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Structural insights into DdCBE in action enable high-precision mitochondrial DNA editing

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Reposted by Hansi Weissensteiner

Heidi M McBride @mitodynamics.bsky.social · 2d

New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org.
rdcu.be/eKKz1 🇨🇦

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Hansi Weissensteiner @whansi.bsky.social · 25d

Structural insights into DdCBE in action enable high-precision mitochondrial DNA editing

www.cell.com/molecular-ce...

Based on cryo-EM structures of functioning DdCBE, Xiang et al. developed a model to guide TALE-recognition region and spacer length design. Application of the model and an engineered editor with a 2–3...

Somatic mtDNA mutations at intermediate levels of heteroplasmy are a source of functional heterogeneity among primary leukemic cells

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Hansi Weissensteiner @whansi.bsky.social · 29d

Somatic mtDNA mutations at intermediate levels of heteroplasmy are a source of functional heterogeneity among primary leukemic cells
www.science.org/doi/full/10....

Somatic mtDNA mutations undergo positive selection, shaping cell fitness and contributing to functional heterogeneity.

www.science.org

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Hansi Weissensteiner @whansi.bsky.social · Sep 6

Nuclear mitochondrial DNA transfer revisited: From genomic noise to hallmark of aging
www.sciencedirect.com/science/arti...

Nuclear mitochondrial DNA transfer revisited: From genomic noise to hallmark of aging

Nuclear insertions of mitochondrial DNA (mtDNA) segments (NUMTs) represent an evolutionarily conserved phenomenon originating from the ancient endosym…

www.sciencedirect.com

Reversible compromise of physiological resilience by accumulation of heteroplasmic mtDNA mutations

Hansi Weissensteiner @whansi.bsky.social · Sep 5

Reversible compromise of physiological resilience by accumulation of heteroplasmic mtDNA mutations | Science www.science.org/doi/10.1126/...

Somatically acquired mitochondrial DNA mutations accumulate with age, but the mechanisms and consequences are poorly understood. Here we show that transient injuries induce a burst of persistent mtDNA...

www.science.org

Hansi Weissensteiner @whansi.bsky.social · Aug 15

Mitochondria protect against an intracellular pathogen by restricting access to folate

www.science.org/doi/10.1126/...

Mitochondria protect against an intracellular pathogen by restricting access to folate

As major consumers of cellular metabolites, mitochondria are poised to compete with invading microbes for the nutrients that they need to grow. Whether cells exploit mitochondrial metabolism to protec...

www.science.org

Reposted by Hansi Weissensteiner

Anupam Patgiri @apatgiri.bsky.social · Jul 17

“A mitochondrial electron surplus induces sleep”

Mitochondrial origins of the pressure to sleep www.nature.com/articles/s41...

Mitochondrial origins of the pressure to sleep - Nature

Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.

Eight babies born after Mitochondrial donation

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Reposted by Hansi Weissensteiner

Eric Topol @erictopol.bsky.social · Jul 17

A big day for preventing mitochondrial diseases from transmitting to the next generation
www.nature.com/articles/d41...
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....

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Reposted by Hansi Weissensteiner

Jim Stewart @jim-ca.bsky.social · Jul 17

8 healthy babies after Mitochondrial Donation treatment - Press Office - Newcastle University share.google/iaZoEyfgHHd9...

The UK’s pioneering licensed IVF technique to reduce the risk of mitochondrial diseases carried out in Newcastle has seen eight babies born, published research shows.

share.google

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Hansi Weissensteiner @whansi.bsky.social · Jul 14

Thanks for citing HaploGrep 2!

Selfish mutations promote age-associated erosion of mtDNA integrity in mammals - Nature Communications

Hansi Weissensteiner @whansi.bsky.social · Jul 2

Selfish mutations promote age-associated erosion of mtDNA integrity in mammals
www.nature.com/articles/s41...

Mutations in mtDNA contribute to mitochondrial disease and aging only if they rise in abundance. Here, the authors show that deleterious mutations reach high abundance by hitchhiking on genomes that h...

JCI Insight - Donor genetics and storage conditions influence mitochondrial DNA and extracellular vesicle levels in RBC units

Hansi Weissensteiner @whansi.bsky.social · Jun 11

Donor genetics and storage conditions influence mitochondrial DNA and extracellular vesicle levels in RBC units insight.jci.org/articles/vie...

insight.jci.org

Hansi Weissensteiner @whansi.bsky.social · May 30

Exciting preprint from @rahulg603.bsky.social and colleagues!

Mechanism of age-related accumulation of mitochondrial DNA mutations in human blood
www.biorxiv.org/content/10.1...

Mechanism of age-related accumulation of mitochondrial DNA mutations in human blood

One of the strongest signatures of aging is an accumulation of mutant mitochondrial DNA (mtDNA) heteroplasmy. Here we investigate the mechanism underlying this phenomenon by calling mtDNA sequence, ab...

www.biorxiv.org

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Hansi Weissensteiner @whansi.bsky.social · May 22

Mitochondria Are More Than Powerhouses—They’re the Motherboard of the Cell

great work by Martin Picard

www.scientificamerican.com/article/why-...

