Mari Sepp
@marisepp.bsky.social
Evo-Devo neurobiologist | Associate Prof. at Institute of Genomics, University of Tartu | SFARI Fellow | EMBO Installation Grantee | Cerebellum development: how it evolved and how it goes wrong
Pinned
Mari Sepp
@marisepp.bsky.social
· Mar 16
Wonderful to have the last (major) part of my postdoctoral work preprinted! Huge thanks to @ioansarr.bsky.social and @tyamadat.bsky.social—it's been a blast. Grateful to be part of the inspiring, collaborative and supportive team @kaessmannlab.bsky.social! #Cerebellum rocks! #EvoDevo #GeneRegulation
Reposted by Mari Sepp
In 2018, Tomasz Nowakowski received our Fellows-to-Faculty Award to jumpstart his new lab. We spoke with him about his research and the Fellows-to-Faculty program, which is open for apps: https://www.simonsfoundation.org/fellows-to-faculty-alum-tomasz-nowakowski-studies-human-cortical-development/
Fellows-to-Faculty Alum Tomasz Nowakowski Studies Human Cortical Development
Simons Foundation Fellows-to-Faculty alumnus Tomasz Nowakowski spoke with the foundation about his experiences with the program.
www.simonsfoundation.org
December 11, 2025 at 1:35 PM
In 2018, Tomasz Nowakowski received our Fellows-to-Faculty Award to jumpstart his new lab. We spoke with him about his research and the Fellows-to-Faculty program, which is open for apps: https://www.simonsfoundation.org/fellows-to-faculty-alum-tomasz-nowakowski-studies-human-cortical-development/
Reposted by Mari Sepp
#ERCCogG granted!!! Immensely grateful for this opportunity. Thanks @erc.europa.eu . Many news coming soon. New lab opening and will be posting positions. 🦈🧠🤍 Go sharkies!
The results of the ERC Consolidator Grant call have been announced! 📣
349 researchers have been selected for funding. Congratulations to all! #ERCCogG!
👉 buff.ly/uu62uFV
#FrontierResearch #EUfunded #HorizonEurope
@scienceinnovation.ec.europa.eu
349 researchers have been selected for funding. Congratulations to all! #ERCCogG!
👉 buff.ly/uu62uFV
#FrontierResearch #EUfunded #HorizonEurope
@scienceinnovation.ec.europa.eu
December 9, 2025 at 5:00 PM
#ERCCogG granted!!! Immensely grateful for this opportunity. Thanks @erc.europa.eu . Many news coming soon. New lab opening and will be posting positions. 🦈🧠🤍 Go sharkies!
Reposted by Mari Sepp
We tend to think of neurons as either excitatory or inhibitory, but some neurons chemically inhibit their downstream targets while electrically exciting their neighbors. What is gained by having an inhibitory neuron excite its neighbor?
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
December 8, 2025 at 6:49 PM
We tend to think of neurons as either excitatory or inhibitory, but some neurons chemically inhibit their downstream targets while electrically exciting their neighbors. What is gained by having an inhibitory neuron excite its neighbor?
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Mari Sepp
JASPAR 2026 is out 🎉
The new release massively expands the TF motif collections and adds a dedicated DeepLearning collection of motifs learned from deep learning models.
Database: jaspar.elixir.no
Paper (NAR): doi.org/10.1093/nar/...
🧵1/2
The new release massively expands the TF motif collections and adds a dedicated DeepLearning collection of motifs learned from deep learning models.
Database: jaspar.elixir.no
Paper (NAR): doi.org/10.1093/nar/...
🧵1/2
JASPAR: An open-access database of transcription factor binding profiles
JASPAR is the largest open-access database of curated and non-redundant transcription factor (TF) binding profiles from six different taxonomic groups.
jaspar.elixir.no
December 3, 2025 at 2:43 PM
JASPAR 2026 is out 🎉
The new release massively expands the TF motif collections and adds a dedicated DeepLearning collection of motifs learned from deep learning models.
Database: jaspar.elixir.no
Paper (NAR): doi.org/10.1093/nar/...
🧵1/2
The new release massively expands the TF motif collections and adds a dedicated DeepLearning collection of motifs learned from deep learning models.
