Ron Orbach
@orbachron.bsky.social
Group Leader at the Azrieli Faculty of Medicine, Bar-Ilan University. Enthusiast of cilia, microtubules, motor proteins, and more.
https://www.orbachlab.com/
https://www.orbachlab.com/
Reposted by Ron Orbach
Miao Gui and @orbachron.bsky.social summarise current structural and functional insights into conserved and lineage-specific MIPs, their roles in shaping ciliary architecture, and the consequences of their disruption on ciliary motility.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
November 7, 2025 at 3:02 PM
Miao Gui and @orbachron.bsky.social summarise current structural and functional insights into conserved and lineage-specific MIPs, their roles in shaping ciliary architecture, and the consequences of their disruption on ciliary motility.
#JCSciliaSI
journals.biologists.com/jcs/article/...
#JCSciliaSI
journals.biologists.com/jcs/article/...
Reposted by Ron Orbach
Our special issue on ‘Cilia and Flagella’ is now out! Huge thanks to all (authors + reviewers) who contributed, and to our wonderful Guest Editors (@cilialab.bsky.social + @lottepedersen.bsky.social) for pulling it together.
Happy reading!
#cilia #flagella
journals.biologists.com/jcs/issue/13...
Happy reading!
#cilia #flagella
journals.biologists.com/jcs/issue/13...
Volume 138 Issue 20 | Journal of Cell Science | The Company of Biologists
Journal of Cell Science publishes cutting-edge science encompassing all aspects of cell biology. It is published by The Company of Biologists, a not-for-profit organisation.
journals.biologists.com
November 3, 2025 at 5:32 PM
Our special issue on ‘Cilia and Flagella’ is now out! Huge thanks to all (authors + reviewers) who contributed, and to our wonderful Guest Editors (@cilialab.bsky.social + @lottepedersen.bsky.social) for pulling it together.
Happy reading!
#cilia #flagella
journals.biologists.com/jcs/issue/13...
Happy reading!
#cilia #flagella
journals.biologists.com/jcs/issue/13...
Ever wondered what microtubule inner proteins (MIPs) are and what they actually do? Or perhaps you already know about them, but find it hard to keep track of which ones are conserved across species and how they support ciliary structure and function?
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
Microtubule inner proteins – bridging structure and function in ciliary biology
Summary: Microtubule inner proteins (MIPs) have been brought into focus by the cryo-EM revolution. This Review outlines current knowledge, emerging functions, links to ciliopathies and outstanding que...
journals.biologists.com
November 3, 2025 at 5:19 AM
Ever wondered what microtubule inner proteins (MIPs) are and what they actually do? Or perhaps you already know about them, but find it hard to keep track of which ones are conserved across species and how they support ciliary structure and function?
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
Reposted by Ron Orbach
Congratulations to our ISF 2025–2026 grant recipients from Bar Ilan’s Azrieli Faculty of Medicine in the Galilee: Dr. Liron Rosenkrantz, Prof. David Karasik, and Prof. Chaim Putterman.
July 27, 2025 at 3:42 PM
Congratulations to our ISF 2025–2026 grant recipients from Bar Ilan’s Azrieli Faculty of Medicine in the Galilee: Dr. Liron Rosenkrantz, Prof. David Karasik, and Prof. Chaim Putterman.
Reposted by Ron Orbach
Daniel's paper is now published in @jcellsci.bsky.social, great experience with @reviewcommons.org 😀
Want to know everything tubulin assembly in trypanosome flagella and other microtubules? Here is the link:
journals.biologists.com/jcs/article/...
Want to know everything tubulin assembly in trypanosome flagella and other microtubules? Here is the link:
journals.biologists.com/jcs/article/...
June 12, 2025 at 8:49 AM
Daniel's paper is now published in @jcellsci.bsky.social, great experience with @reviewcommons.org 😀
Want to know everything tubulin assembly in trypanosome flagella and other microtubules? Here is the link:
journals.biologists.com/jcs/article/...
Want to know everything tubulin assembly in trypanosome flagella and other microtubules? Here is the link:
journals.biologists.com/jcs/article/...