The Hidden Social Lives of Mitochondria

When these energy-giving organelles thrive, so do we

www.scientificamerican.com

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Reposted by Hansi Weissensteiner

Segata Lab @cibiocm.bsky.social · May 16

🥁 NEW:

Commentary in @cellcellpress.bsky.social!

by @msabrysarhan.bsky.social Giacomo Antonello @whansi.bsky.social @cengoni.bsky.social @dmascalzoni.bsky.social @leviwaldron1.bsky.social Nicola Segata, Christian Fuchsberger

www.cell.com/cell/fulltex...

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Human mitochondrial DNA in public metagenomes: Opportunity or privacy threat?

Human DNA is unavoidably present in metagenomic analyses of human microbiomes. While current protocols remove human DNA before submission to public repositories, mitochondrial DNA (mtDNA) has been ove...

#microbiome #genomics #mitochondrialdna #openscience #cellpress #genetics | Christian Fuchsberger

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Hansi Weissensteiner @whansi.bsky.social · May 16

for those on LinkedIn - Christian Fuchsberger wrote a great summary here:

www.linkedin.com/posts/christ...

🚀 Good start to the day, our research, "Human Mitochondrial DNA in Public Metagenomes: Opportunity or Privacy Threat?", has been published in Cell. We explore an important issue in research ...

www.linkedin.com

Hansi Weissensteiner @whansi.bsky.social · May 16

Exciting news! Our commentary is finally out, cudos to the team at EURAC (BZ) and CIBIO (TN) 👏

Human mitochondrial DNA in public metagenomes: Opportunity or privacy threat? www.cell.com/cell/fulltex...

Human mitochondrial DNA in public metagenomes: Opportunity or privacy threat?

Human DNA is unavoidably present in metagenomic analyses of human microbiomes. While current protocols remove human DNA before submission to public repositories, mitochondrial DNA (mtDNA) has been ove...

Mitochondria – the CEO of the cell

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Hansi Weissensteiner @whansi.bsky.social · May 4

Mitochondria – the CEO of the cell
journals.biologists.com/jcs/article-...

Summary: In light of research advances recognizing the roles mitochondria play in directing cellular processes and behaviors, we propose reframing mitochondria as the chief executive organelle of the ...

journals.biologists.com

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Hansi Weissensteiner @whansi.bsky.social · May 1

Mitochondrial DNA disease discovery through evaluation of genotype and phenotype data: The Solve-RD experience

www.cell.com/ajhg/fulltex...

Mitochondrial DNA disease discovery through evaluation of genotype and phenotype data: The Solve-RD experience

Exome and genome reanalysis from the Solve-RD cohort done with an automated mtDNA-filtering pipeline and MitoPhen-based HPO phenotype similarity scoring uncovered previously undiagnosed mtDNA variants...

First map of human brain mitochondria is ‘groundbreaking’ achievement

Reposted by Hansi Weissensteiner

Valentin Riedl @vavatin.bsky.social · Mar 27

The brain’s energy landscape as a potential window into brain health
www.nature.com/articles/d41...

(study led by Martin Picard and Michel Thiebaut de Schotten)

Hundreds of cubes of human brain tissue help scientists to chart the energy-making capabilities of various brain regions.

Mitochondrial DNA signals driving immune responses: Why, How, Where? - Cell Communication and Signaling

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Hansi Weissensteiner @whansi.bsky.social · Apr 24

Mitochondrial DNA signals driving immune responses: Why, How, Where?
biosignaling.biomedcentral.com/articles/10....

There has been a recent expansion in our understanding of DNA-sensing mechanisms. Mitochondrial dysfunction, oxidative and proteostatic stresses, instability and impaired disposal of nucleoids cause t...

biosignaling.biomedcentral.com

Mitochondrial transplantation: Triumphs, challenges, and impacts on nuclear genome remodelling

Hansi Weissensteiner @whansi.bsky.social · Apr 21

Mitochondrial transplantation: Triumphs, challenges, and impacts on nuclear genome remodelling

www.sciencedirect.com/science/arti...

Mitochondria are membrane-bound organelles of eukaryotic cells that play crucial roles in cell functioning and homeostasis, including ATP generation f…

www.sciencedirect.com

Reposted by Hansi Weissensteiner

Matthew Hahn @3rdreviewer.bsky.social · Apr 10

Not really my announcement to make--I am but a lesser co-author--but IQ-TREE 3 has just been released!

(Most credit to Minh Bui and @roblanfear.bsky.social and their labs)

ecoevorxiv.org/repository/v...

IQ-TREE 3: Phylogenomic Inference Software using Complex Evolutionary Models

ecoevorxiv.org

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Hansi Weissensteiner @whansi.bsky.social · Apr 11

Cells are swapping their mitochondria. What does this mean for our health?

www.nature.com/articles/d41...

Cells are swapping their mitochondria. What does this mean for our health?

Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.