Antoine Molaro
@antoinemolaro.bsky.social
Group Leader @GReD_Clermont
Chargé de Recherche @INSERM
Evolutionary biologist studying chromatin also drummer.
Jazz and epistemology. he/his
https://www.igred.fr/en/team/evolutionary-epigenomics-and-genetic-conflicts/
Chargé de Recherche @INSERM
Evolutionary biologist studying chromatin also drummer.
Jazz and epistemology. he/his
https://www.igred.fr/en/team/evolutionary-epigenomics-and-genetic-conflicts/
Pinned
Antoine Molaro
@antoinemolaro.bsky.social
· Mar 31
Hello World! Are you passionate about epigenomics and evolution 🧪🧬🐭🐵 ? Are you looking for a postdoc in a stimulating and inclusive environment ? Look no further... We are seeking creative postdocs for our ERC project EvoEpi @igred.fr ! 👇Details👇
tinyurl.com/PostdocEvoEp...
Repost are appreciated
tinyurl.com/PostdocEvoEp...
Repost are appreciated
Reposted by Antoine Molaro
Permanent Research Group Leader Position, Crete, Greece: Interested to assume long-term responsibilities for the Biodiversity Computing Group www.biocomp.gr I have set up in Crete? Apply now via apella.minedu.gov.gr/en/node/5998 (PDF also in English) - for questions email to [email protected]
December 15, 2025 at 7:23 AM
Permanent Research Group Leader Position, Crete, Greece: Interested to assume long-term responsibilities for the Biodiversity Computing Group www.biocomp.gr I have set up in Crete? Apply now via apella.minedu.gov.gr/en/node/5998 (PDF also in English) - for questions email to [email protected]
Reposted by Antoine Molaro
New preprint from our lab: ‘Retroviral insertions contributed to the divergence of human and chimpanzee brains’. Very proud of this piece which took almost a decade to finish.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Retroviral insertions contributed to the divergence of human and chimpanzee brains
Over the past 5 to 7 million years, humans and chimpanzees have diverged in brain size, structural complexity, and cognitive abilities despite high conservation of protein-coding genes. Notably, the e...
www.biorxiv.org
December 14, 2025 at 8:16 PM
New preprint from our lab: ‘Retroviral insertions contributed to the divergence of human and chimpanzee brains’. Very proud of this piece which took almost a decade to finish.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Antoine Molaro
Fantastic #EvoChromo25. Wonderful iteration, learned a lot - and loved the Nirenberg gold Luger nucleosome prize ! Humor sun and outstanding and thought-provoking science.
December 13, 2025 at 2:37 PM
Fantastic #EvoChromo25. Wonderful iteration, learned a lot - and loved the Nirenberg gold Luger nucleosome prize ! Humor sun and outstanding and thought-provoking science.
Reposted by Antoine Molaro
Took us a bit, but proud of this published version. We now examine the genetic interaction of phosphorylation with oligomerization and where bulk and phospho-Swi6 localize. Wonder if chromatin affinity tuning to enable Suv39 H3K9me3 spreading is a conserved mechanism ?
doi.org/10.1093/nar/...
doi.org/10.1093/nar/...
December 12, 2025 at 11:37 PM
Took us a bit, but proud of this published version. We now examine the genetic interaction of phosphorylation with oligomerization and where bulk and phospho-Swi6 localize. Wonder if chromatin affinity tuning to enable Suv39 H3K9me3 spreading is a conserved mechanism ?
doi.org/10.1093/nar/...
doi.org/10.1093/nar/...
Reposted by Antoine Molaro
@pravrutharaman.bsky.social got super intrigued about EZHIP/CATACOMB, previously identified as a histone H3K27M mimic of PRC2. You can read about her efforts here: www.biorxiv.org/content/10.6... We hope these analyses will help spur more analyses in this very cool gene! 1/
Dynamic evolution of EZHIP, an inhibitor of the Polycomb Repressive Complex 2 in mammals
The Polycomb Repressive Complex 2 (PRC2) is an ancient, conserved chromatin-interacting complex that controls gene expression, facilitating differentiation and cellular identity during development. It...
www.biorxiv.org
December 13, 2025 at 10:08 PM
@pravrutharaman.bsky.social got super intrigued about EZHIP/CATACOMB, previously identified as a histone H3K27M mimic of PRC2. You can read about her efforts here: www.biorxiv.org/content/10.6... We hope these analyses will help spur more analyses in this very cool gene! 1/
Reposted by Antoine Molaro
Please help! We are looking for tissue-specific RNA-seq datasets or pubs with both male and female individual gene expression data, not pooled, from animal species. If you know of any relevant resources, please drop a link in the comments or send me a DM. Also, please help spread the word - thanks!
