Brady Johnston
@bradyajohnston.bsky.social
Scientific animator, structural biologist, creator of #MolecularNodes bradyajohnston.github.io/MolecularNodes/
Reposted by Brady Johnston
Day 2 of #ArtAdventCalendar
Today's new protein is Arc, a protein found in the brain, which can form icosahedral capsids (like viruses) containing its Arc mRNA cargo. They are linked to regulation of synaptic plasticity and forming long-term memories.
More projects: e-nox.net/portfolio/
#SciArt
Today's new protein is Arc, a protein found in the brain, which can form icosahedral capsids (like viruses) containing its Arc mRNA cargo. They are linked to regulation of synaptic plasticity and forming long-term memories.
More projects: e-nox.net/portfolio/
#SciArt
December 2, 2025 at 2:28 PM
Day 2 of #ArtAdventCalendar
Today's new protein is Arc, a protein found in the brain, which can form icosahedral capsids (like viruses) containing its Arc mRNA cargo. They are linked to regulation of synaptic plasticity and forming long-term memories.
More projects: e-nox.net/portfolio/
#SciArt
Today's new protein is Arc, a protein found in the brain, which can form icosahedral capsids (like viruses) containing its Arc mRNA cargo. They are linked to regulation of synaptic plasticity and forming long-term memories.
More projects: e-nox.net/portfolio/
#SciArt
Reposted by Brady Johnston
How do trypanosomes evolve resistance to sleeping sickness drugs?
Mutations in TbAQP2 🔵 can block melarsoprol and pentamidine 🟠 from entering the cell.
It was a pleasure to create this animation for Simone Weyand.
Read more here: elifesciences.org/reviewed-pre...
#blender #b3d #animation #science
Mutations in TbAQP2 🔵 can block melarsoprol and pentamidine 🟠 from entering the cell.
It was a pleasure to create this animation for Simone Weyand.
Read more here: elifesciences.org/reviewed-pre...
#blender #b3d #animation #science
December 1, 2025 at 11:20 AM
How do trypanosomes evolve resistance to sleeping sickness drugs?
Mutations in TbAQP2 🔵 can block melarsoprol and pentamidine 🟠 from entering the cell.
It was a pleasure to create this animation for Simone Weyand.
Read more here: elifesciences.org/reviewed-pre...
#blender #b3d #animation #science
Mutations in TbAQP2 🔵 can block melarsoprol and pentamidine 🟠 from entering the cell.
It was a pleasure to create this animation for Simone Weyand.
Read more here: elifesciences.org/reviewed-pre...
#blender #b3d #animation #science
Reposted by Brady Johnston
Proteins are dynamic structures, but structural biology often shows them as static snapshots. Inspired by long-exposure photography and generative art, I built ProteinCHAOS, an artistic tool inspired by molecular dynamics to capture protein flexibility over time, much like long-exposure images.
November 23, 2025 at 11:18 PM
Proteins are dynamic structures, but structural biology often shows them as static snapshots. Inspired by long-exposure photography and generative art, I built ProteinCHAOS, an artistic tool inspired by molecular dynamics to capture protein flexibility over time, much like long-exposure images.
If there is big biotech announcement happening, #MolecularNodes is being used for it. I only had the realisation in the past day, but it's strange to have my software very quickly become the visual face for $100M announcements and massive scientific breakthroughs.
November 21, 2025 at 2:35 PM
If there is big biotech announcement happening, #MolecularNodes is being used for it. I only had the realisation in the past day, but it's strange to have my software very quickly become the visual face for $100M announcements and massive scientific breakthroughs.
Reposted by Brady Johnston
Some animations I recently created for profluent.bio. As a structural biologist, I’m genuinely fascinated by their work in generative protein design. Congratulations to the team on their new round of funding!
#molecularnodes
#molecularnodes
November 21, 2025 at 1:02 PM
Some animations I recently created for profluent.bio. As a structural biologist, I’m genuinely fascinated by their work in generative protein design. Congratulations to the team on their new round of funding!
#molecularnodes
#molecularnodes
Reposted by Brady Johnston
Your go-to tutorial for simulating mesoscale membranes is here. Look no further for:
-Understanding the state of the field
-A guide for creating new models for your science
-Hands-on tutorials to simulate your very own membranes
See tinyurl.com/punk3tcu and the below 🧵 start your journey 💻
-Understanding the state of the field
-A guide for creating new models for your science
-Hands-on tutorials to simulate your very own membranes
See tinyurl.com/punk3tcu and the below 🧵 start your journey 💻
October 22, 2025 at 2:21 PM
Your go-to tutorial for simulating mesoscale membranes is here. Look no further for:
-Understanding the state of the field
-A guide for creating new models for your science
-Hands-on tutorials to simulate your very own membranes
See tinyurl.com/punk3tcu and the below 🧵 start your journey 💻
-Understanding the state of the field
-A guide for creating new models for your science
-Hands-on tutorials to simulate your very own membranes
See tinyurl.com/punk3tcu and the below 🧵 start your journey 💻
Reposted by Brady Johnston
Bringing invisible ideas to life.
