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Amelia Eisch 🧪🧠👩‍🔬 🐁 @eisch.bsky.social · 22h

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Stephanie L. Grella, PhD @sgrella.bsky.social · 9d

First lab paper out today! Student authors: Mikayla Cutler and Abhi Thati 🎉🤩

Hippocampus | Neuroscience Journal | Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...

Memory is a cornerstone of human behavior, and addiction offers a compelling model of its persistence and plasticity. The scope of engram research has rapidly expanded to include addiction-related ph....

onlinelibrary.wiley.com

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Reposted by Amelia Eisch 🧪🧠👩‍🔬 🐁

PLOS Biology @plosbiology.org · 1d

#WestSyndrome is a severe neurodevelopmental disorder. This study provides a longitudinal picture of glial activation, synaptic remodeling & #LipidMetabolism in a mouse model of West syndrome, uncovering cellular & molecular mechanisms linked to #seizure evolution @plosbiology.org 🧪 plos.io/48tgUkv

3D reconstructions of local synaptic connectivity in hippocampal CA1 pyramidal neurons obtained by volume electron microscopy. Dendritic segments (gray) are shown either alone or with their innervating axons in a wild-type mouse (left) and in a Cyfip2+/R87C knock-in mouse model of West syndrome (right). Yellow puncta indicate postsynaptic densities. Compared with wild-type neurons, knock-in neurons exhibit markedly reduced dendritic spines, with excitatory synapses forming directly on dendritic shafts and showing dense clustering of presynaptic axon terminals. Scale bar, 1 µm. Image credit: Kea Joo Lee and Gyu Hyun Kim.

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Reposted by Amelia Eisch 🧪🧠👩‍🔬 🐁

PLOS Biology @plosbiology.org · 1d

Persistent viral #infections in #insects are not as harmless as once believed. @salehlabparis.bsky.social &co show how such infections in #FruitFlies alter survival, reproduction, behavior & gene expression, revealing the hidden costs of #viral persistence @plosbiology.org 🧪 plos.io/4olpuXm

Cartoon illustration depicting a sick Drosophila melanogaster surrounded by different viruses, symbolizing the impact of persistent viral infections on the model organism. Image credit Rubén González.

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Reposted by Amelia Eisch 🧪🧠👩‍🔬 🐁

Nicole Rust @nicolecrust.bsky.social · 1d

Nice piece today in The DP about Elusive Cures - including the astute observation of a student that it will be difficult for me to return to teaching Intro to Neuroscience (at least how I had been teaching it before 🫢).

www.thedp.com/article/2025...

Psychology professor discusses new book, neurological research at Penn Libraries talk

During the event, Rust discussed a new method for researchers to change their processes and successfully discover cures to brain conditions.

www.thedp.com

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Amelia Eisch 🧪🧠👩‍🔬 🐁 @eisch.bsky.social · 1d

#5Calls

Mark Peifer (He, him) @peiferlabunc.bsky.social · 1d

I called my two Senators--you should too
5calls.org

Reposted by Amelia Eisch 🧪🧠👩‍🔬 🐁

Jeremy Berg @jeremymberg.bsky.social · 1d

My quote of the day

This is the precept by which I have lived: Prepare for the worst; expect the best; and take what comes.

Hannah Arendt

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Reposted by Amelia Eisch 🧪🧠👩‍🔬 🐁

Micah G. Allen @micahgallen.com · 1d

Find something the insula is not a hub for challenge.

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Amelia Eisch 🧪🧠👩‍🔬 🐁 @eisch.bsky.social · 1d

#ScienceJobs #PostdocOpening 🧬🧪

Struan Grant @struangrant.bsky.social · 1d

Open to connecting with potential candidates at #ASHG25 !

Struan Grant @struangrant.bsky.social · 12d

My lab is seeking to co-hire a postdoctoral fellow with the
@shaonsengupta.bsky.social team. See details below!

I'll be #ASHG2025, so open to discuss further there if interest.

careers.chop.edu/us/en/job/10...

