Author | Lightnews

Reposted by Anabel Chang

Proceedings of the National Academy of Sciences @pnas.org · 8d

LLMs can mirror expert judgment but often rely on word patterns rather than reasoning. A new study introduces epistemia, the illusion of knowledge that occurs when surface plausibility replaces verification. In PNAS: https://ow.ly/ry7S50Xcv9b

Prompt used for all LLMs when provided with the scraped HTML homepage.

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Reposted by Anabel Chang

Journal of Cell Biology @jcb.org · 10d

Analysis of native Ist1 dynamics reveals multiple pools of ESCRT-III on #endosomes. New work from Kevin Swift, Iryna Pustova, Anjon Audhya and colleagues @uwmadison.bsky.social: rupress.org/jcb/article/...

#membrane #lipid

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Reposted by Anabel Chang

Journal of Cell Biology @jcb.org · 17d

New study from Swift, Pustova, Audhya et al. @uwmadison.bsky.social defines the native dynamics of the ESCRT-III component Ist1 in mammalian cells, highlighting the existence of multiple, unique pools at #endosomes. rupress.org/jcb/article/...

#membrane #lipid

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Reposted by Anabel Chang

Science Magazine @science.org · 24d

Here's a reminder on #InternationalCoffeeDay: It's OK to take a (coffee) break. ☕

"It’s ... helpful to have a venue to share the day-to-day ups and downs of life as a grad student," a #PhD student wrote in this 2019 #ScienceWorkingLife. https://scim.ag/4nvLTBb

People arm in arm while drinking coffee and holding papers, with text: Why scientists should take more coffee breaks.

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Reposted by Anabel Chang

Journal of Cell Biology @jcb.org · Sep 9

Duque et al @unm.edu show that a core membrane #atg8ylation & #autophagy factor ATG16L1 controls proton V-ATPase under homeostatic conditions, ensuring normo-acidification, preservation of cellular energy charge & function, & defense against #tuberculosis in murine models rupress.org/jcb/article/...

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Reposted by Anabel Chang

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · Sep 3

Virulence priming of Listeria monocytogenes inside replication-permissive endolysosomes https://www.biorxiv.org/content/10.1101/2025.09.02.673654v1

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Reposted by Anabel Chang

bioRxivpreprint @biorxivpreprint.bsky.social · Sep 1

Event-triggered MINFLUX microscopy: smart microscopy to catch and follow rare events https://www.biorxiv.org/content/10.1101/2025.08.27.672674v1

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Anabel Chang @anabelcjw.bsky.social · Aug 30

Live U2OS cells: G3BP1-GFP + MitoTracker, treated with sodium arsenite. Imaged on Elyra 7. #SuperResolution #Microscopy #CellBiology #LiveCellImaging

Reposted by Anabel Chang

Journal of Cell Biology @jcb.org · Aug 28

Identification of organelle-specific #autophagy regulators from tandem #CRISPR screens. New study from Truc Losier, Karyn King, Maxime Rousseaux, and Ryan Russell (@russellbiolab.bsky.social) @uottawa.ca: rupress.org/jcb/article/...

#Biochemistry #CellSignaling

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Reposted by Anabel Chang

bioRxivpreprint @biorxivpreprint.bsky.social · Aug 24

Refractive index mapping below the diffraction limit via single molecule localization microscopy https://www.biorxiv.org/content/10.1101/2025.08.20.670782v1

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Reposted by Anabel Chang

bioRxivpreprint @biorxivpreprint.bsky.social · Aug 18

NRF2 inhibition of alveolar macrophage MHC II expression during Mycobacterium tuberculosis infection https://www.biorxiv.org/content/10.1101/2025.08.16.670319v1

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Reposted by Anabel Chang

Cell Press @cellpress.bsky.social · Aug 17

"Overcoming research bias: The untapped potential of biomedically important but understudied proteins" http://dlvr.it/TMXd85

@einsteinmededu.bsky.social Steven Grudman, Carlos Madrid-Aliste and Andras Fiser
@iScience_CP

Overcoming research bias: The untapped potential of biomedically important but understudied proteins

Biochemistry; Medical biochemistry; Omics; Proteomics

dlvr.it

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Reposted by Anabel Chang

Journal of Cell Biology @jcb.org · Aug 7

Yanzhe Zheng et al. reveal that during starvation, SOD1, linked to #ALS, is transported into #lysosomes through #autophagy and the receptor protein TP53INP1. Within lysosomes, SOD1 regulates ROS levels and safeguards lysosomal activity and integrity. rupress.org/jcb/article/...

