Lee Zamparo
@lzamparo.bsky.social
Interested in ML, comp bio, immunology, and just about anything one hop away from either.
Bullseye
Historian here it’s Hannah Arendt’s death anniversary and she was of course prescient.
December 4, 2025 at 2:56 PM
Bullseye
Today's thought: if Wittgenstein had been alive to see the advent & use of LLMs, he would surely have died of exhaustion induced by continuously yelling at us all.
December 2, 2025 at 8:29 PM
Today's thought: if Wittgenstein had been alive to see the advent & use of LLMs, he would surely have died of exhaustion induced by continuously yelling at us all.
Reposted by Lee Zamparo
Guaranteed funding for five years and a 20% increase in a $39K base stipend if you haul in a fellowship. World class facilities and faculty in metabolism, structural biology, epigenetics, and beyond. Grand Rapids is half the cost of living of California or Boston. Apply by December 1st if interested
October 22, 2025 at 3:55 PM
Guaranteed funding for five years and a 20% increase in a $39K base stipend if you haul in a fellowship. World class facilities and faculty in metabolism, structural biology, epigenetics, and beyond. Grand Rapids is half the cost of living of California or Boston. Apply by December 1st if interested
Reposted by Lee Zamparo
Look around. The case for more, not less, liberal arts education - actual, real education in reading, writing, thinking, arguing, analyzing, & synthesizing by doing the actual hard work for which there is no substitute - is stronger than it’s ever been at any point in human history.
November 30, 2025 at 12:07 AM
Look around. The case for more, not less, liberal arts education - actual, real education in reading, writing, thinking, arguing, analyzing, & synthesizing by doing the actual hard work for which there is no substitute - is stronger than it’s ever been at any point in human history.
Full slush fund. This should not be tolerated in a democracy.
Company given $2M from Skills Development Fund run by Ford family dentist: sources
Company given $2M from Skills Development Fund run by Ford family dentist: sources
The company’s CEO also worked closely with the wife of the minister in charge of the grant program at the time
dlvr.it
November 27, 2025 at 7:25 PM
Full slush fund. This should not be tolerated in a democracy.
If you discuss a "well-known" phenomenon in your paper, it should be a piece of cake to cite some works that support this assertion. A citation-free assertion that something is "well-known" makes me suspicious
November 26, 2025 at 8:50 PM
If you discuss a "well-known" phenomenon in your paper, it should be a piece of cake to cite some works that support this assertion. A citation-free assertion that something is "well-known" makes me suspicious
Highly recommended. If you're looking for a sage voice for independent Canadian journalism with a focus on the environment, look no further
We’ve got a better idea for Black Friday…
Will you swim against the consumer current this week? Our independent journalism is made possible by people like you — and we need to add 400 members to meet our 2025 goal.
Join today and we’ll send you a Narwhal toque!
thenarwhal.ca/black-friday/
Will you swim against the consumer current this week? Our independent journalism is made possible by people like you — and we need to add 400 members to meet our 2025 goal.
Join today and we’ll send you a Narwhal toque!
thenarwhal.ca/black-friday/
November 25, 2025 at 11:18 PM
Highly recommended. If you're looking for a sage voice for independent Canadian journalism with a focus on the environment, look no further
Reposted by Lee Zamparo
we released Olmo 3! lot of exciting stuff but wanna focus on:
🐟Olmo 3 32B Base, the best fully-open base model to-date, near Qwen 2.5 & Gemma 3 on diverse evals
🐠Olmo 3 32B Think, first fully-open reasoning model approaching Qwen 3 levels
🐡12 training datasets corresp to different staged training
🐟Olmo 3 32B Base, the best fully-open base model to-date, near Qwen 2.5 & Gemma 3 on diverse evals
🐠Olmo 3 32B Think, first fully-open reasoning model approaching Qwen 3 levels
🐡12 training datasets corresp to different staged training
November 20, 2025 at 6:20 PM
we released Olmo 3! lot of exciting stuff but wanna focus on:
🐟Olmo 3 32B Base, the best fully-open base model to-date, near Qwen 2.5 & Gemma 3 on diverse evals
🐠Olmo 3 32B Think, first fully-open reasoning model approaching Qwen 3 levels
🐡12 training datasets corresp to different staged training
🐟Olmo 3 32B Base, the best fully-open base model to-date, near Qwen 2.5 & Gemma 3 on diverse evals
🐠Olmo 3 32B Think, first fully-open reasoning model approaching Qwen 3 levels
🐡12 training datasets corresp to different staged training
Reposted by Lee Zamparo
In a new phase 3 trial, people randomly assigned to receive a flu shot made with modified mRNA were 34.5% less likely to be diagnosed with an influenza-like illness than people given a standard flu shot made with inactivated virus.
