Manal Mehta
@manalmehta.bsky.social
Tweeting in my personal capacity.
Reposted by Manal Mehta
“There are currently four people remaining over there to do the work of 15 people. The danger to the national airspace can’t be understated."
"This is a very real threat to the American flying public.”
EXCLUSIVE ⤵️
"This is a very real threat to the American flying public.”
EXCLUSIVE ⤵️
FAA Employees Say Trump and Musk's Purge Is a 'Threat' to Air Safety
Donald Trump and Elon Musk fired hundreds of Federal Aviation Administration employees. The administration argues it won’t affect air safety.
www.rollingstone.com
February 18, 2025 at 5:08 PM
“There are currently four people remaining over there to do the work of 15 people. The danger to the national airspace can’t be understated."
"This is a very real threat to the American flying public.”
EXCLUSIVE ⤵️
"This is a very real threat to the American flying public.”
EXCLUSIVE ⤵️
Reposted by Manal Mehta
SCOOP w/ @jacobrosenberg.bsky.social for @motherjones.com : A DOGE worker wrote in a recently deleted Substack post that he was radicalized by reading a writer who has denied the Holocaust, boosted 9/11 conspiracy theories, & platformed anti-Black racism.
www.motherjones.com/politics/202...
www.motherjones.com/politics/202...
DOGE worker says he was radicalized by reading writer who denied Holocaust
In a since-deleted Substack post, a member of Elon Musk's team praised an essay by Ron Unz—who has since called the Holocaust potentially a "hoax" and said Trayvon Martin was "a violent young thug."
www.motherjones.com
February 16, 2025 at 8:01 PM
SCOOP w/ @jacobrosenberg.bsky.social for @motherjones.com : A DOGE worker wrote in a recently deleted Substack post that he was radicalized by reading a writer who has denied the Holocaust, boosted 9/11 conspiracy theories, & platformed anti-Black racism.
www.motherjones.com/politics/202...
www.motherjones.com/politics/202...
Reposted by Manal Mehta
must feel weird to get fired for the same reason you were hired
"The deleted profile associated with Elez, who was embedded in the Treasury Department to carry out efficiency measures, advocated repealing the Civil Rights Act and backed a 'eugenic immigration policy'" www.wsj.com/tech/doge-st...
Exclusive | DOGE Staffer Resigns Over Racist Posts
A staffer for Elon Musk’s Department of Government Efficiency whose access to U.S. Treasury payment systems was approved by a federal judge on Thursday has links to a deleted social-media account that...
www.wsj.com
February 6, 2025 at 9:15 PM
must feel weird to get fired for the same reason you were hired
hi @dereklowe.bsky.social: have been thinking about this article a lot & would love a Derek Lowe take on it. Tej Parikh argues that booming post pandemic US economy driven by bloated health expenditure; i.e. spending more for subpar outcomes is a feature, not a bug...
www.ft.com/content/fd8c...
www.ft.com/content/fd8c...
Debunking American exceptionalism
How the US’s colossal economy and stock market conceal its flaws
www.ft.com
January 15, 2025 at 1:42 PM
hi @dereklowe.bsky.social: have been thinking about this article a lot & would love a Derek Lowe take on it. Tej Parikh argues that booming post pandemic US economy driven by bloated health expenditure; i.e. spending more for subpar outcomes is a feature, not a bug...
www.ft.com/content/fd8c...
www.ft.com/content/fd8c...
Hi @dereklowe.bsky.social have you ever written about the polypharmacology of Amantadine? 1961 influenza drug that crosses the BBB & now used for CNS disorders? Limited studies showing same efficacy as methylphenidate for #ADHD without side effect profile.
December 24, 2024 at 2:35 PM
Hi @dereklowe.bsky.social have you ever written about the polypharmacology of Amantadine? 1961 influenza drug that crosses the BBB & now used for CNS disorders? Limited studies showing same efficacy as methylphenidate for #ADHD without side effect profile.
Reposted by Manal Mehta
Why is the Biden administration silent on the richest man in the world doing the bidding of Putin?
WHY IS HE STILL A FEDERAL GOVT CONTRACTOR???
WHY IS HE STILL A FEDERAL GOVT CONTRACTOR???
December 20, 2024 at 2:30 PM
Why is the Biden administration silent on the richest man in the world doing the bidding of Putin?
WHY IS HE STILL A FEDERAL GOVT CONTRACTOR???
WHY IS HE STILL A FEDERAL GOVT CONTRACTOR???