#sciart #blender3D #illustration
*illustrations created for Mary Munson’s Lab website at UMass Chan Medical School*
#sciart #blender3D #illustration
*illustrations created for Mary Munson’s Lab website at UMass Chan Medical School*
October 1, 2025 at 8:32 AM
Bringing invisible ideas to life.
#sciart #blender3D #illustration
*illustrations created for Mary Munson’s Lab website at UMass Chan Medical School*
#sciart #blender3D #illustration
*illustrations created for Mary Munson’s Lab website at UMass Chan Medical School*
Reposted by Brady Johnston
I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5)
doi.org/10.1101/2025.09.24.678028 #proteindesign
doi.org/10.1101/2025.09.24.678028 #proteindesign
September 28, 2025 at 9:16 PM
I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5)
doi.org/10.1101/2025.09.24.678028 #proteindesign
doi.org/10.1101/2025.09.24.678028 #proteindesign
Reposted by Brady Johnston
Also, shoutout to @blender.org and @bradyajohnston.bsky.social for making it so easy to turn protein structures into nice images!
5/5
5/5
September 24, 2025 at 12:27 PM
Also, shoutout to @blender.org and @bradyajohnston.bsky.social for making it so easy to turn protein structures into nice images!
5/5
5/5
Reposted by Brady Johnston
so proud to share @jhuapl.bsky.social neuroscience research at #blenderconference2025 @blender.org ❤️
also shoutout to #microscopynodes by @aafkegros.bsky.social, here's to awesome new collabs born at blendercon!!!
also shoutout to #microscopynodes by @aafkegros.bsky.social, here's to awesome new collabs born at blendercon!!!
Blending brains: Tales from the neuro department — Blender Conference 2025
YouTube video by Blender
youtu.be
September 19, 2025 at 11:47 AM
so proud to share @jhuapl.bsky.social neuroscience research at #blenderconference2025 @blender.org ❤️
also shoutout to #microscopynodes by @aafkegros.bsky.social, here's to awesome new collabs born at blendercon!!!
also shoutout to #microscopynodes by @aafkegros.bsky.social, here's to awesome new collabs born at blendercon!!!
Reposted by Brady Johnston
Hello! I'm Behnoush, structural biology scientist from the Broad Institute. I also like to combine proteins structures and other scientific topics with art. Here are some journal cover arts I've created recently. Hope to find old and new friends here.
#Blender #b3d #MolecularNodes #GeometryNodes
#Blender #b3d #MolecularNodes #GeometryNodes
September 19, 2025 at 7:28 PM
Hello! I'm Behnoush, structural biology scientist from the Broad Institute. I also like to combine proteins structures and other scientific topics with art. Here are some journal cover arts I've created recently. Hope to find old and new friends here.
#Blender #b3d #MolecularNodes #GeometryNodes
#Blender #b3d #MolecularNodes #GeometryNodes
Reposted by Brady Johnston
New video about caffeine linked here:
youtu.be/fNR-GY-WoAI
Rendered in #blender3d using @bradyajohnston.bsky.social 's brilliant Molecular Nodes extension.
Make sure you check out the incredible coffee from @thegooddotstore.bsky.social 's Keats & Co by visiting keats.watchclockwork.com
youtu.be/fNR-GY-WoAI
Rendered in #blender3d using @bradyajohnston.bsky.social 's brilliant Molecular Nodes extension.
Make sure you check out the incredible coffee from @thegooddotstore.bsky.social 's Keats & Co by visiting keats.watchclockwork.com
The Incredible Biology Powering Caffeine
YouTube video by Clockwork
youtu.be
September 16, 2025 at 7:15 PM
New video about caffeine linked here:
youtu.be/fNR-GY-WoAI
Rendered in #blender3d using @bradyajohnston.bsky.social 's brilliant Molecular Nodes extension.
Make sure you check out the incredible coffee from @thegooddotstore.bsky.social 's Keats & Co by visiting keats.watchclockwork.com
youtu.be/fNR-GY-WoAI
Rendered in #blender3d using @bradyajohnston.bsky.social 's brilliant Molecular Nodes extension.
