PLMcCarthyBuffalo
@plmbuffalo.bsky.social
180 followers
270 following
120 posts
Translational Hematology Oncology Investigator, Roswell Park Comprehensive Cancer Center, Buffalo, NY
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Reposted by PLMcCarthyBuffalo
Reposted by PLMcCarthyBuffalo
Reposted by PLMcCarthyBuffalo
Nature
@nature.com
· 18d
In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma - Nature
In vivo loss-of-function CRISPR screens were performed to identify genes influencing CAR T cell persistence and function in human multiple myeloma, highlighting CDKN1B as a promising target.
go.nature.com
Reposted by PLMcCarthyBuffalo
Reposted by PLMcCarthyBuffalo
PLMcCarthyBuffalo
@plmbuffalo.bsky.social
· Sep 16
Oxidative-stress-induced telomere instability drives T cell dysfunction in cancer
The functional state of tumor-infiltrating lymphocytes is a critical determinant of
antitumor immunity and response to immunotherapy. Rivadeneira et al. demonstrate that
mitochondrial ROS accumulation...
www.cell.com
Reposted by PLMcCarthyBuffalo
Reposted by PLMcCarthyBuffalo
PLMcCarthyBuffalo
@plmbuffalo.bsky.social
· Sep 10
Scientists reprogram cancer-protecting regulatory T cells to fight tumors
Indiana University School of Medicine scientists have developed a new method that shifts the behavior of immunosuppressive cells in tumors, turning them from cancer protectors into tumor fighters.
medicalxpress.com