December 5, 2025 at 3:20 PM
Please help! We are looking for tissue-specific RNA-seq datasets or pubs with both male and female individual gene expression data, not pooled, from animal species. If you know of any relevant resources, please drop a link in the comments or send me a DM. Also, please help spread the word - thanks!
So long #EvoChromo2025! I encourage you to mark your calendars as soon as the next one is announced. Special congrats to the Nirenberg prize recipients - including our very own @germainekaram.bsky.social
Here is a picture of Germaine receiving her Golden Luger from the hands of Nick Irwin. #ProudPI
Here is a picture of Germaine receiving her Golden Luger from the hands of Nick Irwin. #ProudPI
December 12, 2025 at 2:42 PM
So long #EvoChromo2025! I encourage you to mark your calendars as soon as the next one is announced. Special congrats to the Nirenberg prize recipients - including our very own @germainekaram.bsky.social
Here is a picture of Germaine receiving her Golden Luger from the hands of Nick Irwin. #ProudPI
Here is a picture of Germaine receiving her Golden Luger from the hands of Nick Irwin. #ProudPI
Reposted by Antoine Molaro
Have you ever wondered how new DNA methylation patterns are established?
Paradigm shift ahead! We discovered a new mode of DNA methylation targeting in plants that relies on transcription factors and sequence motifs rather than chromatin modifications to regulate the methylome. rdcu.be/eQ6L5
1/8
Paradigm shift ahead! We discovered a new mode of DNA methylation targeting in plants that relies on transcription factors and sequence motifs rather than chromatin modifications to regulate the methylome. rdcu.be/eQ6L5
1/8
December 11, 2025 at 9:56 PM
Have you ever wondered how new DNA methylation patterns are established?
Paradigm shift ahead! We discovered a new mode of DNA methylation targeting in plants that relies on transcription factors and sequence motifs rather than chromatin modifications to regulate the methylome. rdcu.be/eQ6L5
1/8
Paradigm shift ahead! We discovered a new mode of DNA methylation targeting in plants that relies on transcription factors and sequence motifs rather than chromatin modifications to regulate the methylome. rdcu.be/eQ6L5
1/8
Reposted by Antoine Molaro
Join our online seminar on December 16, 2025, at 16:00 UTC to celebrate the book release "The Paradox of the Organism". More info: https://internalconflictsstn.wordpress.com/ #conference
INTERNAL CONFLICTS AND ORGANISMAL ADAPTATION – ESEB Special Topic Network
INTERNAL CONFLICTS AND ORGANISMAL ADAPTATION – ESEB Special Topic Network
internalconflictsstn.wordpress.com
December 10, 2025 at 10:38 PM
Join our online seminar on December 16, 2025, at 16:00 UTC to celebrate the book release "The Paradox of the Organism". More info: https://internalconflictsstn.wordpress.com/ #conference
Reposted by Antoine Molaro
The Department of Genetics at the University of Cambridge is seeking a talented Postdoctoral Research Associate to work in the group of Dr Felipe Karam Teixeira (www.gen.cam.ac.uk/research-gro...)
➡️For Further details see the link www.cam.ac.uk/jobs/postdoc...
➡️For Further details see the link www.cam.ac.uk/jobs/postdoc...
Postdoctoral Research Associate (Fixed Term)
Applications are invited for a Postdoctoral Research Associate position to work in the group of Dr Felipe Karam Teixeira (https://www.gen.cam.ac.uk/research-groups/research-groups/karam-teixeira) in
www.cam.ac.uk
December 10, 2025 at 11:22 AM
The Department of Genetics at the University of Cambridge is seeking a talented Postdoctoral Research Associate to work in the group of Dr Felipe Karam Teixeira (www.gen.cam.ac.uk/research-gro...)
➡️For Further details see the link www.cam.ac.uk/jobs/postdoc...
➡️For Further details see the link www.cam.ac.uk/jobs/postdoc...
December 10, 2025 at 6:34 AM
Reposted by Antoine Molaro
Confused by all the histones that are cropping up in organisms that are decidedly NOT eukaryotes? check out our review - fantastic work by team NucEvo in the #Lugerlab
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
December 9, 2025 at 3:14 PM
Confused by all the histones that are cropping up in organisms that are decidedly NOT eukaryotes? check out our review - fantastic work by team NucEvo in the #Lugerlab
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
Reposted by Antoine Molaro
Yay! Joy & excitement for the #science ahead & for our #team @ciri-lyon.bsky.social, who is getting @erc.europa.eu #Consolidator grant support to work on the FUNctional EVOlution of mammalian innate immunity #FUNEVO ! So thankful to #ERC and #everyone who contributed & provided support along the way
The results of the ERC Consolidator Grant call have been announced! 📣
349 researchers have been selected for funding. Congratulations to all! #ERCCogG!
