Alasdair Hubbard
@dralhubb.bsky.social
Assistant Professor - research group works on the evolution of AMR and understanding cryptic mechanisms of resistance. All views my own. T1D
Pinned
Really cool to have given a talk at #microbio25, I can cross it off the list! If anyone want to chat about looking into the urobiome as a reservoir of AMR and replicating AMR acquisition in a 3D bladder model, give me a shout!! #microsky #utisky
Reposted by Alasdair Hubbard
Evolution at @bsacandjac.bsky.social
#AntibioticResistance & Mechanisms: @dannagifford.bsky.social found E. coli mutator genotypes don't just increase probability of resistance evolution, they increase probability of aa substitution vs. frameshift/indel - lower costs? dannagifford.com #MicroSky
#AntibioticResistance & Mechanisms: @dannagifford.bsky.social found E. coli mutator genotypes don't just increase probability of resistance evolution, they increase probability of aa substitution vs. frameshift/indel - lower costs? dannagifford.com #MicroSky
Danna Gifford
School of Biological Sciences | Faculty of Biology Medicine and Health | University of Manchester
dannagifford.com
November 28, 2025 at 11:45 AM
Evolution at @bsacandjac.bsky.social
#AntibioticResistance & Mechanisms: @dannagifford.bsky.social found E. coli mutator genotypes don't just increase probability of resistance evolution, they increase probability of aa substitution vs. frameshift/indel - lower costs? dannagifford.com #MicroSky
#AntibioticResistance & Mechanisms: @dannagifford.bsky.social found E. coli mutator genotypes don't just increase probability of resistance evolution, they increase probability of aa substitution vs. frameshift/indel - lower costs? dannagifford.com #MicroSky
Reposted by Alasdair Hubbard
🎉 Congratulations to Oluwatosin Orababa @tosinorababa.bsky.social, one of the winners of our 2025 Infection Science Award! 🦠👏
Get to know them in our new interview: microb.io/3XFyCui
#InfectionScience #Microbiology #ResearchSpotlight
Get to know them in our new interview: microb.io/3XFyCui
#InfectionScience #Microbiology #ResearchSpotlight
November 25, 2025 at 10:00 AM
🎉 Congratulations to Oluwatosin Orababa @tosinorababa.bsky.social, one of the winners of our 2025 Infection Science Award! 🦠👏
Get to know them in our new interview: microb.io/3XFyCui
#InfectionScience #Microbiology #ResearchSpotlight
Get to know them in our new interview: microb.io/3XFyCui
#InfectionScience #Microbiology #ResearchSpotlight
Reposted by Alasdair Hubbard
What drives the acquisition and loss of #AntibioticResistance in Salmonella? @flashton.bsky.social kicking off the @bsacandjac.bsky.social resistance & mechanisms meeting, talking about pathogen genomic surveillance around the world, particularly in Africa www.psi.ox.ac.uk/our-team/phi... #MicroSky
Philip Ashton
Philip Ashton
www.psi.ox.ac.uk
November 27, 2025 at 2:02 PM
What drives the acquisition and loss of #AntibioticResistance in Salmonella? @flashton.bsky.social kicking off the @bsacandjac.bsky.social resistance & mechanisms meeting, talking about pathogen genomic surveillance around the world, particularly in Africa www.psi.ox.ac.uk/our-team/phi... #MicroSky
Reposted by Alasdair Hubbard
Next at @bsacandjac.bsky.social #AntibioticResistance & mechanisms, @jodywinter.bsky.social is explaining how a partnership between academics, clinicians & health workers in Nottingham & Makerere is is sharing best practice in stewardship between UK & Uganda jodywinter.wixsite.com/waaw/cop #MicroSky
COP | Waaw
jodywinter.wixsite.com
November 27, 2025 at 2:36 PM
Next at @bsacandjac.bsky.social #AntibioticResistance & mechanisms, @jodywinter.bsky.social is explaining how a partnership between academics, clinicians & health workers in Nottingham & Makerere is is sharing best practice in stewardship between UK & Uganda jodywinter.wixsite.com/waaw/cop #MicroSky
Reposted by Alasdair Hubbard
Now at @bsacandjac.bsky.social #AntibioticResistance & mechanisms workshop, Kirsty Sands @ineosoxford.bsky.social stresses the dominance of Kleb pneumoniae in neonatal sepsis, and how the work she leads is quantifying the impact of AMR on neonatal sepsis in LMICs: www.ineosoxford.ox.ac.uk/barnards
BARNARDS
Causes and impacts of sepsis in new-born babies
www.ineosoxford.ox.ac.uk
November 27, 2025 at 3:18 PM
Now at @bsacandjac.bsky.social #AntibioticResistance & mechanisms workshop, Kirsty Sands @ineosoxford.bsky.social stresses the dominance of Kleb pneumoniae in neonatal sepsis, and how the work she leads is quantifying the impact of AMR on neonatal sepsis in LMICs: www.ineosoxford.ox.ac.uk/barnards
Reposted by Alasdair Hubbard
OMG no-one has every explained what "MD simulations" actually means before and I think @sykhalid.bsky.social has given me a sufficient understanding in about two minutes - amazing!
