Join us on Feb 19, 9am PT for a spotlight review showcasing breakthrough RNAscope publications from 2025. Debia Wakhloo will highlight key publications utilizing RNAscope, BaseScope, & miRNAscope to address important spatial multiomic questions.
Register: bit.ly/49LASpR
Register: bit.ly/49LASpR
February 12, 2026 at 3:19 PM
Join us on Feb 19, 9am PT for a spotlight review showcasing breakthrough RNAscope publications from 2025. Debia Wakhloo will highlight key publications utilizing RNAscope, BaseScope, & miRNAscope to address important spatial multiomic questions.
Register: bit.ly/49LASpR
Register: bit.ly/49LASpR
High-throughput quantification of huntingtin mRNA expression and aggregation in mouse brain using automated RNAscope imaging. #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.02.09.704866v1
https://www.biorxiv.org/content/10.64898/2026.02.09.704866v1
February 11, 2026 at 5:01 PM
High-throughput quantification of huntingtin mRNA expression and aggregation in mouse brain using automated RNAscope imaging. #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.02.09.704866v1
https://www.biorxiv.org/content/10.64898/2026.02.09.704866v1
High-throughput quantification of huntingtin mRNA expression and aggregation in mouse brain using automated RNAscope imaging. https://www.biorxiv.org/content/10.64898/2026.02.09.704866v1
February 11, 2026 at 2:30 PM
High-throughput quantification of huntingtin mRNA expression and aggregation in mouse brain using automated RNAscope imaging. https://www.biorxiv.org/content/10.64898/2026.02.09.704866v1
High-throughput quantification of huntingtin mRNA expression and aggregation in mouse brain using automated RNAscope imaging. https://www.biorxiv.org/content/10.64898/2026.02.09.704866v1
February 11, 2026 at 2:30 PM
High-throughput quantification of huntingtin mRNA expression and aggregation in mouse brain using automated RNAscope imaging. https://www.biorxiv.org/content/10.64898/2026.02.09.704866v1
For #FluorescenceFriday, activity-trapping experiments to better understand how amphetamine controls attention. RNAscope for glutamate neurons 🟢, inhibitory neurons 🔴 and our "ensemble" 🟣. Quotes for the loaded definition ;)
Image credit to JHU neuro student Suhaas Adiraju 🧠🔬🧪
Image credit to JHU neuro student Suhaas Adiraju 🧠🔬🧪
January 30, 2026 at 3:00 PM
For #FluorescenceFriday, activity-trapping experiments to better understand how amphetamine controls attention. RNAscope for glutamate neurons 🟢, inhibitory neurons 🔴 and our "ensemble" 🟣. Quotes for the loaded definition ;)
Image credit to JHU neuro student Suhaas Adiraju 🧠🔬🧪
Image credit to JHU neuro student Suhaas Adiraju 🧠🔬🧪
#ThrowbackThursday in JHC: "RNAscope Multiplex FISH Signal Assessment in FFPE and Fresh Frozen Tissues: The Effect of Archival Duration on RNA Expression."
Click to read for FREE: bit.ly/3DxNTHk
#RNA #RNAscope #pathology
Click to read for FREE: bit.ly/3DxNTHk
#RNA #RNAscope #pathology
January 22, 2026 at 11:22 PM
#ThrowbackThursday in JHC: "RNAscope Multiplex FISH Signal Assessment in FFPE and Fresh Frozen Tissues: The Effect of Archival Duration on RNA Expression."
Click to read for FREE: bit.ly/3DxNTHk
#RNA #RNAscope #pathology
Click to read for FREE: bit.ly/3DxNTHk
#RNA #RNAscope #pathology
Adipose tissue of an adult mouse after 12 weeks of high-fat diet feeding and 7 days post-traumatic brain injury, combining IF and FISH (RNAscope)."
Congratulations to Gideon van der Linden in UCD, on being selected for our next ECRN Researcher Spotlight! 🎉👏🏅
Congratulations to Gideon van der Linden in UCD, on being selected for our next ECRN Researcher Spotlight! 🎉👏🏅
December 17, 2025 at 6:52 PM
Adipose tissue of an adult mouse after 12 weeks of high-fat diet feeding and 7 days post-traumatic brain injury, combining IF and FISH (RNAscope)."
