A little Christmas gift for the molecular biology nerds! I love the simplicity of this idea: very useful (and small) plasmid selection system that alleviates the need for antibiotics in molbio and bioprocesses. Elegant work by my former PhD student, lab, and colleagues: doi.org/10.1021/acss...
tRNA-Mediated Plasmid Stabilization for Antibiotic-Free Applications in Escherichia coli
Plasmids are essential tools in molecular biology and biotechnology. In research laboratories, it is common to use antibiotic selection markers to ensure that plasmids are stably maintained in a cellu...
doi.org
December 24, 2025 at 7:39 AM
A little Christmas gift for the molecular biology nerds! I love the simplicity of this idea: very useful (and small) plasmid selection system that alleviates the need for antibiotics in molbio and bioprocesses. Elegant work by my former PhD student, lab, and colleagues: doi.org/10.1021/acss...
arXiv:2502.01488v1 Announce Type: new
Abstract: Bioprocesses are often characterised by nonlinear and uncertain dynamics, posing particular challenges for model predictive control (MPC) algorithms due to their computational [1/6 of https://arxiv.org/abs/2502.01488v1]
Abstract: Bioprocesses are often characterised by nonlinear and uncertain dynamics, posing particular challenges for model predictive control (MPC) algorithms due to their computational [1/6 of https://arxiv.org/abs/2502.01488v1]
February 4, 2025 at 6:16 AM
arXiv:2502.01488v1 Announce Type: new
Abstract: Bioprocesses are often characterised by nonlinear and uncertain dynamics, posing particular challenges for model predictive control (MPC) algorithms due to their computational [1/6 of https://arxiv.org/abs/2502.01488v1]
Abstract: Bioprocesses are often characterised by nonlinear and uncertain dynamics, posing particular challenges for model predictive control (MPC) algorithms due to their computational [1/6 of https://arxiv.org/abs/2502.01488v1]
link 📈🤖
Data-driven Bayesian estimation of Monod kinetics () In this paper, we consider the well known problem of non-linear identification of the rates of the reactions involved in cells with Monod functions. In bioprocesses, generating data is very expensive and long and so it is important to i
Data-driven Bayesian estimation of Monod kinetics () In this paper, we consider the well known problem of non-linear identification of the rates of the reactions involved in cells with Monod functions. In bioprocesses, generating data is very expensive and long and so it is important to i
February 11, 2025 at 10:10 PM
link 📈🤖
Data-driven Bayesian estimation of Monod kinetics () In this paper, we consider the well known problem of non-linear identification of the rates of the reactions involved in cells with Monod functions. In bioprocesses, generating data is very expensive and long and so it is important to i
Data-driven Bayesian estimation of Monod kinetics () In this paper, we consider the well known problem of non-linear identification of the rates of the reactions involved in cells with Monod functions. In bioprocesses, generating data is very expensive and long and so it is important to i
uncertainties such as uncertain initial conditions and stochastic dynamics. This challenge is relevant, e.g., in bioprocesses involving microbial consortia, where precise control over population compositions is required. We introduce a novel return [3/7 of https://arxiv.org/abs/2503.22409v1]
March 31, 2025 at 6:02 AM
uncertainties such as uncertain initial conditions and stochastic dynamics. This challenge is relevant, e.g., in bioprocesses involving microbial consortia, where precise control over population compositions is required. We introduce a novel return [3/7 of https://arxiv.org/abs/2503.22409v1]
Hmm, I mght be forgetting school chemistry.. any hot enough burning produces nitroget oxides, no? So do many bioprocesses and that's why even "lifeforms" are contribuing to greenhouse effect - e.g. cultivated soil. Probably why biofuels aren't considered "neutral".
But H2 leakage is just dangerous.
But H2 leakage is just dangerous.
March 22, 2025 at 9:56 AM
Hmm, I mght be forgetting school chemistry.. any hot enough burning produces nitroget oxides, no? So do many bioprocesses and that's why even "lifeforms" are contribuing to greenhouse effect - e.g. cultivated soil. Probably why biofuels aren't considered "neutral".
But H2 leakage is just dangerous.
But H2 leakage is just dangerous.
