Flavien Maucourt
@fmaucourt.bsky.social
Postdoctoral scholar at Lawrence Berkeley National Lab - Mutalik Lab. Phage-host interactions 🧬🧫🧪
He/Him
Lab website: https://sites.google.com/lbl.gov/mutaliklab
RG: https://www.researchgate.net/profile/Flavien-Maucourt
He/Him
Lab website: https://sites.google.com/lbl.gov/mutaliklab
RG: https://www.researchgate.net/profile/Flavien-Maucourt
Reposted by Flavien Maucourt
The host range of generalist and specialist phages in capsule-diverse Klebsiella hosts is driven by the evolvability of receptor-binding proteins
@plosbiology.org from @pilardomingoc.bsky.social
journals.plos.org/plosbiology/...
@plosbiology.org from @pilardomingoc.bsky.social
journals.plos.org/plosbiology/...
The host range of generalist and specialist phages in capsule-diverse Klebsiella hosts is driven by the evolvability of receptor-binding proteins
Capsule diversity limits phage host range by affecting RBP interactions in capsulated bacteria. This study shows that generalist phages evolve host range through RBP mutations and recombination, while...
journals.plos.org
November 27, 2025 at 12:28 PM
The host range of generalist and specialist phages in capsule-diverse Klebsiella hosts is driven by the evolvability of receptor-binding proteins
@plosbiology.org from @pilardomingoc.bsky.social
journals.plos.org/plosbiology/...
@plosbiology.org from @pilardomingoc.bsky.social
journals.plos.org/plosbiology/...
Reposted by Flavien Maucourt
#microsky 🎊🎉
High resolution lineage tracking tech from Robin & Adam D team from Berkeley! 🙌
We have used this for phage-host interaction work too in the forthcoming preprint.
High resolution lineage tracking tech from Robin & Adam D team from Berkeley! 🙌
We have used this for phage-host interaction work too in the forthcoming preprint.
Very excited to share a big part of my dissertation work with the Deutschbauer lab at LBNL and @ucberkeleyofficial.bsky.social! BarTn7: A method for bacterial lineage tracking at sub-species resolution in population, ecological, and evolutionary experiments.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
BarTn7: Optimizing Bacterial Lineage Tracking at Sub-Species Resolution for Population Dynamics in Ecological and Evolutionary Studies
Communities of bacteria undergo population bottlenecks which are crucial to their population, ecological, and evolutionary dynamics. However, conventional amplicon sequencing cannot distinguish such d...
www.biorxiv.org
November 25, 2025 at 10:52 PM
#microsky 🎊🎉
High resolution lineage tracking tech from Robin & Adam D team from Berkeley! 🙌
We have used this for phage-host interaction work too in the forthcoming preprint.
High resolution lineage tracking tech from Robin & Adam D team from Berkeley! 🙌
We have used this for phage-host interaction work too in the forthcoming preprint.
Awesome work from the JBD lab! Genome-wide mutagenesis of phages is so interesting and helpful!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Bacteriophage genome-wide transposon mutagenesis
Bacteriophages have genomes that span a wide size range, are densely packed with coding sequences, and frequently encode genes of unknown function. Classical forward genetics has defined essential gen...
www.biorxiv.org
November 25, 2025 at 7:44 PM
Awesome work from the JBD lab! Genome-wide mutagenesis of phages is so interesting and helpful!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Hey phage lovers,
What do you think of the phage-fantasy paintings I've made?
What do you think of the phage-fantasy paintings I've made?
November 24, 2025 at 11:04 PM
Hey phage lovers,
What do you think of the phage-fantasy paintings I've made?
What do you think of the phage-fantasy paintings I've made?
Wow! Terrific work!
🚀New preprint from our lab!
I am very excited to finally share what has been the main focus of my PhD for the past almost 3 years! It is about viral dark matter and a powerful tool we built to shed light on it. 🧬💡
Continue reading (🧵)
I am very excited to finally share what has been the main focus of my PhD for the past almost 3 years! It is about viral dark matter and a powerful tool we built to shed light on it. 🧬💡
Continue reading (🧵)
November 24, 2025 at 10:45 PM
Wow! Terrific work!
📣 New preprint from phagefoundry.org team 📣
What are the phage-host interactions at a strain-level scale?
Here Avery (Machine Learning) and Lucas (Experimental validation), share their new workflow to predict these interactions!
I am very very grateful to work with these talented scientists!
What are the phage-host interactions at a strain-level scale?
Here Avery (Machine Learning) and Lucas (Experimental validation), share their new workflow to predict these interactions!