We need to stop the anti-science attacks against mRNA vaccines!
We need to stop the anti-science attacks against mRNA vaccines!
November 20, 2025 at 1:03 AM
In a new phase 3 trial, people randomly assigned to receive a flu shot made with modified mRNA were 34.5% less likely to be diagnosed with an influenza-like illness than people given a standard flu shot made with inactivated virus.
We need to stop the anti-science attacks against mRNA vaccines!
We need to stop the anti-science attacks against mRNA vaccines!
Reposted by Lee Zamparo
Come do a PhD internship with me!
You have until Dec 1 to apply to the bioml PhD research internship!
This is where you apply to work with me,
@alexijie.bsky.social @avapamini.bsky.social @lcrawford.bsky.social or Kristen Severson!
(new) link and some instructions below
apply.careers.microsoft.com/careers/job/...
This is where you apply to work with me,
@alexijie.bsky.social @avapamini.bsky.social @lcrawford.bsky.social or Kristen Severson!
(new) link and some instructions below
apply.careers.microsoft.com/careers/job/...
Research Intern - Machine Learning for Biology and Healthcare | Microsoft Careers
Research Interns put inquiry and theory into practice. Alongside fellow doctoral candidates and some of the world's best researchers, Research Interns learn, collaborate, and network for life. Researc...
apply.careers.microsoft.com
November 20, 2025 at 3:31 PM
Come do a PhD internship with me!
Reposted by Lee Zamparo
My first @umasschan.bsky.social/@impvienna.bsky.social affiliated paper is up!
tomtom-lite is a re-implementation of tomtom targeting the ML age of genomics. Fast annotations ("what is this motif?") and simple large-scale discovery of motifs.
Check it out!
academic.oup.com/bioinformati...
tomtom-lite is a re-implementation of tomtom targeting the ML age of genomics. Fast annotations ("what is this motif?") and simple large-scale discovery of motifs.
Check it out!
academic.oup.com/bioinformati...
November 20, 2025 at 2:02 PM
My first @umasschan.bsky.social/@impvienna.bsky.social affiliated paper is up!
tomtom-lite is a re-implementation of tomtom targeting the ML age of genomics. Fast annotations ("what is this motif?") and simple large-scale discovery of motifs.
Check it out!
academic.oup.com/bioinformati...
tomtom-lite is a re-implementation of tomtom targeting the ML age of genomics. Fast annotations ("what is this motif?") and simple large-scale discovery of motifs.
Check it out!
academic.oup.com/bioinformati...
Reposted by Lee Zamparo
Creating a caricature of your critics in order to dodge responsibility for the negative consequences of your votes is the real immaturity here. If you don't want to be held accountable for the way your votes affect Toronto, maybe councillor isn't the right job for you.
November 18, 2025 at 1:06 PM
Creating a caricature of your critics in order to dodge responsibility for the negative consequences of your votes is the real immaturity here. If you don't want to be held accountable for the way your votes affect Toronto, maybe councillor isn't the right job for you.
This is as close as I want to get to the trashful profile in the Times. This take is true, not only supported by how many of them have shamefully acquiesced to Trump this past year, but also by who is corruptly profiting in plain sight from it. Much shame to go around.
the story is about how the American elite is rotten to its very marrow, to the extent that half of it was plotting and scheming about how to use Trump to advance their own venal interests before he even won
November 14, 2025 at 8:07 PM
This is as close as I want to get to the trashful profile in the Times. This take is true, not only supported by how many of them have shamefully acquiesced to Trump this past year, but also by who is corruptly profiting in plain sight from it. Much shame to go around.
the aws cli is utter trash, a total disgrace to the fine lineage of shell tools.
November 12, 2025 at 9:59 PM
the aws cli is utter trash, a total disgrace to the fine lineage of shell tools.
Reposted by Lee Zamparo
you should quit social media if you can.
if you can't, you should use apps that give you and old-school reverse chronological feed of posts from people you follow. yes, like bluesky.
www.gelliottmorris.com/p/you-should...
if you can't, you should use apps that give you and old-school reverse chronological feed of posts from people you follow. yes, like bluesky.
www.gelliottmorris.com/p/you-should...
You should quit social media for good
Platforms optimized for engagement warp our politics, erode attention, and harm our wellbeing. Here’s how I minimize time on the (anti‑)social web.
www.gelliottmorris.com
November 12, 2025 at 1:01 PM
you should quit social media if you can.
if you can't, you should use apps that give you and old-school reverse chronological feed of posts from people you follow. yes, like bluesky.
www.gelliottmorris.com/p/you-should...
if you can't, you should use apps that give you and old-school reverse chronological feed of posts from people you follow. yes, like bluesky.
www.gelliottmorris.com/p/you-should...