Make sure you check out the incredible coffee from @thegooddotstore.bsky.social 's Keats & Co by visiting keats.watchclockwork.com
Reposted by Brady Johnston
What's the opposite of Artificial Intelligence? Naturally Occurring Stupidity?
Whatever it is, that's what I'm here for!
Check out my new film here - made with love, by humans, for humans: youtu.be/iNMxVBnIrwQ
#animation #shortfilm #blender #b3d
Whatever it is, that's what I'm here for!
Check out my new film here - made with love, by humans, for humans: youtu.be/iNMxVBnIrwQ
#animation #shortfilm #blender #b3d
September 2, 2025 at 2:58 PM
What's the opposite of Artificial Intelligence? Naturally Occurring Stupidity?
Whatever it is, that's what I'm here for!
Check out my new film here - made with love, by humans, for humans: youtu.be/iNMxVBnIrwQ
#animation #shortfilm #blender #b3d
Whatever it is, that's what I'm here for!
Check out my new film here - made with love, by humans, for humans: youtu.be/iNMxVBnIrwQ
#animation #shortfilm #blender #b3d
Reposted by Brady Johnston
RosettaFold 3 is here! 🧬🚀
AtomWorks (the foundational data pipeline powering it) is perhaps the really most exciting part of this release!
Congratulations @simonmathis.bsky.social and team!!! ❤️
bioRxiv preprint: www.biorxiv.org/content/10.1...
AtomWorks (the foundational data pipeline powering it) is perhaps the really most exciting part of this release!
Congratulations @simonmathis.bsky.social and team!!! ❤️
bioRxiv preprint: www.biorxiv.org/content/10.1...
August 15, 2025 at 1:26 PM
RosettaFold 3 is here! 🧬🚀
AtomWorks (the foundational data pipeline powering it) is perhaps the really most exciting part of this release!
Congratulations @simonmathis.bsky.social and team!!! ❤️
bioRxiv preprint: www.biorxiv.org/content/10.1...
AtomWorks (the foundational data pipeline powering it) is perhaps the really most exciting part of this release!
Congratulations @simonmathis.bsky.social and team!!! ❤️
bioRxiv preprint: www.biorxiv.org/content/10.1...
Reposted by Brady Johnston
Thrilled to share my first corresponding author paper as a project leader in @hillerlab.bsky.social Amazing work from first author @annaleder.bsky.social We discovered multi-chaperone condensates in the ER that revolutionise the current vision of protein folding!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 11, 2025 at 10:14 AM
Thrilled to share my first corresponding author paper as a project leader in @hillerlab.bsky.social Amazing work from first author @annaleder.bsky.social We discovered multi-chaperone condensates in the ER that revolutionise the current vision of protein folding!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Brady Johnston
🕒 NEW VIDEO 🕒
How can a cell know the time? Let's explore the beautiful 24-hour cycle produced by #KaiC proteins in the cyanobacteria S. Elongatus. Rendered in #blender3d with @bradyajohnston.bsky.social's brilliant Molecular Nodes add-on. #biology
How can a cell know the time? Let's explore the beautiful 24-hour cycle produced by #KaiC proteins in the cyanobacteria S. Elongatus. Rendered in #blender3d with @bradyajohnston.bsky.social's brilliant Molecular Nodes add-on. #biology
August 5, 2025 at 4:00 PM
🕒 NEW VIDEO 🕒
How can a cell know the time? Let's explore the beautiful 24-hour cycle produced by #KaiC proteins in the cyanobacteria S. Elongatus. Rendered in #blender3d with @bradyajohnston.bsky.social's brilliant Molecular Nodes add-on. #biology
How can a cell know the time? Let's explore the beautiful 24-hour cycle produced by #KaiC proteins in the cyanobacteria S. Elongatus. Rendered in #blender3d with @bradyajohnston.bsky.social's brilliant Molecular Nodes add-on. #biology
Reposted by Brady Johnston
Thrilled to see our study on how kinesin-2 motors are switched on and off published in @natsmb.nature.com ⚛️
➡️ www.nature.com/articles/s41...
Congrats to all authors from me and Anthony 🎉 @dunnschool.bsky.social Check out this animation made by talented PhD student @matthew-batisio.bsky.social 😆
➡️ www.nature.com/articles/s41...
Congrats to all authors from me and Anthony 🎉 @dunnschool.bsky.social Check out this animation made by talented PhD student @matthew-batisio.bsky.social 😆
July 29, 2025 at 9:04 AM
Thrilled to see our study on how kinesin-2 motors are switched on and off published in @natsmb.nature.com ⚛️
➡️ www.nature.com/articles/s41...
