Lightnews — Scholar-powered news

Reposted by Estefania Sanchez-Vasquez

Evan Bardot (he/him) @ebardot.bsky.social · 2h

Amazing day at #GastrulationReloaded with thought provoking science and jaw dropping methods.

Also, for no reason at all, re-posting this open Collection: www.nature.com/collections/...

Don’t sweat the deadline, we’ll extend it and I’ll add relevant papers that come to me @natcomms.nature.com

Organizers and self-organization in developmental biology

This collection highlights papers studying self-organization, symmetry breaking, and developmental organizers.

www.nature.com

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Estefania Sanchez-Vasquez @niasv.bsky.social · 12h

Muito obrigada!

Reposted by Estefania Sanchez-Vasquez

Stowers Institute @stowersinstitute.bsky.social · 1d

For 25 years, our scientific images have represented more than data. They’re a window into discovery where curiosity meets the microscope to reveal the mysteries of life. Check out some favorites from the past #Stowers25! 🔬

Learn more about our #research: bit.ly/3W8VqQD

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Reposted by Estefania Sanchez-Vasquez

Beth Cimini 🔬💻📊 @bethcimini.bsky.social · 1d

Big news! Our week-long #bioimageanalysis bootcamp is BACK! Learn how to think about bioimage analysis like the pros do, learn what corrections you should (and shouldn't!) apply to your images, learn open source tools, and more. Apply NOW at broad.io/BAB3 for our January 2026 course!

A flyer for the Bioimage Analysis Beginnings Bootcamp - blue and white with a picture of cells on the top. It says "Learn core bioimage analysis skills using open-source tools for light microscopy. Open to participants at all skill levels." It also says it will be held a the Broad Institute, 415 Main Street, Cambridge MA USA, on Monday to Friday January 12th-16, 2026, from 9-5pm. Registration is $750 academic, $1250 industry, and applications are open at broad.io/BAB3

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Estefania Sanchez-Vasquez @niasv.bsky.social · 1d

VOR!!! HIF1A-mediated pathways promote euploid cell survival in chromosomally mosaic embryos doi.org/10.7554/eLif...

HIF1A-mediated pathways promote euploid cell survival in chromosomally mosaic embryos

Aneuploid mosaic mouse embryos require hypoxia for survival, and understanding these pathways may inform new strategies to support embryo viability.

doi.org

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Reposted by Estefania Sanchez-Vasquez

Development @dev-journal.bsky.social · 2d

Speaking science in a fractured world: making truth land when facts alone cannot

A Perspective by @rebeccacalisi.bsky.social, @kaliceaphd.bsky.social, Jamy Peng, @spiraldoc.bsky.social & @rogerslabucd.bsky.social on how to combat scientific misinformation

journals.biologists.com/dev/article/...

Picture of Perspective title and authors from article PDF

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Reposted by Estefania Sanchez-Vasquez

Mark Peifer (He, him) @peiferlabunc.bsky.social · 3d

I'm very excited to announce that UNC Biology has 6 faculty positions open this year! The first is for an Asst Professor who studies organismal resilience using an integrative approach 1/n
unc.peopleadmin.com/postings/307...

Poster with QR code linking to the position

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Estefania Sanchez-Vasquez @niasv.bsky.social · 4d

This is beautiful ❤️

Reposted by Estefania Sanchez-Vasquez

Luis Cedeño-Rosario, PhD @luisci22.bsky.social · 6d

Are you attending SACNAS NDiSTEM 2025!? Don't miss this awesome session about "How to Identify the Right Mentor for You" hosted by @greisha-ortiz.bsky.social @neuro-explorer-lc.bsky.social @luisci22.bsky.social and @joele-r.bsky.social. #NDiSTEM2025 #SACNAS #STEMResearch #PLI @sacnas.bsky.social 🧪🔬🥼

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Reposted by Estefania Sanchez-Vasquez

Torsten Wittmann @microtubule.bsky.social · 7d

Playing around with how to represent volume in #Snouty light sheet data. Here is a dividing hiPSC with endogenously tagged histone in all three orthogonal projections. Bluer is further away. If anything, it distracts from politics.

