The ONDAAS study reported ~ 9.5 % had albuminuria underscoring the importance of screening
A third of us got it right
#CSNhomecoming
Link pubmed.ncbi.nlm.nih.gov/40416393/
A third of us got it right
#CSNhomecoming
Link pubmed.ncbi.nlm.nih.gov/40416393/
October 15, 2025 at 5:10 PM
Everybody can reply
3 likes
Heterogeneity in the relationships between #albuminuria and glomerular structure in type 1 and type 2 #diabetes.
doi.org/10.1016/j.kint.2025.08.034
#NephySky #MedSky #diabetes #diabeticnephropathy
@uwdeptmedicine.bsky.social
doi.org/10.1016/j.kint.2025.08.034
#NephySky #MedSky #diabetes #diabeticnephropathy
@uwdeptmedicine.bsky.social
October 9, 2025 at 3:54 PM
Everybody can reply
2 likes
1 saves
Preventing Microalbuminuria in Type 2 Diabetes | NEJM
The multicenter double-blind, randomized Bergamo Nephrologic Diabetes Complications Trial (BENEDICT) was designed to assess whether angiotensin-converting–enzyme inhibitors and non-dihydropyridine ...
www.nejm.org
September 17, 2025 at 1:57 AM
Everybody can reply
6 reposts
12 likes
T2k
Let’s talk meds!
-Thiazides, ACEi/ARBs, CCBs (long-acting dihydropyridines) remain first-line
-ACEi/ARBs preferred in all patients with albuminuria ≥30 mg/g
-In T2DM, ACEi/ARBs should be considered even in mild albuminuria (<30 mg/g) to delay progression of DKD #NephJC
Let’s talk meds!
-Thiazides, ACEi/ARBs, CCBs (long-acting dihydropyridines) remain first-line
-ACEi/ARBs preferred in all patients with albuminuria ≥30 mg/g
-In T2DM, ACEi/ARBs should be considered even in mild albuminuria (<30 mg/g) to delay progression of DKD #NephJC
September 17, 2025 at 1:33 AM
Everybody can reply
1 reposts
12 likes
1 saves
And that’s a wrap!
In summary: screen carefully, stratify by risk, account for kidney health, and individualize therapy.
For nephrology, the wins are undeniable: albuminuria testing is mainstream, CKD visibility is heightened, and aldosterone is on the radar.
#NephJC
In summary: screen carefully, stratify by risk, account for kidney health, and individualize therapy.
For nephrology, the wins are undeniable: albuminuria testing is mainstream, CKD visibility is heightened, and aldosterone is on the radar.
#NephJC
September 17, 2025 at 1:54 AM
Everybody can reply
1 reposts
14 likes
T4j
🔟CKD with albuminuria - ACEi/ARB strongly recommended to delay CKD progression and reduce CVD (COR I, LOE A).
📝Still only 35-50% of eligible patients get them. How do we move the needle on this? #NephJC
🔟CKD with albuminuria - ACEi/ARB strongly recommended to delay CKD progression and reduce CVD (COR I, LOE A).
📝Still only 35-50% of eligible patients get them. How do we move the needle on this? #NephJC
September 17, 2025 at 1:49 AM
Everybody can reply
1 reposts
5 likes
I find the criticism somewhat misdirected - the typical EBM over nitpicking
OTOH albuminuria is *not* perfect
More valid criticisms?
- intensive BP lowering & dual RAS inhibition reduces albuminuria without reducing kidney failure
OTOH albuminuria is *not* perfect
More valid criticisms?
- intensive BP lowering & dual RAS inhibition reduces albuminuria without reducing kidney failure
September 6, 2025 at 11:45 PM
Everybody can reply
6 likes
In a mouse model of IgA nephropathy, this #ASNJASN original research finds that FcγRIIB deficiency in macrophages and dendritic cells led to increased albuminuria, kidney dysfunction, and kidney injury. Read more: kidney.pub/JASN0835 #BasicResearch
September 6, 2025 at 6:00 PM
Everybody can reply
1 reposts
4 likes
RCT of dapagliflozin versus placebo.
Designed as crossover study. Looking at albuminuria.
Interestingly there were increases in the PO4, PTH, FGF23.
Thought to be due to increased absorption of PO4 by blocking SGLT2.
https://cjasn.asnjournals.org/content/14/1/66
#KidneyWk
Designed as crossover study. Looking at albuminuria.
Interestingly there were increases in the PO4, PTH, FGF23.
Thought to be due to increased absorption of PO4 by blocking SGLT2.
https://cjasn.asnjournals.org/content/14/1/66
#KidneyWk
November 22, 2024 at 10:38 PM
Everybody can reply
Albuminuria onset in bariatric surgery.
December 5, 2024 at 5:40 AM
Everybody can reply
A persistent eGFR drop with SGLT2 inhibitors is usually a functional change, not CKD, unless markers of kidney damage (e.g., albuminuria) are present. Document as a medication effect, not CKD, unless other evidence suggests true kidney disease. Reassure and monitor the patient are best next steps
December 27, 2024 at 12:25 PM
Everybody can reply
1 likes
BTW there are also other ns-MRAs apart from Finerenone
See from our previous rant; www.nephjc.com/news/2024/10...
