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Invasive pulmonary aspergillosis (IPA) is increasingly recognised in intensive care units (ICU) affecting not only patients with classical immunosuppressive conditions but also other severely ill patients, including those with respiratory viral infections (influenza, COVID-19), advanced chronic obst …

Despite extraordinary scientific and medical resources, the US health-care system underperforms. In this Review we consider the damage wrought by decades of market-based policies that have stimulated ...

Mold pneumonia is a serious complication in cancer patients. Reliable detection of etiologic agents is critical for patient care, but optimal testing strategies are undefined. We performed a prospective study comparing molecular tests (specific and unspecific qPCR and FISH) and culture on bronchoalveolar lavage fluid (BALF) and serum, focusing on aspergillosis and mucormycosis to gain insights into mold detection in high-risk patients. We demonstrate that FISH visualizes fungal elements in BALF, predominantly conidia, suggesting recent fungal exposure or failure to clear inhaled conidia at the time of diagnostic testing. We find that specific qPCRs from BALF are the most sensitive method to detect Aspergillus and Mucorales, superior to broad-range qPCR, culture, and testing of serum. Importantly, Mucorales DNA is mostly co-detected with Aspergillus, suggesting co-infections. Although DNA detection in serum is more likely in mucormycosis than in aspergillosis, sole serum testing may miss mucormycosis, precluding optimal patient care.

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This study aims to evaluate nationwide diagnostic and treatment capacity for IFD across Colombia’s diverse healthcare system.Between March and Septemb…

Using 2018–2024 U.S. death certificate data, 7,063 aspergillosis-attributable deaths (AAMR 2.43/1,000,000 persons) were identified, mostly invasive pulmona

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A new Danish study finds no association between aluminum in childhood vaccines and 50 different health conditions, including autism, asthma, and autoimmune diseases. The findings reaffirm the safety o...

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Vaccination and prior infection elicit neutralizing antibodies targeting SARS-CoV-2, yet the quantitative relationship between serum antibodies and infection risk against viral variants remains uncertain, particularly in underrepresented regions. We investigated the protective correlation of pre-exp …

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