Beyond the crucial data they contain, these digital archives have provided an important space for academic communities to exchange ideas and resources.

Nature Communications - Cryptococcal meningitis is a common infection in patients with compromised CD4 T cell function. Using a CD4 T cell activation tracking mouse the authors show the...

Halted training programs, funding chaos, and hiring freezes jeopardize advancement options for early career researchers.

Understanding how genetic variation translates into complex phenotypes remains a fundamental challenge. In this work, we address this by mapping genome-to-proteome relationships in 800 progeny of a cr...

Candida species are the predominant cause of fungal infections in patients treated in hospital, contributing substantially to morbidity and mortality.…

Author summary There is a desperate need for novel antifungal drugs to augment the few approved options. We have identified a bacterial protein, EntV, that has profound, if unusual, antifungal propert...

Actin filaments created by the Arp2/3 complex form branched networks, that grow and push against cellular membranes. We employ theory and simulation to describe how membrane surfaces accelerate filame...

Co-infection with Staphylococcus aureus and Candida albicans leads to worsened disease severity compared to mono-microbial infection. Because our understanding of the mechanisms driving enhanced disea...

Critics say linking funds to adherence to the White House’s principles undermines academic freedom

Engineered aminoacyl-tRNA synthetase (aaRS) mutants have been developed that facilitate ultrafast bioorthogonal noncanonical amino acid tagging (BONCAT) of newly synthesized proteins in diverse bacteria, including ESKAPE pathogens. The substrate polyspecificity of the aaRS mutants enables pulse-chase BONCAT and differential tagging of temporally distinct nascent proteomes in cells.

Cells tightly control the homeostatic levels and subcellular localizations of membrane phospholipids through the regulation of the activities of numerous lipid-metabolizing enzymes and lipid transfer ...

The former director of a CDC center reveals how political ideology is undermining science, threatening vaccine policy and endangering public health across the U.S.

This administration's first 6 months have been characterized by destruction, division, and chaos.

Despite being a virulence factor, candidalysin toxin is essential for Candida albicans to penetrate the oral epithelium to establish and maintain non-infectious colonization