Simon Bayly
@simonbayly.bsky.social
Reformed chemist 👨🔬 IP licensing and spinouts at the Francis Crick Institute. Also post about cycling 🚲 Opinion my own etc.
Pinned
Simon Bayly
@simonbayly.bsky.social
· Oct 17
Welcome new Bluesky users! If you are into biotech, please use the feed I created: bsky.app/profile/did:...
We are still finding out things about how AAVs work
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
AAV2 Bypasses Direct Endosomal Escape by Using AAVR to Access the Trans-Golgi Network en Route to the Nucleus
Vectors based on the adeno-associated virus are widely used as delivery methods in gene therapy applications, yet understanding of the mechanisms governing its intracellular trafficking remains incomp...
www.biorxiv.org
November 27, 2025 at 3:22 PM
We are still finding out things about how AAVs work
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Simon Bayly
Researchers at the Crick, @psich.bsky.social and @esrf.fr have developed a new way to look deeper into brain cell connections by using a particle accelerator and a kind of resin borrowed from the aerospace industry.
www.crick.ac.uk/news/2025-11...
www.crick.ac.uk/news/2025-11...
From aerospace to neuroscience: new imaging tech captures the brain’s intricate connections
Inspired by technologies used in aerospace engineering, scientists have developed a way to capture the brain’s intricate structures using X-rays without destroying the samples.
www.crick.ac.uk
November 27, 2025 at 12:10 PM
Researchers at the Crick, @psich.bsky.social and @esrf.fr have developed a new way to look deeper into brain cell connections by using a particle accelerator and a kind of resin borrowed from the aerospace industry.
www.crick.ac.uk/news/2025-11...
www.crick.ac.uk/news/2025-11...
G named as DS of Ineos
Geraint Thomas est nommé à la tête de la direction sportive d'Ineos Grenadiers. Après avoir raccroché en tant que coureur, le Gallois (39 ans) reste au sein de la structure britannique, où il a évolué depuis la création de l'équipe en 2010.
November 27, 2025 at 11:01 AM
G named as DS of Ineos
Reposted by Simon Bayly
#AlphaFold is five years old — these charts show how it revolutionized science
40k citations
Alphafold database has been used by more than 3.3 million people worldwide
www.nature.com/articles/d41...
40k citations
Alphafold database has been used by more than 3.3 million people worldwide
www.nature.com/articles/d41...
AlphaFold is five years old — these charts show how it revolutionized science
Since it was unveiled in 2020, Google DeepMind's game-changing AI tool has helped researchers all over the world to predict the 3D structures of hundreds of millions of proteins.
www.nature.com
November 27, 2025 at 10:44 AM
#AlphaFold is five years old — these charts show how it revolutionized science
40k citations
Alphafold database has been used by more than 3.3 million people worldwide
www.nature.com/articles/d41...
40k citations
Alphafold database has been used by more than 3.3 million people worldwide
www.nature.com/articles/d41...
We are all mosaics and get more mosaicky with age
November 26, 2025 at 1:49 PM
We are all mosaics and get more mosaicky with age
Clues about aetiology of Alzheimer’s from an immune system perspective
Our new study on #systemsimmunology analysis of #Alzheimers patients is out now at @alzdemjournals.bsky.social!
This is the culmination of a collaboration with Rik Vandenberghe, Stephanie Humblet-Baron and Lidia Yshii's labs at KU Leuven. 🧵1/8
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
This is the culmination of a collaboration with Rik Vandenberghe, Stephanie Humblet-Baron and Lidia Yshii's labs at KU Leuven. 🧵1/8
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
A systems immunology analysis of Alzheimer's disease reveals an age‐ and environmental exposure‐independent disturbance in B cell maturation
INTRODUCTION Alzheimer's disease is a severe neurodegenerative disorder, with multifactorial mechanisms of disease development and progression. Evidence from genetic association studies, animal mode...
alz-journals.onlinelibrary.wiley.com
November 26, 2025 at 12:20 PM
Clues about aetiology of Alzheimer’s from an immune system perspective
Vaccines save lives
November 26, 2025 at 10:00 AM
Vaccines save lives
Reposted by Simon Bayly
Data Corner: UK and Swiss universities dominate Europe’s spin-out rankings, powered by stronger funding and early-stage support. #EU institutions are improving, but still struggle to scale technologies at home.
