I like the military term “canalization,” the use of obstacles to force the enemy into increasingly narrow avenues of approach until they arrive just where you want them.
November 9, 2025 at 3:24 PM
I like the military term “canalization,” the use of obstacles to force the enemy into increasingly narrow avenues of approach until they arrive just where you want them.
How do #plants dynamically modulate their shoot branching for optimal returns? @zoenahas.bsky.social &co show that BRC1 modulates bud competitiveness by reducing #auxin efflux, integrating hormonal cues to fine-tune branching patterns @plosbiology.org @slcuplants.bsky.social 🧪 plos.io/4pnrwY2
September 16, 2025 at 8:34 AM
How do #plants dynamically modulate their shoot branching for optimal returns? @zoenahas.bsky.social &co show that BRC1 modulates bud competitiveness by reducing #auxin efflux, integrating hormonal cues to fine-tune branching patterns @plosbiology.org @slcuplants.bsky.social 🧪 plos.io/4pnrwY2
The discovery of loss-induced canalization in single slabs of α-MoO3 represents a significant step forward in the quest to control light at the nanoscale.
https://s.mtrbio.com/unfvxgeqpc
https://s.mtrbio.com/unfvxgeqpc
January 23, 2025 at 8:01 PM
The discovery of loss-induced canalization in single slabs of α-MoO3 represents a significant step forward in the quest to control light at the nanoscale.
https://s.mtrbio.com/unfvxgeqpc
https://s.mtrbio.com/unfvxgeqpc
Reflections on Canalization and Psychopathology (— as discussed in a recent paper by Carhart-Harris, Friston, and colleagues.)
A new descriptive metaphor for psychological entrenchment in mental illness
awaisaftab.substack.com/p/reflection...
A new descriptive metaphor for psychological entrenchment in mental illness
awaisaftab.substack.com/p/reflection...
Reflections on Canalization and Psychopathology
A new descriptive metaphor for psychological entrenchment in mental illness
awaisaftab.substack.com
September 16, 2023 at 5:44 PM
Reflections on Canalization and Psychopathology (— as discussed in a recent paper by Carhart-Harris, Friston, and colleagues.)
A new descriptive metaphor for psychological entrenchment in mental illness
awaisaftab.substack.com/p/reflection...
A new descriptive metaphor for psychological entrenchment in mental illness
awaisaftab.substack.com/p/reflection...
Nice paper by Elizabeth Smith et al from Zach Nimchuck's lab on the canalization of #flower production across thermal environments
www.sciencedirect.com/science/arti...
#devbio #plantscience #botany
www.sciencedirect.com/science/arti...
#devbio #plantscience #botany
Canalization of flower production across thermal environments requires Florigen and CLAVATA signaling
The maintenance of invariant developmental phenotypes across disparate environments is termed canalization, but few examples of canalization mechanism…
www.sciencedirect.com
July 14, 2025 at 5:53 PM
Nice paper by Elizabeth Smith et al from Zach Nimchuck's lab on the canalization of #flower production across thermal environments
www.sciencedirect.com/science/arti...
#devbio #plantscience #botany
www.sciencedirect.com/science/arti...
#devbio #plantscience #botany
TMK interacting network of receptor like kinases for auxin canalization and beyond https://www.biorxiv.org/content/10.1101/2025.02.28.640727v1
March 2, 2025 at 12:02 PM
TMK interacting network of receptor like kinases for auxin canalization and beyond https://www.biorxiv.org/content/10.1101/2025.02.28.640727v1
Lifestyle related exposures show decanalization for BMI but canalization for WHR, reflecting different evolutionary pressures on the architectures of weight-related traits. Could be explained by recent human behaviors driving BMI vs stabilizing selection for metabolism for WHR.
May 5, 2025 at 11:22 PM
Lifestyle related exposures show decanalization for BMI but canalization for WHR, reflecting different evolutionary pressures on the architectures of weight-related traits. Could be explained by recent human behaviors driving BMI vs stabilizing selection for metabolism for WHR.
May 5, 2025 at 11:32 PM
A correlation pattern exists for PV but it's not clear whether it is owed to a shared genetic basis between means and canalization for the trait: https://t.co/RyN5ArEGAY
December 8, 2024 at 4:06 PM
A correlation pattern exists for PV but it's not clear whether it is owed to a shared genetic basis between means and canalization for the trait: https://t.co/RyN5ArEGAY
Presumably we all experience varying degrees of canalization in different areas of our psychic life? No one would be completely free of this right?
September 16, 2023 at 7:57 PM
Presumably we all experience varying degrees of canalization in different areas of our psychic life? No one would be completely free of this right?