👉 buff.ly/uu62uFV
#FrontierResearch #EUfunded #HorizonEurope
@scienceinnovation.ec.europa.eu
349 researchers have been selected for funding. Congratulations to all! #ERCCogG!
👉 buff.ly/uu62uFV
#FrontierResearch #EUfunded #HorizonEurope
@scienceinnovation.ec.europa.eu
December 9, 2025 at 5:17 PM
Yay! Joy & excitement for the #science ahead & for our #team @ciri-lyon.bsky.social, who is getting @erc.europa.eu #Consolidator grant support to work on the FUNctional EVOlution of mammalian innate immunity #FUNEVO ! So thankful to #ERC and #everyone who contributed & provided support along the way
Reposted by Antoine Molaro
Sophie Polo has been awarded an Impulscience grant from the Bettencourt Schueller Foundation to fund a research project on the establishment and maintenance of the inactive X chromosome in response to DNA breaks. This is wonderful news for the lab! We thank the Foundation for their support.
Sophie Polo
Les chromosomes, gardiens de notre identité génétique, subissent des dommages qui peuvent compromettre la santé et le destin des cellules.
www.fondationbs.org
December 9, 2025 at 10:34 AM
Sophie Polo has been awarded an Impulscience grant from the Bettencourt Schueller Foundation to fund a research project on the establishment and maintenance of the inactive X chromosome in response to DNA breaks. This is wonderful news for the lab! We thank the Foundation for their support.
Reposted by Antoine Molaro
The results of the ERC Consolidator Grant call have been announced! 📣
349 researchers have been selected for funding. Congratulations to all! #ERCCogG!
👉 buff.ly/uu62uFV
#FrontierResearch #EUfunded #HorizonEurope
@scienceinnovation.ec.europa.eu
349 researchers have been selected for funding. Congratulations to all! #ERCCogG!
👉 buff.ly/uu62uFV
#FrontierResearch #EUfunded #HorizonEurope
@scienceinnovation.ec.europa.eu
December 9, 2025 at 11:01 AM
The results of the ERC Consolidator Grant call have been announced! 📣
349 researchers have been selected for funding. Congratulations to all! #ERCCogG!
👉 buff.ly/uu62uFV
#FrontierResearch #EUfunded #HorizonEurope
@scienceinnovation.ec.europa.eu
349 researchers have been selected for funding. Congratulations to all! #ERCCogG!
👉 buff.ly/uu62uFV
#FrontierResearch #EUfunded #HorizonEurope
@scienceinnovation.ec.europa.eu
Reposted by Antoine Molaro
✨New preprint!
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
December 9, 2025 at 7:52 AM
✨New preprint!
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
Reposted by Antoine Molaro
Amazing. Got my first unsolicited email review of a paper from an AI company, also telling me what follow up work to do. So inexpensive to get even more insights! This is wonderful, and I am planning to budget for this in all future work, right below the priority to fund a space circus on the moon.
December 8, 2025 at 8:36 PM
Amazing. Got my first unsolicited email review of a paper from an AI company, also telling me what follow up work to do. So inexpensive to get even more insights! This is wonderful, and I am planning to budget for this in all future work, right below the priority to fund a space circus on the moon.
Reposted by Antoine Molaro
How to keep in step when your (protein) partner speeds up…
Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.
Congrats to whole team!
www.science.org/doi/10.1126/...
Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.
Congrats to whole team!
www.science.org/doi/10.1126/...
Rapid compensatory evolution within a multiprotein complex preserves telomere integrity
Intragenomic conflict with selfish genetic elements spurs adaptive changes in subunits of essential multiprotein complexes. Whether and how these adaptive changes disrupt interactions within such comp...
www.science.org
November 28, 2025 at 5:22 PM
How to keep in step when your (protein) partner speeds up…
Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.
Congrats to whole team!
www.science.org/doi/10.1126/...
Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.
Congrats to whole team!
www.science.org/doi/10.1126/...
Reposted by Antoine Molaro
We have just published a tribute to John Gurdon, reflecting on his scientific legacy and the profound influence he had on generations of developmental biologists.
The piece is available open access in Nature Communications:
www.nature.com/articles/s41...
The piece is available open access in Nature Communications:
www.nature.com/articles/s41...
Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon - Nature Communications
Nature Communications - Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon
www.nature.com
December 5, 2025 at 8:05 AM
We have just published a tribute to John Gurdon, reflecting on his scientific legacy and the profound influence he had on generations of developmental biologists.
The piece is available open access in Nature Communications:
www.nature.com/articles/s41...
The piece is available open access in Nature Communications:
www.nature.com/articles/s41...