Reposted by Ron Orbach
✨Thanks to amazing students @tobiaskletter.bsky.social, postdocs @biswashere.bsky.social & collaborators @vasilyzaburdaev.bsky.social & ALMF @embl.org ✨
👉Cytoplasmic material properties control spindle architecture and scaling 👉 out today @natcellbio.nature.com rdcu.be/eqPr8
👉Cytoplasmic material properties control spindle architecture and scaling 👉 out today @natcellbio.nature.com rdcu.be/eqPr8
Cell state-specific cytoplasmic density controls spindle architecture and scaling
Nature Cell Biology - Kletter et al. show that cell state-specific cytoplasmic density controls spindle architecture and scaling in neural differentiation, suggesting that the physical properties...
rdcu.be
June 13, 2025 at 10:58 AM
✨Thanks to amazing students @tobiaskletter.bsky.social, postdocs @biswashere.bsky.social & collaborators @vasilyzaburdaev.bsky.social & ALMF @embl.org ✨
👉Cytoplasmic material properties control spindle architecture and scaling 👉 out today @natcellbio.nature.com rdcu.be/eqPr8
👉Cytoplasmic material properties control spindle architecture and scaling 👉 out today @natcellbio.nature.com rdcu.be/eqPr8
Reposted by Ron Orbach
📣 Happy to share our review on host-microbiome genomics!
We synthesize the growing field exploring interactions between human genetics and the microbiome, building a roadmap for mapping the dialogue between our genes and microbes
Out now in Nature Reviews Genetics👇
www.nature.com/articles/s41...
We synthesize the growing field exploring interactions between human genetics and the microbiome, building a roadmap for mapping the dialogue between our genes and microbes
Out now in Nature Reviews Genetics👇
www.nature.com/articles/s41...
June 4, 2025 at 11:02 PM
📣 Happy to share our review on host-microbiome genomics!
We synthesize the growing field exploring interactions between human genetics and the microbiome, building a roadmap for mapping the dialogue between our genes and microbes
Out now in Nature Reviews Genetics👇
www.nature.com/articles/s41...
We synthesize the growing field exploring interactions between human genetics and the microbiome, building a roadmap for mapping the dialogue between our genes and microbes
Out now in Nature Reviews Genetics👇
www.nature.com/articles/s41...
Reposted by Ron Orbach
Can we break past the usual limits of #SuperResolution #Microscopy—achieving deep-imaging, high-res, large FOV imaging without the trade-offs?
🧬🔬 YES: with #DNA_PAINT + Spinning Disk Confocal + Optical Photon Reassignment (#SDC-OPR)!
📄 www.nature.com/articles/s41... @natcomms.nature.com!
🧵👇
🧬🔬 YES: with #DNA_PAINT + Spinning Disk Confocal + Optical Photon Reassignment (#SDC-OPR)!
📄 www.nature.com/articles/s41... @natcomms.nature.com!
🧵👇
Super-resolution imaging in whole cells and tissues via DNA-PAINT on a spinning disk confocal with optical photon reassignment - Nature Communications
Zaza and colleagues demonstrate that DNA-PAINT on a spinning disk confocal microscope with optical photon reassignment enables high-resolution imaging across large fields and imaging depths, resolving...
www.nature.com
May 30, 2025 at 3:10 PM
Can we break past the usual limits of #SuperResolution #Microscopy—achieving deep-imaging, high-res, large FOV imaging without the trade-offs?
🧬🔬 YES: with #DNA_PAINT + Spinning Disk Confocal + Optical Photon Reassignment (#SDC-OPR)!
📄 www.nature.com/articles/s41... @natcomms.nature.com!
🧵👇
🧬🔬 YES: with #DNA_PAINT + Spinning Disk Confocal + Optical Photon Reassignment (#SDC-OPR)!
📄 www.nature.com/articles/s41... @natcomms.nature.com!
🧵👇
Reposted by Ron Orbach
Muñoz-Hernández, Xu, et al. @mike-wieczorek.bsky.social @ethz.ch report #cryoEM structures revealing how NEDD1’s C terminus forms an α-helical tetramer that docks onto the γ-TuRC without inducing major conformational changes in the complex during its recruitment to MTOCs rupress.org/jcb/article/...
May 21, 2025 at 4:10 PM
Muñoz-Hernández, Xu, et al. @mike-wieczorek.bsky.social @ethz.ch report #cryoEM structures revealing how NEDD1’s C terminus forms an α-helical tetramer that docks onto the γ-TuRC without inducing major conformational changes in the complex during its recruitment to MTOCs rupress.org/jcb/article/...
What a treat! After far too long, the lab finally took a break for some well-earned fun. We spent the morning biking through Agamon Hula, surrounded by beautiful scenery and nesting birds, and wrapped up with a delicious lunch. Here's to more outings like this in the future! 🚲
May 14, 2025 at 6:00 PM
What a treat! After far too long, the lab finally took a break for some well-earned fun. We spent the morning biking through Agamon Hula, surrounded by beautiful scenery and nesting birds, and wrapped up with a delicious lunch. Here's to more outings like this in the future! 🚲
The Orbach Lab had a great time at the Annual Meeting of the Israel Society for Microscopy at Expo Tel Aviv.