🧪 Nature has its own cleanup crew!
Effective Microorganisms (EMOs)—a powerful mix of bacteria, yeasts & fungi—are transforming pollution treatment through eco-friendly bioprocesses. Low-cost, sustainable, and scalable.
👉 www.mdpi.com/2673-9976/31...
#MDPIProceedings #BlueSkyScience #NatureSky
Effective Microorganisms (EMOs)—a powerful mix of bacteria, yeasts & fungi—are transforming pollution treatment through eco-friendly bioprocesses. Low-cost, sustainable, and scalable.
👉 www.mdpi.com/2673-9976/31...
#MDPIProceedings #BlueSkyScience #NatureSky
June 18, 2025 at 3:42 AM
🧪 Nature has its own cleanup crew!
Effective Microorganisms (EMOs)—a powerful mix of bacteria, yeasts & fungi—are transforming pollution treatment through eco-friendly bioprocesses. Low-cost, sustainable, and scalable.
👉 www.mdpi.com/2673-9976/31...
#MDPIProceedings #BlueSkyScience #NatureSky
Effective Microorganisms (EMOs)—a powerful mix of bacteria, yeasts & fungi—are transforming pollution treatment through eco-friendly bioprocesses. Low-cost, sustainable, and scalable.
👉 www.mdpi.com/2673-9976/31...
#MDPIProceedings #BlueSkyScience #NatureSky
Simultaneous enumeration of yeast and bacterial cells in the context of industrial bioprocesses https://www.biorxiv.org/content/10.1101/2024.06.26.600471v1
Simultaneous enumeration of yeast and bacterial cells in the context of industrial bioprocesses https://www.biorxiv.org/content/10.1101/2024.06.26.600471v1
In scenarios where yeast and bacterial cells coexist, e.g. the food and bioethanol industries, it wo
www.biorxiv.org
June 27, 2024 at 8:17 AM
Simultaneous enumeration of yeast and bacterial cells in the context of industrial bioprocesses https://www.biorxiv.org/content/10.1101/2024.06.26.600471v1
Final boarding call for your future in bioengineering🚀
Takeoff tomorrow Mar 31, 23:59—last chance to apply for our PhD positions
🎯Computational Design of Optimal Bioprocesses
🔬Optimal Compartmentalization of Metabolic Pathways
Hop on before it’s too late www.circularbioengineering.at/jobsprogram2
Takeoff tomorrow Mar 31, 23:59—last chance to apply for our PhD positions
🎯Computational Design of Optimal Bioprocesses
🔬Optimal Compartmentalization of Metabolic Pathways
Hop on before it’s too late www.circularbioengineering.at/jobsprogram2
March 30, 2025 at 8:46 PM
Final boarding call for your future in bioengineering🚀
Takeoff tomorrow Mar 31, 23:59—last chance to apply for our PhD positions
🎯Computational Design of Optimal Bioprocesses
🔬Optimal Compartmentalization of Metabolic Pathways
Hop on before it’s too late www.circularbioengineering.at/jobsprogram2
Takeoff tomorrow Mar 31, 23:59—last chance to apply for our PhD positions
🎯Computational Design of Optimal Bioprocesses
🔬Optimal Compartmentalization of Metabolic Pathways
Hop on before it’s too late www.circularbioengineering.at/jobsprogram2
It is high time we all reconsidered the exclusive focus on nth plant TEAs. Lead author Tuhin Poddar does a great job outlining the options for TEA that's more relevant to near-term scale-up of bioprocesses in our new COBIOT article: authors.elsevier.com/sd/article/S...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
January 21, 2025 at 6:30 PM
It is high time we all reconsidered the exclusive focus on nth plant TEAs. Lead author Tuhin Poddar does a great job outlining the options for TEA that's more relevant to near-term scale-up of bioprocesses in our new COBIOT article: authors.elsevier.com/sd/article/S...