I am very very grateful to work with these talented scientists!
We built GenoPHI: a machine learning workflow that predicts phage-host interactions at strain level. This could help rapidly select phages to treat drug-resistant bacterial infections or for microbiome engineering without exhaustive lab testing.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
November 24, 2025 at 5:54 PM
📣 New preprint from phagefoundry.org team 📣
What are the phage-host interactions at a strain-level scale?
Here Avery (Machine Learning) and Lucas (Experimental validation), share their new workflow to predict these interactions!
I am very very grateful to work with these talented scientists!
What are the phage-host interactions at a strain-level scale?
Here Avery (Machine Learning) and Lucas (Experimental validation), share their new workflow to predict these interactions!
I am very very grateful to work with these talented scientists!
www.science.org/doi/10.1126/...
Beautiful paper describing the structure of E.coli bacteriophage Bas63!
Beautiful paper describing the structure of E.coli bacteriophage Bas63!
Cryo-EM structure of bacteriophage Bas63 reveals structural conservation and diversity in the Felixounavirus genus
Cryo-EM of phage Bas63 reveals unique capsid and tail features, offering insights into Felixounavirus evolution and architecture.
www.science.org
November 15, 2025 at 12:05 AM
www.science.org/doi/10.1126/...
Beautiful paper describing the structure of E.coli bacteriophage Bas63!
Beautiful paper describing the structure of E.coli bacteriophage Bas63!
Reposted by Flavien Maucourt
Targeted delivery of diverse biomolecules with engineered bacterial nanosyringes - @zhangf.bsky.social go.nature.com/46OFcoj
Targeted delivery of diverse biomolecules with engineered bacterial nanosyringes - Nature Biotechnology
Ribonucleoproteins, nucleic acids and proteins are delivered into target cell types with nanosyringes.
go.nature.com
August 12, 2025 at 2:54 PM
Targeted delivery of diverse biomolecules with engineered bacterial nanosyringes - @zhangf.bsky.social go.nature.com/46OFcoj
Reposted by Flavien Maucourt
This is really heartbreaking. So many, so many ppl suffering. 😢
NEW: A letter from an anonymous federal worker. Please read and share: www.muellershewrote.com/p/letter-fro...
Letter From a Federal Worker
This is a heartbreaking letter that a federal worker has asked me to share with the public.
www.muellershewrote.com
February 19, 2025 at 1:00 PM
This is really heartbreaking. So many, so many ppl suffering. 😢
Reposted by Flavien Maucourt
NSF stopping salaries of postdocs and researchers is outrageous to say the least.
January 31, 2025 at 6:53 AM
NSF stopping salaries of postdocs and researchers is outrageous to say the least.
Reposted by Flavien Maucourt
If you are in the USA, & want to do something worthwhile,
call your elected official.
This is damn 🚨 urgent.
Do it today.
call your elected official.
This is damn 🚨 urgent.
Do it today.
It is very easy to call your representatives’ offices. They have to log your calls and the call numbers are meaningful. You don’t even have to try to convince anyone; just call and tell them your concerns. They are there to represent you. Let them know what that means. www.usa.gov/elected-offi...
Find and contact elected officials | USAGov
Use USAGov’s Contact Your Elected Officials tool to get contact information for your members of Congress, the president, and state and local officials.
www.usa.gov
January 28, 2025 at 3:31 PM
If you are in the USA, & want to do something worthwhile,
call your elected official.
This is damn 🚨 urgent.
Do it today.
call your elected official.
This is damn 🚨 urgent.
Do it today.
Reposted by Flavien Maucourt
Excited to share the major work of my dissertation, out now in @currentbiology.bsky.social! We use Drosophila genetics to dissect the evolution of phage-derived toxins that were horizontally transferred to insects and now function as potent anti-parasitoid defenses (1/n): tinyurl.com/2k9ypyxr
Experimental horizontal transfer of phage-derived genes to Drosophila confers innate immunity to parasitoids
Metazoan parasites have played a major role in shaping innate immunity in animals. Insect hosts and parasitoid wasps are excellent models for illumina…
www.sciencedirect.com
December 20, 2024 at 5:58 PM
Excited to share the major work of my dissertation, out now in @currentbiology.bsky.social! We use Drosophila genetics to dissect the evolution of phage-derived toxins that were horizontally transferred to insects and now function as potent anti-parasitoid defenses (1/n): tinyurl.com/2k9ypyxr
Reposted by Flavien Maucourt
Celebrating 🎉 holidays!
December 12, 2024 at 4:38 PM
Celebrating 🎉 holidays!