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Reposted by Anabel Chang

Journal of Cell Biology @jcb.org · Jul 23

A Biotin-HaloTag ligand enables efficient affinity capture of protein variants from live cells. New tools developed by Anoop Kumar Yadav, Abhijeet Jadhav, Hana Polasek-Sedlackova @hanasedlackova.bsky.social and colleagues: rupress.org/jcb/article/...

#Technology #Chromatin #epigenetics #CellCycle

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Reposted by Anabel Chang

Science Magazine @science.org · Jul 11

Exclusive: In response to White House concerns about allegedly risky research on viruses, bacteria, and other pathogens, the National Institutes of Health has begun a crackdown on dozens of studies it was funding, ScienceInsider has learned. scim.ag/44oJIbw

Exclusive: NIH suspends dozens of pathogen studies over ‘gain-of-function’ concerns

Trump executive order leads to pauses on U.S.-funded research into TB, influenza, COVID-19, and other diseases, dismaying some scientists

scim.ag

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Anabel Chang @anabelcjw.bsky.social · Jul 6

www.nature.com/articles/s41...

A CRISPR/Cas9 screen reveals proteins at the endosome-Golgi interface that modulate cellular anti-sense oligonucleotide activity - Nature Communications

Antisense oligonucleotide (ASO) cellular activity requires endosomal escape. Here, the authors show that disrupting Golgi-endosome protein AP1M1 enhances ASO activity by prolonging ASO endosomal resid...

www.nature.com

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Reposted by Anabel Chang

Science Magazine @science.org · Jun 28

Bacteria leverage a secretion system to kill and scavenge nutrients from nearby competitors.

Learn more in a new #SciencePerspective: scim.ag/44y3iC6

Bacteria that possess a type VI secretion system (T6SS) inject toxins directly into neighboring cells that may be competing for local resources. Toxins break down the cell wall of susceptible cells, causing the release of nutrients that the attacking bacteria can consume for growth and proliferation. However, this can cause spatial segregation of the bacterial cell population, restricting attacks to the boundaries of predator cell groups and prey cell groups. This might limit the number of cells that can leverage the T6SS system for predation.

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Reposted by Anabel Chang

Nature @nature.com · Jun 24

Nature research paper: Targeting de novo purine biosynthesis for tuberculosis treatment

https://go.nature.com/3SYNS3i

Targeting de novo purine biosynthesis for tuberculosis treatment - Nature

The validation of inhibitors targeting PurF, a novel drug target for tuberculosis drug discovery, is described.

go.nature.com

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Reposted by Anabel Chang

Journal of Cell Biology @jcb.org · Mar 4

Tanaka, Oide, @tomokokubori.bsky.social, Arasaki et al. reveal that the bacterial pathogen #Legionella pneumophila ubiquitinates Rab5 to recruit a Rab5 inactivator RabGAP-5 to its phagosome, thereby excluding Rab5 and facilitating its intracellular replication. rupress.org/jcb/article/...

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Reposted by Anabel Chang

Nature Portfolio @natureportfolio.nature.com · Mar 1

A study in Nature Medicine provides a comprehensive map of the contributions of environment and genetics to mortality and incidence of common age-related diseases, suggesting that the exposome shapes distinct patterns of disease and mortality risk. #Medsky 🧪

Integrating the environmental and genetic architectures of aging and mortality - Nature Medicine

Based on a systematic analysis of environmental exposures associated with aging and mortality in the UK Biobank, the relative contributions of such exposures and genetic risk for mortality and a range of age-related diseases were compared, highlighting the potential beneficial effects of environment-focused interventions.

go.nature.com

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