Long-term cold adaptation leads to increased thermal plasticity of male body size and thermal canalization of fecundity in populations of Drosophila melanogaster: an experimental evolution study https://www.biorxiv.org/content/10.1101/2023.11.13.566815v1
Long-term cold adaptation leads to increased thermal plasticity of male body size and thermal canalization of fecundity in populations of Drosophila melanogaster: an experimental evolution study https://www.biorxiv.org/content/10.1101/2023.11.13.566815v1
From laboratory populations of Drosophila melanogaster maintained at 25{degrees}C for decades, new p
www.biorxiv.org
November 16, 2023 at 2:34 AM
Long-term cold adaptation leads to increased thermal plasticity of male body size and thermal canalization of fecundity in populations of Drosophila melanogaster: an experimental evolution study https://www.biorxiv.org/content/10.1101/2023.11.13.566815v1
I can see that argument, but I don't think it's possible to draw a bright, clear line between them. It's difficult to say where runaway canalization leaves off and dementia begins, and I think it's a mistake to pretend dementia is purely neurological, without any environmental component.
September 19, 2025 at 5:55 PM
I can see that argument, but I don't think it's possible to draw a bright, clear line between them. It's difficult to say where runaway canalization leaves off and dementia begins, and I think it's a mistake to pretend dementia is purely neurological, without any environmental component.
Finally, the paper went online after 4 years since Prof Qingdong Ou started his research on the topic
"Natural van der Waals canalization lens for non-destructive nanoelectronic circuit imaging and inspection" in Advanced Materials
advanced.onlinelibrary.wiley.com/doi/10.1002/...
"Natural van der Waals canalization lens for non-destructive nanoelectronic circuit imaging and inspection" in Advanced Materials
advanced.onlinelibrary.wiley.com/doi/10.1002/...
May 9, 2025 at 9:22 PM
Finally, the paper went online after 4 years since Prof Qingdong Ou started his research on the topic
"Natural van der Waals canalization lens for non-destructive nanoelectronic circuit imaging and inspection" in Advanced Materials
advanced.onlinelibrary.wiley.com/doi/10.1002/...
"Natural van der Waals canalization lens for non-destructive nanoelectronic circuit imaging and inspection" in Advanced Materials
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Very happy and excited to share the final study of my PhD out in @MolBioEvol. All results from this study can be explored through our Rshiny: https://canalization-gibsonlab.shinyapps.io/rshiny/
https://academic.oup.com/mbe/advance-article-abstract/doi/10.1093/molbev/msac053/6547257
https://academic.oup.com/mbe/advance-article-abstract/doi/10.1093/molbev/msac053/6547257
May 5, 2025 at 10:46 PM
Very happy and excited to share the final study of my PhD out in @MolBioEvol. All results from this study can be explored through our Rshiny: https://canalization-gibsonlab.shinyapps.io/rshiny/
https://academic.oup.com/mbe/advance-article-abstract/doi/10.1093/molbev/msac053/6547257
https://academic.oup.com/mbe/advance-article-abstract/doi/10.1093/molbev/msac053/6547257
Using 10 complex traits and 151 environmental exposures, we compare the prevalence-risk curves wrt exposures to ask the questions 1.For which trait-exposure combination does PGSxE exist? If it exists, can we develop a modeling framework to assess decanalization vs canalization?
May 5, 2025 at 10:51 PM
Using 10 complex traits and 151 environmental exposures, we compare the prevalence-risk curves wrt exposures to ask the questions 1.For which trait-exposure combination does PGSxE exist? If it exists, can we develop a modeling framework to assess decanalization vs canalization?
TOW links TIR1/AFB-mediated signalling with Receptor-Like Kinases in auxin canalization https://www.biorxiv.org/content/10.1101/2025.04.25.650570v1
April 29, 2025 at 2:18 PM
TOW links TIR1/AFB-mediated signalling with Receptor-Like Kinases in auxin canalization https://www.biorxiv.org/content/10.1101/2025.04.25.650570v1
Scientists from @slcuplants.bsky.social combined experiments & modelling to demonstrate how local signals in plant buds link up with whole-plant hormone flows to control branching.
Research summary
www.slcu.cam.ac.uk/news/bud-to-...
Research summary
www.slcu.cam.ac.uk/news/bud-to-...
![(A) A stem segment with two axillary buds illustrates two regulatory hubs controlling shoot branching (i) local expression of the transcription factor BRC1, a repressor of bud activation, and (ii) systemic regulation of the auxin transport network. A canalization-based model of shoot branching postulates that bud activation requires the establishment of canalized auxin transport from the bud into the main stem, the dynamics of which is influenced by autocatalytic feedback in auxin flow between the bud and the stem, and the relative auxin source and sink strengths of the bud and stem, respectively. The relationship between BRC1- and auxin-transport-mediated regulation is not known. (B) Arabidopsis bud activation occurs in at least two phases: a slow-growing lag phase, then a switch to rapid outgrowth. Typical timescale 10–12 days. Modified from Nahas and colleagues [46]. (C) Diagram illustrating the four possible growth outcomes for bud activation on 2-node explants, and their representation in a Mitchison plot. Mitchison plots present the length of the top bud versus that of the bottom bud over time in each explant. Explants where at least one bud grows are termed active, otherwise, they are inactive. Within active explants, there are three possible outcomes: both buds grow, or only either the top or the bottom bud activates. All graphics were drawn by hand using Adobe Illustrator by Zoe Nahas.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:4bwsoqi74cykql32jxcsxjv5/bafkreihclzqgillm2d2eooz3hsmugs565vsk43757jyuzktb4hoeihmzwq@jpeg)
September 19, 2025 at 1:50 PM
Scientists from @slcuplants.bsky.social combined experiments & modelling to demonstrate how local signals in plant buds link up with whole-plant hormone flows to control branching.