Reposted by Antoine Molaro
More marsupial fun from @lab-turner.bsky.social. Congrats @sermenchero.bsky.social
Marsupial single-cell transcriptomics identifies temporal diversity in mammalian developmental programs - PubMed
Single-cell transcriptomics has demonstrated conserved and divergent programs of organogenesis in mammals, but existing studies have focused on eutherians. Marsupials exhibit short gestation and complete development externally, necessitating accelerated differentiation of anterior features required …
pubmed.ncbi.nlm.nih.gov
December 4, 2025 at 8:35 AM
More marsupial fun from @lab-turner.bsky.social. Congrats @sermenchero.bsky.social
Reposted by Antoine Molaro
Another envelope protein in the human genome. Expressed in the placenta, of course.
The human endogenous retroviral envelope HEMO protein interacts with BACE2: Novel partnership acquired in the primate lineage - PubMed
Endogenous retroviruses (ERV) represent 8 to 10% of mammalian genome. While most ERV are defective, a few retroviral genes, such as the envelope syncytins, were exapted during evolution and likely contributed to the emergence of placental mammals. We have previously identified the oldest full-length …
pubmed.ncbi.nlm.nih.gov
December 4, 2025 at 8:32 AM
Another envelope protein in the human genome. Expressed in the placenta, of course.
Reposted by Antoine Molaro
SMBE2026 Symposium 4 | Mining the archive: evolutionary genomics from public repositories
📨 Abstract submission
smbe2026.org/abstracts
📋 Programme details
smbe2026.org/programme
#SMBE2026
📨 Abstract submission
smbe2026.org/abstracts
📋 Programme details
smbe2026.org/programme
#SMBE2026
December 4, 2025 at 9:38 AM
SMBE2026 Symposium 4 | Mining the archive: evolutionary genomics from public repositories
📨 Abstract submission
smbe2026.org/abstracts
📋 Programme details
smbe2026.org/programme
#SMBE2026
📨 Abstract submission
smbe2026.org/abstracts
📋 Programme details
smbe2026.org/programme
#SMBE2026
Reposted by Antoine Molaro
Open postdoc position at @sangerinstitute.bsky.social Tree of Life to contribute to the Biodiversity Cell Atlas, with a focus on spatial transcriptomics.
Apply by January 4
sanger.wd103.myworkdayjobs.com/en-GB/Wellco...
Please share with anyone who might be interested!
Apply by January 4
sanger.wd103.myworkdayjobs.com/en-GB/Wellco...
Please share with anyone who might be interested!
Postdoctoral Fellow - Biodiversity Cell Atlas
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...
sanger.wd103.myworkdayjobs.com
December 3, 2025 at 12:27 PM
Open postdoc position at @sangerinstitute.bsky.social Tree of Life to contribute to the Biodiversity Cell Atlas, with a focus on spatial transcriptomics.
Apply by January 4
sanger.wd103.myworkdayjobs.com/en-GB/Wellco...
Please share with anyone who might be interested!
Apply by January 4
sanger.wd103.myworkdayjobs.com/en-GB/Wellco...
Please share with anyone who might be interested!
Reposted by Antoine Molaro
New Paper from the Murphy Lab - A Collaboration w Mitch O'Connell's group at URMC. Led by our joint student Brandon Park. Check it out!!
CUT&Tag Overcomes Biases of ChIP and Establishes Chromatin Patterns for Repetitive Genomic Loci: iScience www.cell.com/iscience/ful...
CUT&Tag Overcomes Biases of ChIP and Establishes Chromatin Patterns for Repetitive Genomic Loci: iScience www.cell.com/iscience/ful...
CUT&Tag Overcomes Biases of ChIP and Establishes Chromatin Patterns for Repetitive Genomic Loci
New in situ chromatin profiling methods, such as CUT&Tag, have streamlined studies
of chromatin features by eliminating the need for up-front purification, but we find
that some features are not equal...
www.cell.com
October 17, 2025 at 5:48 PM
New Paper from the Murphy Lab - A Collaboration w Mitch O'Connell's group at URMC. Led by our joint student Brandon Park. Check it out!!
CUT&Tag Overcomes Biases of ChIP and Establishes Chromatin Patterns for Repetitive Genomic Loci: iScience www.cell.com/iscience/ful...
CUT&Tag Overcomes Biases of ChIP and Establishes Chromatin Patterns for Repetitive Genomic Loci: iScience www.cell.com/iscience/ful...
Reposted by Antoine Molaro
Pls Repost: I am putting together an edition of “Methods in Molecular Biology” focused on early development, encompassing gastrulation. I am making a list of potential authors for chapters. If interested, please contact me - An excellent opportunity for trainees to co-author with their advisors.
December 3, 2025 at 12:43 PM
Pls Repost: I am putting together an edition of “Methods in Molecular Biology” focused on early development, encompassing gastrulation. I am making a list of potential authors for chapters. If interested, please contact me - An excellent opportunity for trainees to co-author with their advisors.