Lightnews — Scholar-powered news

Jamie Cate

@jhdcate.bsky.social

1.6K followers 760 following 230 posts

Ribosomes and RNA language models. Professor at UC Berkeley. https://sites.google.com/berkeley.edu/cate-lab/home

sites.google.com

Posts Media Videos Starter Packs

Pinned

Jamie Cate @jhdcate.bsky.social · Nov 10

RNA language models and ribosome engineering. Built from a hackathon sponsored by @innovativegenomics.bsky.social with @cgemcci.bsky.social. What a great experience!

doi.org/10.1101/2024...

RNA language models predict mutations that improve RNA function

Structured RNA lies at the heart of many central biological processes, from gene expression to catalysis. While advances in deep learning enable the prediction of accurate protein structural models, R...

doi.org

5 36

Reposted by Jamie Cate

STAT @statnews.com · 12h

Baby KJ, in a tiny tuxedo, shows up at the #STATSummit. His parents Kyle and Nicole Muldoon give an update on how he’s doing after his life-saving CRISPR treatment for a rare liver disease earlier this year.

Read their story: www.statnews.com/2025/05/15/c...

6 13

Reposted by Jamie Cate

Matthew Stiegler @matthewstiegler.bsky.social · 7h

Every time you see Mike Davis do Mike Davis things, think about Gorsuch reportedly helping land Davis a job at DOJ, then choosing him as a clerk when he was on the 10th Circuit, then choosing him as a clerk when he was on the Supreme Court.

Tom Joscelyn @tomjoscelyn.bsky.social · 9h

Hakeem Jeffries posted pictures of two Rep. Members posing with “Young Republicans” who were part of a racist text thread (as reported by Politico).

In response, Mike Davis (well-connected in Trump World & on the Hill) called Jeffries a “house slave” for George Soros - proving Jeffries’ point.

12 210 720

Reposted by Jamie Cate

Evelina Tutucci @anilevetu.bsky.social · 7h

And it's out!
Our paper on the optimization of smFISH to quantify cytokine mRNAs in T cells is published in EMBO Journal.
Using this protocol, we gathered interesting insights on cytokine mRNAs co-expression and localization in these teeny tiny human cells.
www.embopress.org/doi/full/10....

1 4 8

Reposted by Jamie Cate

Derek Lowe @dereklowe.bsky.social · 9h

I'm happy to see that there will be at least 140 "No Kings" protests across my state of Massachusetts on Saturday. I'll be out there, showing that I oppose this administration's policies.

And what's more, I want its officials to have to answer for their mistakes and for their outright crimes.

2 9 74

Reposted by Jamie Cate

Josh Mendell @mendell-lab.bsky.social · 1d

Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇

Oxidative stress sensing by the translation elongation machinery promotes production of detoxifying selenoproteins

Selenocysteine, incorporated into polypeptides at recoded termination codons, plays an essential role in redox biology. Using GPX1 and GPX4, selenoenzymes that mitigate oxidative stress, as reporters,...

www.biorxiv.org

1 24 60

Jamie Cate @jhdcate.bsky.social · 9h

Do you have your U.S. flags for this Saturday? Do you know where you’ll be?

nokings.org#map

No Kings

As the president escalates his authoritarian power grab, the NO KINGS non-violent movement continues to rise stronger. We are united once again to remind the world: America has No Kings and the power ...

nokings.org

Reposted by Jamie Cate

Chanda Prescod-Weinstein 🌌 @chanda.blacksky.app · 11h

DOE's public statements about this say that all the ad hoc committees, including HEPAP, will be replaced by a single committee. As an STS researcher, I am compelled to point out that this overlaps with the Nazi playbook for taking over German physics. My slides about how they did that:🧪⚛️🔭

APS April 2017.pdf

drive.google.com

2 47 120

Reposted by Jamie Cate

Tim Onion @bencollins.bsky.social · 14h

Almost like we founded the entire country on opposing this exact sentence.

Aaron Rupar @atrupar.com · 14h

Bessent: "No kings equals no paychecks"

170 2.5K 10K

Jamie Cate @jhdcate.bsky.social · 14h

@joedobbs.bsky.social great work. Do you see h44 rearrangements in the 30S during initiation? I wonder if having the P-tRNA stick around after recycling might prevent that.

Reposted by Jamie Cate

joe dobbs @joedobbs.bsky.social · 22h

Check out our preprint! With new molecular mechanisms, 140 subtomogram averages, and ~600 annotated cells under different conditions, we @embl.org were able to describe bacterial populations with in-cell #cryoET. And there’s a surprise at the end 🕵️

www.biorxiv.org/content/10.1...
#teamtomo

8 31 96

Reposted by Jamie Cate

Anshul Kundaje @anshulkundaje.bsky.social · 1d

Friendly reminder that there is only one official release of ChromBPNet at our lab GitHub github.com/kundajelab/chr…

There are other versions floating around eg. in the CRESTED package that are NOT anywhere close to the official implementation. 1/

https://github.com/kundajelab/chr…

2 2 8

Reposted by Jamie Cate

Meng-meng Fu @mengmengfu.bsky.social · 2d

We used live-cell imaging with plus-end binding protein EB3 to determine microtubule polarity in astrocytes for the first time. They are ~88% plus-ends out.