November 27, 2025 at 4:05 PM
OMG no-one has every explained what "MD simulations" actually means before and I think @sykhalid.bsky.social has given me a sufficient understanding in about two minutes - amazing!
Reposted by Alasdair Hubbard
Now at @bsacandjac.bsky.social, @sykhalid.bsky.social explains that, while the outer leaflet of the Gram- OM is a calm sea anchored by OmpA to the cell wall, the phospholipids of the inner leaflet are paddling about madly beneath the surface. #MicroSky khalidlab.web.ox.ac.uk/publications
Publications
khalidlab.web.ox.ac.uk
November 27, 2025 at 4:20 PM
Now at @bsacandjac.bsky.social, @sykhalid.bsky.social explains that, while the outer leaflet of the Gram- OM is a calm sea anchored by OmpA to the cell wall, the phospholipids of the inner leaflet are paddling about madly beneath the surface. #MicroSky khalidlab.web.ox.ac.uk/publications
Reposted by Alasdair Hubbard
Synthetic teixobactin development: Ishwar Singh is telling @bsacandjac.bsky.social #antibioticResistance & mechanisms meeting about the long and winding road to promising new molecules with good bioactivity www.liverpool.ac.uk/people/ishwa... #MicroSky
Dr Ishwar Singh | Our people | University of Liverpool
www.liverpool.ac.uk
November 27, 2025 at 4:42 PM
Synthetic teixobactin development: Ishwar Singh is telling @bsacandjac.bsky.social #antibioticResistance & mechanisms meeting about the long and winding road to promising new molecules with good bioactivity www.liverpool.ac.uk/people/ishwa... #MicroSky
Reposted by Alasdair Hubbard
'Bacterial dietitian' @danybeste.bsky.social is telling @bsacandjac.bsky.social #AntibioticResistance & mechanisms workshop how switching C sources affects Tb antibiotic tolerance - can we use this info to design adjuvants that increase sensitivity? www.surrey.ac.uk/people/dany-... #MicroSky
Dr Dany Beste | University of Surrey
https://www.surrey.ac.uk/people/dany-beste#research#MicroSky
November 27, 2025 at 5:00 PM
'Bacterial dietitian' @danybeste.bsky.social is telling @bsacandjac.bsky.social #AntibioticResistance & mechanisms workshop how switching C sources affects Tb antibiotic tolerance - can we use this info to design adjuvants that increase sensitivity? www.surrey.ac.uk/people/dany-... #MicroSky
Reposted by Alasdair Hubbard
Flash talk 1 @bsacandjac.bsky.social #AntibioticResistance & mechanisms! Ahmed Alomar selected E. coli for colistin resistance: clinical isolates evolved higher MIC than MG1655, associated with mutations in pmrA/B, many of those in pmrA not previously described. @imibirmingham.bsky.social #MicroSky
November 27, 2025 at 5:18 PM
Flash talk 1 @bsacandjac.bsky.social #AntibioticResistance & mechanisms! Ahmed Alomar selected E. coli for colistin resistance: clinical isolates evolved higher MIC than MG1655, associated with mutations in pmrA/B, many of those in pmrA not previously described. @imibirmingham.bsky.social #MicroSky
Reposted by Alasdair Hubbard
Flash talk 2 @bsacandjac.bsky.social #AntibioticResistance & mechanisms! @taylorwr.bsky.social found that E. coli damaged but not killed by b-lactams die when they try to divide on abx-free solid medium, but not in liquid - so do plate count assays overestimate b-lactam killing? #MicroSky
November 27, 2025 at 5:31 PM
Flash talk 2 @bsacandjac.bsky.social #AntibioticResistance & mechanisms! @taylorwr.bsky.social found that E. coli damaged but not killed by b-lactams die when they try to divide on abx-free solid medium, but not in liquid - so do plate count assays overestimate b-lactam killing? #MicroSky
Reposted by Alasdair Hubbard