📌 Read more here: buff.ly/ecD6Ixv
📌 Read more here: buff.ly/ecD6Ixv
Data Corner: UK and Swiss universities dominate European spin-out rankings
European university and research organisation spin-outs are creating more value than ever. But EU institutions are lagging behind the UK and Switzerland in the rankings, according to a new Dealroom…
sciencebusiness.net
November 26, 2025 at 9:40 AM
Data Corner: UK and Swiss universities dominate Europe’s spin-out rankings, powered by stronger funding and early-stage support. #EU institutions are improving, but still struggle to scale technologies at home.
📌 Read more here: buff.ly/ecD6Ixv
📌 Read more here: buff.ly/ecD6Ixv
Reposted by Simon Bayly
Artificial cells with liquid–liquid phase separation–regulated cell-free protein synthesis
doi.org/10.1073/pnas...
doi.org/10.1073/pnas...
November 26, 2025 at 7:28 AM
Artificial cells with liquid–liquid phase separation–regulated cell-free protein synthesis
doi.org/10.1073/pnas...
doi.org/10.1073/pnas...
Absolutely shameful from the BBC
I wish I didn’t have to share this. But the BBC has decided to censor my first Reith Lecture.
They deleted the line in which I describe Donald Trump as “the most openly corrupt president in American history.” /1
They deleted the line in which I describe Donald Trump as “the most openly corrupt president in American history.” /1
November 25, 2025 at 11:47 AM
Absolutely shameful from the BBC
Reposted by Simon Bayly
If you want to read something completely nuts from the unregulated world of direct to consumer genomics, look no further.
And when I say completely nuts, I’m being restrained and polite. Criminal is another word that springs to mind.
And when I say completely nuts, I’m being restrained and polite. Criminal is another word that springs to mind.
"Concerns about the legitimacy and integrity of Nucleus Genomics", by X account @sichuan_mala
totalhealthoptimization.com/2025/11/21/c...
totalhealthoptimization.com/2025/11/21/c...
Concerns about the legitimacy and integrity of Nucleus Genomics – Total Health Optimization
totalhealthoptimization.com
November 25, 2025 at 2:13 AM
If you want to read something completely nuts from the unregulated world of direct to consumer genomics, look no further.
And when I say completely nuts, I’m being restrained and polite. Criminal is another word that springs to mind.
And when I say completely nuts, I’m being restrained and polite. Criminal is another word that springs to mind.
Reposted by Simon Bayly
Fun fact: November 28, 2001:
"ENRON, which had been a component of the S&P; 500, was removed at the end of trading Thursday and replaced by NVIDIA Corp., a Santa Clara, Calif.-based maker of computer-graphics chips."
"ENRON, which had been a component of the S&P; 500, was removed at the end of trading Thursday and replaced by NVIDIA Corp., a Santa Clara, Calif.-based maker of computer-graphics chips."
November 22, 2025 at 7:44 PM
Fun fact: November 28, 2001:
"ENRON, which had been a component of the S&P; 500, was removed at the end of trading Thursday and replaced by NVIDIA Corp., a Santa Clara, Calif.-based maker of computer-graphics chips."
"ENRON, which had been a component of the S&P; 500, was removed at the end of trading Thursday and replaced by NVIDIA Corp., a Santa Clara, Calif.-based maker of computer-graphics chips."
I voted for the cyclo[48]carbon
It's that time again: C&EN's molecule of the year poll is now open! Vote for your favorite molecule of 2025: cen.acs.org/synthesis/Mo...
