Dagan Segal
@dagansegal.bsky.social
quantitative imaging in pediatric cancer. postdoc @Danuser Lab, UTSW Find me at dagansegal.bsky.social
Pinned
Dagan Segal
@dagansegal.bsky.social
· Jan 28
Preprint Alert📣
Our work
✳️uncovers a distinct cancer cell state with survival advantages in the pediatric cancer *Ewing Sarcoma*
✳️implicates membrane invaginations called *caveolae* that drive survival through subcellular organization of signaling molecules on the cell surface.
Check it out! 👇
Our work
✳️uncovers a distinct cancer cell state with survival advantages in the pediatric cancer *Ewing Sarcoma*
✳️implicates membrane invaginations called *caveolae* that drive survival through subcellular organization of signaling molecules on the cell surface.
Check it out! 👇
hi @zebrafishrock.bsky.social community! Who of my friends am I going to see at ZDM18 in Boston next week?!? Excited!
October 8, 2025 at 8:41 PM
hi @zebrafishrock.bsky.social community! Who of my friends am I going to see at ZDM18 in Boston next week?!? Excited!
Reposted by Dagan Segal
My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...
Mechanical confinement governs phenotypic plasticity in melanoma - Nature
Mechanical confinement of cancer cells at the tumour–microenvironment interface induces phenotype switching through chromatin remodelling by HMGB2, leading to a more invasive and drug-resistant state ...
www.nature.com
August 27, 2025 at 5:18 PM
My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...
Reposted by Dagan Segal
Females are larger than males. How? Here is one solution- they have MORE nuclei in their flight muscles and grow LARGER heart and fat body cells with MORE ribosomal mRNAs. Fun collaboration of @jeromeavellaneda.bsky.social with @soumitrakp.bsky.social & Brian Oliver www.biorxiv.org/content/10.1...
August 29, 2025 at 1:57 PM
Females are larger than males. How? Here is one solution- they have MORE nuclei in their flight muscles and grow LARGER heart and fat body cells with MORE ribosomal mRNAs. Fun collaboration of @jeromeavellaneda.bsky.social with @soumitrakp.bsky.social & Brian Oliver www.biorxiv.org/content/10.1...
Reposted by Dagan Segal
I am delighted to announce that the UW Department of Biochemistry has opened searches for TWO tenure-track positions.
Descriptions and links in the following two posts.
Descriptions and links in the following two posts.
August 28, 2025 at 8:47 PM
I am delighted to announce that the UW Department of Biochemistry has opened searches for TWO tenure-track positions.
Descriptions and links in the following two posts.
Descriptions and links in the following two posts.
Reposted by Dagan Segal
Big day for our team: our pheochromocytoma and paraganglioma (PPGL) organoid paper is now up on bioRxiv!
This was a tour de force across 6 institutions, 37 authors, building patient-derived organoids from 35 PPGL patients /🧵
🔗 www.biorxiv.org/content/10.1...
This was a tour de force across 6 institutions, 37 authors, building patient-derived organoids from 35 PPGL patients /🧵
🔗 www.biorxiv.org/content/10.1...
Patient-derived organoids reveal hypoxia-driven plasticity and therapeutic vulnerabilities in pheochromocytomas and paragangliomas
Pheochromocytomas and paragangliomas (PPGLs) are rare chromaffin cell-derived neuroendocrine tumors of sympathetic (catecholamine-producing) or parasympathetic (nonsecretory) origin, frequently driven...
www.biorxiv.org
August 26, 2025 at 8:34 PM
Big day for our team: our pheochromocytoma and paraganglioma (PPGL) organoid paper is now up on bioRxiv!
This was a tour de force across 6 institutions, 37 authors, building patient-derived organoids from 35 PPGL patients /🧵
🔗 www.biorxiv.org/content/10.1...
This was a tour de force across 6 institutions, 37 authors, building patient-derived organoids from 35 PPGL patients /🧵
🔗 www.biorxiv.org/content/10.1...
This @nightsciencepod.bsky.social episode with Martin Schwartz was so awesome!
The idea to toss all the "ego" aspects of science (including worries/insecurities about career prospects) and follow the curiosity/passion path to do your best work is something I strive for every day.
The idea to toss all the "ego" aspects of science (including worries/insecurities about career prospects) and follow the curiosity/passion path to do your best work is something I strive for every day.
August 26, 2025 at 5:00 PM
This @nightsciencepod.bsky.social episode with Martin Schwartz was so awesome!
The idea to toss all the "ego" aspects of science (including worries/insecurities about career prospects) and follow the curiosity/passion path to do your best work is something I strive for every day.