## Automated Microbial Metabolic Flux Prediction and Optimization using Hybrid Spectral Deconvolution and Reinforcement Learning (HS-RL)
**Abstract:** Real-time monitoring of microbial metabolic states is critical for optimizing bioprocesses. Current methods often lack the speed, accuracy, and…
**Abstract:** Real-time monitoring of microbial metabolic states is critical for optimizing bioprocesses. Current methods often lack the speed, accuracy, and…
## Automated Microbial Metabolic Flux Prediction and Optimization using Hybrid Spectral Deconvolution and Reinforcement Learning (HS-RL)
**Abstract:** Real-time monitoring of microbial metabolic states is critical for optimizing bioprocesses. Current methods often lack the speed, accuracy, and predictive capabilities necessary for dynamic control. This paper proposes Hybrid Spectral Deconvolution and Reinforcement Learning (HS-RL), a novel system for real-time prediction and optimization of microbial metabolic flux distributions based on Raman spectral data and a reinforcement learning agent. HS-ML leverages non-negative matrix factorization (NMF) for rapid spectral deconvolution of multiple metabolic components into singular integrand representations, enabling dynamic flux estimation.
freederia.com
November 27, 2025 at 9:07 AM
## Automated Microbial Metabolic Flux Prediction and Optimization using Hybrid Spectral Deconvolution and Reinforcement Learning (HS-RL)
**Abstract:** Real-time monitoring of microbial metabolic states is critical for optimizing bioprocesses. Current methods often lack the speed, accuracy, and…
**Abstract:** Real-time monitoring of microbial metabolic states is critical for optimizing bioprocesses. Current methods often lack the speed, accuracy, and…
The warnings say not to use it if you take insulin or experience hypoglycemia so this is explicitly marketed toward people looking to track their bioprocesses. What could possibly go wrong
December 3, 2024 at 2:50 PM
The warnings say not to use it if you take insulin or experience hypoglycemia so this is explicitly marketed toward people looking to track their bioprocesses. What could possibly go wrong
Just finished my PhD thesis, now waiting for my Viva. So, it's time:
know anyone interested in a BioTech guy, focused on microbiology/biochemistry, who went through food and beverage, toxicology, bioprocesses, programming, material science...with academic and industrial experience?
Gimme a shout!🧪
know anyone interested in a BioTech guy, focused on microbiology/biochemistry, who went through food and beverage, toxicology, bioprocesses, programming, material science...with academic and industrial experience?
Gimme a shout!🧪
January 29, 2025 at 12:16 PM
Just finished my PhD thesis, now waiting for my Viva. So, it's time:
know anyone interested in a BioTech guy, focused on microbiology/biochemistry, who went through food and beverage, toxicology, bioprocesses, programming, material science...with academic and industrial experience?
Gimme a shout!🧪
know anyone interested in a BioTech guy, focused on microbiology/biochemistry, who went through food and beverage, toxicology, bioprocesses, programming, material science...with academic and industrial experience?
Gimme a shout!🧪
The PhD floodgates are opening 🌊
We too are on the hunt for brilliant minds—check it out www.circularbioengineering.at/jobsprogram2
🎯 PhD 2.8 Computational Design of Optimal Bioprocesses
🔬 PhD 2.9 Optimal Compartmentalization of Metabolic Pathways
Twice the fun—join the adventure @univie.ac.at 🚀
We too are on the hunt for brilliant minds—check it out www.circularbioengineering.at/jobsprogram2
🎯 PhD 2.8 Computational Design of Optimal Bioprocesses
🔬 PhD 2.9 Optimal Compartmentalization of Metabolic Pathways
Twice the fun—join the adventure @univie.ac.at 🚀
March 8, 2025 at 3:31 PM
The PhD floodgates are opening 🌊
We too are on the hunt for brilliant minds—check it out www.circularbioengineering.at/jobsprogram2
🎯 PhD 2.8 Computational Design of Optimal Bioprocesses
🔬 PhD 2.9 Optimal Compartmentalization of Metabolic Pathways
Twice the fun—join the adventure @univie.ac.at 🚀
We too are on the hunt for brilliant minds—check it out www.circularbioengineering.at/jobsprogram2
🎯 PhD 2.8 Computational Design of Optimal Bioprocesses
🔬 PhD 2.9 Optimal Compartmentalization of Metabolic Pathways
Twice the fun—join the adventure @univie.ac.at 🚀
RRID:SCR_018681 was used by the authors of the Acta Astronautica paper "ARTHROSPIRA-C space flight experiment: Validation of biomass and oxygen production bioprocesses in a space bioreactor prior to upload to space". Thank you for making your methods matter! #reproducibility #OpenScience
doi.org
April 3, 2025 at 7:00 AM
RRID:SCR_018681 was used by the authors of the Acta Astronautica paper "ARTHROSPIRA-C space flight experiment: Validation of biomass and oxygen production bioprocesses in a space bioreactor prior to upload to space". Thank you for making your methods matter! #reproducibility #OpenScience
Apply by September 11 to join Takeda's R&D Science Day 2025 on October 16 in Vienna! -> Opportunity for innovators, start-ups, spin-offs, subject matter experts, and application-oriented academic researchers focusing e.g. on bioprocesses, AI and formulation
www.linkedin.com/feed/update/...