Mohammed presented a poster full of exciting microscopy data and got some great feedback from the community.
Big thanks to the organizers and everyone who stopped by!
Mohammed presented a poster full of exciting microscopy data and got some great feedback from the community.
Big thanks to the organizers and everyone who stopped by!
May 7, 2025 at 7:30 AM
The Orbach Lab had a great time at the Annual Meeting of the Israel Society for Microscopy at Expo Tel Aviv.
Mohammed presented a poster full of exciting microscopy data and got some great feedback from the community.
Big thanks to the organizers and everyone who stopped by!
Mohammed presented a poster full of exciting microscopy data and got some great feedback from the community.
Big thanks to the organizers and everyone who stopped by!
Reposted by Ron Orbach
🚨🚨 Dear friends in North America: I will be taking a 1-year sabbatical at @uwmadisonmmi.bsky.social with the wonderful @markjmandel.bsky.social (bringing the #mucus back to the marine world) from August 2025. If you want to meet up, let me know! Please share
a purple octopus with big eyes is crawling on the ground in the ocean .
ALT: a purple octopus with big eyes is crawling on the ground in the ocean .
media.tenor.com
April 21, 2025 at 6:11 PM
🚨🚨 Dear friends in North America: I will be taking a 1-year sabbatical at @uwmadisonmmi.bsky.social with the wonderful @markjmandel.bsky.social (bringing the #mucus back to the marine world) from August 2025. If you want to meet up, let me know! Please share
It was a real pleasure to present our work at The Biophysics of Motile Cilia – from Structure to Function meeting at the Physikzentrum Bad Honnef. Grateful for the fruitful discussions with both biologists and physicists, and for the opportunity to meet so many inspiring new colleagues.
April 2, 2025 at 4:10 PM
It was a real pleasure to present our work at The Biophysics of Motile Cilia – from Structure to Function meeting at the Physikzentrum Bad Honnef. Grateful for the fruitful discussions with both biologists and physicists, and for the opportunity to meet so many inspiring new colleagues.
Reposted by Ron Orbach
We're on the cover of @science.org this week. Awesome work by @florentwaltz.bsky.social. #CryoET is reaching crazy resolutions inside cells, and this is just the beginning. Fantastic interpretation of the proton motive force by @verenaresch.bsky.social. Always a pleasure making #SciArt with you!🧪🧶🧬🌾
In a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion.
Learn more in this week's issue: scim.ag/3FA3Ygq
Learn more in this week's issue: scim.ag/3FA3Ygq
March 20, 2025 at 10:37 PM
We're on the cover of @science.org this week. Awesome work by @florentwaltz.bsky.social. #CryoET is reaching crazy resolutions inside cells, and this is just the beginning. Fantastic interpretation of the proton motive force by @verenaresch.bsky.social. Always a pleasure making #SciArt with you!🧪🧶🧬🌾
Reposted by Ron Orbach
I am super excited to share our latest work on the structures of doublet microtubules from trypanosomatid parasites, the causative agents of leishmaniasis, Chagas disease, and African sleeping sickness. tinyurl.com/48sh3xn5
Evolutionary adaptations of doublet microtubules in trypanosomatid parasites
The movement and pathogenicity of trypanosomatid species, the causative agents of trypanosomiasis and leishmaniasis, are dependent on a flagellum that contains an axoneme of dynein-bound doublet micro...
tinyurl.com
March 13, 2025 at 9:22 PM
I am super excited to share our latest work on the structures of doublet microtubules from trypanosomatid parasites, the causative agents of leishmaniasis, Chagas disease, and African sleeping sickness. tinyurl.com/48sh3xn5
Reposted by Ron Orbach
Lab's first published paper!! 🚨 We introduce Perceived Immunity (PI) - a new construct capturing perceived immune efficacy. Using a novel scale, we show that PI prospectively predicts physical symptoms up to 14 months later, beyond baseline symptoms.
Why is this important? Read on… 🧵
Why is this important? Read on… 🧵
🎉New open access article by Nofar Mizrachi supervised by @lironrozenkrantz.bsky.social, to which I was happy to contribute: bpspsychub.onlinelibrary.wiley.com/doi/10.1111/.... Across 3 studies, we show that people's beliefs about their immune system predicted the course of somatic symptoms over 1 y.
