Computational and Structural Biotechnology Journal (CSBJ)
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Computational and Structural Biotechnology Journal (CSBJ)
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Computational and Structural Biotechnology Journal (CSBJ) is an online open-access journal and is composed of four specialty sections: • General • Smart Hospital • Nanoscience & Advanced Materials • Quantum Biology & Biophotonics

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⚡️ How does the Hv1 proton channel conduct protons faster than diffusion should allow?

🔗 Fluctuating hydrogen-bond network of the Hv1 ion channel. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#Biophysics #MolecularDynamics #StructuralBiology
Fluctuating hydrogen-bond network of the Hv1 ion channel. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.021
November 10, 2025 at 1:38 PM
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🔗CRISPR-epigenetic crosstalk: From bidirectional regulation to therapeutic potential. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚CSBJ: www.csbj.org

#CRISPR #Epigenetics #GeneEditing #MolecularBiology #Epigenomics #PrecisionMedicine #Genomics #SyntheticBiology
CRISPR-epigenetic crosstalk: From bidirectional regulation to therapeutic potential. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.031
November 10, 2025 at 1:04 PM
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🔗 SegDecon bridges histology and transcriptomics through AI-based nuclei segmentation and image-informed spatial deconvolution. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#SpatialTranscriptomics #Histology #SystemsBiology #AI #CellBiology
SegDecon bridges histology and transcriptomics through AI-based nuclei segmentation and image-informed spatial deconvolution. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.041
November 10, 2025 at 12:28 PM
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🔗 Single-residue engineering of lambda (λ) antibody light chains reduces conformational flexibility and enhances thermal stability. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#MonoclonalAntibodies #mAbs #Immunology #MolecularDynamics
Single-residue engineering of lambda (λ) antibody light chains reduces conformational flexibility and enhances thermal stability. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.045
November 10, 2025 at 8:45 AM
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🔗 Public Omics Explorer (POE): Enabling integrative semantic search across GEO omics datasets based on PubMed publications. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#Bioinformatics #Genomics #SemanticSearch #AI #FAIRData #DataDiscovery
Public Omics Explorer (POE): Enabling integrative semantic search across GEO omics datasets based on PubMed publications. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.11.004
November 7, 2025 at 2:41 AM
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🔗 MM-DRPNet: A multimodal dynamic radial partitioning network for enhanced protein–ligand binding affinity prediction. Computational and Structural Biotechnology Journal, doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#StructuralBiology #ProteinLigandInteraction #DrugDesign #ComputationalChemistry
MM-DRPNet: A multimodal dynamic radial partitioning network for enhanced protein–ligand binding affinity prediction. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.11.050
November 3, 2025 at 2:00 AM
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💡 Can AI find the viral “on switch” that triggers infection?

🔗 Machine and deep learning to predict viral fusion peptides. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#MachineLearning #Virology #AI #ProteinEngineering #Bioinformatics
Machine and deep learning to predict viral fusion peptides. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.02.011
November 1, 2025 at 11:51 PM
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🔗 Dynamical features of smooth muscle actin pathological mutants: The arginine-257(258)-Cysteine cases. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#MolecularDynamics #ProteinScience #Actin #RareDiseases #Biophysics #CryoEM #DrugDiscovery
Dynamical features of smooth muscle actin pathological mutants: The arginine-257(258)-Cysteine cases. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.02.010
November 1, 2025 at 11:24 PM
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🔗 RoseTTAFold diffusion-guided short peptide design: a case study of binders against Keap1/Nrf2. Computational and Structural Biotechnology Journal, doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#StructuralBiology #PeptideTherapeutics #RoseTTAFold #ProteinEngineering #MolecularDynamics #DrugDesign
RoseTTAFold diffusion-guided short peptide design: a case study of binders against Keap1/Nrf2. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.02.032
October 31, 2025 at 12:35 AM
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🔗Computationally derived structural insights into Rare Earth selectivity in lanmodulin and its variants. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚CSBJ: www.csbj.org

#RareEarths #Lanmodulin #ComputationalBiology #Sustainability #RareEarthElements #ProteinEng
Computationally derived structural insights into Rare Earth selectivity in lanmodulin and its variants. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.02.005
October 27, 2025 at 3:18 AM
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🔗 Analysis of Fbox substrate adapter proteins using ProteoSync, a program for projection of evolutionary conservation onto protein atomic coordinates. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#ProteinScience #StructuralBiology #PyMOL
Analysis of Fbox substrate adapter proteins using ProteoSync, a program for projection of evolutionary conservation onto protein atomic coordinates. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.09.012
October 23, 2025 at 10:58 AM
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🔗 1H NMR urinary metabolomic analysis in recreational athletes: Impact of physical exercise, high intensity interval training and whole body cryostimulation. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚CSBJ: www.csbj.org