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Reposted by Amelia Eisch 🧪🧠👩‍🔬 🐁

PLOS Biology @plosbiology.org · 2d

#WestSyndrome is a severe neurodevelopmental disorder. This study provides a longitudinal picture of glial activation, synaptic remodeling & #LipidMetabolism in a mouse model of West syndrome, uncovering cellular & molecular mechanisms linked to #seizure evolution @plosbiology.org 🧪 plos.io/48tgUkv

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Reposted by Amelia Eisch 🧪🧠👩‍🔬 🐁

Granite Geek NH @granitegeeknh.bsky.social · 2d

TIL that when New Hampshire decided to build a state hospital for "the insane" in 1838, Portsmouth wanted to be the site. Among its arguments:

that it was “the best fish market in the world and that fish was the cheapest and best food for insane persons”

www.dhhs.nh.gov/about-dhhs/l....

www.dhhs.nh.gov

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Reposted by Amelia Eisch 🧪🧠👩‍🔬 🐁

Lisa Fazio @lkfazio.bsky.social · 2d

"However, if you are debating whether the Trump administration’s proposed changes to university policies are reasonable or not, you are missing the point entirely. The compact is a thinly veiled invitation for universities to relinquish their self-governance"

stanforddaily.com/2025/10/12/f...

From the Community | We must refuse the 'Compact for Academic Excellence in Higher Education'

Associate professor Greg Martin writes on behalf of the Stanford's AAUP chapter to condemn the White House's compact on higher education.

stanforddaily.com

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Reposted by Amelia Eisch 🧪🧠👩‍🔬 🐁

PLOS Biology @plosbiology.org · 1d

Genetic architectures of #ComplexTraits vary widely. @yuvalsim.bsky.social @jkpritch.bsky.social @gs2747.bsky.social &co show these diffs arise from mutational target size & heritability per site; when controlled for, all tested traits have similar architectures @plosbiology.org 🧪 plos.io/47mZXqT

Heritability and target size underlie differences between trait architectures:

examples for three traits. Top: Height (blue) and platelet crit (red) have the same heritability per site h2/L, but height has a much higher mutational target size L. This results in many more hits for height (1533) than for platelet crit (648) (2 left panels). However, the marginal distributions of effect sizes, MAFs, and z-scores of hits are nearly identical for the two traits (3 right panels). Middle: Height (blue) and FEV1 (gold) differ in h2/L, but have similar L. Consequently, the joint distribution of z-scores and MAFs of their hits are markedly different (2 left panels), as are the marginal distributions of hit effect sizes, MAFs and z-scores (right). Bottom: After scaling by their respective , and imposing the more stringent scaled significance threshold (corresponding to FEV1) for both traits, the joint distribution of z-scores and MAFs of their hits (2 left panels) and the corresponding marginal distributions (3 right panels) are highly similar.

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Reposted by Amelia Eisch 🧪🧠👩‍🔬 🐁

Tracy Bale @thebalelab.bsky.social · 1d

acnp.org/annual-meeti...

Promising Targets at @acnporg.bsky.social ! 💊 This a great way to ensure your late breaking pharmacology - clinical trial unblinding, drug study or preclinical pharmacological study gets attention! Was a very hot session last year. 👏

Submissions - ACNP

acnp.org

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Reposted by Amelia Eisch 🧪🧠👩‍🔬 🐁

Cientifico Latino, Inc. @cientificolatino.com · 1d

Last year, we helped 100 students save $31K in grad school app fees, giving students from underserved communities the freedom to apply widely.

This year we lost 16 partners = $8.2K setback = 110 fewer dreams.

🎓 You can change that.
💸 Donate to open 110 new doors.

givebutter.com/supportCL

Flyer for a Donation Call where there was a lost of 16 grad school app fee waiver partners this year, totaling $8,250 in waived fees for aspiring scientists gone, that is 110 applications that may never be submitted.

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Reposted by Amelia Eisch 🧪🧠👩‍🔬 🐁

Joanna Dabrowska @handle.invalid · 1d

Corrected proof - sharable version available here 👇
www.sciencedirect.com/science/arti...

Joanna Dabrowska @handle.invalid · 18d

Our work on mind-boggling CRF-BNST neurons is out! 🥳
🔹Sex & estrous matter: CRF neurons⬇️anxious arousal (yup) after unpredictable fear in diestrus👧not👦
🔹👧show⬆️contextual fear, independent of CRF/estrous
✨Anxiety-potentiated startle🟰👍 readout in🚶‍♀️&🐀
www.biologicalpsychiatryjournal.com/article/S000...

Activity of corticotropin-releasing factor neurons in the bed nucleus of the stria terminalis reduces anxiety-potentiated startle in female rats in an estrous phase-dependent manner

The prevalence of post-traumatic stress disorder (PTSD) and anxiety disorders is higher in women than men. The severity of hallmark symptoms including hypervigilance and fear reactivity to unpredictab...

www.biologicalpsychiatryjournal.com

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Reposted by Amelia Eisch 🧪🧠👩‍🔬 🐁

Mick Craig @mickcraig.bsky.social · 1d

Delighted that our main #TeamReuniens paper is finally out in @plosbiology.org. Been a long time in the making, congratulations to Lilya and all the team. A thread to follow soon, after I've had some sleep... #NeuroSkyence

journals.plos.org/plosbiology/...

