Lars Dietrich
@laahrs.bsky.social
I love bacteria.
Biofilm metabolism & antibiotic tolerance dietrichlab.com
Biological Sciences, Columbia University
(a yawn is a silent scream for coffee)
Biofilm metabolism & antibiotic tolerance dietrichlab.com
Biological Sciences, Columbia University
(a yawn is a silent scream for coffee)
Reposted by Lars Dietrich
Each such discovery is a game changer for our understanding of eukaryote evolution, and this paper is no exception. Meet Solarion, which displays yet again novel types of subcellular structures. Congrats to all authors on a fascinating story. #protistsonsky
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Rare microbial relict sheds light on an ancient eukaryotic supergroup - Nature
The discovery of an unusual protist named Solarion arienae, which has a mitochondrial genome with some intriguing features, provides insight into the early radiation of eukaryotic groups.
www.nature.com
November 21, 2025 at 9:30 AM
Each such discovery is a game changer for our understanding of eukaryote evolution, and this paper is no exception. Meet Solarion, which displays yet again novel types of subcellular structures. Congrats to all authors on a fascinating story. #protistsonsky
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Lars Dietrich
Introducing ** Incendiamoeba **, a eukaryote that can live at temperatures well beyond what we thought possible. 63C!!
Read @hbrappap.bsky.social thread to see what we’ve already started to learn from this amazing organism!
doi.org/10.1101/2025...
#MicroSky #protistsonsky 🧪 #evobio
Read @hbrappap.bsky.social thread to see what we’ve already started to learn from this amazing organism!
doi.org/10.1101/2025...
#MicroSky #protistsonsky 🧪 #evobio
So happy to announce our new preprint, “A geothermal amoeba sets a new upper temperature limit for eukaryotes.” We cultured a novel amoeba from Lassen Volcanic NP (CA, USA) that divides at 63°C (145°F) 🔥 - a new record for euk growth!
#protistsonsky 🧵
#protistsonsky 🧵
November 25, 2025 at 9:03 PM
Introducing ** Incendiamoeba **, a eukaryote that can live at temperatures well beyond what we thought possible. 63C!!
Read @hbrappap.bsky.social thread to see what we’ve already started to learn from this amazing organism!
doi.org/10.1101/2025...
#MicroSky #protistsonsky 🧪 #evobio
Read @hbrappap.bsky.social thread to see what we’ve already started to learn from this amazing organism!
doi.org/10.1101/2025...
#MicroSky #protistsonsky 🧪 #evobio
Reposted by Lars Dietrich
Very happy to share our work on lipopolysaccharide assembly by the Lpt complex, published today in @natcomms.nature.com
Fantastic collaboration with @raffaeleieva.bsky.social l and t @pstansfeld.bsky.social
Congrats to all authors, especially Haoxiang, Axel & Violette
🔗 doi.org/10.1038/s414...
Fantastic collaboration with @raffaeleieva.bsky.social l and t @pstansfeld.bsky.social
Congrats to all authors, especially Haoxiang, Axel & Violette
🔗 doi.org/10.1038/s414...
Structural basis of lipopolysaccharide assembly by the outer membrane translocon holo-complex - Nature Communications
The asymmetric distribution of lipopolysaccharide (LPS) on the surface of the bacterial outer membrane is essential and crucial for antibiotic resistance. Here, authors characterize the LPS translocon...
doi.org
November 24, 2025 at 3:22 PM
Very happy to share our work on lipopolysaccharide assembly by the Lpt complex, published today in @natcomms.nature.com
Fantastic collaboration with @raffaeleieva.bsky.social l and t @pstansfeld.bsky.social
Congrats to all authors, especially Haoxiang, Axel & Violette
🔗 doi.org/10.1038/s414...
Fantastic collaboration with @raffaeleieva.bsky.social l and t @pstansfeld.bsky.social
Congrats to all authors, especially Haoxiang, Axel & Violette
🔗 doi.org/10.1038/s414...