www.linkedin.com/feed/update/...
#bioeurope | LISAvienna
Final reminder: Apply by September 11 to join Takeda's R&D Science Day 2025 on October 16 in Vienna!
Takeda invites innovators, start-ups, spin-offs, subject matter experts, and application-oriented ...
www.linkedin.com
September 2, 2025 at 7:13 AM
Apply by September 11 to join Takeda's R&D Science Day 2025 on October 16 in Vienna! -> Opportunity for innovators, start-ups, spin-offs, subject matter experts, and application-oriented academic researchers focusing e.g. on bioprocesses, AI and formulation
www.linkedin.com/feed/update/...
www.linkedin.com/feed/update/...
Actus Mer/Sea News: "New" organism being prepared for biotechnology applications - Basis for next-gen bioprocesses - @TU_Muenchen http://dlvr.it/SKXKtb
January 26, 2025 at 5:11 AM
Actus Mer/Sea News: "New" organism being prepared for biotechnology applications - Basis for next-gen bioprocesses - @TU_Muenchen http://dlvr.it/SKXKtb
+104% in 2,3-butanediol productivity
Check out #MathiasGotsmy's latest paper 📝 on designing competitive, green bioprocesses for 2,3-butanediol production ⚗️
🔗 doi.org/10.1016/j.cs...
Curious for more? Swing by Poster #48 at #ESIB!
Check out #MathiasGotsmy's latest paper 📝 on designing competitive, green bioprocesses for 2,3-butanediol production ⚗️
🔗 doi.org/10.1016/j.cs...
Curious for more? Swing by Poster #48 at #ESIB!
November 19, 2024 at 5:32 PM
+104% in 2,3-butanediol productivity
Check out #MathiasGotsmy's latest paper 📝 on designing competitive, green bioprocesses for 2,3-butanediol production ⚗️
🔗 doi.org/10.1016/j.cs...
Curious for more? Swing by Poster #48 at #ESIB!
Check out #MathiasGotsmy's latest paper 📝 on designing competitive, green bioprocesses for 2,3-butanediol production ⚗️
🔗 doi.org/10.1016/j.cs...
Curious for more? Swing by Poster #48 at #ESIB!
Our R&D services include the development of #bioprocesses. Would you like to know how we solved a challenge for a #pharma partner involving high protein yields and a difficult to purify #enzyme? The answer is in this article. t1p.de/c904a
Efficient bioprocess design drives enzyme development for pharma applications
Producing CRISPR nucleases for use as RNPs can be difficult - but we found a solution
t1p.de
March 6, 2025 at 1:04 PM
Our R&D services include the development of #bioprocesses. Would you like to know how we solved a challenge for a #pharma partner involving high protein yields and a difficult to purify #enzyme? The answer is in this article. t1p.de/c904a
Our review article got published in 'Biotechnology Advances':
"Decoding bioprocesses with transcriptomics: current status and future potential"
doi.org/10.1016/j.bi...
#Biotech #ScaleUp #ScaleDown #Transcriptomics
@puckerlab.bsky.social
"Decoding bioprocesses with transcriptomics: current status and future potential"
doi.org/10.1016/j.bi...