Research summary
www.slcu.cam.ac.uk/news/bud-to-...
Research summary
www.slcu.cam.ac.uk/news/bud-to-...
1/3 We are really happy to announce the latest version of our CANA Python package which allows the quantification of dynamical #redundancy and #canalization in #automata #complexnetworks, including effective connectivity and symmetry. #dynamics #BooleanNetworks
doi.org/10.1093/bioi...
doi.org/10.1093/bioi...
CANA v1.0.0: efficient quantification of canalization in automata networks
AbstractSummary. The biomolecular networks underpinning cell function exhibit canalization, or the buffering of fluctuations required to function in a nois
doi.org
September 3, 2025 at 9:45 PM
1/3 We are really happy to announce the latest version of our CANA Python package which allows the quantification of dynamical #redundancy and #canalization in #automata #complexnetworks, including effective connectivity and symmetry. #dynamics #BooleanNetworks
doi.org/10.1093/bioi...
doi.org/10.1093/bioi...
Seaford began silting up so a 'cut' was made so the river would flow into the sea where it is now. That's where 'New Haven' comes from. The river still wandered east by 1698, until a storm broke through the shingle. In 18th canalization and drainage helped the mouth stay put at Newhaven.
May 22, 2024 at 6:52 PM
Seaford began silting up so a 'cut' was made so the river would flow into the sea where it is now. That's where 'New Haven' comes from. The river still wandered east by 1698, until a storm broke through the shingle. In 18th canalization and drainage helped the mouth stay put at Newhaven.
Yeah they actually had cities the size of London. With a canalization aswell.
November 26, 2024 at 4:46 PM
Yeah they actually had cities the size of London. With a canalization aswell.
Rendel is mostly cited as someone who empirically studied the phenomenon of phenotypic canalization during his years in Edinburgh, under Waddington. Later he went to CSIRO (Australia) where he worked on breeding, for what he is also quite recognized there. https://t.co/nZWEMdHgTf
December 8, 2024 at 4:05 PM
Rendel is mostly cited as someone who empirically studied the phenomenon of phenotypic canalization during his years in Edinburgh, under Waddington. Later he went to CSIRO (Australia) where he worked on breeding, for what he is also quite recognized there. https://t.co/nZWEMdHgTf
@aaronecarroll Physical anthropology literature tended to support early canalization view from c.1880s-1980s. Now, more contested. (2/n)
November 12, 2024 at 3:42 AM
@aaronecarroll Physical anthropology literature tended to support early canalization view from c.1880s-1980s. Now, more contested. (2/n)
There is a big, old, deep, generalized aversion in the US against canalization and in-road obstacles.
IIRC, Eno talks about the difficulty of importing to the US the pedestrian refuge islands he saw in Paris at crossings in large boulevards.
Meanwhile in Paris
IIRC, Eno talks about the difficulty of importing to the US the pedestrian refuge islands he saw in Paris at crossings in large boulevards.
Meanwhile in Paris
May 28, 2025 at 4:15 PM
There is a big, old, deep, generalized aversion in the US against canalization and in-road obstacles.
IIRC, Eno talks about the difficulty of importing to the US the pedestrian refuge islands he saw in Paris at crossings in large boulevards.
Meanwhile in Paris
IIRC, Eno talks about the difficulty of importing to the US the pedestrian refuge islands he saw in Paris at crossings in large boulevards.
Meanwhile in Paris
the help immigrants receive are handouts in proportion to corporate welfare, which does take away from schools, hospitals, water, canalization, transport = public services
Large companies taking tax cuts and government grants to benefit billionaires are the gangsters
#ClassWar Tax the Rich
Large companies taking tax cuts and government grants to benefit billionaires are the gangsters
#ClassWar Tax the Rich
August 27, 2025 at 7:25 PM
the help immigrants receive are handouts in proportion to corporate welfare, which does take away from schools, hospitals, water, canalization, transport = public services
Large companies taking tax cuts and government grants to benefit billionaires are the gangsters
#ClassWar Tax the Rich
Large companies taking tax cuts and government grants to benefit billionaires are the gangsters
#ClassWar Tax the Rich
LV did not exhibit a pattern of decanalization at these temperatures, meaning that variability for both components of preadult viability changed independently. For LV also means, canalization and their plasticities varied independently. https://t.co/sTsLhKgqvt
December 8, 2024 at 4:06 PM
LV did not exhibit a pattern of decanalization at these temperatures, meaning that variability for both components of preadult viability changed independently. For LV also means, canalization and their plasticities varied independently. https://t.co/sTsLhKgqvt