#chemsky 🧪
#chemsky 🧪
November 24, 2025 at 7:45 PM
I voted for the cyclo[48]carbon
Reposted by Simon Bayly
💥CONTAM CALENDAR GIVEAWAY💥
Here's your chance to win a ContamCalendar 2026! 🗓️🍄🦠
Just follow @contamclub.bsky.social and repost this post to enter the competition
Winner will be randomly selected from Bluesky or Twitter on Wednesday @ 6pm UTC
Here's your chance to win a ContamCalendar 2026! 🗓️🍄🦠
Just follow @contamclub.bsky.social and repost this post to enter the competition
Winner will be randomly selected from Bluesky or Twitter on Wednesday @ 6pm UTC
November 24, 2025 at 4:12 PM
💥CONTAM CALENDAR GIVEAWAY💥
Here's your chance to win a ContamCalendar 2026! 🗓️🍄🦠
Just follow @contamclub.bsky.social and repost this post to enter the competition
Winner will be randomly selected from Bluesky or Twitter on Wednesday @ 6pm UTC
Here's your chance to win a ContamCalendar 2026! 🗓️🍄🦠
Just follow @contamclub.bsky.social and repost this post to enter the competition
Winner will be randomly selected from Bluesky or Twitter on Wednesday @ 6pm UTC
It's time for the highly enlightening Year in Review from @lifescivc.bsky.social
www.youtube.com/watch?v=JrNo...
#biotech
www.youtube.com/watch?v=JrNo...
#biotech
Atlas Venture Year in Review 2025 - B. Booth
YouTube video by Atlas Venture
www.youtube.com
November 24, 2025 at 4:34 PM
It's time for the highly enlightening Year in Review from @lifescivc.bsky.social
www.youtube.com/watch?v=JrNo...
#biotech
www.youtube.com/watch?v=JrNo...
#biotech
Reposted by Simon Bayly
#MitoRxTherapeutics, a biotech based in the UK and led by CEO Jon Rees raised a £5.5 million (USD ≈ 7.2 m) pre-Series A round. The company develops mitochondrial-targeted small molecules for obesity
November 24, 2025 at 12:50 PM
#MitoRxTherapeutics, a biotech based in the UK and led by CEO Jon Rees raised a £5.5 million (USD ≈ 7.2 m) pre-Series A round. The company develops mitochondrial-targeted small molecules for obesity
Reposted by Simon Bayly
‼️🚨🗓️ CONTAMCALENDAR 2026 🗓️🚨‼️
Excited to say the ContamCalendar is back for its fifth edition! We’ve created a fresh new design, folding out for an A3 monthly spread. It’s our best yet, we hope you’ll love it 🗓️🦠🧫🍄
Get yours here ➡️ www.contam.club ⬅️
Excited to say the ContamCalendar is back for its fifth edition! We’ve created a fresh new design, folding out for an A3 monthly spread. It’s our best yet, we hope you’ll love it 🗓️🦠🧫🍄
Get yours here ➡️ www.contam.club ⬅️
November 21, 2025 at 3:30 PM
‼️🚨🗓️ CONTAMCALENDAR 2026 🗓️🚨‼️
Excited to say the ContamCalendar is back for its fifth edition! We’ve created a fresh new design, folding out for an A3 monthly spread. It’s our best yet, we hope you’ll love it 🗓️🦠🧫🍄
Get yours here ➡️ www.contam.club ⬅️
Excited to say the ContamCalendar is back for its fifth edition! We’ve created a fresh new design, folding out for an A3 monthly spread. It’s our best yet, we hope you’ll love it 🗓️🦠🧫🍄
Get yours here ➡️ www.contam.club ⬅️
Reposted by Simon Bayly
It's confirmed. Abbott will acquire Exact Sciences $EXAS for $23B
November 20, 2025 at 6:30 PM
It's confirmed. Abbott will acquire Exact Sciences $EXAS for $23B
Sofinnova's new fund includes a commitment from the UK goverment economic development bank lifesciencesweek.london/resource/bri...
British Business Bank commits €30 million to Sofinnova Partners’ €650 million Capital XI fund
The British Business Bank has announced a €30 million commitment to Sofinnova Partners (Sofinnova) new €650 million ($750 million) fund, Sofinnova Capital XI.
lifesciencesweek.london
November 20, 2025 at 6:28 PM
Sofinnova's new fund includes a commitment from the UK goverment economic development bank lifesciencesweek.london/resource/bri...
Reposted by Simon Bayly
I hate to be the one to tell you this, but, due to its position in the supply chain, NVIDIA earnings are a lagging indicator of any bursting of an investment bubble in AI.