#Biotech #ScaleUp #ScaleDown #Transcriptomics
@puckerlab.bsky.social
Redirecting
doi.org
October 19, 2025 at 6:24 AM
Our review article got published in 'Biotechnology Advances':
"Decoding bioprocesses with transcriptomics: current status and future potential"
doi.org/10.1016/j.bi...
#Biotech #ScaleUp #ScaleDown #Transcriptomics
@puckerlab.bsky.social
"Decoding bioprocesses with transcriptomics: current status and future potential"
doi.org/10.1016/j.bi...
#Biotech #ScaleUp #ScaleDown #Transcriptomics
@puckerlab.bsky.social
We’re in Trondheim now for our 4th GA hosted by SINTEF. Today we assess this year’s progress and discuss the best ways to move forward. Tomorrow brings us deeper into SINTEF’s labs for CO2 research, catalysis and bioprocesses. More from Norway soon.
#GreenHydrogen #CleanEnergy #Sustainability
#GreenHydrogen #CleanEnergy #Sustainability
June 2, 2025 at 9:39 AM
We’re in Trondheim now for our 4th GA hosted by SINTEF. Today we assess this year’s progress and discuss the best ways to move forward. Tomorrow brings us deeper into SINTEF’s labs for CO2 research, catalysis and bioprocesses. More from Norway soon.
#GreenHydrogen #CleanEnergy #Sustainability
#GreenHydrogen #CleanEnergy #Sustainability
3️⃣ Automated & adaptive ML pipelines:
- Bioprocesses change dynamically (media shifts, cell culture drift).
- AutoML & adaptive learning can fine-tune models in real-time based on new sensor data.
- Bottleneck? Regulatory constraints on adaptive ML for GMP compliance.
February 10, 2025 at 8:57 AM
3️⃣ Automated & adaptive ML pipelines:
- Bioprocesses change dynamically (media shifts, cell culture drift).
- AutoML & adaptive learning can fine-tune models in real-time based on new sensor data.
- Bottleneck? Regulatory constraints on adaptive ML for GMP compliance.
Hybrid modeling framework for bioprocesses with minimal prior knowledge and limited data https://www.biorxiv.org/content/10.1101/2025.11.14.688550v1
November 17, 2025 at 1:46 AM
Hybrid modeling framework for bioprocesses with minimal prior knowledge and limited data https://www.biorxiv.org/content/10.1101/2025.11.14.688550v1
Simultaneous enumeration of yeast and bacterial cells in the context of industrial bioprocesses https://www.biorxiv.org/content/10.1101/2024.06.26.600471v1
Simultaneous enumeration of yeast and bacterial cells in the context of industrial bioprocesses https://www.biorxiv.org/content/10.1101/2024.06.26.600471v1
In scenarios where yeast and bacterial cells coexist, e.g. the food and bioethanol industries, it wo
www.biorxiv.org
June 27, 2024 at 8:17 AM
Simultaneous enumeration of yeast and bacterial cells in the context of industrial bioprocesses https://www.biorxiv.org/content/10.1101/2024.06.26.600471v1
Our perspective on C1 utilizing bioprocesses moved online, a super teamwork made it possible 👏
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Industrial applicability of enzymatic and whole-cell processes for the utilization of C1 building blocks - Nature Communications
Significant process has been made in using one carbon sources toward biomanufacturing. Here, the authors explore how to strength its competitiveness, and highlight latest technologies and the released...
www.nature.com
August 1, 2025 at 6:46 PM
Our perspective on C1 utilizing bioprocesses moved online, a super teamwork made it possible 👏
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Kareem T. Elgindy, Muneerah Al Nuwairan: Periodic Fractional Control in Bioprocesses for Clean Water and Ecosystem Health https://arxiv.org/abs/2508.01022 https://arxiv.org/pdf/2508.01022 https://arxiv.org/html/2508.01022
August 5, 2025 at 6:40 AM
Kareem T. Elgindy, Muneerah Al Nuwairan: Periodic Fractional Control in Bioprocesses for Clean Water and Ecosystem Health https://arxiv.org/abs/2508.01022 https://arxiv.org/pdf/2508.01022 https://arxiv.org/html/2508.01022