Author | Lightnews

Reposted by Chlanda lab

Max Renner @maxrenner.bsky.social · 1d

Our new preprint is out 🥳🥳🥳

Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?

👇

2 43 91

Reposted by Chlanda lab

Harry Low’s Lab @lowlab.bsky.social · 5d

Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.

For more details and to apply please see

www.imperial.ac.uk/jobs/search-...

1 40 48

Reposted by Chlanda lab

Jeremy Keown @jeremykeown.bsky.social · 11d

warwick.ac.uk/fac/cross_fa...

I am advertising for a PhD position in my group. We'll be investigating how pathogenic RNA viruses replicate in the nucleus. The project will teach cryoEM/ET, virus culture, and in vitro assays.

If you're interested reach out and I'd be happy to have a chat.

Dr Jeremy Keown

warwick.ac.uk

18 13

Chlanda lab @chlandalab.bsky.social · 10d

Thank you, Lars, for the invitation and for the opportunity to share the work. It was a great meeting and also a very nice opportunity to go again to beautiful Umeå!

2

Chlanda lab @chlandalab.bsky.social · 11d

Mysteries of trafficking of the vRNP segmented genome and assembly of influenza A virus revealed by in situ cryo-ET!
🔗 rdcu.be/eMmct
We are very excited that our paper is finally out!
🎉 Big congratulations to Moritz Wachsmuth-Melm and to everyone involved.

1 29 72

Reposted by Chlanda lab

Cell Biology J-Club @cellclub.bsky.social · 18d

“Kiss-shrink-run” unifies mechanisms for synaptic vesicle exocytosis and hyperfast recycling | Science www.science.org/doi/10.1126/...

“Kiss-shrink-run” unifies mechanisms for synaptic vesicle exocytosis and hyperfast recycling

Synaptic vesicle (SV) exocytosis underpins neuronal communication, yet its nanoscale dynamics remain poorly understood owing to limitations in visualizing rapid events in situ. Here, we used optogenet...

www.science.org

5 9

Reposted by Chlanda lab

Jakob Meier-Credo @meiercredo.bsky.social · Sep 19

Check out our new preprint on an integrated pipeline combining in situ #cryo-ET with MALDI #MSImaging for single-cell identification and classification from previously analysed EM-grids.
Link: www.biorxiv.org/content/10.1...

1 14 54

Reposted by Chlanda lab

Guenter Resch @nexperion.net · Sep 23

Happy to announce "Technical Innovations Using #SerialEM: A Community Meeting", a new format of hybrid meeting David Mastronarde and I are organizing in April 2026. For more info, a preliminary list of speakers, pre-registration etc. visit
www.nexperion.net/semcm2026

22 50

Reposted by Chlanda lab

Lars-Anders Carlson @lacarlson.bsky.social · Sep 22

Since it was published at peak holiday season, I'm taking the liberty to re-introduce our recent review article. We hope it will be a useful overview of RNA virus replication strategies, and how in situ cryo-EM have helped us understand them:
www.sciencedirect.com/science/arti...

Illuminating druggable dark matter in RNA virus replication using in situ cryo-EM

Viral proteins typically exist in the context of complex virions or in the even more complex host cells in which they replicate. Hence, meaningful ins…

www.sciencedirect.com

6 11

Reposted by Chlanda lab

Tanmay Bharat @tbharat-lab.bsky.social · Aug 31

Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging

Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social

www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social

3 59 140

Reposted by Chlanda lab

oleksiykovtun.bsky.social @oleksiykovtun.bsky.social · Aug 21

One week left to apply for a fully funded PhD position in my group! Please repost. jobrxiv.org/job/max-plan...

PhD student in cryo-ET of membrane trafficking at MPI-NAT in Göttingen, DE

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobrxiv.org

4 11

Reposted by Chlanda lab

François Mayer @francoismayer.bsky.social · Jun 13

Awesome malaria study out now in Nature Microbiology:

An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission

By Franziska Hentzschel, Matthias Marti, Freddy Frischknecht & colleagues!

@freddyfrischknecht.bsky.social

www.nature.com/articles/s41...

