CRISPR screen by @mitodynamics.bsky.social & colleagues identifies Mitochondrial anchored protein ligase (MAPL) as a regulator of gasdermin-mediated release of mtDNA from lysosomes, driving pyroptotic cell death; Depletion of MAPL, LRRK2 or VPS35 blocks cell death
www.nature.com/articles/s41...

Thanks Marco! It all came from a genome wide Crispr screen so we were surprised too!

Mitochondrial anchored protein ligase (MAPL) induces pyroptosis through an inflammatory pathway involving mitochondria and lysosomes @natcellbio.nature.com
@mitodynamics.bsky.social @mitocollier.bsky.social @mcgilluniversity.bsky.social
www.nature.com/articles/s41...

New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org.
rdcu.be/eKKz1 🇨🇦

Yes! That’s what I was talking about so I agree 100%!

Also in this Issue:
- Editorial from Ana Garcia-Saez & @mitodynamics.bsky.social
- Interviews with Tom MacVicar, Samantha Lewis & Heidi McBride
- Mitochondria–membrane contacts poster
- Quality control of un-imported mitochondrial proteins poster
- Mitochondrial cholesterol transport Perspective

Thank you to everyone who submitted and reviewed! And to Seema and the editors for making it a seamless experience. Keep sending your work to JCS - it’s a fantastic journal and a science family that cares.

youtube.com/watch?v=V11q...
The election in Canada is so important. Please give this thoughtful interview a listen before you vote. Canada can provide leadership and vision through this tumultuous period if we put Carney the helm.

So happy to see the swell of science activism today! Never forget the power you have. US innovation is second to none - use it now! We may boo your dear leader but we’ve got your back!

Thanks Alex. It is so horrifying to imagine the callous insanity in your White House. I know you all have a lot to deal with but these threats are shaking the foundation for all Canadians, and the world. Stay strong! We shall overcome. We must.

Congratulations Anu! Such an important need for this.

In Melbourne for Aussiemit2024! Grateful for the invitation and excited to catch up with the awesome Aussie science.

www.mcgill.ca/neuro/channe...

My laboratory discovered a mechanism to make Lewy Bodies in dopaminergic neurons. Lewy Bodies are a hallmark of Parkinson's disease. The key? Immune challenge, demonstrating a role for the immune system in Parkinson's

People working on #cancermetabolism, #mitochondrialbiology, #metabolism, please reach out! Share this so I can follow who is here! I will share paper on cancer metabolism, but anything else related to mitochondria and metabolism.

Hello! Just migrating over in search of some good science, cell biology, mitochondria, and all things new and exciting.