NeuroXess just implanted their 6th participant and so did Neucyber (a Zhongguancun Development Group subsidiary). Decoding speech and cursor control, these two Chinese ECoG BCIs are propelled by the govt's strategic directive to establish BCI dominance by 2030. Read Emily Mullin take on these latest developments in the comments below.

I’m especially excited to share our new preprint on an Ai agent that adds cell-type interpretability to brain-computer interfaces! Preprint: https://lnkd.in/e_sfidPp As a brief overview, we can now record from many neurons at once, but we usually don’t know what kinds of cells they are—so interpretation often stops at “a unit fired.” Also, for the last few months we’ve seen a lot of #aiagents that act as automated tools for scientific discovery, but we wanted to see if we could actually augment science with them. In this work, we introduce BCI-Agent, an AI tool that adds a molecular lens to extracellular recordings. By treating spike waveforms as clues, it infers putative cell types—so we can ask not just what happened, but which kinds of neurons may be involved. We validate with optotagged datasets and by checking anatomical plausibility against a molecular atlas (e.g., Allen). We also show how the same logic could help interpret human #neuropixel recordings, where molecular labeli

In our recent paper (https://lnkd.in/eMBiJxC5) with Profs. L. Kishon-Rabin, G. O'Donoghue and R. Romeo, we retrospectively analyze sales data from all three major cochlear implant companies in 11 countries over a seven-year period, representing the majority of global pediatric cochlear implantations. The data indicate that cochlear implantation in hearing-impaired infants is primarily performed during the second year of life, with no change over the last 7 years. We link the development of the auditory system to the development of motor skills and multimodal representations. We emphasize the significance of active interaction and thus the motor and other sensory systems in the child’s development, arguing for an instrumental role of sensorimotor contingencies in establishing an appropriate neural representation of the physical world. Based on a review of 200 articles, we summarize the milestones of auditory and communication development and advocate for providing access to sound in p

Excited to share that our work is now published in Nature! https://lnkd.in/gctwetV2 We’ve developed high-density, soft bioelectronic fibers for multimodal sensing and stimulation, using a unique thin-film rolling process. This breakthrough allows us now to integrate hundreds/thousands of sensors and electronic components on tiny fibers as thin as a human hair. These fibers can be used by clinicians and doctors as tiny implants to precisely read and send signals from deep within the human body in a minimally invasive and tissue compatible way. This represents a significant step forward in accessing internal physiological information in areas like the brain and the GI tract, bringing innovations to fields from electroceuticals and brain-computer interfaces to advanced medical interventions and postoperative monitoring. While we focused on biomedical, and clinical applications, these fibers have potential for many other areas like wearables, e-textiles, and soft robotics. I am incred

(YouTube, Chinese w/o captions but graphical English subtitles) Blind patient treated with ZM-02 optogenetic gene therapy https://lnkd.in/e7mRsE_B via Zhongmou Therapeutics; #RP #blindness #optogenetics | 14 comments on LinkedIn

We’re proud to share that Nature Biomedical Engineering has published our foundational scientific report, providing an overview of Precision Neuroscience's system design and capabilities, results from preclinical animal experiments, and our first-in-human data from 2023. This is the first high-bandwidth brain–computer interface achieved without open surgery, pointing the way toward a safer, more scalable path forward for brain–computer interfaces. Many thanks to our clinical collaborators, including Dr Peter Konrad, Kate Gelman, and the WVU Rockefeller Neuroscience Institute. Read the full study below. Springer Nature #Neurotech #PrecisionNeuroscience #MedicalDevices #BCI https://lnkd.in/eNdzfg79

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Neuralink captures Wall Street's eye, sparks debate over brain interfaces and future "neuro elite" https://thedebrief.org/neuralink-captures-wall-streets-eye-sparks-debate-over-brain-interfaces-and-future-neuro-elite/ by @chrissynewton.bsky.social ; this reads much like a #Neuralink infomercial; #BCI #NeuroTech

Neuralink has moved to validate its controversial brain-implant technology in the scientific arena by submitting its first study for peer review and publication.

A new BCI report from Morgan Stanley describes why BCI is more than a traditional MedTech opportunity. Here is my hot take! First, this is an update to their prior report, where they looked at the healthcare opportunity for BCI and estimated a $400B TAM. In the new report, they look at the platform opportunity for BCI and the relationship with AI based on some new analysis and discussion with some of the BCI founders. Some takeaways: BCI is a platform opportunity: They correctly (in my mind), revise their description of BCI as a platform technology. This is distinct from traditional medical device companies that target a small number of related indications. Instead, BCI companies are creating somewhat general-purpose interfaces that can be used for a variety of applications, which diversifies their market opportunities (and risk) in ways that are very different from single-indication MedTech companies. BCIs stand to gain a lot from AI (and visa versa): I also agree with their t

Using the new SONIC benchmark, the Paradromics Connexus® BCI achieved an information transfer rate of 200+ bits per second (bps) with negligible delay.   But numbers can’t always convey the real-world impact of a high performing #BCI, so we created the animation below.   The animation shows that the Connexus BCI (top left) decodes fluid text at the reading rate of a skilled reader. (See the blog linked in the comments to learn the details).     For comparison, on the top right, we show the typing speed representative of the initial published data transfer rates for other Intracortical BCIs.   In the example on the bottom, we display the text at the approximate rate of Endovascular BCI (based on reported outcomes).   The difference in user experience is immediately apparent. #NeuroTech #BrainComputerInterface #Neuroengineering

E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves. We discovered a new cell barcoding approach exceeding comparable methods by more than 750x. This is the heart of PRISM. We integrated this capability with microscopy and AI image analysis to automatically trace neurons at high resolution and annotate them with molecular features. This is a key advance towards economically viable brain mapping - 95% of costs stem from neuron tracing. It is also an important step towards democratizing neuron tracing for everyday neuroscience. Solving these problems is critical for curing brain disorders, building safer and human-like AI, and even simulating brain function. In our first pilot study, we acquired a unique dataset in mouse hippocampus. Barcodes improved the accuracy of tracing g