Database: jaspar.elixir.no
Paper (NAR): doi.org/10.1093/nar/...
🧵1/2
Reposted by Mari Sepp
Claudia Feng's Ph.D work is now out, co-led with @brittavelten.bsky.social and @steglelab.bsky.social . Large-scale CRISPRi perturbations in genetically heterogenous iPSC lines, with single cell readout - enjoy :)
Happy to see this out now in Cell Genomics: A genome-scale single-cell CRISPRi map of trans gene regulation across human pluripotent stem cell lines: www.cell.com/cell-genomic...
A genome-scale single-cell CRISPRi map of trans gene regulation across human pluripotent stem cell lines
Feng et al. present the first genome-scale CRISPR interference perturbation map with
scRNA-seq readout across many genetic backgrounds in human pluripotent cells, pioneering
population-scale CRISPR pe...
www.cell.com
December 3, 2025 at 11:04 AM
Claudia Feng's Ph.D work is now out, co-led with @brittavelten.bsky.social and @steglelab.bsky.social . Large-scale CRISPRi perturbations in genetically heterogenous iPSC lines, with single cell readout - enjoy :)
Reposted by Mari Sepp
Deadline approaching for participating in the international Stanford Course on Neural Assembloids in spring 2026!
This is an immersive, hands-on course on generating, probing and manipulating stem cell-derived neural #assembloids and #organoids for disease and development modeling.
This is an immersive, hands-on course on generating, probing and manipulating stem cell-derived neural #assembloids and #organoids for disease and development modeling.
December 2, 2025 at 1:09 AM
Deadline approaching for participating in the international Stanford Course on Neural Assembloids in spring 2026!
This is an immersive, hands-on course on generating, probing and manipulating stem cell-derived neural #assembloids and #organoids for disease and development modeling.
This is an immersive, hands-on course on generating, probing and manipulating stem cell-derived neural #assembloids and #organoids for disease and development modeling.
Reposted by Mari Sepp
Reposted by Mari Sepp
We are looking for a postdoc to join our team! If you're interested in translating a cutting edge genomics technology (www.nature.com/articles/s41...) to real-life applications in hematology, this is for you. We offer a unique working environment ON THE BEACH: recruitment.crg.eu/content/jobs...
November 20, 2025 at 9:36 AM
We are looking for a postdoc to join our team! If you're interested in translating a cutting edge genomics technology (www.nature.com/articles/s41...) to real-life applications in hematology, this is for you. We offer a unique working environment ON THE BEACH: recruitment.crg.eu/content/jobs...
Reposted by Mari Sepp
NEW pub in @science.org 🥳
Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?
For over 15 years, #phylogenomic studies have been divided.
We provide new evidence suggesting that...
🔗: www.science.org/doi/10.1126/...
Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?
For over 15 years, #phylogenomic studies have been divided.
We provide new evidence suggesting that...
🔗: www.science.org/doi/10.1126/...
November 13, 2025 at 8:34 PM
NEW pub in @science.org 🥳
Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?
For over 15 years, #phylogenomic studies have been divided.
We provide new evidence suggesting that...
🔗: www.science.org/doi/10.1126/...
Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?
For over 15 years, #phylogenomic studies have been divided.
We provide new evidence suggesting that...
🔗: www.science.org/doi/10.1126/...
Reposted by Mari Sepp
Interested in applying for our Fellows-to-Faculty Award? Watch the recording of our informational webinar for more details on the program: https://www.simonsfoundation.org/grant/fellows-to-faculty-award/#:~:text=Brain%20(SCPAB).-,Informational%20Webinar,-An%20informational%20webinar #science
Fellows-to-Faculty Award
The Fellows-to-Faculty Award is a new iteration of the previously offered Simons Foundation Independence Awards.
www.simonsfoundation.org
November 11, 2025 at 7:56 PM
Interested in applying for our Fellows-to-Faculty Award? Watch the recording of our informational webinar for more details on the program: https://www.simonsfoundation.org/grant/fellows-to-faculty-award/#:~:text=Brain%20(SCPAB).-,Informational%20Webinar,-An%20informational%20webinar #science
Reposted by Mari Sepp
Our intelligence and cognitive abilities are perhaps due to an expansion of our cerebral cortex. But surprisingly, compared to highly intelligent birds, primates have many more neurons in their cerebellum as compared to the cerebral cortex.
doi.org/10.1073/pnas...
doi.org/10.1073/pnas...