Congrats to all authors from me and Anthony 🎉 @dunnschool.bsky.social Check out this animation made by talented PhD student @matthew-batisio.bsky.social 😆
➡️ www.nature.com/articles/s41...
Congrats to all authors from me and Anthony 🎉 @dunnschool.bsky.social Check out this animation made by talented PhD student @matthew-batisio.bsky.social 😆
Reposted by Brady Johnston
Today is #StructureSunday, where we highlight awesome structures by our @arc_gov_au CCeMMP members 🎉 Today we feature the "The structure of h12-LOX in hexameric form" by Mobbs et al. PDB 8GHD. 📷 Rendered using #Blender 📷 🤩1/2
July 20, 2025 at 3:16 AM
Today is #StructureSunday, where we highlight awesome structures by our @arc_gov_au CCeMMP members 🎉 Today we feature the "The structure of h12-LOX in hexameric form" by Mobbs et al. PDB 8GHD. 📷 Rendered using #Blender 📷 🤩1/2
Reposted by Brady Johnston
pay us £1500 for the privilege of doing our graphic design work for free
July 16, 2025 at 2:06 PM
pay us £1500 for the privilege of doing our graphic design work for free
Reposted by Brady Johnston
Happy to share our latest work on the structure and assembly of holocentric kinetochores! Huge thanks to Ines for a very fruitful collaboration, Claudio for all the support, and congratulations to Christine and all co-authors!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
July 15, 2025 at 4:36 PM
Happy to share our latest work on the structure and assembly of holocentric kinetochores! Huge thanks to Ines for a very fruitful collaboration, Claudio for all the support, and congratulations to Christine and all co-authors!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Brady Johnston
What's New in Geometry Nodes in Blender 4.5
YouTube video by harry blends
youtu.be
July 15, 2025 at 2:03 PM
Reposted by Brady Johnston
We have a new position going at the UWA OceanOmics Centre - level 5 bioinformatics research officer. Should suit a MSc-level graduate
external.jobs.uwa.edu.au/cw/en/job/52...
Work with TONS of fish genomes, and most of the genomics data out there - Revio, PromethION, Illumina
#bioinformatics
external.jobs.uwa.edu.au/cw/en/job/52...
Work with TONS of fish genomes, and most of the genomics data out there - Revio, PromethION, Illumina
#bioinformatics
Prospective staff : Jobs at UWA : The University Of Western Australia
external.jobs.uwa.edu.au
July 14, 2025 at 1:22 AM
We have a new position going at the UWA OceanOmics Centre - level 5 bioinformatics research officer. Should suit a MSc-level graduate
external.jobs.uwa.edu.au/cw/en/job/52...
Work with TONS of fish genomes, and most of the genomics data out there - Revio, PromethION, Illumina
#bioinformatics
external.jobs.uwa.edu.au/cw/en/job/52...
Work with TONS of fish genomes, and most of the genomics data out there - Revio, PromethION, Illumina
#bioinformatics
Reposted by Brady Johnston
Excited to share our latest work using AI-designed proteins to block heme-piracy by E. coli. Published in @natcomms.nature.com. A team effort between my lab and the @knottrna.bsky.social lab, with experimental work led by the talented @danielrfox.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Inhibiting heme piracy by pathogenic Escherichia coli using de novo-designed proteins - Nature Communications
Many pathogens encode transporters that extract heme directly from host proteins. In this study, the authors demonstrate the utility of de novo-designed proteins in understanding the mechanism behind ...
www.nature.com
July 9, 2025 at 11:55 PM
Excited to share our latest work using AI-designed proteins to block heme-piracy by E. coli. Published in @natcomms.nature.com. A team effort between my lab and the @knottrna.bsky.social lab, with experimental work led by the talented @danielrfox.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 8, 2025 at 6:38 PM
Reposted by Brady Johnston
In our latest preprint on bioRxiv, we present the in situ structure of
the human gap junction at 14 Å resolution using cryo-ET.
The structure provides a blueprint for investigating how connexin
regulation shapes intercellular communication in health and disease.
the human gap junction at 14 Å resolution using cryo-ET.
The structure provides a blueprint for investigating how connexin
regulation shapes intercellular communication in health and disease.
July 8, 2025 at 5:33 AM
In our latest preprint on bioRxiv, we present the in situ structure of
the human gap junction at 14 Å resolution using cryo-ET.
The structure provides a blueprint for investigating how connexin
regulation shapes intercellular communication in health and disease.
the human gap junction at 14 Å resolution using cryo-ET.
The structure provides a blueprint for investigating how connexin
regulation shapes intercellular communication in health and disease.