Flash talk 4 @bsacandjac.bsky.social #AntibioticResistance & mechanisms! Caleb Marsh is designing dual efflux inhibitor-abx molecules, then testing them in @ukhsa.bsky.social's open innovation platform for abx development. Very promising drops in MIC & spontaneous resistance rates. #MicroSky
November 27, 2025 at 5:55 PM
Flash talk 4 @bsacandjac.bsky.social #AntibioticResistance & mechanisms! Caleb Marsh is designing dual efflux inhibitor-abx molecules, then testing them in @ukhsa.bsky.social's open innovation platform for abx development. Very promising drops in MIC & spontaneous resistance rates. #MicroSky
Reposted by Alasdair Hubbard
Flash talk 3 @bsacandjac.bsky.social #AntibioticResistance & mechanisms! @mwilde.bsky.social on AMR gene silencing via mutation & reversion: engineering in SNP in a carbapenemase alters AST profile, but effect depends on genetic background. #MicroSky
November 27, 2025 at 5:46 PM
Flash talk 3 @bsacandjac.bsky.social #AntibioticResistance & mechanisms! @mwilde.bsky.social on AMR gene silencing via mutation & reversion: engineering in SNP in a carbapenemase alters AST profile, but effect depends on genetic background. #MicroSky
Reposted by Alasdair Hubbard
gggenomes: A Grammar of Graphics for Comparative Genomics thackl.github.io/gggenomes/ #Rstats
A Grammar of Graphics for Comparative Genomics
An extension of ggplot2 for creating complex genomic maps. It builds on the power of ggplot2 and tidyverse adding new ggplot2-style geoms & positions and dplyr-style verbs to manipulate the…
thackl.github.io
November 18, 2025 at 7:02 PM
gggenomes: A Grammar of Graphics for Comparative Genomics thackl.github.io/gggenomes/ #Rstats
Reposted by Alasdair Hubbard
New paper out of the lab this week. Looking at the genomic diversity in isolates from outbreaks of Lactococcosis, and potential virulence mechanisms of the emerging causative pathogen L. pertauri.
doi.org/10.1002/mbo3...
doi.org/10.1002/mbo3...
Comparative Genomics of Lactococcus spp. From Global Aquaculture Outbreaks Reveals Virulence Determinants, Antibiotic Resistance, and Phage Defence Mechanisms
Lactococcus petauri predominated in isolates from outbreaks of lactococcosis, suggesting a shift in disease aetiology. Genomic analysis revealed diverse virulence factors, prophage and resistance gen...
doi.org
November 15, 2025 at 11:07 AM
New paper out of the lab this week. Looking at the genomic diversity in isolates from outbreaks of Lactococcosis, and potential virulence mechanisms of the emerging causative pathogen L. pertauri.
doi.org/10.1002/mbo3...
doi.org/10.1002/mbo3...
Reposted by Alasdair Hubbard
Reposted by Alasdair Hubbard
Very pleased to plug our latest preprint, lead author @microberamon.bsky.social - fantastic collaboration with labs of Dario Carugo (Oxford) and Martha Clokie (Leicester) https:// - and others #UTISKy #UTI #IDSky #MicroSky www.biorxiv.org/content/10.1101/2025.11.12.688052v1 more below👇🧵
Effect of human urinary microenvironment and fluid flow on antibiotic and phage therapy efficacy against uropathogenic Escherichia coli
Urinary tract infections (UTI) remain a major global health burden, with high recurrence despite antibiotic treatment. The escalating prevalence of antimicrobial resistance further compromises therape...
www.biorxiv.org
November 13, 2025 at 9:20 AM
Very pleased to plug our latest preprint, lead author @microberamon.bsky.social - fantastic collaboration with labs of Dario Carugo (Oxford) and Martha Clokie (Leicester) https:// - and others #UTISKy #UTI #IDSky #MicroSky www.biorxiv.org/content/10.1101/2025.11.12.688052v1 more below👇🧵
Reposted by Alasdair Hubbard
What Rosalind Franklin truly contributed to the discovery of DNA’s structure. A really informative article, perfect for a weekend coffee read. www.nature.com/articles/d41...
