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npariente.bsky.social
Nonia Pariente
@npariente.bsky.social
3.7K followers 2.2K following 470 posts
Editor in Chief of the #NonProfit, #OpenAccess journal @plosbiology.org Former Chief Editor of Nature Microbiology.
#Virologist. #Feminist. #Spaniard in the UK. #Galician. #European always.
Views my own.

https://orcid.org/0000-0002-3666-5683
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npariente.bsky.social
Nonia Pariente @npariente.bsky.social · Nov 22
Hi Bluesky! 👋
Dipping my toes here given the dumpsterfire over at X. I am Editor in Chief of #PLOSBiology, interested in all things #science.
#virologist, passionate about #OpenScience & making #publication process constructive & transparent.
I look forward to rebuilding community here!
Reposted by Nonia Pariente
professor-dave.bsky.social
All men over 50 have the right to a PSA test. It's not a screening program because you have to ask you GP. GO AND ASK! Especially if you are black or had a family member with prostate cancer.
November 28, 2025 at 5:07 PM
npariente.bsky.social
I'm excited about our recent mini-collection on #interoception!

Our Editorial highlights four pieces showcasing the breadth of the field: hepatic, gut and cardiorespiratory interoception & an exploration of how this could all inform “Whole Person Health”
#neurosky 🧪 🧵 ⬇️
plos.io/4r2SRzL
Artistic rendering of a brain in communication with different organs - generated using ChatGPT with scientific input from Wen G Chen and Helene M Langevin
November 28, 2025 at 5:21 PM
Reposted by Nonia Pariente
plosbiology.org
A day in the life of a brain. This study develops a pipeline to infer molecular properties of c-FOS-labelled active #neurons and analyze the networks they form. The authors use this pipeline to characterize #brain activity over the course of a day @plosbiology.org 🧪 plos.io/3JZa0to
Top: Visualizations of neurons in major brain regions for each time window (2 brains for each time point). Bottom: Visualization of different brain regions, which are colored based on their centrality at different time windows (left to right: ZT0-4, ZT8-12, ZT12-16, ZT20-24) and from different views (top: horizontal, bottom: coronal).
November 17, 2025 at 8:55 AM
Reposted by Nonia Pariente
gweissbart.bsky.social
Why are leaf cells of so many different sizes?
Our paper explores how giant cells form!
We also provide automatic cell-type classification and perform statistical quantification of cell spatial organization.
If interested, check it out in @plosbiology.org. Thanks Pau and @roederlab.bsky.social
November 17, 2025 at 9:33 AM
Reposted by Nonia Pariente
jarome.bsky.social
Why did I only just find out that that there are water striders that live IN (ON!!) THE OPEN OCEAN? 🧪

OCEAN STRIDERS!!
Why did only one genus of insects, Halobates, take to the high seas?
Oceans cover over 70% of the earth’s surface and house a dizzying array of organisms, including five species of the peppercorn-sized ocean-skater Halobates, which live exclusively at the ocean surface...
journals.plos.org
November 19, 2025 at 12:24 PM
Reposted by Nonia Pariente
ellinoralseth.bsky.social
Very happy to see this piece out in @plosbiology.org, on the bacterial immune systems and microbial communities. It was a great team effort with Rafael Custodio, @brockhurstlab.bsky.social , @brownlab.bsky.social, and Edze Westra! 🦠🧫 #phagesky #mevosky

journals.plos.org/plosbiology/...
Bacterial immune systems as causes and consequences of microbiome structure
Bacterial immune systems have evolved in response to diverse molecular "parasites", yet their ecological roles remain poorly understood. This Essay explores how interactions between mobile genetic ele...
journals.plos.org
November 19, 2025 at 6:35 PM
Reposted by Nonia Pariente
stuwest.bsky.social
Amazing leaf camouflage experiments paired up with phylogeny showing how they got there. journals.plos.org/plosbiology/... @benitoexplains.bsky.social
November 13, 2025 at 4:56 PM
npariente.bsky.social
While you are recovering from #SfN25, you may want to take a look at our collection of articles on #neurotechnology

Good post-turkey reading!

