciting study from @frisophagy.bsky.social in @chinnery in the Chinnery lab @mrc-mbu.bsky.social. Congratulations to all authors involved in the study! #mitochondria
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations | Science
www.science.org/doi/10.1126/...
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations | Science
www.science.org/doi/10.1126/...
Reposted by Robert Screaton
🚨How do mitochondria sense and respond to metabolic stress from the environment in diabetes? 🤔
In new work out in #ScienceAdvances, we show that innate immune signaling promotes β cell compensation for metabolic stress by engaging mitophagy. 🚨1/n
www.science.org/doi/10.1126/...
In new work out in #ScienceAdvances, we show that innate immune signaling promotes β cell compensation for metabolic stress by engaging mitophagy. 🚨1/n
www.science.org/doi/10.1126/...
TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and Parkin-independent mitophagy
TRAF6 bridges innate immune signaling to mitophagy to promote glucose control during metabolic stress.
www.science.org
October 8, 2025 at 8:28 PM
🚨How do mitochondria sense and respond to metabolic stress from the environment in diabetes? 🤔
In new work out in #ScienceAdvances, we show that innate immune signaling promotes β cell compensation for metabolic stress by engaging mitophagy. 🚨1/n
www.science.org/doi/10.1126/...
In new work out in #ScienceAdvances, we show that innate immune signaling promotes β cell compensation for metabolic stress by engaging mitophagy. 🚨1/n
www.science.org/doi/10.1126/...
front 3 rows half empty for an elimination game, guess they know who's going to win 📝
October 7, 2025 at 11:51 PM
front 3 rows half empty for an elimination game, guess they know who's going to win 📝