Simon Bayly
@simonbayly.bsky.social
1.4K followers 770 following 1.5K posts
Reformed chemist 👨‍🔬 IP licensing and spinouts at the Francis Crick Institute. Also post about cycling 🚲 Opinion my own etc.
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simonbayly.bsky.social
Welcome new Bluesky users! If you are into biotech, please use the feed I created: bsky.app/profile/did:...
Reposted by Simon Bayly
radinbio.bsky.social
Here are some “leaf” or phyllid cells from moss Physcomitrium patens gametophore. Cells are expressing a green fluorescence marker that labels the vacuolar membrane. Chloroplasts' autofluorescence is in magenta.
Can you spot dividing chloroplasts?
#microscopymonday #moss #plantcells
The image shows several elongated rhomboid-shaped cells, filled with ovoid chrooroplasts in magenta, as well as a network of bubble-like vacuoles.
Reposted by Simon Bayly
iid.bsky.social
This is why “natural language programming” is a foolish idea and always has been. We invented mathematics for a reason, and the reason is the inherent limitations of natural language. Trying to force mathematics back into natural language is like trying to build a car out of horses
simonbayly.bsky.social
Chronobot enables time resolved cryo-EM, the type of data that is needed for dynamic protein structure models.
crick.ac.uk
Congratulations to Radoslav Enchev, this year’s winner of the Sir David Cooksey Prize in Translation.

Radoslav led development on the ‘Chronobot’ platform, which uses AI to greatly improve the efficiency of using structural biology to identify potential new drugs.

www.crick.ac.uk/news/2025-10...
AI-guided 'Chronobot' system wins Crick Translation Prize
The Sir David Cooksey Prize in Translation 2025 has been awarded to Radoslav Enchev for delivering a groundbreaking disruptive technology at the interface of structural biology, AI and drug discovery ...
www.crick.ac.uk
simonbayly.bsky.social
It would be very funny if this contravenes UK bribery laws
simonbayly.bsky.social
Uh oh, some cells like to play fancy dress with DNA 🧬
raflynn5.bsky.social
We’re excited to report work led by postdoc Jennifer Porat in the lab, finding that DNA accumulates on the surface of living cells and that the secreted extracellular protein DNASE1L3 can modulate its levels on B and T cells. With a new twist for ATAC-seq as well www.biorxiv.org/content/10.1...
DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells
The extracellular space is a critical environment for discriminating self versus non-self nucleic acids and initiating the appropriate immune responses through signaling cascades to relay information ...
www.biorxiv.org
Reposted by Simon Bayly
velo-velo-velo.bsky.social
Five for Tadej Pogačar 🇮🇹🏆 Add another consecutive Lombardia win and more history made for the Slovenian 💥💥

Race report up on Velo now. https://bit.ly/4ozWprl
📸 Getty Images
Reposted by Simon Bayly
simonbayly.bsky.social
Do you like my new key ring?
Reposted by Simon Bayly
simonbayly.bsky.social
Also Illumina’s investment in Grail
simonbayly.bsky.social
Do you like my new key ring?
simonbayly.bsky.social
Incredible opportunity!
crick.ac.uk
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.

Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.

Apply now ➡️ www.crick.ac.uk/careers-stud...
simonbayly.bsky.social
Only being able to say HELL WRLD seems apt somehow
simonbayly.bsky.social
Wow
vscooper.micropopbio.org
Holy moly
jcamthrash.bsky.social
Direct single-molecule detection and super-resolution imaging with a low-cost portable smartphone-based microscope www.nature.com/articles/s41... #jcampubs
simonbayly.bsky.social
So proud to be in the top 3%!
yougov.co.uk
How many browsing tabs do you typically have open?*

1: 6%
2-5: 54%
6-10: 14%
11-20: 8%
21-30: 2%
More than 30: 3%

*across all windows, on desktop/laptop

yougov.co.uk/topics/techn...
simonbayly.bsky.social
The global population is still increasing. What reason could there be that these people want more babies of their particular race? (rhetorical)
simonbayly.bsky.social
This isn’t going to end well
alexhanna.bsky.social
I'm not an economist but seems worrying that the whole US economy is seven companies in a trenchcoat, passing the same $20 up and down
carlquintanilla.bsky.social
NVIDIA and OpenAi:

Concerns that their “increasingly complex and interconnected web of business transactions is artificially propping up the trillion-dollar AI boom.“

@bloomberg.com $NVDA 👀
www.bloomberg.com/news/feature...
Reposted by Simon Bayly
simonbayly.bsky.social
Morning folks. Should we turn this into a ‘Station F’ for UK life sciences/biotech?
A photo of the building in Kings Cross that was being built for Merck/MSd
Reposted by Simon Bayly
dereklowe.bsky.social
I don’t think I’ve ever had more fun in the lab than when I was making MOFs myself (and trying to use them for small-molecule X-ray structure determination). So let me celebrate by posting a few of the MOF crystals I prepared:
Bright green transparent metal-organic framework crystals prepared with copper and a “multipronged” carboxylic acid ligand. The crystals formed blocky roughly rectangular pieces with some very large emerald-like chunks. Pink/red transparent metal-organic framework crystals prepared with cobalt  and a “multipronged” carboxylic acid ligand. The crystals formed as a mixture of long rectangular types and aggregated chunks. Purple transparent metal-organic framework crystals prepared with cobalt and a “multipronged” carboxylic acid ligand. The crystals formed long slightly blocky needles. Clear transparent metal-organic framework crystals prepared with zirconium and a “multipronged” carboxylic acid ligand. The crystals formed chunky hexagons.