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Reposted by Estefania Sanchez-Vasquez

Ricard Solé @ricardsole.bsky.social · 7d

How does life construct itself from within, and how might we learn to emulate its generative logic? Glad to be soon talking and discussing with @philipcball.bsky.social @bertaverd.bsky.social and other great colleagues at this @royalsociety.org event royalsociety.org/science-even...

Generative biology: new approaches to study developmental design principles | Royal Society

Theo Murphy meeting organised by Dr Jake Cornwall-Scoones, Dr Dirk Benzinger, and Professor Sally Lowell.

royalsociety.org

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Reposted by Estefania Sanchez-Vasquez

Rodrigo Fernandez-Gonzalez @rodrigofg.bsky.social · Nov 11

A quick re-intro: we are interested in the mechanisms of collective cell behaviour, particularly cell movement. We use fly embryos, quantitative microscopy, image analysis and computer-based modelling. One of the systems where we study collective cell movement is the wound healing response.

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Reposted by Estefania Sanchez-Vasquez

Miki Ebisuya @ebisuyamiki.bsky.social · 7d

New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains
1/
doi.org/10.1101/2025...

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Reposted by Estefania Sanchez-Vasquez

Shifaan Thowfeequ @shifaant.bsky.social · 7d

The 'sparks' of life! Our latest work on the role of #calcium dynamics in the early #embryo. 🎇🔬🐁

@idrm.ox.ac.uk @oxforddpag.bsky.social @srinivas-lab.bsky.social #lightsheetmicroscopy #GCAMP

PLOS Biology @plosbiology.org · 8d

During #development, distal visceral #endoderm (DVE) cells migrate to shape A-P axis specification. @m-stower.bsky.social @srinivas-lab.bsky.social &co reveal the role of Ca2+ dynamics in this, showing that inhibition of #calcium transients causes DVE arrest @plosbiology.org 🧪 plos.io/4nHWxF4

Epiblast Ca2+ waves propagate from the apical to basal domain. The images show selected time points from movies of E5.5 GCaMP6f embryos imaged using a ZEISS lattice light-sheet 7 microscope. Top row: An example of an epiblast wave involving a large proportion of the tissue captured by imaging a volume of the embryo at 20-s intervals. A total of 9/16 embryos showed at least one epiblast Ca2+ wave. Bottom row: Faster imaging at 5-s interval revealed that the Ca2+ wave in the epiblast can be preceded by a transient in a neighboring VE cell—this was observed in 5/19 events from 9 embryos (white arrowheads).

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Reposted by Estefania Sanchez-Vasquez

Sheila Teves @sheilateves.bsky.social · 8d

How does a “universal” transcription factor evolve to do species-specific jobs?
Our new preprint reveals how divergence in TBP’s domains shapes transcriptional specialization across eukaryotes.

Read it here 👉

www.biorxiv.org/content/10.1...

#MolecularEvolution #Transcription

Molecular determinants underlying functional divergence of TBP homologs

The TATA-box binding protein (TBP) is a highly conserved basal transcription factor and a core component of the pre-initiation complex (PIC) for all three eukaryotic RNA polymerases (RNA Pols). Despit...

www.biorxiv.org

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Reposted by Estefania Sanchez-Vasquez

SEBD @sebioldev.bsky.social · 9d

We are very pleased to announce our joint meeting with the German @gfeev.bsky.social and the Dutch Developmental Biology Societies, which will take place in Potsdam from the 10-13th of March 2026. Registration is now open! www.uni-potsdam.de/en/gfe-meeti...

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Reposted by Estefania Sanchez-Vasquez

Edda Schulz @eddaschulz.bsky.social · 9d

⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial

Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology

Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.

www.nature.com

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Reposted by Estefania Sanchez-Vasquez

Reto Fiolka @retof.bsky.social · 9d

We present multi-immersion Oblique Plane microscope (miOPM), a light-sheet platform that can be adapted to a wide range of applications, from sensitive live cell imaging to imaging organs and cleared tissues.
www.biorxiv.org/content/10.1...