I think Hiddo is presenting MIRO-CKD data on Saturday at #KidneyWk
See from our previous rant; www.nephjc.com/news/2024/10...
I think Hiddo is presenting MIRO-CKD data on Saturday at #KidneyWk
October 20, 2025 at 11:28 AM
Everybody can reply
Bexagliflozin lowered blood pressure, lowered albuminuria, no change in GFR. #KidneyWk #HighImpact
December 2, 2024 at 7:53 PM
Everybody can reply
3. Consistency Across Subgroups:
The protective effects were consistent across different patient groups, including those with varying eGFR levels, albuminuria severity, and diabetes status.
November 21, 2024 at 11:53 PM
Everybody can reply
CKD Stage 3a with diabetes.
90% reduction in albuminuria with losartan, dapagliflozin, and finerenone.
90% reduction in albuminuria with losartan, dapagliflozin, and finerenone.
November 24, 2024 at 8:38 AM
Everybody can reply
1 quotes
Deletion of Nudt19 Increases Albuminuria in Mice Fed a High Fat Diet https://www.biorxiv.org/content/10.1101/2025.03.22.644727v1
March 25, 2025 at 8:02 PM
Everybody can reply
Heerspink brings the N-1 trials from his #KidneyWk lecture to fruition
Is the flozin albuminuria reduction reproducible? Is the individual variability random or similar with repeat exposures?
jamanetwork.com/journals/jam...
In @jama.com #NephSky
Is the flozin albuminuria reduction reproducible? Is the individual variability random or similar with repeat exposures?
jamanetwork.com/journals/jam...
In @jama.com #NephSky
March 25, 2025 at 1:43 AM
Everybody can reply
3 reposts
13 likes
Impact of smartphone-enabled home urinary albumin-to-creatinine ratio testing on albuminuria screening and management https://www.medrxiv.org/content/10.1101/2025.06.11.25329440v1
June 18, 2025 at 3:57 PM
Everybody can reply
preprint alert - sharing our study "Impact of smartphone-enabled home urinary albumin-to-creatinine ratio testing on albuminuria screening and management" www.medrxiv.org/content/10.1...
Impact of smartphone-enabled home urinary albumin-to-creatinine ratio testing on albuminuria screening and management
Objective: We investigated the impact of smartphone-enabled home urinary albumin creatinine ratio (UACR) testing on albuminuria screening and management in a prospective propensity score-matched cohor...
www.medrxiv.org
June 18, 2025 at 4:45 PM
Everybody can reply
2 likes
Although low albumin doesn't always mean more toxicity, and can be the opposite clinical effect. Ceftriaxone in cirrhotics is cleared more rapidly due to more free drug being available to clear, and loop diuretics require substantially higher doses in either hypoalbuminemia or severe albuminuria.
January 4, 2025 at 1:27 AM
Everybody can reply
4 likes
The study was 60 weeks.
Primary outcome was change in albuminuria
Secondary outcome was change in eGFR
They randomized 861 patients and 37 patients were switched from 3 mg to 24m mg after 9 months.
Primary outcome was change in albuminuria
Secondary outcome was change in eGFR
They randomized 861 patients and 37 patients were switched from 3 mg to 24m mg after 9 months.
November 24, 2024 at 4:25 AM
Everybody can reply
Among diverse US Hispanic/Latino adults with CKD, higher LE8 score (better cardiovascular health) was associated with a slower decline in eGFR and lower albuminuria over six years. bit.ly/CJASN0656
#ASNCJASN
#eGFR
#ASNCJASN
#eGFR
March 19, 2025 at 7:00 PM
Everybody can reply
1 quotes
3 likes
www.nature.com/articles/s41... 🧪. Large study of over 1m quantifies the independent associations of albuminuria and eGFR with the incidence of overall cancer, and among selected site-specific cancers, using data from eligible cohorts in the Chronic Kidney Disease Prognosis Consortium (CKD-PC).
Chronic kidney disease and incident cancer risk: an individual participant data meta-analysis - British Journal of Cancer
British Journal of Cancer - Chronic kidney disease and incident cancer risk: an individual participant data meta-analysis
www.nature.com
September 8, 2025 at 11:27 AM
Everybody can reply
1 reposts
5 likes
The relationship between low levels of albuminuria and cardiovascular mortality among apparently healthy adults https://www.medrxiv.org/content/10.1101/2023.12.21.23300378v1
The relationship between low levels of albuminuria and cardiovascular mortality among apparently healthy adults https://www.medrxiv.org/content/10.1101/2023.12.21.23300378v1
Background: Albuminuria is associated with cardiovascular events among adults with underlying cardio
www.medrxiv.org
December 24, 2023 at 5:59 PM
Everybody can reply
Joslin study found that early progressive renal decline (early GFR loss) begins in patients w/ norm renal function. It is the 1st manifestation of DKD (NOT albuminuria, as previously thought), said Dr Krolewski.
#STP2018 @ToxPathNet
#STP2018 @ToxPathNet
December 1, 2024 at 7:32 PM
Everybody can reply