Reposted by Lars Dietrich
New release of the TrackMate single particle tracking plugin for ImageJ by @jytinevez.bsky.social looks amazing! forum.image.sc/t/trackmate-...
Loads of new features, most excitingly to me deep learning segmentation algorithms including Omnipose (for cells), and Spotiflow (for spots) #bioimaging
Loads of new features, most excitingly to me deep learning segmentation algorithms including Omnipose (for cells), and Spotiflow (for spots) #bioimaging
TrackMate v8 - segmentation editor and Python CLI integration
TrackMate v8: 2D Segmentation Editor & Python CLI Integration Hi everyone, I am excited to announce TrackMate v8, a major update introducing key improvements for both end-users and developers. Mai...
forum.image.sc
November 24, 2025 at 2:14 PM
New release of the TrackMate single particle tracking plugin for ImageJ by @jytinevez.bsky.social looks amazing! forum.image.sc/t/trackmate-...
Loads of new features, most excitingly to me deep learning segmentation algorithms including Omnipose (for cells), and Spotiflow (for spots) #bioimaging
Loads of new features, most excitingly to me deep learning segmentation algorithms including Omnipose (for cells), and Spotiflow (for spots) #bioimaging
Reposted by Lars Dietrich
Weird word of the day: "kleptosquamy." The testate amoeba Awerintzewia cyclostoma steals scales from other amoeboid organisms to build its own shell. This one has robbed Quadrulella, Netzelia, various euglyphids, and even an Acanthocystis. Kleptosquamy! #amoebae #ProtistsOnSky #biology #nature
November 21, 2025 at 12:00 AM
Weird word of the day: "kleptosquamy." The testate amoeba Awerintzewia cyclostoma steals scales from other amoeboid organisms to build its own shell. This one has robbed Quadrulella, Netzelia, various euglyphids, and even an Acanthocystis. Kleptosquamy! #amoebae #ProtistsOnSky #biology #nature
Fluorescein-based dyes are not valid reporters of oxidative stress in bacteria, and conclusions based on their use must be reconsidered | PNAS www.pnas.org/doi/10.1073/...
Fluorescein-based dyes are not valid reporters of oxidative stress in bacteria, and conclusions based on their use must be reconsidered | PNAS
Dihydrodichlorofluorescein derivatives have been employed as reporters of intracellular
reactive oxygen species (ROS) in innumerable studies. Their...
www.pnas.org
November 19, 2025 at 12:06 PM
Fluorescein-based dyes are not valid reporters of oxidative stress in bacteria, and conclusions based on their use must be reconsidered | PNAS www.pnas.org/doi/10.1073/...
Reposted by Lars Dietrich
Resolution limits attmepts to deconvolute spatial transcriptomics & estimate cellular composition. This study presents Cell2Spatial, which maps #scRNAseq data to #SpatialTranscriptomics spots, facilitating precise reconstruction of tissue architecture @plosbiology.org 🧪 plos.io/47MhTvl
November 18, 2025 at 1:55 PM
Resolution limits attmepts to deconvolute spatial transcriptomics & estimate cellular composition. This study presents Cell2Spatial, which maps #scRNAseq data to #SpatialTranscriptomics spots, facilitating precise reconstruction of tissue architecture @plosbiology.org 🧪 plos.io/47MhTvl
Reposted by Lars Dietrich
Prashant Singh in the lab of Tina Iverson at Vanderbilt published this image of the bacterial 🦠flagellar motor, a detailed molecular model made possibly by CryoEM 🔬.
The similarity to mechanical motors are strong enough we can use terms like stator, rotor, rod & gearing to describe it.
The similarity to mechanical motors are strong enough we can use terms like stator, rotor, rod & gearing to describe it.
November 17, 2025 at 10:31 PM
Prashant Singh in the lab of Tina Iverson at Vanderbilt published this image of the bacterial 🦠flagellar motor, a detailed molecular model made possibly by CryoEM 🔬.
The similarity to mechanical motors are strong enough we can use terms like stator, rotor, rod & gearing to describe it.
The similarity to mechanical motors are strong enough we can use terms like stator, rotor, rod & gearing to describe it.
