Patients with CVID are at increased risk following infection with virus, due to poor B cell function.

The pandemic allowed us to examine how CVID patients reacted to a novel antigen.

Here we characterized B cell function. across multiple immunization events.

www.medrxiv.org/content/10.1...

#LocationLocationLocation! Wang Eisenstein Waizman @yaleschoolofmed.bsky.social &co show @ Science Immunology that physical, chemical, & radiation skin damage induces IL33 activating ILC2 & transferring to distal barrier tissues the capacity to induce antibodies causing #allergic responses!

CAR NK cells are being explored as an off-the-shelf cell-therapy. How and against what are they being tested?

Lasse and Emil from our group did a fantastic deep dive into all clinical trials being conducted using CAR NKs. Check out our review: link.springer.com/article/10.1... #CAR #NK #Immunology

Assessing CAR T cells cytotoxic capacity at the single-cell level can be tricky.

Here we provide a method for encapsulating >500.000 single CAR T cells with single target cells in droplets together with reagents to examine killing using standard flow cytometry:

app.jove.com/t/67657/drop...

A detailed look at fresh samples taken from asteroid Bennu confirms that organic chemistry (and the molecules of life) are everywhere:

Tumours escape the immune system by mutating to decrease their immunogenicity. In this study, now in
@natcomms.bsky.social, we described that immune cells can adapt to IFNg-driven escape, enhancing their fitness and thereby counteracting tumour escape www.nature.com/articles/s41...

Fantastic photo and super cool work. It reminds me of this study from 2012 where the authors compare T cell movement to sharks: www.nature.com/articles/nat... and youtu.be/0uf6vJq8lQY?.... I wonder how this study holds up against all these new fancy ways to track sharks

We’re excited to announce the winning entries of the #RSPPhotoComp 2024! Follow along as we reveal the beautiful winning images of each category. Starting with #Behaviour and overall winner, 'The Hunt from Above' by @albiangela.bsky.social, with the help of drone pilot, @augustpaula.bsky.social.

This is a concerning update about the ongoing status of #H5N1:

"In nature, the occurrence of this single mutation could be an indicator of human pandemic risk"

#IDSky #InfectiousDiseases #EpiSky #Epidemics

www.science.org/doi/10.1126/...

Here are the videos... congrats to the authors seems like a really fun project to be working on. As a paraglider, I would love to see it navigating air space, finding thermals and landing!

New post on some preliminary – but troubling – signals about the direction H5N1 might be taking: kucharski.substack.com/p/h5n1-influ...

The strain on scientific publishing: we set out to characterise the remarkable growth of the scientific literature in the last few years, in spite of declining growth in total scientists. What is going on?

direct.mit.edu/qss/article/...

A 🧵 1/n
#AcademicSky #PhDchat #ScientificPublishing #SciPub

CD20-CD19 tandem CAR R/R DLBCL @niravshahmd #ASH24:
- 69 pts, 27% 3+ LOT, no bridging in 14d between apheresis & infusion
- 91% got fresh product
- ORR 73%, CR 49%
- 1-yr PFS/OS 42%/72%, mDOR 11 mos
- all CRS G1-2, 3 pts G3 ICANS
Reducing V2V & B2V time always good! #lymsm #celltherapy

Since I've been here for a while… here are some useful features on Bluesky that you might not have discovered yet! 🧵

Lady Mary Montagu’s role in promoting smallpox inoculation in Britain under the Hanoverians comes up in this edition from 2006 www.bbc.co.uk/sounds/play/...

Hey peeps, skeeps, skypes, whatever we are - I made a couple lists. Check them out and make suggestions for #celltherapy #genetherapy #immunotherapy must follows

Interesting new paper utilizing NK receptors on T cells as a way to improve therapeutic efficiency against solid tumors: www.cell.com/cell-reports... #CART #immunology