The idea to toss all the "ego" aspects of science (including worries/insecurities about career prospects) and follow the curiosity/passion path to do your best work is something I strive for every day.
What an exciting announcement! Best of luck to @itaiyanai.bsky.social and Martin Lercher on this new endeavor. The cultural shift is much needed. I am on board!
🚀 Today we're launching the 'Night Science Institute', a non-for-profit organization to lead a cultural shift in science! You may say we're dreamers 😉, but we think we're not the only ones. Perhaps today you will join us to make the Day Science and Night Science parts of the process live as one!
August 26, 2025 at 4:57 PM
What an exciting announcement! Best of luck to @itaiyanai.bsky.social and Martin Lercher on this new endeavor. The cultural shift is much needed. I am on board!
Now online! www.youtube.com/channel/UCs9...
August 21, 2025 at 2:38 PM
Now online! www.youtube.com/channel/UCs9...
Reposted by Dagan Segal
🎉 Congrats to postdoc Horacio Martín Pallarés on being named a 2025 @pewtrusts.org Latin American Fellow!
His work in the @bazzinilab.bsky.social (a 2010 PEW Fellow) investigates how #Zika & #dengue viruses hijack host cells.
Read about the fellowship and full circle moment: bit.ly/4mHWJTS
His work in the @bazzinilab.bsky.social (a 2010 PEW Fellow) investigates how #Zika & #dengue viruses hijack host cells.
Read about the fellowship and full circle moment: bit.ly/4mHWJTS
August 12, 2025 at 3:47 PM
🎉 Congrats to postdoc Horacio Martín Pallarés on being named a 2025 @pewtrusts.org Latin American Fellow!
His work in the @bazzinilab.bsky.social (a 2010 PEW Fellow) investigates how #Zika & #dengue viruses hijack host cells.
Read about the fellowship and full circle moment: bit.ly/4mHWJTS
His work in the @bazzinilab.bsky.social (a 2010 PEW Fellow) investigates how #Zika & #dengue viruses hijack host cells.
Read about the fellowship and full circle moment: bit.ly/4mHWJTS
I keep getting more and more followers here but i think they are mostly bots, right?
August 12, 2025 at 7:45 PM
I keep getting more and more followers here but i think they are mostly bots, right?
Reposted by Dagan Segal
To celebrate the summer, our ReSCU-Net paper is out @jcb.org !! Work led by our dungeon master @ray-hawkins.bsky.social, developing a novel neural network architecture and applying it to explore the role of gap junctions in embryonic wound healing in #Drosophila 🧪.
shorturl.at/xNRKn
shorturl.at/xNRKn
August 11, 2025 at 2:59 PM
To celebrate the summer, our ReSCU-Net paper is out @jcb.org !! Work led by our dungeon master @ray-hawkins.bsky.social, developing a novel neural network architecture and applying it to explore the role of gap junctions in embryonic wound healing in #Drosophila 🧪.
shorturl.at/xNRKn
shorturl.at/xNRKn
This already happened and I wasnt on top of posting 😅
Thankful for the great opportunity to share my work at @bppbseminar.bsky.social .This is such an engaging and fun community and seminar series, highly recommend! Stay tuned for a recording (they are also on top of their youtube channel!).
Thankful for the great opportunity to share my work at @bppbseminar.bsky.social .This is such an engaging and fun community and seminar series, highly recommend! Stay tuned for a recording (they are also on top of their youtube channel!).
Please join BPPB on Fri July 25 for talks by Dagan Segal (Insights from zebrafish into cancer cell adaptation) and Trevor GrandPre (Trait-space patterning is dictated by the tempo & mode of mutation). For more information & to sign up for our email list, please visit sites.google.com/view/bppb-se...
August 8, 2025 at 9:20 PM
This already happened and I wasnt on top of posting 😅
Thankful for the great opportunity to share my work at @bppbseminar.bsky.social .This is such an engaging and fun community and seminar series, highly recommend! Stay tuned for a recording (they are also on top of their youtube channel!).
Thankful for the great opportunity to share my work at @bppbseminar.bsky.social .This is such an engaging and fun community and seminar series, highly recommend! Stay tuned for a recording (they are also on top of their youtube channel!).
Time to find creative new ways to fund science!
Funding policy for 2025 from NCI. Was just released: 4 percentile…maybe!
www.cancer.gov/grants-train...
www.cancer.gov/grants-train...
Funding Policy - Research Grants
NCI funding policy for research project grant (RPG) awards reflects the funding goals of the institute, NIH, and HHS.
www.cancer.gov
July 23, 2025 at 11:06 PM
Time to find creative new ways to fund science!