3/x

1 5 9

Reposted by Jamie Cate

Frances Yap @ribo1214.bsky.social · 1d

Glucose capping of 5'-mRNAs in E. coli 😱, presumably is installed during transcriptional initiation #MicroSky #RNASky www.pnas.org/doi/10.1073/...

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

www.pnas.org

8 17

Reposted by Jamie Cate

paris martineau @paris.nyc · 1d

my latest investigation for @consumerreports.org is based on months of reporting and 60+ lab tests of leading protein supplements

we found that most protein powders and shakes have more lead in one serving than our experts say is safe to have in a day (🧵)

www.consumerreports.org/lead/protein...

Protein Powders and Shakes Contain High Levels of Lead - Consumer Reports

CR tests of 23 popular protein powders and shakes found that most contain high levels of lead.

www.consumerreports.org

280 3.2K 6K

Reposted by Jamie Cate

Scott Shapiro @scottjshapiro.bsky.social · 1d

Is this bad cause it seems bad

karl rove knausgård @uhactually.bsky.social · 2d

Lmao WaPo has fewer than 100K circulation now. It turns out “alienate your liberal subscriber base” is not a good strategy when the Republicans also hate you. www.forbes.com/sites/andyme...

The Washington Post Is Running Out Of Readers Willing To Pay

Once a titan of American journalism, The Washington Post now struggles to reach even 100,000 print subscribers most days.

www.forbes.com

19 13 99

Jamie Cate @jhdcate.bsky.social · 1d

On my reading list for today.

jamelle @jamellebouie.net · 1d

we’ll see how his mayoral tenure shakes out but i am convinced that Mamdani has the juice. not just the charisma to win an election but the temperament to govern and the measured pragmatism of someone who genuinely believes what they’re saying and wants to accomplish real things.

Inside the Improbable, Audacious and (So Far) Unstoppable Rise of Zohran Mamdani

www.nytimes.com

Reposted by Jamie Cate

Richard Sever @richardsever.bsky.social · 1d

Readers of this paper www.biorxiv.org/content/10.1... will immediately know know this paper exists www.nature.com/articles/s41... .

The challenge for the discovery space is to make the reverse true.

On the overlap of transcription factor binding and regulatory targets: functional and regulatory coherence of top-bound targets is masked by weakly bound ones

A recent study that systematically mapped genomic bindings and regulatory effects of transcription factors (TFs) reported a surprisingly low overlap between TF binding and regulatory targets in Saccha...

www.biorxiv.org

1 2 8

Reposted by Jamie Cate

Joshua Weitz @joshuasweitz.bsky.social · 2d

As expected, the first 9 compacts were a trial run.

They have now come for all of us.

And each of us, and all of us, should say no.

Scoop via @liamknox.bsky.social at Bloomberg:

www.bloomberg.com/news/article...

Trump Offers All Colleges Preferential Funding Plan Rejected by MIT

The Trump administration is inviting all US colleges to participate in a compact — initially rejected by the Massachusetts Institute of Technology — that would grant preferential federal funding in re...

www.bloomberg.com

2 50 95

Reposted by Jamie Cate

Molly Jong-Fast @mollyjongfast.bsky.social · 2d

Solidarity is the only way

800 5.5K 23K

Reposted by Jamie Cate

Marc Elias @marcelias.bsky.social · 2d

The is literally nothing more American and patriotic than declaring: No Kings.

420 6.2K 28K

Reposted by Jamie Cate

Kieran Healy @kjhealy.co · 2d

A couple of parking signs for anyone who wants to print them out for this coming Saturday.

Parking Signs

If you want to print out a poster for October 18th, here are two; fully-guaranteed countrywide but maybe especially suitable for in and around New York. No King Anytime sign ...

kieranhealy.org

49 780 2.5K

Reposted by Jamie Cate

J. Mijin Cha @jmijin.bsky.social · 2d

New coal leases in the Powder River Basin have been paused after the first one had only a bid for 1/10th of a penny. They are trying to blame previous administrations, but the writing is on the wall. We should be supporting coal workers and communities not doing wtf this clown show is doing.

US postpones Wyoming coal lease sale after disappointing Montana auction

The Trump administration has postponed a scheduled sale of coal leases on federal lands in Wyoming two days after a disappointing auction in Montana, an Interior Department spokesperson said on Wednesday.

www.reuters.com

3 83 240

Reposted by Jamie Cate

jamelle @jamellebouie.net · 2d

"The liberty and security of our fellow citizens is our great object, and not the prompt execution of the laws. Indecision, delay, blunders, nay villainous actions in the administration of government, are trifles compared to legalizing the full exertion of a tyrannical disposition."

3 180 820

Reposted by Jamie Cate

Clément Madru @cryoclem.bsky.social · 2d

Our work on ribosome hibernation in archaea is out!
We identified Hib, a new hibernation factor broadly distributed across archaea.
Check out the preprint 👉 biorxiv.org/content/10.1101/2025.10.11.676729v1
(1/🧵)

2 22 49

Reposted by Jamie Cate

Mark Z. Jacobson @mzjacobson.bsky.social · 2d

Picture perfect California weekend

195th & 196th days in 2025 with >100% WindWaterSolar for part of day

WWS peaked at 135% of demand both days

Gas down 19% v '24 & 37% v '23
Batteries up 57% v '24 & 205% v '23
Solar up 15% v '24 & 44% v '23

WWS 54.6% of demand v 46.7% in '23

14 55