November 9, 2025 at 4:55 PM
Our intelligence and cognitive abilities are perhaps due to an expansion of our cerebral cortex. But surprisingly, compared to highly intelligent birds, primates have many more neurons in their cerebellum as compared to the cerebral cortex.
doi.org/10.1073/pnas...
doi.org/10.1073/pnas...
Reposted by Mari Sepp
Share this funding opportunity! We offer the Fellows-to-Faculty program to nurture new talent in the basic sciences and to broaden the community of scientists contributing to Simons Foundation Autism Research Initiative (SFARI) and Simons Collaboration on Plasticity and the Aging Brain (SCPAB).
Applications for our Fellows-to-Faculty Award are now open! This program supports early career scientists in #autism or #neuroscience research by facilitating their transition into tenure-track faculty positions. Apply by 1/14/2026: www.simonsfoundation.org/2025/10/31/a... #science
Applications for Fellows-to-Faculty Awards Now Open
Applications for Fellows-to-Faculty Awards Now Open on Simons Foundation
www.simonsfoundation.org
November 3, 2025 at 7:26 PM
Share this funding opportunity! We offer the Fellows-to-Faculty program to nurture new talent in the basic sciences and to broaden the community of scientists contributing to Simons Foundation Autism Research Initiative (SFARI) and Simons Collaboration on Plasticity and the Aging Brain (SCPAB).
Reposted by Mari Sepp
Stoked to share our latest work entitled: “Large-scale discovery of neural enhancers for cis-regulation therapies”
shorturl.at/H3Qww
This is an enormous team effort that I had the honour of spearheading with Nick Page and Florence Chardon.
Bluetorial below.
shorturl.at/H3Qww
This is an enormous team effort that I had the honour of spearheading with Nick Page and Florence Chardon.
Bluetorial below.
November 5, 2025 at 3:09 PM
Stoked to share our latest work entitled: “Large-scale discovery of neural enhancers for cis-regulation therapies”
shorturl.at/H3Qww
This is an enormous team effort that I had the honour of spearheading with Nick Page and Florence Chardon.
Bluetorial below.
shorturl.at/H3Qww
This is an enormous team effort that I had the honour of spearheading with Nick Page and Florence Chardon.
Bluetorial below.
Reposted by Mari Sepp
🚀 𝗣𝗼𝘀𝘁𝗱𝗼𝗰 𝗢𝗽𝗲𝗻𝗶𝗻𝗴
We’re recruiting an ERC-funded Postdoctoral Researcher to explore how 3D gene regulatory networks evolved during human and primate brain development, using cutting-edge single-cell multiomics, organoid models, and CRISPR screens.
👉 Apply by Nov 30 | www.bonevlab.com/join
We’re recruiting an ERC-funded Postdoctoral Researcher to explore how 3D gene regulatory networks evolved during human and primate brain development, using cutting-edge single-cell multiomics, organoid models, and CRISPR screens.
👉 Apply by Nov 30 | www.bonevlab.com/join
November 5, 2025 at 2:03 PM
🚀 𝗣𝗼𝘀𝘁𝗱𝗼𝗰 𝗢𝗽𝗲𝗻𝗶𝗻𝗴
We’re recruiting an ERC-funded Postdoctoral Researcher to explore how 3D gene regulatory networks evolved during human and primate brain development, using cutting-edge single-cell multiomics, organoid models, and CRISPR screens.
👉 Apply by Nov 30 | www.bonevlab.com/join
We’re recruiting an ERC-funded Postdoctoral Researcher to explore how 3D gene regulatory networks evolved during human and primate brain development, using cutting-edge single-cell multiomics, organoid models, and CRISPR screens.
👉 Apply by Nov 30 | www.bonevlab.com/join
Happy to have contributed to this work on how transposable elements shape the regulatory landscape of cerebellar cells - together with @tyamadat.bsky.social , @ioansarr.bsky.social and @kaessmannlab.bsky.social. Tetsuya's scientific journey is just taking off - definitely one to watch!