Hippocampal pyramidal cells of the CA1 region are not a major target of the thalamic nucleus reuniens

Excitatory input from the prefrontal cortex to hippocampus pyramidal cells is commonly believed to be mediated through the thalamic nucleus reuniens brain region. This study shows in rodents that this...

journals.plos.org

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Reposted by Amelia Eisch 🧪🧠👩‍🔬 🐁

Greg Pak @gregpak.net · 1d

Jubilee cosplayers, your time has come.

Indivisible ❌👑 @indivisible.org · 1d

On Saturday, we wear yellow. ❌👑

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Reposted by Amelia Eisch 🧪🧠👩‍🔬 🐁

Ishmail Abdus-Saboor @ishmailsaboor.bsky.social · 1d

We were just having this conversation @meera-sundaram.bsky.social! Using C.elegans as a model in your lab as a PhD student, I learned to think about biological systems as integrated networks. This has shaped my approach to studying the nervous system, attempting to link the body and brain.

Meera Sundaram @meera-sundaram.bsky.social · 3d

Reaffirming the value of model organisms in training scientific minds @ishmailsaboor.bsky.social exactly what we were talking about re your #Celegans background setting you up for creative work in other systems! www.nature.com/articles/s41...

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Reposted by Amelia Eisch 🧪🧠👩‍🔬 🐁

Sebastian S. Cocioba @atinygreencell.bsky.social · 1d

"DNA synthesis is solved"
"We can just print any sequence"
"Biology and biotech are solved fields"
"Sequence-agnostic synthesis is on the horizon"

*plant introns enter the chat*

Humbug.

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Reposted by Amelia Eisch 🧪🧠👩‍🔬 🐁

Jeremy Berg @jeremymberg.bsky.social · 1d

Good post with a good argument about universities and the "compact", basically the same argument that applies to law firms

If this is how the leadership responds to extortion threats that go against their values, why would you trust them to protect your interests?

www.instagram.com/reel/DPwXVbR...

ai.for.the.planet on Instagram: "MIT FTWCheck my LinkTree for link to a petition! #collegeapplications #universities #academicsView all 10 comments"

MIT FTWCheck my LinkTree for link to a petition! #collegeapplications #universities #academics

www.instagram.com

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Reposted by Amelia Eisch 🧪🧠👩‍🔬 🐁

megan peters 🧠 @meganakpeters.bsky.social · 2d

📣 BIG NEWS EVERYONE. I am so excited to announce…

🎉 I’m moving to University College London @ucl.ac.uk to join the Experimental Psychology department in @uclpals.bsky.social! 🎉

The big move happens in spring/summer. So I’m already exploring recruiting staff & students at UCL for fall 2026!

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Reposted by Amelia Eisch 🧪🧠👩‍🔬 🐁

Jeremy Berg @jeremymberg.bsky.social · 2d

Looking forward to this discussion at the STAT Summit in Boston this Thursday.

Inside the Upheaval at NIH session with Jeremy Berg, Eric Green, and Mallory Harris, moderated by Anil Oza.

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Reposted by Amelia Eisch 🧪🧠👩‍🔬 🐁

Ewan St. John Smith @psalmotoxin.bsky.social · 3d

Interesting paper quantifying behavioural interactions across 5 naked mole-rat colonies over time: learn more about the strong social bonds of breeders & more here www.science.org/doi/10.1126/...

Quantitative and systematic behavioral profiling reveals social complexity in eusocial naked mole-rats

Automated tracking in naked mole-rats reveals behavioral specificity of breeders and diversity of nonbreeders in a colony.

www.science.org

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Amelia Eisch 🧪🧠👩‍🔬 🐁 @eisch.bsky.social · 2d

😂😂😂

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Reposted by Amelia Eisch 🧪🧠👩‍🔬 🐁

Kyle Grice @gricechemistry.bsky.social · 3d

Chemistry folks! IONiC has some Learning objects on MOFs if you want to use them in your teaching, given the Nobel prize last week. A collection was made this week, check it out here: www.ionicviper.org/viper-bites/...

What a Nobel Week! | VIPEr

www.ionicviper.org

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