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William G. Wade

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H-index: 58
Medicine 49%
Public Health 27%
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Reposted by William G. Wade

emmseveri.bsky.social
www.biorxiv.org/content/10.1...

#microsky but feels more like Horrible Histories!
The oral microbiome of King Richard III of England
Metagenomic investigation of archaeological dental calculus has provided insights into the changing oral health, disease, and diet of past human societies, but little is known about the oral microbiot...
www.biorxiv.org
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Reposted by William G. Wade

emmseveri.bsky.social
www.jbc.org/article/S002...

#microsky #sialic acid

Interesting story, the starting Q v. important
Sialic acid identity modulates host tropism of sialoglycan-binding viridans group streptococci
Microbial interactions with multiple species may expand the range of potential hosts, supporting both pathogen reservoirs and zoonotic spillover. Viridans group streptococci interact with host cells b...
www.jbc.org
1

Reposted by William G. Wade

emmseveri.bsky.social
www.nature.com/articles/s41...

#microsky
Discovery of a widespread chemical signalling pathway in the Bacteroidota - Nature
The N-acyl-cyclolysine system regulates the expression of co-localized operons encoding diverse secreted molecules in Bacteroidota.
www.nature.com
15 26

by William G. Wade

Don’t think much of the standard of English at that school if they say “heart-wrenching”. It’s “heart-rending” or “gut-wrenching”!
1

Reposted by William G. Wade, Mart Krupovìč

deemteam.bsky.social
📣 We are proud of the publication of the second paper of @bbaker24.bsky.social PhD thesis. In collaboration with friends in Halifax we have studied the difficult question of the phylogeny of the DPANN archaea, composed of several phyla of highly reduced, fast-evolving epiparasites 🧵

rdcu.be/erkkU
Phylogenomic analyses indicate the archaeal superphylum DPANN originated from free-living euryarchaeal-like ancestors
Nature Microbiology - Phylogenetic reconstructions with conserved protein markers from the 11 known DPANN phyla reveal their monophyletic placement within the Euryarchaeota.
rdcu.be
2 19 48

Reposted by William G. Wade, Marc Strous, Andrew L. Jackson

nonresidentdesi.bsky.social
Thrilled to share our new paper in @science.org describing our discovery that bacteria can switch from competitors to bonafide predators when resources run dry—arming nanoscale “spears” (T6SS) to stab & consume neighbours.

www.science.org/doi/10.1126/...

#MicroSKy #Microbiology
Antagonism as a foraging strategy in microbial communities
In natural habitats, nutrient availability limits bacterial growth. We discovered that bacteria can overcome this limitation by acquiring nutrients by lysing neighboring cells through contact-dependen...
www.science.org
12 71 130

Reposted by William G. Wade, Mya Breitbart

chmoei.bsky.social
📢 Big day for archaeal microbiology!

Today, we jointly shed light on the mysterious world of archaeal extracellular vesicles from human gut archaea - published in @natcomms.nature.com ‬ in parallel with our precious colleagues around @mkrupovic.bsky.social 🇦🇹🤝🇫🇷.
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Reposted by William G. Wade

batbilegbor.bsky.social
Exciting progress! In our new preprint, we show that episymbiont Saccharibacteria can directly modulate epithelial immunity—a big step in understanding how these elusive microbes interact with the human host. Kudos to Deepak Chouhan and our amazing collaborators! www.biorxiv.org/content/10.1...
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Reposted by William G. Wade, John De Vos, Jacalyn Duffin , and 1 more

sethabramson.bsky.social
In a world of Matts, be a Derek.
450 8K 32K

Reposted by William G. Wade, Cary L. Cooper, Derrick L. Cogburn , and 2 more

richardbranson.bsky.social
President Zelenskyy has been one of the greatest leaders of our time, guiding Ukraine through the darkest period of its recent history, rising up to Russia’s unwarranted aggression, being an inspiration to the Ukrainian people and ensuring that Ukraine’s voice is heard on the world stage.
2.8K 21K 120K

by William G. Wade

Currant bun
1

Reposted by William G. Wade, Alan W. Walker

natmicrobiol.nature.com
EDITORIAL: Ensuring rigour of low-biomass microbiome research

Read it here: www.nature.com/articles/s41...