Very cool work using zebrafish model to bring new insight into pediatric cancer initiation! Congrats @jackkucinski.bsky.social @kendalllab.bsky.social and team!
I’m happy to share our published work in @cp-cellreports.bsky.social! With zebrafish modeling of rhabdomyosarcoma, we showed that PAX3::FOXO1 utilizes homeobox motif recognition to initially bind closed DNA and activate neural programs present in the human disease. www.cell.com/cell-reports...
Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivo
Kucinski et al. use embryonic zebrafish modeling to understand initial chromatin regulatory
mechanisms of fusion-driven pediatric rhabdomyosarcoma. They found that the PAX3::FOXO1
oncoprotein function...
www.cell.com
July 23, 2025 at 6:34 PM
Very cool work using zebrafish model to bring new insight into pediatric cancer initiation! Congrats @jackkucinski.bsky.social @kendalllab.bsky.social and team!
Very cool thread on something I knew very little about!
What is buckling, and why is it relevant in understanding epithelial morphogenesis? 🧐
I am @onenimesa.bsky.social and I will share some papers to understand this aspect of #EpithelialMechanics
I am @onenimesa.bsky.social and I will share some papers to understand this aspect of #EpithelialMechanics
May 26, 2025 at 2:25 AM
Very cool thread on something I knew very little about!
Such cool work! Check out this recent paper by my colleague @jamieson-ai.bsky.social et al. with immediate real-world impact!
First post on bsky to share our working published in @nejm.org (AI): Rubrics to Prompts! Deploying AI in the real world with a great team.
ai.nejm.org/doi/full/10....
ai.nejm.org/doi/full/10....
Rubrics to Prompts: Assessing Medical Student Post-Encounter Notes with AI
This case study, conducted at UT Southwestern Medical Center’s Simulation Center,
describes the first successful prospective deployment of a generative artificial intelligence
(AI)–based automated ...
ai.nejm.org
May 14, 2025 at 6:37 PM
Such cool work! Check out this recent paper by my colleague @jamieson-ai.bsky.social et al. with immediate real-world impact!
Reposted by Dagan Segal
REMINDER: Last chance to submit a scientific picture or art of a embryos, stem cells or organoids to the YEN Image Competition. Deadline is 1st May!
#YEN2025
#YEN2025
April 29, 2025 at 4:04 PM
REMINDER: Last chance to submit a scientific picture or art of a embryos, stem cells or organoids to the YEN Image Competition. Deadline is 1st May!
#YEN2025
#YEN2025
Benny was my PhD mentor. Infectious enthusiasm and burning curiosity is exactly right. He was such a great mentor to me and many others and he will be sorely missed.
יהיה זכרו ברוך. May his memory be a blessing.
יהיה זכרו ברוך. May his memory be a blessing.
Sad news. Benny Shilo, a pioneer in dev bio & Drosophila genetics, has died.
I'll remember the infectious enthusiasm and burning curiosity he brought to every conversation I had with him.
I'll remember the infectious enthusiasm and burning curiosity he brought to every conversation I had with him.
Our field has lost an amazing scientist, mentor, and old friend. Benny, along with Mike Hoffman, had a brilliant idea in the early 1980s. The first oncogenes were being cloned and they realized if we wanted to understand their roles in cancer, we needed to understand their normal function 1/n 🧪
April 17, 2025 at 2:35 PM
Benny was my PhD mentor. Infectious enthusiasm and burning curiosity is exactly right. He was such a great mentor to me and many others and he will be sorely missed.
יהיה זכרו ברוך. May his memory be a blessing.
יהיה זכרו ברוך. May his memory be a blessing.
Hey @drlizhaynes.bsky.social Thanks for representing!
(Not tattooed myself but respect the art of self expression :))
www.nature.com/articles/d41...
(Not tattooed myself but respect the art of self expression :))
www.nature.com/articles/d41...
Science on our sleeves: the research that inspires our tattoos
Inked scientists choose scientific images to mark career accomplishments and illustrate their research passion.
www.nature.com
April 16, 2025 at 2:39 PM
Hey @drlizhaynes.bsky.social Thanks for representing!
(Not tattooed myself but respect the art of self expression :))
www.nature.com/articles/d41...
(Not tattooed myself but respect the art of self expression :))
www.nature.com/articles/d41...