Reposted by Lars Dietrich
Happy to share our latest T6SS review:
nature.com/articles/s41...
Thank you, Jan, Danny (@dannyjamesward.bsky.social), Joana (@joanampereira.bsky.social), as well as reviewers and editors @natrevmicro.nature.com!
nature.com/articles/s41...
Thank you, Jan, Danny (@dannyjamesward.bsky.social), Joana (@joanampereira.bsky.social), as well as reviewers and editors @natrevmicro.nature.com!
The type VI secretion system and associated effector proteins - Nature Reviews Microbiology
In this Review, Basler and colleagues examine the type VI secretion system (T6SS), focusing on the diversity of antibacterial T6SS effectors and the evolutionary forces that shape them. They explain h...
nature.com
November 17, 2025 at 10:08 AM
Happy to share our latest T6SS review:
nature.com/articles/s41...
Thank you, Jan, Danny (@dannyjamesward.bsky.social), Joana (@joanampereira.bsky.social), as well as reviewers and editors @natrevmicro.nature.com!
nature.com/articles/s41...
Thank you, Jan, Danny (@dannyjamesward.bsky.social), Joana (@joanampereira.bsky.social), as well as reviewers and editors @natrevmicro.nature.com!
Reposted by Lars Dietrich
In muddy sediments all over the world, tiny bacteria eat and grow by building electrically conducting wires into the muck.
Now, researchers say they have discovered how these miniature electricians, known as cable bacteria, do it. https://scim.ag/4i2s2Yu
Now, researchers say they have discovered how these miniature electricians, known as cable bacteria, do it. https://scim.ag/4i2s2Yu
Metal scaffolds turn bacteria into live wires
Mud-dwelling cable bacteria construct metal organic frameworks to grow
scim.ag
November 17, 2025 at 5:12 PM
In muddy sediments all over the world, tiny bacteria eat and grow by building electrically conducting wires into the muck.
Now, researchers say they have discovered how these miniature electricians, known as cable bacteria, do it. https://scim.ag/4i2s2Yu
Now, researchers say they have discovered how these miniature electricians, known as cable bacteria, do it. https://scim.ag/4i2s2Yu
Reposted by Lars Dietrich
We're just 6 months away from @keystoneSymposia.bsky.social Beyond #Antibiotics : Emerging Strategies Combating #BacterialInfection, May 2026 in Breckenridge! 👉Scholarship and short talk abstract deadlines are Jan 7! 🧐 keysym.us/KSBeyondAntibiotics26 #KSBeyondAntibiotics26
Beyond Antibiotics: Emerging Strategies for Combating Bacterial Infection | Keystone Symposia
Join us at the Keystone Symposia on Beyond Antibiotics: Emerging Strategies for Combating Bacterial Infection, May 2026, in Breckenridge, with field leaders!
keysym.us
November 4, 2025 at 2:47 PM
We're just 6 months away from @keystoneSymposia.bsky.social Beyond #Antibiotics : Emerging Strategies Combating #BacterialInfection, May 2026 in Breckenridge! 👉Scholarship and short talk abstract deadlines are Jan 7! 🧐 keysym.us/KSBeyondAntibiotics26 #KSBeyondAntibiotics26
Reposted by Lars Dietrich
Ray: Just a note to say STC is officially back up and running!! You can view our new home via smallthingsconsidered.blog
November 3, 2025 at 1:10 AM
Ray: Just a note to say STC is officially back up and running!! You can view our new home via smallthingsconsidered.blog
Reposted by Lars Dietrich
“Cellular Olympics” our catalog of freeky ultra fast cellular superhero’s is freely available “Ann Rev of microbiology”
www.annualreviews.org/content/jour...
This is a compilation of world’s fastest single cell organisms - enjoy this buffet of rare delightful protists with mind bending speeds. 🧪
www.annualreviews.org/content/jour...