<em>British Journal of Health Psychology</em> | Wiley Online Library
Objective
While ample research links health beliefs to physical health in both healthy and clinical populations, the specific health beliefs that drive this effect remain underexplored. Addressing t.....
bpspsychub.onlinelibrary.wiley.com
December 18, 2024 at 8:47 PM
Lab's first published paper!! 🚨 We introduce Perceived Immunity (PI) - a new construct capturing perceived immune efficacy. Using a novel scale, we show that PI prospectively predicts physical symptoms up to 14 months later, beyond baseline symptoms.
Why is this important? Read on… 🧵
Why is this important? Read on… 🧵
Reposted by Ron Orbach
The world is full of crazy and sad news, but here is a protein that localizes to only one of the two flagella
February 1, 2025 at 9:39 AM
The world is full of crazy and sad news, but here is a protein that localizes to only one of the two flagella
Reposted by Ron Orbach
Dr. Moran Yadid is leading a groundbreaking international consortium with experts from Finland & Germany to develop an innovative personally tailored approach for treating heart muscle enlargement caused by a genetic mutation. The consortium operates under grant from the European Union.
February 2, 2025 at 8:15 AM
Dr. Moran Yadid is leading a groundbreaking international consortium with experts from Finland & Germany to develop an innovative personally tailored approach for treating heart muscle enlargement caused by a genetic mutation. The consortium operates under grant from the European Union.
Reposted by Ron Orbach
How Do We Teach Doctors to Teach? We concluded a new & unique year-long course in medical education aimed to develop the teaching methods of clinical faculty. The course focused on teaching and assessment, emphasizing active learning, integrating theoretical knowledge, and working in small groups
January 21, 2025 at 10:14 AM
How Do We Teach Doctors to Teach? We concluded a new & unique year-long course in medical education aimed to develop the teaching methods of clinical faculty. The course focused on teaching and assessment, emphasizing active learning, integrating theoretical knowledge, and working in small groups
Reposted by Ron Orbach
Introducing the Tzafon Data and Bio-Bank - Israel’s first-ever bio-bank integrating biological samples and bacteria! this transformative bio-bank fueling both research and industry, is a collaboration with Tzafon Medical Center,To be led by Prof. Avi Peretz, Dr. Hagar Tadmor, and Dr. Maya Azrad.
January 29, 2025 at 9:18 AM
Introducing the Tzafon Data and Bio-Bank - Israel’s first-ever bio-bank integrating biological samples and bacteria! this transformative bio-bank fueling both research and industry, is a collaboration with Tzafon Medical Center,To be led by Prof. Avi Peretz, Dr. Hagar Tadmor, and Dr. Maya Azrad.
Reposted by Ron Orbach
1/3 Our paper about miRNA target complementarity in Cnidaria is finally published in @emboreports.bsky.social This work was led by the talented Yael Admoni with help from Arie and Rubi in collaboration with the labs of @thecocodium.bsky.social and Michal Rabani
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
miRNA-target complementarity in cnidarians resembles its counterpart in plants | EMBO reports
imageimagemiRNAs in plants and cnidarian animals operate similarly by binding their targets
with nearly-full complementarity, in contrast to miRNAs in bilaterian animals that
bind via a short seed-mat...
www.embopress.org
January 3, 2025 at 8:02 AM
1/3 Our paper about miRNA target complementarity in Cnidaria is finally published in @emboreports.bsky.social This work was led by the talented Yael Admoni with help from Arie and Rubi in collaboration with the labs of @thecocodium.bsky.social and Michal Rabani
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Ron Orbach
Dr. Sivan Spitzer has achieved an extraordinary achievement: securing Bar-Ilan University's first-ever prestigious €22M EU-IHI grant from the European Union. The grant is for developing an innovative platform to improve medication adherence among patients with cardio-metabolic conditions
January 13, 2025 at 8:57 AM
Dr. Sivan Spitzer has achieved an extraordinary achievement: securing Bar-Ilan University's first-ever prestigious €22M EU-IHI grant from the European Union. The grant is for developing an innovative platform to improve medication adherence among patients with cardio-metabolic conditions
Reposted by Ron Orbach
Join us for the fantastic annual @cshlnews.bsky.social #Xenopus cell & developmental Biology course.
Deadline for application is Jan 31st.
meetings.cshl.edu/courses.aspx...
Deadline for application is Jan 31st.
meetings.cshl.edu/courses.aspx...
January 22, 2025 at 11:22 AM
Join us for the fantastic annual @cshlnews.bsky.social #Xenopus cell & developmental Biology course.
Deadline for application is Jan 31st.
meetings.cshl.edu/courses.aspx...
Deadline for application is Jan 31st.
meetings.cshl.edu/courses.aspx...