Reposted by Lee Zamparo
Great piece by Zadie Smith. When the right talks about classics or "Western" culture, these works are only important to the extent that it demonstrates their superiority, they have no interest in art in and of itself beyond that www.theguardian.com/commentisfre...
November 12, 2025 at 2:29 PM
Great piece by Zadie Smith. When the right talks about classics or "Western" culture, these works are only important to the extent that it demonstrates their superiority, they have no interest in art in and of itself beyond that www.theguardian.com/commentisfre...
That warm fuzzy feeling when you rediscover a bug in cpython that's been closed as `not planned` 🤪
November 12, 2025 at 3:28 PM
That warm fuzzy feeling when you rediscover a bug in cpython that's been closed as `not planned` 🤪
Reposted by Lee Zamparo
Are you an early-stage graduate student (2nd or 3rd year) or early-stage postdoc based in the US or Canada, working primarily in Drosophila? Would you like to help improve the experience of all trainees working in Drosophila research? If so, read on.
(Please repost to reach a broad audience.)
(Please repost to reach a broad audience.)
November 12, 2025 at 4:49 AM
Are you an early-stage graduate student (2nd or 3rd year) or early-stage postdoc based in the US or Canada, working primarily in Drosophila? Would you like to help improve the experience of all trainees working in Drosophila research? If so, read on.
(Please repost to reach a broad audience.)
(Please repost to reach a broad audience.)
Reposted by Lee Zamparo
*Urgently* looking for emergency reviewers for the ARR October Interpretability track 🙏🙏
ReSkies much appreciated
ReSkies much appreciated
November 11, 2025 at 10:29 AM
*Urgently* looking for emergency reviewers for the ARR October Interpretability track 🙏🙏
ReSkies much appreciated
ReSkies much appreciated
Reposted by Lee Zamparo
We have recently uploaded our revised manuscript “Evaluating the role of pre-training dataset size and diversity on single-cell foundation model performance”.
TL;DR: More models, more tasks => same results.
TL;DR: More models, more tasks => same results.
November 7, 2025 at 8:07 PM
We have recently uploaded our revised manuscript “Evaluating the role of pre-training dataset size and diversity on single-cell foundation model performance”.
TL;DR: More models, more tasks => same results.
TL;DR: More models, more tasks => same results.
Reposted by Lee Zamparo
How much shit will Ontario continue to eat?
"Despite Ford stating speed cameras are ineffective, regional data shows that since launching its program in February (following a pilot program that had been in place since 2021), average speeds in school zones have decreased by 15 km/h."
Waterloo Region forges ahead with speed cameras despite looming ban
The Region of Waterloo will go ahead with turning on six speed cameras despite Doug Ford’s scathing condemnation
buff.ly
November 6, 2025 at 1:46 PM
How much shit will Ontario continue to eat?
Reposted by Lee Zamparo
The way all of these people convinced themselves that Mamdani is antisemitic is a subject far more worthy of media examination than any of the ‘groupthink on campuses!’ thinkpieces we’ve been subjected to
November 5, 2025 at 8:58 PM
The way all of these people convinced themselves that Mamdani is antisemitic is a subject far more worthy of media examination than any of the ‘groupthink on campuses!’ thinkpieces we’ve been subjected to
First submission as an AE of TMLR. I hope I can do it justice 😁
November 5, 2025 at 5:12 PM
First submission as an AE of TMLR. I hope I can do it justice 😁
Reposted by Lee Zamparo
A study out today in @natgenet.nature.com from Core Investigator Luke Gilbert, Haolong Li, & others identifies PTGES3 as a critical regulator of androgen receptor (AR) protein levels in prostate cancer, revealing a potential new target for tumors that become treatment-resistant.
November 5, 2025 at 4:21 PM
A study out today in @natgenet.nature.com from Core Investigator Luke Gilbert, Haolong Li, & others identifies PTGES3 as a critical regulator of androgen receptor (AR) protein levels in prostate cancer, revealing a potential new target for tumors that become treatment-resistant.
Prosecution rests, defence may rest too? All this loafing around won't bring us to a conclusion
Day 3 of the “no more than 2” day trial of Sandwich Guy. The prosecution intends to rest; the defense hasn’t decided yet. Dispute over jury instructions continues, a few morsels (sorry) to follow.
November 5, 2025 at 4:51 PM
Prosecution rests, defence may rest too? All this loafing around won't bring us to a conclusion