Reposted by Dagan Segal
NEW PAPER, JUST OUT! 👀
Insects from the '70s and '80s were already collecting microplastic, decades before the term microplastic even existed. 🤯
A thread on the surprising history of this pollutant and the incredible insect larvae that helped us uncover it. 🐛
Let's dive in! 🧵👇 1/x
Insects from the '70s and '80s were already collecting microplastic, decades before the term microplastic even existed. 🤯
A thread on the surprising history of this pollutant and the incredible insect larvae that helped us uncover it. 🐛
Let's dive in! 🧵👇 1/x
April 9, 2025 at 10:07 AM
NEW PAPER, JUST OUT! 👀
Insects from the '70s and '80s were already collecting microplastic, decades before the term microplastic even existed. 🤯
A thread on the surprising history of this pollutant and the incredible insect larvae that helped us uncover it. 🐛
Let's dive in! 🧵👇 1/x
Insects from the '70s and '80s were already collecting microplastic, decades before the term microplastic even existed. 🤯
A thread on the surprising history of this pollutant and the incredible insect larvae that helped us uncover it. 🐛
Let's dive in! 🧵👇 1/x
Reposted by Dagan Segal
Groundbreaking study in Cell from @leventallab.bsky.social: phospholipid asymmetry is a defining feature of the plasma membrane and cholesterol fills the holes — major implications for how this membrane works. A #lipidtime must-read! www.cell.com/cell/abstrac...
Cell membranes sustain phospholipid imbalance via cholesterol asymmetry
This work challenges a major assumption in cell biology by showing that lipid bilayers
can have drastically different phospholipid abundances between their two leaflets.
This lipid abundance asymmetry...
www.cell.com
April 3, 2025 at 3:07 PM
Groundbreaking study in Cell from @leventallab.bsky.social: phospholipid asymmetry is a defining feature of the plasma membrane and cholesterol fills the holes — major implications for how this membrane works. A #lipidtime must-read! www.cell.com/cell/abstrac...
Reposted by Dagan Segal
Talks...on the train! What? @odedrechavi.bsky.social, @natanellae.bsky.social, @meital.bsky.social, @svobodalab.bsky.social, @paveltomancak.bsky.social, @itaiyanai.bsky.social, @zernickagoetz.bsky.social Register now for: "an atmosphere of enthusiasm, lucid criticism, nonconformism, and friendship".
Who does that? We rented a train JUST for the conference, that will take the participants from Prague to the woods of Bohemia. There'll be talks ON THE TRAIN. In Prague we'll have 5 locations with different atmospheres.
#theconferencetoendallconferences Register now:
woodstock.img.cas.cz
#theconferencetoendallconferences Register now:
woodstock.img.cas.cz
April 1, 2025 at 5:31 PM
Talks...on the train! What? @odedrechavi.bsky.social, @natanellae.bsky.social, @meital.bsky.social, @svobodalab.bsky.social, @paveltomancak.bsky.social, @itaiyanai.bsky.social, @zernickagoetz.bsky.social Register now for: "an atmosphere of enthusiasm, lucid criticism, nonconformism, and friendship".
Outer ear = gills! First step towards creating human mermaids🧜♀️🌊
This insanely cool paper is making my day!!! (Cue arguments about Haeckel being right!) Congrats to Gage Crump, Andrew Gillis, @goodfrognosis.bsky.social and all the other authors. Well done!
pubmed.ncbi.nlm.nih.gov/39788155/
pubmed.ncbi.nlm.nih.gov/39788155/
Repurposing of a gill gene regulatory program for outer-ear evolution - PubMed
How new structures emerge during evolution has long fascinated biologists. An example is how the diminutive bones of the mammalian middle ear arose from ancestral fish jawbones<sup>1</sup>. By contras...
pubmed.ncbi.nlm.nih.gov
March 22, 2025 at 9:09 PM
Outer ear = gills! First step towards creating human mermaids🧜♀️🌊
Look who's on bluesky! I recommend you follow @assafzaritsky.bsky.social
Hello, World!
March 21, 2025 at 3:59 PM
Look who's on bluesky! I recommend you follow @assafzaritsky.bsky.social
Reposted by Dagan Segal
📢 #AI & #CellularPhysiology researchers 👉 tune in via Zoom March 30-April 1 for a free livestream of our conference on the emerging intersection of AI and biological research.
Topics will range from AI-driven genomic insights to dataset challenges & more.
🔗Register to watch: janelia.news/register
Topics will range from AI-driven genomic insights to dataset challenges & more.
🔗Register to watch: janelia.news/register
March 21, 2025 at 3:55 PM
📢 #AI & #CellularPhysiology researchers 👉 tune in via Zoom March 30-April 1 for a free livestream of our conference on the emerging intersection of AI and biological research.
Topics will range from AI-driven genomic insights to dataset challenges & more.
🔗Register to watch: janelia.news/register
Topics will range from AI-driven genomic insights to dataset challenges & more.
🔗Register to watch: janelia.news/register