With the sweeping powers that SCOTUS gave POTUS, is Biden really impotent when it comes to curtailing Musk? Something doesn’t add up. Imagine what Trump would do if he were in Biden’s shoes.
December 19, 2024 at 1:00 AM
With the sweeping powers that SCOTUS gave POTUS, is Biden really impotent when it comes to curtailing Musk? Something doesn’t add up. Imagine what Trump would do if he were in Biden’s shoes.
Reposted by Manal Mehta
We cannot let a person who has a nematode in his brain, who was addicted to heroin for 14 years, and who drove his wife to take her own life, who has sexual assault allegations against him, and a fetish with dead animals – to make *any* kind of health decisions for *anyone*.
December 13, 2024 at 2:38 PM
We cannot let a person who has a nematode in his brain, who was addicted to heroin for 14 years, and who drove his wife to take her own life, who has sexual assault allegations against him, and a fetish with dead animals – to make *any* kind of health decisions for *anyone*.
"48 per cent of respondents asked generative AI chatbots such as ChatGPT, Gemini, Copilot and Claude health-focused questions." www.ft.com/content/c41b...
December 11, 2024 at 3:35 PM
"48 per cent of respondents asked generative AI chatbots such as ChatGPT, Gemini, Copilot and Claude health-focused questions." www.ft.com/content/c41b...
Surprising number of references to drug discovery in this article.
@dereklowe.bsky.social Can quantum computing make a big difference in revolutionizing drug discovery?
@dereklowe.bsky.social Can quantum computing make a big difference in revolutionizing drug discovery?
Google said its quantum computer needed less than five minutes to perform a mathematical calculation that one of the world’s most powerful supercomputers could not complete in 10 septillion years, a length of time that exceeds the age of the known universe.
Google Makes New Quantum Computing Breakthrough
Google unveiled an experimental machine capable of tasks that a traditional supercomputer could not master in 10 septillion years. (That’s older than the universe.)
www.nytimes.com
December 10, 2024 at 2:13 AM
Surprising number of references to drug discovery in this article.
@dereklowe.bsky.social Can quantum computing make a big difference in revolutionizing drug discovery?
@dereklowe.bsky.social Can quantum computing make a big difference in revolutionizing drug discovery?
Thank you @timnitgebru.bsky.social I have been wondering this for a long time: how to the tech workers enabling people like Musk feel? Is your view an outlier in Silicon Valley?
I was invited to write my reflection on what I thought was a critical moment in tech last year & what it means for the future of tech. I didn't get into tech to build machines primarily used to kill more people more efficiently or help a few men amass billions.
www.nytimes.com/2024/12/05/s....
www.nytimes.com/2024/12/05/s....
As War Rages, Tech Workers Are Protesting
As Silicon Valley chases military tech and funding, it’s losing sight of what inspires its workers.
www.nytimes.com
December 5, 2024 at 11:43 PM
Thank you @timnitgebru.bsky.social I have been wondering this for a long time: how to the tech workers enabling people like Musk feel? Is your view an outlier in Silicon Valley?
What do you think of Setd1a as a target for Sangamo, @urnov.bsky.social?
“They estimated that a mutation on a single gene, called Setd1a, raised the risk 20-fold.”
www.wsj.com/health/healt...
“They estimated that a mutation on a single gene, called Setd1a, raised the risk 20-fold.”
www.wsj.com/health/healt...
November 27, 2024 at 8:05 PM
What do you think of Setd1a as a target for Sangamo, @urnov.bsky.social?
“They estimated that a mutation on a single gene, called Setd1a, raised the risk 20-fold.”
www.wsj.com/health/healt...
“They estimated that a mutation on a single gene, called Setd1a, raised the risk 20-fold.”
www.wsj.com/health/healt...
Yes, 100%
there are massive, huge, glaring issues with the social media ban for kids but I think people who are Online maybe don't really understand how much normie parents support and want this
November 27, 2024 at 12:10 AM
Yes, 100%
It Trump “fixes” this and saves the system money, Democrats get all the blame for allowing such nonsense to continue. This is common sense.
A costly symptom of our complicated drug reimbursement system: People in the same Medicare drug plan face wildly different prices for the same drug
Medicare Pays Wildly Different Prices for the Same Drug
Middlemen negotiate prescription costs at thousands of different price points, depending on your insurance plan.
www.wsj.com
November 26, 2024 at 1:40 PM
It Trump “fixes” this and saves the system money, Democrats get all the blame for allowing such nonsense to continue. This is common sense.
100!