#neurosky 🧪
November 28, 2025 at 5:09 PM
Reposted by Nonia Pariente
peterhotezmdphd.bsky.social
journals.plos.org/plosbiology/...
Lysenko
November 20, 2025 at 3:35 AM
Reposted by Nonia Pariente
tatsuya-amano.bsky.social
How English-centric metrics distort global scientific productivity - a nice coverage of our recent paper (doi.org/10.1371/jour...) in @plosbiology.org
www.the-scientist.com/how-english-...
#languagebarriers
How English-Centric Metrics Distort Global Scientific Productivity
New research shows how language and income shape who gets credited for scientific output—and why women and non-native English speakers face persistent gaps.
www.the-scientist.com
November 21, 2025 at 6:05 AM
Reposted by Nonia Pariente
sethabramson.bsky.social
Pure, uncut Nazism.
November 28, 2025 at 5:15 AM
npariente.bsky.social
How does the arms race between #bacterial defense systems and mobile genetic elements contribute to #microbiome community structure?

Read below for an insightful exploration of this issue! It will not disappoint
@plosbiology.org 🧪
#bacteria #immune #phage #ecology
November 28, 2025 at 5:02 PM
Reposted by Nonia Pariente
nataliepeluso.com
Such a cool paper!

Participants synchronised blinks with music, with pure rhythmic tones, & this synchronisation was functional - greater blink synching improved detection of subtle differences in pitch - all associated with ↗️ superior longitudinal fasciculus 🤩

journals.plos.org/plosbiology/...
Eye blinks synchronize with musical beats during music listening
Human movements are known to synchronize with rhythmic patterns in music. This study expands our understanding of embodied music perception, by revealing that spontaneous eye blinks also align with mu...
journals.plos.org
November 25, 2025 at 1:20 AM
Reposted by Nonia Pariente
sullivan-lab.bsky.social
🚨NEW paper: Benchmarking Hi-C for virus–host inference
journals.plos.org/plosbiology/...

A clear baseline for anyone mapping virus–host interactions that establishes robust, benchmarked thresholds for Hi-C linkages.