November 20, 2025 at 5:28 PM
I hate to be the one to tell you this, but, due to its position in the supply chain, NVIDIA earnings are a lagging indicator of any bursting of an investment bubble in AI.
Reposted by Simon Bayly
In a new phase 3 trial, people randomly assigned to receive a flu shot made with modified mRNA were 34.5% less likely to be diagnosed with an influenza-like illness than people given a standard flu shot made with inactivated virus.
We need to stop the anti-science attacks against mRNA vaccines!
We need to stop the anti-science attacks against mRNA vaccines!
November 20, 2025 at 1:03 AM
In a new phase 3 trial, people randomly assigned to receive a flu shot made with modified mRNA were 34.5% less likely to be diagnosed with an influenza-like illness than people given a standard flu shot made with inactivated virus.
We need to stop the anti-science attacks against mRNA vaccines!
We need to stop the anti-science attacks against mRNA vaccines!
Reposted by Simon Bayly
Look
if you had one ring
with one Pd in it,
and pull everything onto one thread
in one moment.
would you break it
or just let it slip?
Great work by @jamesormson.bsky.social and @tomasnicolas.bsky.social now in @angewandtechemie.bsky.social! #chemsky
onlinelibrary.wiley.com/doi/10.1002/...
if you had one ring
with one Pd in it,
and pull everything onto one thread
in one moment.
would you break it
or just let it slip?
Great work by @jamesormson.bsky.social and @tomasnicolas.bsky.social now in @angewandtechemie.bsky.social! #chemsky
onlinelibrary.wiley.com/doi/10.1002/...
Template‐Controlled Mechanochemical Dissociation of a Rotaxane
The presence or absence of the Pd template used in rotaxane formation selectively leads to two different mechanochemical dissociation pathways. The Pd maintains a smaller cavity size that favors diss....
onlinelibrary.wiley.com
November 20, 2025 at 1:27 PM
Look
if you had one ring
with one Pd in it,
and pull everything onto one thread
in one moment.
would you break it
or just let it slip?
Great work by @jamesormson.bsky.social and @tomasnicolas.bsky.social now in @angewandtechemie.bsky.social! #chemsky
onlinelibrary.wiley.com/doi/10.1002/...
if you had one ring
with one Pd in it,
and pull everything onto one thread
in one moment.
would you break it
or just let it slip?
Great work by @jamesormson.bsky.social and @tomasnicolas.bsky.social now in @angewandtechemie.bsky.social! #chemsky
onlinelibrary.wiley.com/doi/10.1002/...
European #Spinouts Report just dropped dealroom.co/reports/euro...
European Spinouts Report - 2025 | Dealroom.co
dealroom.co
November 20, 2025 at 11:22 AM
European #Spinouts Report just dropped dealroom.co/reports/euro...
Reposted by Simon Bayly
“university spin-out sector was an “incredible UK success story and it has only happened in the last decade, starting with the Oxford, Cambridge and Imperial ‘triangle’ and it is spreading out beyond, to Edinburgh, Manchester, Sheffield, Leeds”.
www.thetimes.com/article/ad65...
www.thetimes.com/article/ad65...
Don’t squeeze university spin-outs, Jeremy Hunt warns Labour
The former chancellor says Britain’s burgeoning research-led companies underpin future growth and cautions that overzealous policy could ‘kill the golden goose’
www.thetimes.com
November 19, 2025 at 7:20 AM
“university spin-out sector was an “incredible UK success story and it has only happened in the last decade, starting with the Oxford, Cambridge and Imperial ‘triangle’ and it is spreading out beyond, to Edinburgh, Manchester, Sheffield, Leeds”.
www.thetimes.com/article/ad65...
www.thetimes.com/article/ad65...
Netherlands agrees common template for university #spinouts thenextleap.is/news/dutch-s...
The Next Leap » Dutch universities launch standard IP agreement
The National IP Deal Term Principles were developed and will be used by all technology transfer offices in the country going forward.
thenextleap.is
November 19, 2025 at 11:13 AM
Netherlands agrees common template for university #spinouts thenextleap.is/news/dutch-s...