#SportsMedicine #HIIT #Cryotherapy #NMR
1H NMR urinary metabolomic analysis in recreational athletes: Impact of physical exercise, high intensity interval training and whole body cryostimulation. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.05.007
October 21, 2025 at 5:49 PM
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🔗 Aggregation dynamics of a 150 kDa Aβ42 oligomer: Insights from cryo electron microscopy and multimodal analysis. Computational and Structural Biotechnology Journal, doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#CryoEM #ProteinAggregation #Biophysics #StructuralBiology #Alzheimers #Neuroscience
Aggregation dynamics of a 150 kDa Aβ42 oligomer: Insights from cryo electron microscopy and multimodal analysis. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.11.024
October 21, 2025 at 3:09 PM
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🔗 Integrating AlphaFold pLDDT Scores into CABS-flex for enhanced protein flexibility simulations. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#Biophysics #ProteinDynamics #AlphaFold #CABSflex #StructuralBiology #MolecularModeling
Integrating AlphaFold pLDDT Scores into CABS-flex for enhanced protein flexibility simulations. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.11.047
October 20, 2025 at 10:46 PM
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🔗 Replacement of a single residue in an antibody abolishes cognate antigen binding, as predicted by theoretical methods. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#AntibodyEngineering #StructuralBiology #ProteinModeling #Biophysics #FTIR
Replacement of a single residue in an antibody abolishes cognate antigen binding, as predicted by theoretical methods. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.018
October 20, 2025 at 4:12 PM
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🔗 AlphaFold3 prediction of protein-protein complex: Is it ready for thermodynamic analysis?. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#AlphaFold3 #ProteinDesign #MolecularModeling #ComputationalBiology #StructuralBiology #Thermodynamics
AlphaFold3 prediction of protein-protein complex: Is it ready for thermodynamic analysis?. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.015
October 19, 2025 at 8:08 PM
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🧪 Can ionic liquids fine-tune enzyme activity and chirality without genetic modification?

🔗 Influence of ionic liquids on enzymatic asymmetric carboligations. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#Biocatalysis #Enzymology #Chirality
Influence of ionic liquids on enzymatic asymmetric carboligations. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.09.029
October 18, 2025 at 8:02 AM
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🧬 Can cells “remember” their identity without changing their DNA?

🔗 Epigenetic memory: The role of the crosstalk between histone modifications and DNA methylation. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#Epigenetics #DNA #Genomics
Epigenetic memory: The role of the crosstalk between histone modifications and DNA methylation. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.08.034
October 18, 2025 at 6:58 AM
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🔗 Dynamic energy conversion in protein catalysis: From brownian motion to enzymatic function. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#ProteinDynamics #EnzymaticCatalysis #Biophysics #StructuralBiology #EnzymeEngineering #Biochemistry
Dynamic energy conversion in protein catalysis: From brownian motion to enzymatic function. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.07.050
October 16, 2025 at 10:24 AM
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🔗 Structure analysis of human gut microbiota associated with single-celled gut protists using Next-Generation Sequencing of 16S and 18S rRNA genes. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#Microbiome #GutHealth #Metagenomics #Microbiota
Structure analysis of human gut microbiota associated with single-celled gut protists using Next-Generation Sequencing of 16S and 18S rRNA genes. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.06.006
October 15, 2025 at 8:48 AM
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🧬 Can we trust AI to pick the next high-performance enzyme?

🔗 Structure-filtered search of enzyme variants. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#ProteinEngineering #AlphaFold #EnzymeDiscovery #SyntheticBiology #StructuralBiology
Structure-filtered search of enzyme variants. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.09.039
October 14, 2025 at 7:54 AM
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🔗 C. perfringens enterotoxin-claudin pore complex: Models for structure, mechanism of pore assembly and cation permeability. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#StructuralBiology #AlphaFold2 #ProteinComplex #Claudin #Bioinformatics
C. perfringens enterotoxin-claudin pore complex: Models for structure, mechanism of pore assembly and cation permeability. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.11.048
October 12, 2025 at 11:43 PM
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🔗 Quantum neural networks meet federated learning for DNA mutation prediction. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ Quantum Biology & Biophotonics: www.csbj.org/qbio

#Genomics #QuantumBiology #DNA #QuantumComputing #QNN #ArtificialIntelligence
Quantum neural networks meet federated learning for DNA mutation prediction. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.09.036
October 11, 2025 at 7:26 AM
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🔗 Influence of PARP1 on CRISPR/Cas9 induced double strand break repair in proliferating cells. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#CRISPR #GenomeEditing #Genomics #DNARepair #PARP1 #GeneticEngineering #MolecularBiology #GeneTherapy
Influence of PARP1 on CRISPR/Cas9 induced double strand break repair in proliferating cells. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.001
October 8, 2025 at 11:14 PM
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🔗 When does molecular dynamics improve RNA models? Insights from CASP15 and practical guidelines. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#RNA #StructuralBiology #ComputationalBiology #Bioinformatics #MolecularSimulation #Biophysics
When does molecular dynamics improve RNA models? Insights from CASP15 and practical guidelines. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.003
October 8, 2025 at 12:25 AM