An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission - Nature Microbiology

A unique Arp2/3 complex in malaria parasites enables DNA segregation during the rapid formation of male gametes by safeguarding the attachment of chromosomes to the mitotic spindle.

www.nature.com

10 28

Reposted by Chlanda lab

Emily Bruce @brucelab.bsky.social · Jun 10

Really enjoyed writing about one of my favorite topics (influenza filaments). There is so much exciting new filament research now, it is clearly no longer 'the graveyard of postdocs' Bob Lamb called the topic during my PhD. www.embopress.org/doi/full/10....

Influenza filaments: a graveyard of postdocs no longer? | The EMBO Journal

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

www.embopress.org

8 19

Chlanda lab @chlandalab.bsky.social · Jun 11

Very nice News&Views summary written by
‪@brucelab.bsky.social‬ about our work and work by Ed Partlow et al. (NIH) that influenza A virus filamentous morphology plays an important role in infection (www.nature.com/articles/s41...) can.
‪Thank you!
(www.embopress.org/doi/full/10....)

6 12

Chlanda lab @chlandalab.bsky.social · Jun 11

We are happy this work by Sarah Peterl et al. is out in EMBO J! It was an exciting collaborative effort of several groups in the SFB1129 consortium on pathogen replication and spread. Check out the correlated light and scanning EM method to study virus morphology changes during spread!

4 10

Chlanda lab @chlandalab.bsky.social · Jun 5

Very well deserved, congratulations, Tanmay!

2

Reposted by Chlanda lab

Yi-Wei Chang @yiweichang.bsky.social · May 15

Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals.
www.science.org/doi/10.1126/...

Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis

Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...

www.science.org

7 56 120

Reposted by Chlanda lab

Harry Low’s Lab @lowlab.bsky.social · Apr 28

Please RT. Post-doc opportunity alert! 💥 closing 5th May.. Come join our team (thelowlab.org) at Imperial, London, working on bacterial secretion systems. The position is funded by the Wellcome Trust.

For more details and to apply please see

www.imperial.ac.uk/jobs/search-...

26 14

Reposted by Chlanda lab

Florent Waltz @florentwaltz.bsky.social · Apr 25

Check out the latest version of MemBrain, spearheaded by computation superstar @lorenzlamm.bsky.social ! It can segment, pick particles and give you metrics on everything!

Lorenz Lamm @lorenzlamm.bsky.social · Apr 25

🦠🧠 MemBrain update! 🧠🦠
We’ve updated our preprint! It now covers the full MemBrain v2 pipeline for end-to-end membrane analysis in #CryoET: segmentation, particle picking, and spatial statistics.
🔗 Preprint: doi.org/10.1101/2024...
🔗 Code: github.com/CellArchLab/...
🧵(1/6) #TeamTomo

8 26

Reposted by Chlanda lab

MRC Laboratory of Molecular Biology @mrclmb.bsky.social · Apr 23

A colder frontier in cryo-EM 🧪🔬

Chris Russo’s group, inc. Joshua Dickerson, adapted #cryoEM to work at liquid helium temperatures (13 kelvins), where every frame captured contains more information than the equivalent using liquid nitrogen (81 kelvins).

Read more: tinyurl.com/mwwcunkc

#LMBResearch

The electron cryo-microscope adapted for use at liquid nitrogen temperatures within its custom-made black box.

23 49

Reposted by Chlanda lab

Jan Philipp Kreysing @jpkreysing.bsky.social · Apr 11

New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇

3 67 220

Reposted by Chlanda lab

Sven Klumpe @svenklumpe.bsky.social · Apr 9

Thrilled to share these experiments on shaping focused ion beams to explore different ways of milling. Here, we explore using different beam geometries to generate cellular thin sections/lamellae. The video shows elongating the beam on a charging spot burn www.biorxiv.org/content/10.1...

2 20 57

Reposted by Chlanda lab

Daniel Hurdiss @danielhurdiss.bsky.social · Mar 26

I’m delighted that we could contribute the #cryoEM data to this incredible antiviral discovery project from the group of @neytsjohan.bsky.social 💊

"A coronavirus assembly inhibitor that targets the viral membrane protein"

www.nature.com/articles/s41...

A huge congrats to everyone involved! 🎉

4 26 89

Chlanda lab @chlandalab.bsky.social · Mar 22

Congratulations Florent, Ben, and the team! Beautiful work!

1 3