Key results: 👇
Benchmarking with synthetic communities provides a baseline for virus-host inferences from Hi-C proximity linking
Virus discovery has accelerated but linking viruses to hosts remains challenging. This study uses synthetic microbiomes to optimize and benchmark Hi-C for virus-host linkage inference, and applies thi...
journals.plos.org
November 21, 2025 at 7:31 PM
Reposted by Nonia Pariente
plosbiology.org
Sleep supports brain health partly by regulating fluid dynamics to clear waste. @ulvlarsen.bsky.social &co probe the relation between #sleep & fluid movement in the human #brain, finding that #SleepPressure & intensity have distinct effects on brain pulsations @plosbiology.org 🧪 plos.io/3XQWCL6
Sleep pressure and slow-wave-rich NREM sleep exert distinct effects on cerebral vasomotion and on brain pulsations driven by respiratory and cardiac forces. Heightened sleep pressure (following 35 h of wakefulness) promotes vasomotion (yellow box). Slow-wave-rich NREM sleep enhances brain pulsations driven by the respiratory and cardiac cycles—more so in gray and white matter than in the ventricles (red boxes). The respiration- and cardiac-driven brain pulsations also intensify with deeper sleep (N3 > N2) and correlate with EEG delta power, which is a measure of slow-wave activity (light vs. dark red boxes).
November 25, 2025 at 2:07 PM
Reposted by Nonia Pariente
plosbiology.org
#Virus discovery has accelerated but linking viruses to hosts is hard. @sullivan-lab.bsky.social use synthetic #microbiomes to optimize & benchmark #Hi-C for virus-host linkage inference, applying this to existing #soil data to reveal 100s of novel linkages @plosbiology.org 🧪 plos.io/3MlAENO
Comparison of virus-host prediction from Hi-C and in silico tools. Top: Eular plot showing the overlap of viruses with host predictions obtained from the experimental Hi-C linkage approach, or one of two in silico tools (iPHoP and VirMatcher) that use different probabilistic models to aggregate output of various sequence-based features to create host prediction scores. Bottom: Comparison of virus-host predictions across all samples between Hi-C and iPHoP, shown with and without applying a Z-score filter for the Hi-C linkages. Black bars indicate congruent predictions identified from both tools and gray bars indicate non-congruent predictions. Note: Although many viruses had multiple predicted hosts from each tool, only the top-scoring prediction for each virus was considered in this comparison.
November 26, 2025 at 9:05 AM
Reposted by Nonia Pariente
plosbiology.org
#BrainHealth & physical health should be studied together: Multivariate study of #UKBioBank by @sarahgenon.bsky.social &co uncovers links between #cardiometabolic health, physical robustness, #brain structure & #neurotransmitter systems @plosbiology.org 🧪 plos.io/48j0UQg
Overview of the analyses. Top panel: Latent dimensions were searched using RCCA, linking cortical thickness and gray matter volume measures (parcel-wise across the whole brain cortex) with a wide set of risk factors for non-communicable diseases. Bottom panel: In order to interpret the latent dimension, the brain loadings were compared with several brain features. Created in BioRender.
November 26, 2025 at 9:08 AM
Reposted by Nonia Pariente
plosbiology.org
Sleep supports brain health partly by regulating fluid dynamics to clear waste. @ulvlarsen.bsky.social &co probe the relation between #sleep & fluid movement in the human #brain, finding that #SleepPressure & intensity have distinct effects on brain pulsations @plosbiology.org 🧪 plos.io/3XQWCL6
Sleep pressure and slow-wave-rich NREM sleep exert distinct effects on cerebral vasomotion and on brain pulsations driven by respiratory and cardiac forces. Heightened sleep pressure (following 35 h of wakefulness) promotes vasomotion (yellow box). Slow-wave-rich NREM sleep enhances brain pulsations driven by the respiratory and cardiac cycles—more so in gray and white matter than in the ventricles (red boxes). The respiration- and cardiac-driven brain pulsations also intensify with deeper sleep (N3 > N2) and correlate with EEG delta power, which is a measure of slow-wave activity (light vs. dark red boxes).
November 26, 2025 at 9:10 AM
Reposted by Nonia Pariente
plosbiology.org
PLK1 is associated with #cancer progression and correlates with patient survival in cutaneous #melanoma. This study uses a mouse model of melanoma to show that PLK1 stabilizes BACH1, which regulates genes involved in cancer metabolism & #metastasis @plosbiology.org 🧪 plos.io/4omT3qW
A working model to illustrate how PLK1 promotes melanoma progression through BACH1. PLK1 could prevent BACH1 from proteasome degradation, resulting in hyper-activation of BACH1. Consequently, the downstream targets of BACH1 were regulated accordingly, thus promoting metabolic reprogramming and metastasis in melanoma. This figure was created with BioRender.com.
November 27, 2025 at 2:07 PM
npariente.bsky.social
Cool paper in @plosbiology.org on the alignment of brain activity when people are sharing a task
plosbiology.org PLOS Biology @plosbiology.org · 1d
How do #brains align during social interaction? @manuelvarlet.bsky.social &co show that interbrain info alignment emerges rapidly & strengthens with practice; distinct neural processes support sensory synchrony (early) & shared cognitive representation (late) @plosbiology.org 🧪 plos.io/3KnoweJ