So excited to see this out on bioRxiv! Huge thanks to @kaessmannlab.bsky.social and the amazing cerebellum team (@marisepp.bsky.social and @ioansarr.bsky.social) for all the support and insightful discussions that made this work possible!!
Did transposable elements shape brain evolution — and if so, which ones, and in which cell states and lineages? Led by @tyamadat.bsky.social, we explored this question in cerebellum development using sequence-based deep learning models!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 17, 2025 at 7:25 AM
Happy to have contributed to this work on how transposable elements shape the regulatory landscape of cerebellar cells - together with @tyamadat.bsky.social , @ioansarr.bsky.social and @kaessmannlab.bsky.social. Tetsuya's scientific journey is just taking off - definitely one to watch!
Reposted by Mari Sepp
Excited to share the preprint from my main postdoc project! It’s been a long journey—huge thanks to everyone who made it possible, especially @leticiarm1618.bsky.social for being the best collaborator one could ask for, and the amazing @kaessmannlab.bsky.social lab for the invaluable support!
We are thrilled to share our new preprint entitled “The origin and molecular evolution of the mammalian liver cell architecture” www.biorxiv.org/content/10.1...
October 15, 2025 at 1:39 PM
Excited to share the preprint from my main postdoc project! It’s been a long journey—huge thanks to everyone who made it possible, especially @leticiarm1618.bsky.social for being the best collaborator one could ask for, and the amazing @kaessmannlab.bsky.social lab for the invaluable support!
Reposted by Mari Sepp
We are thrilled to share our new preprint entitled “The origin and molecular evolution of the mammalian liver cell architecture” www.biorxiv.org/content/10.1...
October 15, 2025 at 12:51 PM
We are thrilled to share our new preprint entitled “The origin and molecular evolution of the mammalian liver cell architecture” www.biorxiv.org/content/10.1...
Reposted by Mari Sepp
Vertebrate Genome Evolution. Annual Symposium of the @louisjeantetfdn.bsky.social Foundation in Geneva. Free access on site and on line. Great speakers for a super interesting topic. #SvantePaabo #HenrikKaessmann organisers 🙏 See you there! @biology-unige.bsky.social @genevunige.bsky.social
October 3, 2025 at 7:14 AM
Vertebrate Genome Evolution. Annual Symposium of the @louisjeantetfdn.bsky.social Foundation in Geneva. Free access on site and on line. Great speakers for a super interesting topic. #SvantePaabo #HenrikKaessmann organisers 🙏 See you there! @biology-unige.bsky.social @genevunige.bsky.social
Reposted by Mari Sepp
Announcing our 9 new Fellows-to-Faculty Fellows! These awards help senior postdoctoral researchers with fresh perspectives on autism & neuroscience transition to tenure-track faculty positions: https://www.simonsfoundation.org/simons-foundation-announces-recipients-of-2025-fellows-to-faculty-awards/
Simons Foundation Announces Recipients of 2025 Fellows-to-Faculty Awards
The Simons Foundation is pleased to announce the 2025 class of Fellows-to-Faculty Fellows.
www.simonsfoundation.org
September 16, 2025 at 7:26 PM
Announcing our 9 new Fellows-to-Faculty Fellows! These awards help senior postdoctoral researchers with fresh perspectives on autism & neuroscience transition to tenure-track faculty positions: https://www.simonsfoundation.org/simons-foundation-announces-recipients-of-2025-fellows-to-faculty-awards/
Reposted by Mari Sepp
👇 !!!
Register to attend the #LouisJeantetSymposium on vertebrate genome #evolution. Organised by Svante Pääbo and
@kaessmannlab.bsky.social . Free event, full line up of speakers 👉 www.jeantet.ch/en/
📆Tuesday 14 October, 08h15
📍CMU - Auditoire Alex-F. Müller (A250)
@genevunige.bsky.social
@kaessmannlab.bsky.social . Free event, full line up of speakers 👉 www.jeantet.ch/en/
📆Tuesday 14 October, 08h15
📍CMU - Auditoire Alex-F. Müller (A250)
@genevunige.bsky.social
September 11, 2025 at 1:09 PM
👇 !!!