What Rosalind Franklin truly contributed to the discovery of DNA’s structure
Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.
www.nature.com
November 8, 2025 at 9:21 AM
What Rosalind Franklin truly contributed to the discovery of DNA’s structure. A really informative article, perfect for a weekend coffee read. www.nature.com/articles/d41...
Reposted by Alasdair Hubbard
Help, #MicroSky! We bought the Ausubel PA14NR transposon library, but half of the stock plates disappeared from a shared -80 and we've been unable to trace them 😭 Would anyone in the UK be willing to give us copies of these stocks please? I can supply proof purchase. And my eternal thanks.
November 3, 2025 at 3:24 PM
Help, #MicroSky! We bought the Ausubel PA14NR transposon library, but half of the stock plates disappeared from a shared -80 and we've been unable to trace them 😭 Would anyone in the UK be willing to give us copies of these stocks please? I can supply proof purchase. And my eternal thanks.
Reposted by Alasdair Hubbard
🔊 Applications for the tenure-track illuminate global challenge fellowships at Queen’s are now open!
Comes with 5 years protected research time, a PhD studentship, & 60k start-up. I had one of these before getting my FLF, happy to chat to anyone interested!
www.qub.ac.uk/Research/fel...
Comes with 5 years protected research time, a PhD studentship, & 60k start-up. I had one of these before getting my FLF, happy to chat to anyone interested!
www.qub.ac.uk/Research/fel...
Our Illuminate Global Challenges Fellowships | Research | Queen's University Belfast
www.qub.ac.uk
October 30, 2025 at 12:19 PM
🔊 Applications for the tenure-track illuminate global challenge fellowships at Queen’s are now open!
Comes with 5 years protected research time, a PhD studentship, & 60k start-up. I had one of these before getting my FLF, happy to chat to anyone interested!
www.qub.ac.uk/Research/fel...
Comes with 5 years protected research time, a PhD studentship, & 60k start-up. I had one of these before getting my FLF, happy to chat to anyone interested!
www.qub.ac.uk/Research/fel...
Reposted by Alasdair Hubbard
Back by absolutely zero demand, its the Hubbard annual pumpkin carving competition. Which is best, left or right?! #Halloween
October 29, 2025 at 7:21 PM
Back by absolutely zero demand, its the Hubbard annual pumpkin carving competition. Which is best, left or right?! #Halloween
Back by absolutely zero demand, its the Hubbard annual pumpkin carving competition. Which is best, left or right?! #Halloween
October 29, 2025 at 7:21 PM
Back by absolutely zero demand, its the Hubbard annual pumpkin carving competition. Which is best, left or right?! #Halloween
My beautiful boy enjoying autumn!
October 26, 2025 at 6:39 PM
My beautiful boy enjoying autumn!
Reposted by Alasdair Hubbard
🧪If you are interested in #microbial growth data, you may have have a look at μGrowthDB; an open repository designed to store, visualize, analyze & share quantitative measurements of species abundances and metabolite profiles from monocultures & communities of known composition.
#microsky #mevosky
#microsky #mevosky
October 14, 2025 at 8:59 AM
🧪If you are interested in #microbial growth data, you may have have a look at μGrowthDB; an open repository designed to store, visualize, analyze & share quantitative measurements of species abundances and metabolite profiles from monocultures & communities of known composition.
#microsky #mevosky
#microsky #mevosky
Wonderful news today that my PhD student @mwilde.bsky.social will be giving a talk at the BSAC Antimicrobial Resistance and Mechanisms Workshop in November. Brilliant to see an excellent students hard work being rewarded! #microsky
October 20, 2025 at 7:32 PM
Wonderful news today that my PhD student @mwilde.bsky.social will be giving a talk at the BSAC Antimicrobial Resistance and Mechanisms Workshop in November. Brilliant to see an excellent students hard work being rewarded! #microsky