The image represents alignment in the information that is represented in the neural signal of two interacting brains, as measured through Interbrain RSA (Representational Similarity Analysis). Image credit: Denise Moerel & Manuel Varlet
November 28, 2025 at 4:49 PM
Reposted by Nonia Pariente
pilardomingoc.bsky.social
Very proud of @celiaferriolg.bsky.social! Amazing experimental evolution for phage optimization and for host range expansion, allowing us to understand the evolvability of phage RBPs. This work is part of her PhD project at the #EnBivirLab @i2sysbio.es @uv.es @ccbiologiquesuv.bsky.social
plosbiology.org PLOS Biology @plosbiology.org · 8h
Capsule diversity limits #phage host range by affecting receptor-binding protein (RBP) interactions in capsulated #bacteria. @pilardomingoc.bsky.social &co show that generalist phages evolve host range via RBP mutation & recombination, but specialists remain stable @plosbiology.org 🧪 plos.io/48nvOqY
Graphic representation of the recombination events in the Sugarlandvirus I and J variants. Top left: Representation of the variants isolates in the different strains in the three lines. Genome fragments of each parent are represented in a different color. Regions with the most abundant recombination events are marked and associated with a schematic representation of the functional annotation and intergenomic similarity between the two parental phages. Bottom left: 3D folding of the RBPγ. The consensus recombinant region, which is associated with the infection of the K-type 47, is represented in light orange. Variable positions detected in the protein sequence alignment of the variants are represented as hot pink spheres. The table indicates the percentage of identity of the parental protein sequences in three protein regions limited by the amino acids indicated. Right: Transmission electron microscopy (TEM) image of Klebsiella myoviruses artificially coloured, showing their characteristic contractile tails and icosahedral capsids. Image acquired by the Environmental and Biomedical Virology group (Institute for Integrative Systems Biology, Universitat de València-CSIC).
November 28, 2025 at 9:36 AM
Reposted by Nonia Pariente
plosbiology.org
GlcNAc build-up acts as a key metabolic signal in #Streptomyces, but how does it triggers developmental responses? @gillesvanwezel.bsky.social &co show that the enzyme NagS dehydrates GlcNAc-6P into a reactive intermediate, triggering a toxicity-based checkpoint @plosbiology.org 🧪 plos.io/44pE08I
Top: (Top row) Sensitivity of S. coelicolor mutants to GlcNAc. Spores (5 × 105 CFU) of S. coelicolor M145 and its mutant derivatives ∆nagB, SMA11, ∆nagB∆nagS, ∆nagB∆nagSC (∆nagB∆nagS expressing nagS) and ∆nagB∆nagSE (∆nagB∆nagS with empty plasmid pSET152) were streaked on MM agar plates with 1% mannitol (Mann) and 1% mannitol plus 10 mM GlcNAc (GlcNAc). (Bottom row) NagS and its role in GlcNAc sensing. Spores of M145 and ∆nagS were plated on MM and R5 with 0, 0.001, 0.01, 0.1, 1, 5, 10, 20, 50, 100, 150, and 200 mM GlcNAc. Note that nagS mutants hardly respond to GlcNAc. Bottom: Model for the metabolic control of development by GlcNAc and NagS. During late vegetative growth of streptomycetes, the old vegetative or substrate hyphae are degraded in a process of programmed cell death (PCD), to produce the nutrients required to build the aerial mycelium (see mycelial drawings on the right). Mycelial lysis results in breakdown of the cell-wall, leading to the accumulation of GlcNAc-6P, which is a major nutritional signal for the onset of development and antibiotic production. NagS converts GlcNAc-6P into 6P-chromogen I (denoted as X-Ac-6P), which in turn is deacetylated by NagA into a toxic metabolite (denoted as X-6P) that resembles ribose. The toxic metabolite promotes cell lysis, thus releasing more GlcNAc-6P that serves as substrate for NagS and NagA. A salvage pathway then switches off the toxic pathway again. For this, GlcNAc-6P is converted by NagA and NagB into Fructose-6P (Fru-6P), which enters the pentose phosphate pathway (PPP), thereby producing 6-phosphogluconate (6-PG), a metabolic inhibitor of NagS. Thus, production of toxic metabolites ceases and the transition to aerial growth can be initiated. Arrows with round ends represent inhibition, dashed arrow shows proposed activity.
November 28, 2025 at 2:01 PM
npariente.bsky.social
Introduce yourself with 5 animals you’ve seen in the wild:
Octopus
Jellyfish
Grey Crowned Crane
Oyster catcher
Lion
danosher.bsky.social Dan Osher @danosher.bsky.social · 1h
Introduce yourself with 5 animals you’ve seen in the wild:

Armadillos
Humpback whales
Tarantulas
Bald Eagles
Brown bears
napaaqtuk.bsky.social Dr. Kat Napaaqtuk❄️ @napaaqtuk.bsky.social · 1h
Introduce yourself with 5 animals you've seen in the wild:

Caribou
Ravens
Seals
Kea
Turkeys
November 28, 2025 at 4:40 PM
npariente.bsky.social
#VaccinesWork

Graph shows the effect of decreased vaccination (incidence numbers were even lower in prior years)

🧪
neillewisjr.bsky.social Neil Lewis, Jr. @neillewisjr.bsky.social · 2h
The magnitude of the change over time is striking.
www.nbcnews.com/health/healt...
Weekly measles cases in the U.S. CDC data plotted by NBC News
November 28, 2025 at 3:52 PM
Reposted by Nonia Pariente
theatlantic.com
This holiday, give a gift that opens conversations. Right now, you can give a year of unlimited access to The Atlantic—that means daily articles, beautiful magazine issues, audio, games, live events, and more—plus a signature Atlantic tote as a free bonus.* theatln.tc/h13C4AoP
November 28, 2025 at 3:45 PM