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Çağrı Çevrim @cagricevrim.bsky.social · 10h

Thank you!

Reposted by Çağrı Çevrim

Emma Rawlins @labrawlins.bsky.social · 1d

Exciting collaborative post doc opportunity to study lung disease mechanisms working with 2 friendly labs @jennydickens41.bsky.social @labrawlins.bsky.social and GSK colleagues www.jobs.cam.ac.uk/job/52936/

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Çağrı Çevrim @cagricevrim.bsky.social · 1d

Thank you!

Reposted by Çağrı Çevrim

Roland Pease @peaseroland.bsky.social · 3d

The kind of surprise that keeps me on social media.
Another preprint to check out.

Kara McKinley @karalmckinley.bsky.social · 4d

Lab’s 1st preprint!

Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.

@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.

He is on the job market!

Çağrı Çevrim @cagricevrim.bsky.social · 4d

I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵

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Çağrı Çevrim @cagricevrim.bsky.social · 1d

Thank you!

Çağrı Çevrim @cagricevrim.bsky.social · 1d

Thank you!

1

Çağrı Çevrim @cagricevrim.bsky.social · 2d

Thank you Smita!

Çağrı Çevrim @cagricevrim.bsky.social · 2d

Thank you!

Çağrı Çevrim @cagricevrim.bsky.social · 3d

Thanks Aida ❤️

Reposted by Çağrı Çevrim

Shefali @iamshef.bsky.social · 3d

Amazing work - and this will open so many doors for women health care. It's insane how little we know about female physiology. Congratulations @cagricevrim.bsky.social and the team on this incredible endeavor! 👏🏽🎉
#womenhealth 💪🏽

Çağrı Çevrim @cagricevrim.bsky.social · 4d

I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵

Induction of menstruation in mice reveals the regulation of menstrual shedding

During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...

www.biorxiv.org

2 5

Reposted by Çağrı Çevrim

Dafni Hadjieconomou @drosostalis.bsky.social · 3d

Wowed!

Çağrı Çevrim @cagricevrim.bsky.social · 4d

I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵

Induction of menstruation in mice reveals the regulation of menstrual shedding

During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...

www.biorxiv.org

1 1 3

Reposted by Çağrı Çevrim

Neha Ghosh @nehaghosh.bsky.social · 3d

Menstruation- a natural regenerative process in women, yet understudied and under discussed. But, this phenomenal work is a start for making all the difference 🎉

Çağrı Çevrim @cagricevrim.bsky.social · 4d

I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵

Induction of menstruation in mice reveals the regulation of menstrual shedding

During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...

www.biorxiv.org

2 3

Reposted by Çağrı Çevrim

Navin Pokala 🇺🇸🇺🇦🇨🇦🇬🇱 @navinpokala.bsky.social · 3d

This is a really interesting study with an incredibly creative approach, applying chemical-genetic tools usually used for neuroscience research towards understanding the molecular and cellular mechanisms underlying menstruation.

Çağrı Çevrim @cagricevrim.bsky.social · 4d

I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵

Induction of menstruation in mice reveals the regulation of menstrual shedding

During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...

www.biorxiv.org

2 5

Reposted by Çağrı Çevrim

Iain Cheeseman @iaincheeseman.bsky.social · 4d

An epic story and a must read. This is really beautiful work to understand the most amazing monthly regeneration event - menstruation. The authors reconstitute this process in mice (which don’t normally menstruate) allowing important new insights. Will also be a powerful model for future work.

Kara McKinley @karalmckinley.bsky.social · 4d

Lab’s 1st preprint!

Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.

@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.

He is on the job market!

Çağrı Çevrim @cagricevrim.bsky.social · 4d

I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵

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Çağrı Çevrim @cagricevrim.bsky.social · 4d

I know, right??

1

Reposted by Çağrı Çevrim

Hannah Haberkern @hannah-haberkern.bsky.social · 4d

Amazing! Hard to believe this didn't exist until now.

Çağrı Çevrim @cagricevrim.bsky.social · 4d

I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵

Induction of menstruation in mice reveals the regulation of menstrual shedding

During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...

www.biorxiv.org

1 2 4

Reposted by Çağrı Çevrim

@NicoliLab @nicolilab.bsky.social · 4d

OMG 😱 a true game changer for biology! Menstruation is a natural miracle of tissue regeneration. Amazing biology to come!

Çağrı Çevrim @cagricevrim.bsky.social · 4d

I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵

Induction of menstruation in mice reveals the regulation of menstrual shedding

During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...

www.biorxiv.org

1 6 15

Reposted by Çağrı Çevrim

Adam Gracz @graczlab.bsky.social · 4d

This is probably one of the coolest and most creative mouse models I’ve ever seen!

Kara McKinley @karalmckinley.bsky.social · 4d

Lab’s 1st preprint!

Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.

@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.

He is on the job market!

Çağrı Çevrim @cagricevrim.bsky.social · 4d

I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵

1 3 6

Çağrı Çevrim @cagricevrim.bsky.social · 4d

Thank you for your kind words ❤️ Coming from someone who works with Hofstenia, that means a lot!

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Çağrı Çevrim @cagricevrim.bsky.social · 4d

Thank you!
It’s nice to see other people sharing our excitement!

1

Çağrı Çevrim @cagricevrim.bsky.social · 4d

Thanks Anna! ❤️

Çağrı Çevrim @cagricevrim.bsky.social · 4d

Thank you!

1

Çağrı Çevrim @cagricevrim.bsky.social · 4d

Last but not least, a huge thanks to all co-authors and collaborators.
This was truly a team effort that brought together many people with different expertise.

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Çağrı Çevrim @cagricevrim.bsky.social · 4d

In short, we developed the first transgenic menstruating mouse and discovered a new principle of endometrial layering and regeneration.
X-Mens opens the door to studying menstrual biology and pathologies with precision and help closing the longstanding gap in women’s health research.

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Çağrı Çevrim @cagricevrim.bsky.social · 4d

So the entire endometrium is organized radially, from undifferentiated fibroblasts to the most mature decidual cells.

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