Joe Sabatino
@jsabatino37.bsky.social
MS Neurologist, T cell immunologist, UCSF Dept of Neurology, Weill Institute for Neurosciences.
All posts are my own and not on behalf of UCSF
All posts are my own and not on behalf of UCSF
Reposted by Joe Sabatino
New online! Towards primary prevention of multiple sclerosis
Towards primary prevention of multiple sclerosis
Nature Reviews Neurology, Published online: 27 November 2025; doi:10.1038/s41582-025-01164-wMultiple sclerosis is among the most common causes of disability in the young and its prevention is a feasible, albeit ambitious, goal. In this Perspective, Dobson et al. discuss the challenges in developing and testing preventive interventions in MS and propose strategies and solutions.
bit.ly
November 27, 2025 at 12:47 PM
New online! Towards primary prevention of multiple sclerosis
Reposted by Joe Sabatino
We are #absolutely #thrilled to #present @cp-immunity.bsky.social - Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils: Immunity www.cell.com/immunity/ful...
Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils
Human T cell responses are often studied using blood, yet most T cells reside in tissues.
By comparing T cell receptor repertoires from millions of T cells from autologous
tonsils and blood, Sureshcha...
www.cell.com
November 26, 2025 at 3:47 PM
We are #absolutely #thrilled to #present @cp-immunity.bsky.social - Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils: Immunity www.cell.com/immunity/ful...
Reposted by Joe Sabatino
Excited to see our TIRTL-seq method published in Nature Methods www.nature.com/articles/s41...! Some updates after the revision: (1/4)
TIRTL-seq: deep, quantitative and affordable paired TCR repertoire sequencing - Nature Methods
TIRTL-seq is a high-throughput method for paired T cell receptor sequencing at the cohort scale.
www.nature.com
November 25, 2025 at 10:38 PM
Excited to see our TIRTL-seq method published in Nature Methods www.nature.com/articles/s41...! Some updates after the revision: (1/4)
Reposted by Joe Sabatino
Two complementary studies from our group out today: a therapeutic peptide vaccine trial for fibrolamellar carcinoma (FLC) & TIRTL-Seq, our robust method for deep quantitative paired TCR sequencing a🧵w/ @markyarchoan.bsky.social & @pogorely.bsky.social www.nature.com/articles/s41...
TIRTL-seq: deep, quantitative and affordable paired TCR repertoire sequencing - Nature Methods
TIRTL-seq is a high-throughput method for paired T cell receptor sequencing at the cohort scale.
www.nature.com
November 24, 2025 at 9:38 PM
Two complementary studies from our group out today: a therapeutic peptide vaccine trial for fibrolamellar carcinoma (FLC) & TIRTL-Seq, our robust method for deep quantitative paired TCR sequencing a🧵w/ @markyarchoan.bsky.social & @pogorely.bsky.social www.nature.com/articles/s41...
Reposted by Joe Sabatino
📢 SIGN & SHARE THE PETITION! 📢
New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
Sign the Petition
Support a New York State Biomedical Institute for a Healthier, More Affordable Future
c.org
November 24, 2025 at 3:53 PM
📢 SIGN & SHARE THE PETITION! 📢
New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
Reposted by Joe Sabatino
Resolving the mysteries of brain clearance and immune surveillance: @cp-neuron.bsky.social www.cell.com/neuron/fullt...
November 24, 2025 at 4:13 PM
Resolving the mysteries of brain clearance and immune surveillance: @cp-neuron.bsky.social www.cell.com/neuron/fullt...
Reposted by Joe Sabatino
We are #hiring a postdoctoral fellow! Please share!
Join our B-cell team @Emory to lead NIH-funded projects on human neuro-immunology and autoimmunity in a co-mentorship and collaboration with neuroscientist Dr. Grace Gombolay.
Please apply here: faculty-emory.icims.com/jobs/156609/...
#BYourCell
Join our B-cell team @Emory to lead NIH-funded projects on human neuro-immunology and autoimmunity in a co-mentorship and collaboration with neuroscientist Dr. Grace Gombolay.
Please apply here: faculty-emory.icims.com/jobs/156609/...
#BYourCell
Careers | Emory University | Atlanta GA
faculty-emory.icims.com
November 21, 2025 at 6:42 PM
We are #hiring a postdoctoral fellow! Please share!
Join our B-cell team @Emory to lead NIH-funded projects on human neuro-immunology and autoimmunity in a co-mentorship and collaboration with neuroscientist Dr. Grace Gombolay.
Please apply here: faculty-emory.icims.com/jobs/156609/...