#microsky #microbiomesky 🧪
Ensuring rigour of low-biomass microbiome research - Nature Microbiology
Determining whether human organs house a resident microbiome is challenging and the findings can be controversial. However, forging collaborations and careful study design can help overcome these issu...
www.nature.com
15 29

Reposted by William G. Wade

atranscendedman.bsky.social
London study finds L. crispatus in the vaginal microbiome reduces inflammation by blocking harmful signals and activating anti-inflammatory pathways.

May protect against infections and preterm birth.

www.nature.com/articles/s41...
Lactobacillus crispatus S-layer proteins modulate innate immune response and inflammation in the lower female reproductive tract - Nature Communications
Here, the authors show that vaginal lactobacilli associated with optimal health interact selectively with a restricted subset of anti-inflammatory receptors through their Surface Layer Proteins, both ...
www.nature.com
4 5

Reposted by William G. Wade

biorxiv-microbiol.bsky.social
The Porphyromonas gingivalis lipid A 1-phosphatase LpxE has unique features and requires a functional type IX secretion system for its activity https://www.biorxiv.org/content/10.1101/2024.12.20.629629v1
2 1

by Michael Wagner — Reposted by William G. Wade

michiwagner4.bsky.social

🌟 Exciting news! Our latest collaborative research with team @aarhusuni.bsky.social introduces pH-FISH, a novel technique combining pH ratiometry and FISH to simultaneously unravel microbial identity and local biofilm pH. 🔬 🧪 #MicroSky

link.springer.com/article/10.1...

#Microbiome #Biofilms
pH-FISH: coupled microscale analysis of microbial identity and acid–base metabolism in complex biofilm samples - Microbiome
Background Correlative structural and chemical imaging of biofilms allows for the combined analysis of microbial identity and metabolism at the microscale. Here, we developed pH-FISH, a method that co...
link.springer.com
20 39

by Jonathan A. Eisen — Reposted by William G. Wade

phylogenomics.bsky.social
An important read for all microbiome researchers #microbiomania www.theguardian.com/science/2024...
There’s little evidence of a ‘brain microbiome’ | Letter
Letters: Prof Mark Pallen, Dr Aimee Parker, Prof Nick Loman and Prof Alan Walker take issue with an article that discussed the existence of a brain microbiome and its impact on diseases
www.theguardian.com
3 22 62

Reposted by William G. Wade, Kevin Denny, Miguel Á. Malo , and 3 more

pyhatanja.bsky.social
Big news from Finnish publication forum. Almost all MDPI and Frontiers journals will be downgraded to level 0 and thus are not considered as properly peer reviewed trustworthy scientific journals.
julkaisufoorumi.fi/en/news/chan...
Changes to the classification
julkaisufoorumi.fi
18 280 410

by William G. Wade

One of my favourite nerdy facts!

Reposted by William G. Wade

batbilegbor.bsky.social
Excited to share our new preprint on the detailed investigation of Type 4 pili in epibiont oral Saccharibacteria! Led by Alex Grossman from our lab, and with Jun Liu (Yale), Jeff McLean (UW) and Xuesong He. Check it out: biorxiv.org/content/10.1...
11 21

Reposted by William G. Wade, Victor A. Albert

zandraselina.bsky.social
The final chapter of my PhD thesis is finally out! Led by the brilliant Irina Velsko, we investigated if we can study past migrations in Oceania using #aDNA from archaeological dental calculus: www.nature.com/articles/s41...
Exploring the potential of dental calculus to shed light on past human migrations in Oceania - Nature Communications
Preservation of oral microbiome ancient DNA from Oceania is much better than human ancient DNA. The authors leverage this to demonstrate that oral microbial community composition in Oceania is not onl...
www.nature.com
14 42