Congratulations to Gideon van der Linden in UCD, on being selected for our next ECRN Researcher Spotlight! 🎉👏🏅
Congratulations to Gideon van der Linden in UCD, on being selected for our next ECRN Researcher Spotlight! 🎉👏🏅
Renesa iteratively imaged a dozen RNAs at once to address whether localized RNAs travel singly or co-packaged with other RNAs. We thought we would uncover patterns of colocalization reflecting shared transport. But it turns out, abundance best predicted how often RNAs were found together 🧪
December 17, 2025 at 6:20 PM
Renesa iteratively imaged a dozen RNAs at once to address whether localized RNAs travel singly or co-packaged with other RNAs. We thought we would uncover patterns of colocalization reflecting shared transport. But it turns out, abundance best predicted how often RNAs were found together 🧪
For #FluorescenceFriday - RNAscope marking subfields of the hippocampus in a section of postmortem human 🧠 tissue. Image credit to the Imaging Development team @lieberinstitute.bsky.social 🔬🧪👩🔬
December 5, 2025 at 2:01 PM
For #FluorescenceFriday - RNAscope marking subfields of the hippocampus in a section of postmortem human 🧠 tissue. Image credit to the Imaging Development team @lieberinstitute.bsky.social 🔬🧪👩🔬
We have seen it also in the NiR channel. Their opal 690 is strong (RNAscope as well). Thanks for your feedback!
November 29, 2025 at 5:14 PM
We have seen it also in the NiR channel. Their opal 690 is strong (RNAscope as well). Thanks for your feedback!
Yes, we'd sometimes have bleedthrough in red and green channels from opal 690 while using standard RNAscope protocol. Only from cells with very high signal though.
November 29, 2025 at 6:50 AM
Yes, we'd sometimes have bleedthrough in red and green channels from opal 690 while using standard RNAscope protocol. Only from cells with very high signal though.
Giving thanks to all this holiday season. We appreciate you #AdvancingYourMultiomicRNAscope in so many spatial ways using RNAscope ISH technology. Learn more about our #SpatialMultiomics at www.bio-techne.com/multiomics #GetMultiomicin2026
November 26, 2025 at 10:07 PM
Giving thanks to all this holiday season. We appreciate you #AdvancingYourMultiomicRNAscope in so many spatial ways using RNAscope ISH technology. Learn more about our #SpatialMultiomics at www.bio-techne.com/multiomics #GetMultiomicin2026
In this recent study, RNAscope mapping showed limited CB1R–MOR co-expression, mainly in thalamic glutamatergic neurons, suggesting cannabinoid–opioid synergy arises from parallel activation in distinct circuits rather than direct receptor interaction
Cannabinoid CB1 receptor and mu-opioid receptor interaction: new insights from conditional knockout mice
Neuropsychopharmacology - Cannabinoid CB1 receptor and mu-opioid receptor interaction: new insights from conditional knockout mice
www.nature.com
November 26, 2025 at 3:30 PM
In this recent study, RNAscope mapping showed limited CB1R–MOR co-expression, mainly in thalamic glutamatergic neurons, suggesting cannabinoid–opioid synergy arises from parallel activation in distinct circuits rather than direct receptor interaction
Yes Selene, I did a lot smFISH and RNAscope in brain tissue, happy to help wherever needed.
November 25, 2025 at 5:03 AM
Yes Selene, I did a lot smFISH and RNAscope in brain tissue, happy to help wherever needed.
For #FluorescenceFriday, some very new images of island clusters of cells expressing DRD1, RXFP1 and OPRM1 in nucleus accumbens of human 🧠. And thanks for the suggestions Reviewer Two - we're on it :)
Image credit to Ishbel del Rosario and @svitlanabach.bsky.social 🔬🧪👩🔬
Image credit to Ishbel del Rosario and @svitlanabach.bsky.social 🔬🧪👩🔬
November 21, 2025 at 1:24 PM
For #FluorescenceFriday, some very new images of island clusters of cells expressing DRD1, RXFP1 and OPRM1 in nucleus accumbens of human 🧠. And thanks for the suggestions Reviewer Two - we're on it :)
Image credit to Ishbel del Rosario and @svitlanabach.bsky.social 🔬🧪👩🔬
Image credit to Ishbel del Rosario and @svitlanabach.bsky.social 🔬🧪👩🔬
We're here at #SfN25 @sfn.org - come meet us at booth #3217 Day 1 was so much fun!
Unlock the complex brain microenvironment with true #spatialmultiomics and learn how RNAscope technology can equip you with tools to drive breakthroughs in neuroscience
info.bio-techne.com/advance-disc...
Unlock the complex brain microenvironment with true #spatialmultiomics and learn how RNAscope technology can equip you with tools to drive breakthroughs in neuroscience
info.bio-techne.com/advance-disc...
November 18, 2025 at 12:54 AM
We're here at #SfN25 @sfn.org - come meet us at booth #3217 Day 1 was so much fun!
Unlock the complex brain microenvironment with true #spatialmultiomics and learn how RNAscope technology can equip you with tools to drive breakthroughs in neuroscience
info.bio-techne.com/advance-disc...
Unlock the complex brain microenvironment with true #spatialmultiomics and learn how RNAscope technology can equip you with tools to drive breakthroughs in neuroscience
info.bio-techne.com/advance-disc...