#BYourCell
Join our B-cell team @Emory to lead NIH-funded projects on human neuro-immunology and autoimmunity in a co-mentorship and collaboration with neuroscientist Dr. Grace Gombolay.
Please apply here: faculty-emory.icims.com/jobs/156609/...
#BYourCell
Exciting new work from Carson Moseley and Scott Zamvil demonstrating a possible mechanism linking aquaporinopathy in #NMOSD and #Sjogrens disease
www.neurology.org/doi/10.1212/...
www.neurology.org/doi/10.1212/...
Neurology® Journals
www.neurology.org
November 21, 2025 at 10:04 PM
Exciting new work from Carson Moseley and Scott Zamvil demonstrating a possible mechanism linking aquaporinopathy in #NMOSD and #Sjogrens disease
www.neurology.org/doi/10.1212/...
www.neurology.org/doi/10.1212/...
No need to yell, but I share the authors' enthusiasm with this exciting work
EBV INFECTION OUTCOMES DETERMINED BY MONOCYTE AND TREG-DRIVEN IMMUNE DYNAMICS IN AN EX VIVO PBMC MODEL https://www.biorxiv.org/content/10.1101/2025.11.20.689441v1
November 21, 2025 at 5:45 PM
No need to yell, but I share the authors' enthusiasm with this exciting work
The Elusive B Cell Antigen in Multiple Sclerosis: Time to Rethink CNS B Cell Functions
www.mdpi.com/1422-0067/26...
www.mdpi.com/1422-0067/26...
www.mdpi.com
November 21, 2025 at 4:33 PM
The Elusive B Cell Antigen in Multiple Sclerosis: Time to Rethink CNS B Cell Functions
www.mdpi.com/1422-0067/26...
www.mdpi.com/1422-0067/26...
🧪For anyone interested in EBV in autoimmunity, I strongly urge you to read this incredible study by @shady-myounis.bsky.social, Bill Robinson, and @tobiaslanz.bsky.social. It is not only a scientific tour de force, it has a deeply provocative discussion that everyone in the field should consider 1/
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells to promote pathogenic antinuclear T and B cell responses in lupus.
www.science.org
November 19, 2025 at 5:24 PM
🧪For anyone interested in EBV in autoimmunity, I strongly urge you to read this incredible study by @shady-myounis.bsky.social, Bill Robinson, and @tobiaslanz.bsky.social. It is not only a scientific tour de force, it has a deeply provocative discussion that everyone in the field should consider 1/
Reposted by Joe Sabatino
November 18, 2025 at 4:00 PM
Reposted by Joe Sabatino
Very happy to share our latest manuscript about TCR-epitope recognition specificity: www.biorxiv.org/content/10.1...
www.biorxiv.org
November 18, 2025 at 7:21 AM
Very happy to share our latest manuscript about TCR-epitope recognition specificity: www.biorxiv.org/content/10.1...
Reposted by Joe Sabatino
Hey #immunosky people - anyone got any experience encoding multiple MHC-I binding peptides in APCs using minigenes and care to give some advice?
November 13, 2025 at 4:05 AM
Hey #immunosky people - anyone got any experience encoding multiple MHC-I binding peptides in APCs using minigenes and care to give some advice?
Retrospective In Silico Analysis of Routine Laboratory Data Supports a Specific Association of Epstein–Barr Virus and Multiple Sclerosis
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Retrospective In Silico Analysis of Routine Laboratory Data Supports a Specific Association of Epstein–Barr Virus and Multiple Sclerosis
To study the association of Epstein–Barr virus (EBV) and multiple sclerosis (MS) as compared to 10 different control diseases, 10,669 patients with MS and 42,222 controls were identified by ICD10 cod...
onlinelibrary.wiley.com
November 13, 2025 at 3:56 PM
Retrospective In Silico Analysis of Routine Laboratory Data Supports a Specific Association of Epstein–Barr Virus and Multiple Sclerosis
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells to promote pathogenic antinuclear T and B cell responses in lupus.
www.science.org
November 12, 2025 at 7:42 PM
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Joe Sabatino
Our latest manuscript that identifies altered proteins in tissue derived extracellular vesilces from normal appearing white matter in MS. Journal of Extracellular Vesicles - Wiley Online Library isevjournals.onlinelibrary.wiley.com/doi/10.1002/...