This is a compilation of world’s fastest single cell organisms - enjoy this buffet of rare delightful protists with mind bending speeds. 🧪
October 24, 2025 at 10:57 AM
“Cellular Olympics” our catalog of freeky ultra fast cellular superhero’s is freely available “Ann Rev of microbiology”
www.annualreviews.org/content/jour...
This is a compilation of world’s fastest single cell organisms - enjoy this buffet of rare delightful protists with mind bending speeds. 🧪
www.annualreviews.org/content/jour...
This is a compilation of world’s fastest single cell organisms - enjoy this buffet of rare delightful protists with mind bending speeds. 🧪
Reposted by Lars Dietrich
Holy moly
Direct single-molecule detection and super-resolution imaging with a low-cost portable smartphone-based microscope www.nature.com/articles/s41... #jcampubs
Direct single-molecule detection and super-resolution imaging with a low-cost portable smartphone-based microscope - Nature Communications
Loretan and colleagues present a low-cost smartphone-based microscope capable of detecting single-molecule fluorescence. This approach opens doors to personalised and widely distributed applications in diagnostics, biosensing, and science education.
www.nature.com
October 8, 2025 at 8:59 PM
Holy moly
Reposted by Lars Dietrich
Job alert ‼️ UChicago Micro is hiring! Open to tenured/tenure track faculty at all levels in any area of microbiology. Come join our amazing and growing department. apply.interfolio.com/174404
October 4, 2025 at 6:44 PM
Job alert ‼️ UChicago Micro is hiring! Open to tenured/tenure track faculty at all levels in any area of microbiology. Come join our amazing and growing department. apply.interfolio.com/174404
Reposted by Lars Dietrich
New in JB: Déraspe, Roy et al. perform a comparative genomics study of the PA7-clade of P. aeruginosa - now recognized as a distinct species, Pseudomonas paraeruginosa. This analysis revealed 2 sub-clades, the lack of T3SS & multiresistance.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
October 3, 2025 at 2:04 PM
New in JB: Déraspe, Roy et al. perform a comparative genomics study of the PA7-clade of P. aeruginosa - now recognized as a distinct species, Pseudomonas paraeruginosa. This analysis revealed 2 sub-clades, the lack of T3SS & multiresistance.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
Reposted by Lars Dietrich
DYK most P. aeruginosa carry filamentous phage(s) that don't need to kill the cell to reproduce?
We 👉🏻@nanamikubota.bsky.social show that these Pf phages can go ROGUE.
"Filamentous cheater phages drive bacterial and phage populations to lower fitness"
🔗 authors.elsevier.com/c/1lt5I3QW8S...
We 👉🏻@nanamikubota.bsky.social show that these Pf phages can go ROGUE.
"Filamentous cheater phages drive bacterial and phage populations to lower fitness"
🔗 authors.elsevier.com/c/1lt5I3QW8S...
October 2, 2025 at 3:55 PM
DYK most P. aeruginosa carry filamentous phage(s) that don't need to kill the cell to reproduce?
We 👉🏻@nanamikubota.bsky.social show that these Pf phages can go ROGUE.
"Filamentous cheater phages drive bacterial and phage populations to lower fitness"
🔗 authors.elsevier.com/c/1lt5I3QW8S...
We 👉🏻@nanamikubota.bsky.social show that these Pf phages can go ROGUE.
"Filamentous cheater phages drive bacterial and phage populations to lower fitness"
🔗 authors.elsevier.com/c/1lt5I3QW8S...
Reposted by Lars Dietrich
Metabolic response of a chemolithoautotrophic archaeon to carbon limitation journals.asm.org/doi/full/10.... #jcampubs
October 2, 2025 at 3:22 PM
Metabolic response of a chemolithoautotrophic archaeon to carbon limitation journals.asm.org/doi/full/10.... #jcampubs
Reposted by Lars Dietrich
View from the lab now. Did I mention that we are recruiting faculty microbiologists?
www.linkedin.com/posts/vaughn...
www.linkedin.com/posts/vaughn...
September 29, 2025 at 2:43 PM
View from the lab now. Did I mention that we are recruiting faculty microbiologists?
www.linkedin.com/posts/vaughn...
www.linkedin.com/posts/vaughn...