Its brinjal, everyone must accept this
The reason y'all call zucchini courgette and eggplant aubergine is because of a posh food fad that stole words from French. Eggplant is actually the older English word.
(We use zucchini because it was introduced by Italian immigrants)
(We use zucchini because it was introduced by Italian immigrants)
November 22, 2024 at 12:07 AM
100!
About time…
The International Criminal Court issued arrest warrants on Thursday for Prime Minister Benjamin Netanyahu of Israel and the former Israeli defense minister, Yoav Gallant, for war crimes in Gaza. It also issued a warrant for Hamas’s military chief, Muhammad Deif.
Follow live updates. nyti.ms/40Xlq6T
Follow live updates. nyti.ms/40Xlq6T
November 21, 2024 at 2:16 PM
About time…
I enjoyed @anjahuja.bsky.social's piece in the FT on the implications of RFK Jr. as the face of Science in the Trump administration. Given that RFK's running mate, Nicole Shanahan, was a patent attorney, does anyone have more insight into the highlighted bits below... www.ft.com/content/3226...
November 21, 2024 at 12:07 PM
I enjoyed @anjahuja.bsky.social's piece in the FT on the implications of RFK Jr. as the face of Science in the Trump administration. Given that RFK's running mate, Nicole Shanahan, was a patent attorney, does anyone have more insight into the highlighted bits below... www.ft.com/content/3226...
Interesting (& scary) RFP from DARPA: Looking to fund the development of inhibitors "to counteract the accidental or intentional misuse of gene editing technologies." Seems right up your alley, @urnov.bsky.social sam.gov/opp/d04ec5d6...
November 21, 2024 at 1:50 AM
Interesting (& scary) RFP from DARPA: Looking to fund the development of inhibitors "to counteract the accidental or intentional misuse of gene editing technologies." Seems right up your alley, @urnov.bsky.social sam.gov/opp/d04ec5d6...
If a Nobel laureate has to deal with this, imagine what hurdles minorities and women in science have to overcome.
And big-lab-group-think is a stifling influence. Last month I gave a talk at a local big pharma site and the director/host literally asked me “if [insert three big names of field] haven’t already thought of the idea you presented, how could it possibly be true/important?”
November 20, 2024 at 12:26 PM
If a Nobel laureate has to deal with this, imagine what hurdles minorities and women in science have to overcome.
Like Donald Like Matthew
TUITION REIMBURSEMENT stahhp abcnews.go.com/US/gaetz-10k...
November 20, 2024 at 4:01 AM
Like Donald Like Matthew
Looking forward to Nav 1.7 data! Could be transformative for patients. @dereklowe.bsky.social
It's a superb target and the nonclinical data they published are compelling - as are the Sangamo data (Brian Zeitler I think presented these at least a year ago if not more).
I am glad at least one company is taking this to clinic (and of course I'm emotionally biased here to Sangamo).
I am glad at least one company is taking this to clinic (and of course I'm emotionally biased here to Sangamo).
November 20, 2024 at 2:26 AM
Looking forward to Nav 1.7 data! Could be transformative for patients. @dereklowe.bsky.social
Hi @dereklowe.bsky.social given positive data for Fabry, Prion, and clearance of IND for neuropathic pain ( Nav 1.7), I’d be curious on what you think of slide below on potential targets for other monogenic diseases enabled by Sangamo’s STAC BBB capsid. See thread below.
If Sangamo's novel STAC-BBB Capsid is successful, isn't this one of the most exciting and extraordinary opportunities in genomic medicine? The pipeline is truly limitless. Initial Prion data looks promising - how can that be replicated across other monogenic diseases? cc: @urnov.bsky.social
November 20, 2024 at 1:31 AM
Hi @dereklowe.bsky.social given positive data for Fabry, Prion, and clearance of IND for neuropathic pain ( Nav 1.7), I’d be curious on what you think of slide below on potential targets for other monogenic diseases enabled by Sangamo’s STAC BBB capsid. See thread below.
Reposted by Manal Mehta
Another absolutely massive indication: “FDA has cleared the IND [for] investigational epigenetic regulator for the treatment of intractable pain” Nav 1.7. Big wow if this works & remarkable that it’s wholly owned: investor.sangamo.com/news-release... $SGMO
investor.sangamo.com
November 20, 2024 at 1:24 AM
Another absolutely massive indication: “FDA has cleared the IND [for] investigational epigenetic regulator for the treatment of intractable pain” Nav 1.7. Big wow if this works & remarkable that it’s wholly owned: investor.sangamo.com/news-release... $SGMO