Extracellular Vesicles From Multiple Sclerosis White Matter Exhibit Synaptic, Mitochondrial, Complement and Ageing‐Related Pathway Dysregulation
This study characterizes extracellular vesicles (EVs) separated from postmortem normal-appearing white matter of multiple sclerosis (MS) and control brains. Proteomic analysis revealed downregulation...
isevjournals.onlinelibrary.wiley.com
November 12, 2025 at 4:50 PM
Our latest manuscript that identifies altered proteins in tissue derived extracellular vesilces from normal appearing white matter in MS. Journal of Extracellular Vesicles - Wiley Online Library isevjournals.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Joe Sabatino
Meeting report @natimmunol.nature.com
Neuroimmune interactions in health and disease
www.nature.com/articles/s41...
Neuroimmune interactions in health and disease
www.nature.com/articles/s41...
November 12, 2025 at 12:49 AM
Meeting report @natimmunol.nature.com
Neuroimmune interactions in health and disease
www.nature.com/articles/s41...
Neuroimmune interactions in health and disease
www.nature.com/articles/s41...
Dynamic relationship between cerebrospinal fluid immune cells and tissue damage markers in multiple sclerosis
academic.oup.com/braincomms/a...
academic.oup.com/braincomms/a...
Dynamic relationship between cerebrospinal fluid immune cells and tissue damage markers in multiple sclerosis
Zaic et al. report that relapsing-remitting multiple sclerosis patients show elevated cerebrospinal fluid T and B lymphocytes compared with controls, with
academic.oup.com
November 7, 2025 at 6:13 PM
Dynamic relationship between cerebrospinal fluid immune cells and tissue damage markers in multiple sclerosis
academic.oup.com/braincomms/a...
academic.oup.com/braincomms/a...
Congrats to Martineau Louine, Michael Wilson, and colleagues!
Cerebrospinal fluid transcriptional immune pathways linked to survival in HIV-associated tuberculous meningitis
www.medrxiv.org/content/10.1...
Cerebrospinal fluid transcriptional immune pathways linked to survival in HIV-associated tuberculous meningitis
www.medrxiv.org/content/10.1...
Cerebrospinal fluid transcriptional immune pathways linked to survival in HIV-associated tuberculous meningitis
BACKGROUND: TB meningitis (TBM) has up to 50% mortality in people living with HIV. We investigated differences in cerebrospinal fluid (CSF) host immune responses associated with acute mortality. METHO...
www.medrxiv.org
November 7, 2025 at 5:28 PM
Congrats to Martineau Louine, Michael Wilson, and colleagues!
Cerebrospinal fluid transcriptional immune pathways linked to survival in HIV-associated tuberculous meningitis
www.medrxiv.org/content/10.1...
Cerebrospinal fluid transcriptional immune pathways linked to survival in HIV-associated tuberculous meningitis
www.medrxiv.org/content/10.1...
Reposted by Joe Sabatino
Again for the lovers of #TCRs Molecular mimicry as a driver of T cell-mediated tumour immunity: Trends in Immunology www.cell.com/trends/immun...
Molecular mimicry as a driver of T cell-mediated tumour immunity
Recently, a large pool of antigens derived from viral and bacterial microorganisms
showing molecular mimicry with tumour-cell-expressed antigens was identified. These
antigens can be presented by MHC ...
www.cell.com
November 6, 2025 at 4:25 PM
Again for the lovers of #TCRs Molecular mimicry as a driver of T cell-mediated tumour immunity: Trends in Immunology www.cell.com/trends/immun...
Reposted by Joe Sabatino
Persistent Classical and Atypical Memory B Cells Underlie Heterogeneous Vaccine Responses in Ocrelizumab-Treated Multiple Sclerosis https://www.biorxiv.org/content/10.1101/2025.11.03.686372v1
November 5, 2025 at 1:16 AM
Persistent Classical and Atypical Memory B Cells Underlie Heterogeneous Vaccine Responses in Ocrelizumab-Treated Multiple Sclerosis https://www.biorxiv.org/content/10.1101/2025.11.03.686372v1
Reposted by Joe Sabatino
Reposted by Joe Sabatino
How is the persistence of compartmentalized inflammation sustained in MS?
Our new study in
@cp-immunity.bsky.social
offers some hints.
cell.com/immunity/ful...
Thanks and congratulations to all contributors
Our new study in
@cp-immunity.bsky.social
offers some hints.
cell.com/immunity/ful...
Thanks and congratulations to all contributors
October 29, 2025 at 3:01 PM
How is the persistence of compartmentalized inflammation sustained in MS?
Our new study in
@cp-immunity.bsky.social
offers some hints.
cell.com/immunity/ful...
Thanks and congratulations to all contributors
Our new study in
@cp-immunity.bsky.social
offers some hints.
cell.com/immunity/ful...
Thanks and congratulations to all contributors