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Reposted by Estefania Sanchez-Vasquez

Hao Yin @haoyin.bsky.social · 9d

#Senescence #Mechanobiology

Matrix #Viscoelasticity ⏬NIH3T3 Fibroblast Senescence (UV)

Polyacrylamide (3 kPa) + linear alginate polymer (for viscosity Loss modulus 0/100/200/300 Pa)
Does UV modify matrix mechanics?🧐

+⏫Integrin (Not FA-enriched)-YAP

#JMaterChemB 2025
pubs.rsc.org/en/content/a...

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Reposted by Estefania Sanchez-Vasquez

Virtual Gastrulation Zoom Talks @vgzt2021.bsky.social · 9d

Dear VGZT enthusiasts,
Do you—or someone in your lab—work on exciting developmental biology research? Showcase it at VGZT, a global online seminar series connecting developmental biologists across all career stages. Apply here: www.tinyurl.com/VGZT-Nomination

VGZT Season 7 - Nomination

Virtual Gastrulation Zoom Talks (VGZT) is an opportunity to share your science with an engaged, international audience of developmental biologists. Running from October 2025 to July 2026, this online ...

www.tinyurl.com

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Reposted by Estefania Sanchez-Vasquez

dave dougan @douganlab.bsky.social · 9d

And now for something completely different in co-translational targeting: Molecular Cell www.cell.com/molecular-ce...

And now for something completely different in co-translational targeting

In two recent papers in Cell, Zhu et al. and Luo et al. use selective ribosome profiling to identify the substrates and timing of co-translational protein targeting to mitochondria. The results sugges...

www.cell.com

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Reposted by Estefania Sanchez-Vasquez

Fillip Port @crisprflydesign.bsky.social · 11d

High levels of Cas9 are toxic in sensory neurons. Reducing Cas9 levels with uORFs avoids toxicity and is compatible with efficient editing. From @thompsonpeerlab.bsky.social. Fly lines @vdrc-flies.bsky.social

#CRISPR #Drosophila

www.biorxiv.org/content/10.1...

Figure from the preprint showing sensory neuron morphology with different levels of Cas9 expression.

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Reposted by Estefania Sanchez-Vasquez

Kevin Terretaz @kwolbachia.bsky.social · 11d

I’m happy to share some plugins I’ve been developping this summer: "Channels and Contrast" and LUTs Manager!
I can’t find new bugs and ideas by now so I need your help to please test them in your machines and report bugs, feedbacks and ideas! forum.image.sc/t/looking-fo...

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Reposted by Estefania Sanchez-Vasquez

Alliance of Genome Resources @alliancegenome.bsky.social · 12d

Nature has published an article on the crisis facing MODs
Model organism databases face budget cuts and closures www.nature.com/articles/d41...
@zfinmod.bsky.social @xenbase.bsky.social @yeastgenome.bsky.social @mousegenome.bsky.social @ratgenome.bsky.social @geneontology.bsky.social @nature.com

Model organism databases face budget cuts and closures

Beyond the crucial data they contain, these digital archives have provided an important space for academic communities to exchange ideas and resources.

www.nature.com

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Estefania Sanchez-Vasquez @niasv.bsky.social · 12d

🥰🥰🥰🥰

feña Palominos @fishfena.bsky.social · 12d

🚨 🚨 Science Alert: Join us by the end of the month at the @sacnas.bsky.social NDiSTEM 2025 Meeting! We’ll be hosting a workshop with Emma Rangel-Huerta from @stowersinstitute.bsky.social and @niasv.bsky.social from @ucscscience.bsky.social to talk about navigating a PhD in life sciences 🤩🫶

latinxdb.bsky.social @latinxdb.bsky.social · 13d

🚨LatinxDB organize: “Why didn’t I know this before? What to expect from a PhD or a postdoc in life sciences”

Thanks Estefania Vasquez, M. Fernanda Palominos and Emma Rangel for creating this space and discussion. @niasv.bsky.social @fishfena.bsky.social

Join us at 2025NDiSTEM @sacnas.bsky.social

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