Reposted by William G. Wade

heykatray.bsky.social
This Perspective was a fun one to work on recently, examining the characteristics & role of small intestinal #microbiota, somewhat overlooked (tech difficulties in sampling, low microbial biomass) but important to health

www.nature.com/articles/s41...
🔓 rdcu.be/d0hBg

#GastroSky #Microsky
The figure shows the biogeographic characteristics of the gastrointestinal tract in humans and mice. There are distinct differences in multiple factors (length, pH) between human and mouse intestine. The small intestine exhibits distinct biogeographical characteristics, including length, pH, transit times, plicae circulares, mucus thickness, surface area ratio and microbiota profiles, compared with the large intestine.
1 11 28

Reposted by William G. Wade

pathogenomenick.bsky.social
Planning and Analyzing a Low-Biomass Microbiome Study: A Data Analysis Perspective academic.oup.com/jid/advance-... paging @faecalmatters.bsky.social
Planning and Analyzing a Low-Biomass Microbiome Study: A Data Analysis Perspective
Low-biomass microbiome studies show great potential alongside major controversies. This review surveys key methodological challenges and discusses experime
academic.oup.com
7 14

Reposted by William G. Wade

acritschristoph.bsky.social
Spatial mapping of mobile genetic elements and their bacterial hosts in complex microbiomes (June 2024)

www.nature.com/articles/s41...
Spatial mapping of mobile genetic elements and their bacterial hosts in complex microbiomes - Nature Microbiology
Simultaneous DNA-FISH and multiplexed rRNA-FISH spatially map antimicrobial resistance plasmids and phage with their host taxa in polyspecies human oral biofilm samples, revealing hotspots of genetic ...
www.nature.com
8 8

by William G. Wade

onlinelibrary.wiley.com/doi/10.1002/...
Fusobacterium is toxic for head and neck squamous cell carcinoma and its presence may determine a better prognosis
Click on the article title to read more.
onlinelibrary.wiley.com
3

Reposted by William G. Wade

wvschaik.bsky.social
Inaccurate viral prediction leads to overestimated diversity of the archaeal virome in the human gut

www.nature.com/articles/s41...
Inaccurate viral prediction leads to overestimated diversity of the archaeal virome in the human gut - Nature Communications
Nature Communications - Inaccurate viral prediction leads to overestimated diversity of the archaeal virome in the human gut
www.nature.com
5 4

Reposted by William G. Wade

onisillos.bsky.social
Something to keep in your quote armory:

"...many papers in the literature report microbial associations that go against basic understanding of microbial ecology, some of which can be likened to reporting blue whales in the Himalayas or African elephants in Antarctica."
Recognizing the reagent microbiome - Nature Microbiology
A noticeable part of the microbiome literature, especially that working with low-biomass samples, is plagued by reagent contamination. Here we describe visual, statistical, methodical and ecological techniques to facilitate recognition of signals that represent contamination.
www.nature.com
3 15 27

Reposted by William G. Wade

wvschaik.bsky.social
Job claxon!

Colleagues at the School of Dentistry of the University of Birmingham are advertising for an Assistant/Associate Prof post in oral microbiology:

www.jobs.ac.uk/job/DFL084/a...
www.jobs.ac.uk/job/DFL092/a...
Assistant Professor in Microbiology at University of Birmingham
Discover an exciting academic career path as a Assistant Professor in Microbiology at jobs.ac.uk. Don't miss out on this job opportunity - apply today!
www.jobs.ac.uk
8 2

Reposted by William G. Wade

rachelmwheatley.bsky.social
Working on AMR and the microbiome? 🦠🧫 I am organising a one-day workshop at Magdalen in May. The aim is to bring together a small group of researchers for a day of talks and discussions, ft mix of research topics & career stages.

Are you interested?
forms.gle/26hx1UhvBBfh...
#MicroSky
Workshop: Probing the interface between AMR and the microbiome
One-day workshop held in Magdalen College (Oxford) on Wednesday 22nd May 2024 to connect researchers working on antimicrobial resistance (AMR) and the microbiome. Organised by Dr Rachel Wheatley (emai...
forms.gle
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