Reposted by Lars Dietrich
New in JB: In this minireview, Rotaru, Kotoky et al. explore the Kotoky review the surface biology of Methanosarcina, an archaeon, with respect to their EET strategies, and biogeochemical and industrial roles. Some cool biology!
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
September 30, 2025 at 12:01 PM
New in JB: In this minireview, Rotaru, Kotoky et al. explore the Kotoky review the surface biology of Methanosarcina, an archaeon, with respect to their EET strategies, and biogeochemical and industrial roles. Some cool biology!
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
Reposted by Lars Dietrich
There seems to quite a few new faces lately, so if I haven’t already added you, but you’d like added please let me know and for anyone interested in following more microbial natural products folks, then our starter pack is now 100 strong go.bsky.app/72NeGsT
September 24, 2025 at 7:39 PM
There seems to quite a few new faces lately, so if I haven’t already added you, but you’d like added please let me know and for anyone interested in following more microbial natural products folks, then our starter pack is now 100 strong go.bsky.app/72NeGsT
Reposted by Lars Dietrich
PhD fellowship in biofilm-phage interactions - with Mette Burmølle at University of Copenhagen 🇩🇰
deadline 1 October 2025
employment.ku.dk/faculty?show...
#phagesky #microsky
deadline 1 October 2025
employment.ku.dk/faculty?show...
#phagesky #microsky
PhD fellowship in biofilm-phage interactions
employment.ku.dk
September 28, 2025 at 2:26 PM
PhD fellowship in biofilm-phage interactions - with Mette Burmølle at University of Copenhagen 🇩🇰
deadline 1 October 2025
employment.ku.dk/faculty?show...
#phagesky #microsky
deadline 1 October 2025
employment.ku.dk/faculty?show...
#phagesky #microsky
Reposted by Lars Dietrich
Microbiologist Paula Welander studies fossils, but not dinosaur bones or ammonite imprints. Instead, she looks for microscopic clues left behind by microbes that lived millions of years ago.
The Humble Microbe Could Help Us Understand Life Itself
Unlocking the basic science of microbes, especially those that live in extreme environments, could help us find life elsewhere in the universe.
buff.ly
September 27, 2025 at 12:03 AM
Microbiologist Paula Welander studies fossils, but not dinosaur bones or ammonite imprints. Instead, she looks for microscopic clues left behind by microbes that lived millions of years ago.
Reposted by Lars Dietrich
🚨 Microbiologists! We are recruiting Assistant / Associate Professors in 3 collaborative areas of our U. Pittsburgh School of Medicine.
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...
Faculty Professor Associate - Full-Time | Vaughn Cooper
We are recruiting Faculty microbiologists in three (3) different, complementary, and collaborative areas at the University of Pittsburgh associated with the School of Medicine.
1) Fundamental researc...
www.linkedin.com
September 23, 2025 at 10:31 PM
🚨 Microbiologists! We are recruiting Assistant / Associate Professors in 3 collaborative areas of our U. Pittsburgh School of Medicine.
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...
Reposted by Lars Dietrich
A molecular-resolution look into the near-native architecture of the spinach chloroplast🌱. This one was a long time in the oven, but we're happy to finally share our "version of record". What long-standing debates did we settle? Check back for a short thread🧵 on Monday. #TeamTomo #PlantScience 🧪🧶🧬🔬🌾
🌱 Using ‘compelling’ methods, including #CryoET, researchers mapped spinach thylakoid membranes at single-molecule precision, revealing how photosynthetic complexes are organised and settling long-standing debates on chloroplast architecture.
buff.ly/j3TSIkn
buff.ly/j3TSIkn
September 20, 2025 at 7:24 PM
A molecular-resolution look into the near-native architecture of the spinach chloroplast🌱. This one was a long time in the oven, but we're happy to finally share our "version of record". What long-standing debates did we settle? Check back for a short thread🧵 on Monday. #TeamTomo #PlantScience 🧪🧶🧬🔬🌾