Reposted by Mari Sepp
Huge congrats @klehto.bsky.social on this achievement!! Her work has already enriched the @estbiobank.bsky.social and will continue to do so! 💙🖤🤍
Are adult attention deficit hyperactivity disorder (ADHD) features truly the same as childhood ADHD?
Kelli Letho, a new ERC Starting Grantee at the University of Tartu will dissect the causal mechanisms of adult ADHD features
More 👉 buff.ly/nci5eve
#ERCStG #FontierResearch @klehto.bsky.social
Kelli Letho, a new ERC Starting Grantee at the University of Tartu will dissect the causal mechanisms of adult ADHD features
More 👉 buff.ly/nci5eve
#ERCStG #FontierResearch @klehto.bsky.social
September 4, 2025 at 11:44 AM
Huge congrats @klehto.bsky.social on this achievement!! Her work has already enriched the @estbiobank.bsky.social and will continue to do so! 💙🖤🤍
Reposted by Mari Sepp
🧠 Opportunity for a post-doctoral position on human neurobiology, funded by the @erc.europa.eu!
🧫You want to use human pluripotent stem cell based models to understand the evolution of human cerebellar neurons and disorders, this position is for you!
🔗Apply here: emploi.cnrs.fr/Offres/CDD/U...
🧫You want to use human pluripotent stem cell based models to understand the evolution of human cerebellar neurons and disorders, this position is for you!
🔗Apply here: emploi.cnrs.fr/Offres/CDD/U...
Portail Emploi CNRS - Offre d'emploi - Postdoctoral researcher in human neurobiology (M/F)
emploi.cnrs.fr
July 30, 2025 at 8:26 AM
🧠 Opportunity for a post-doctoral position on human neurobiology, funded by the @erc.europa.eu!
🧫You want to use human pluripotent stem cell based models to understand the evolution of human cerebellar neurons and disorders, this position is for you!
🔗Apply here: emploi.cnrs.fr/Offres/CDD/U...
🧫You want to use human pluripotent stem cell based models to understand the evolution of human cerebellar neurons and disorders, this position is for you!
🔗Apply here: emploi.cnrs.fr/Offres/CDD/U...
Reposted by Mari Sepp
🔬 New preprint out!
Thrilled to share our new preprint, where we uncover the molecular diversity and developmental origins of cerebellar astrocytes using multi-omic approaches.
📄 www.biorxiv.org/content/10.1...
#scRNAseq #astrocytes #neuroscience #glia #cerebellum @biorxiv-neursci.bsky.social
Thrilled to share our new preprint, where we uncover the molecular diversity and developmental origins of cerebellar astrocytes using multi-omic approaches.
📄 www.biorxiv.org/content/10.1...
#scRNAseq #astrocytes #neuroscience #glia #cerebellum @biorxiv-neursci.bsky.social
Just a moment...
Verifying you are human. This may take a few seconds.
https://biorxiv.org/content/10.110…
July 29, 2025 at 7:05 AM
🔬 New preprint out!
Thrilled to share our new preprint, where we uncover the molecular diversity and developmental origins of cerebellar astrocytes using multi-omic approaches.
📄 www.biorxiv.org/content/10.1...
#scRNAseq #astrocytes #neuroscience #glia #cerebellum @biorxiv-neursci.bsky.social
Thrilled to share our new preprint, where we uncover the molecular diversity and developmental origins of cerebellar astrocytes using multi-omic approaches.
📄 www.biorxiv.org/content/10.1...
#scRNAseq #astrocytes #neuroscience #glia #cerebellum @biorxiv-neursci.bsky.social
Reposted by Mari Sepp
The Anne West lab at Duke is hiring a postdoc to work on nuclear cell biology in neurogenesis. Please help me spread the word! Applications to [email protected].
July 27, 2025 at 8:27 PM
The Anne West lab at Duke is hiring a postdoc to work on nuclear cell biology in neurogenesis. Please help me spread the word! Applications to [email protected].
Reposted by Mari Sepp
1
To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!
🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...
To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!
🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...
July 27, 2025 at 5:26 PM
1
To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!
🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...
To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!
🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...