Meet the team while reviewing our posters (87, 73, 74, 72) at
@sitcancer
Empowering immuno-oncology with scalable assays and fully automated same-section #spatialmultiomics, powered by #RNAscope & delivering unmatched precision and flexibility. Learn More: bit.ly/3JnTtyY
@sitcancer
Empowering immuno-oncology with scalable assays and fully automated same-section #spatialmultiomics, powered by #RNAscope & delivering unmatched precision and flexibility. Learn More: bit.ly/3JnTtyY
November 8, 2025 at 12:55 AM
Meet the team while reviewing our posters (87, 73, 74, 72) at
@sitcancer
Empowering immuno-oncology with scalable assays and fully automated same-section #spatialmultiomics, powered by #RNAscope & delivering unmatched precision and flexibility. Learn More: bit.ly/3JnTtyY
@sitcancer
Empowering immuno-oncology with scalable assays and fully automated same-section #spatialmultiomics, powered by #RNAscope & delivering unmatched precision and flexibility. Learn More: bit.ly/3JnTtyY
Usamos hibridación fluorescente in situ de molécula única #RNAScope y HALO de @indicalabs.bsky.social para visualizar la organización espacial de estas poblaciones neuronales de la Habénula humana. 🔬 Por ejemplo, neuronas MHb.2 que expresan CHAT se agruparon de forma separada de otras células de MHb
November 5, 2025 at 11:47 PM
Usamos hibridación fluorescente in situ de molécula única #RNAScope y HALO de @indicalabs.bsky.social para visualizar la organización espacial de estas poblaciones neuronales de la Habénula humana. 🔬 Por ejemplo, neuronas MHb.2 que expresan CHAT se agruparon de forma separada de otras células de MHb
Single molecule fluorescence in situ hybridization #RNAScope and HALO from @indicalabs.bsky.social was used to visualize the spatial organization of these human Hb neuronal populations. 🔬 For example, MHb.2 neurons that highly expressed CHAT clustered separately from other MHb cell types
November 4, 2025 at 9:31 PM
Single molecule fluorescence in situ hybridization #RNAScope and HALO from @indicalabs.bsky.social was used to visualize the spatial organization of these human Hb neuronal populations. 🔬 For example, MHb.2 neurons that highly expressed CHAT clustered separately from other MHb cell types
Louis Kolling, Debra Fadool @dafadool.bsky.social and colleagues find that the superficial tufted & mitral cell output neurons of the mouse olfactory bulb have dual roles in insulin sensing.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
October 22, 2025 at 12:16 PM
Louis Kolling, Debra Fadool @dafadool.bsky.social and colleagues find that the superficial tufted & mitral cell output neurons of the mouse olfactory bulb have dual roles in insulin sensing.
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
Highlight: journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
Deep Disentangled Representation Learning Reveals Neuron Subtype-Specific Nuclear Morphologies Across Aging in Mice and Humans [new]
Neuron subtype nuclear changes w/ aging in mice & humans via deep learning on RNAscope images.
Neuron subtype nuclear changes w/ aging in mice & humans via deep learning on RNAscope images.
October 17, 2025 at 5:08 PM
Deep Disentangled Representation Learning Reveals Neuron Subtype-Specific Nuclear Morphologies Across Aging in Mice and Humans [new]
Neuron subtype nuclear changes w/ aging in mice & humans via deep learning on RNAscope images.
Neuron subtype nuclear changes w/ aging in mice & humans via deep learning on RNAscope images.
We also had fun with a wide range of techniques from RNAscope and western blot on human DRG, to skin nerve-terminal fractionation, peptide arrays, CRISPR gene editing in cultured and in-vivo DRG.
All converging on one conclusion: FGFR3-autoantibodies bind FGFR3 to sensitize pain.
#CRISPR #HumanDRG
All converging on one conclusion: FGFR3-autoantibodies bind FGFR3 to sensitize pain.
#CRISPR #HumanDRG
October 9, 2025 at 5:05 PM
What's the function of #histamine -1-receptors (H1Rs) on cortical astrocytes? @kiraposkanzer.bsky.social & co show that astrocytic H1R signaling modulates Ca2+ activity, extracellular adenosine & REM #sleep, revealing a key #astrocyte role in sleep-wake regulation @plosbiology.org 🧪 plos.io/4gRj9Ap
October 3, 2025 at 4:26 PM
What's the function of #histamine -1-receptors (H1Rs) on cortical astrocytes? @kiraposkanzer.bsky.social & co show that astrocytic H1R signaling modulates Ca2+ activity, extracellular adenosine & REM #sleep, revealing a key #astrocyte role in sleep-wake regulation @plosbiology.org 🧪 plos.io/4gRj9Ap
What's the function of #histamine -1-receptors (H1Rs) on cortical astrocytes? @kiraposkanzer.bsky.social & co show that astrocytic H1R signaling modulates Ca2+ activity, extracellular adenosine & REM #sleep, revealing a key #astrocyte role in sleep-wake regulation @plosbiology.org 🧪 plos.io/4gRj9Ap
October 3, 2025 at 12:56 PM
What's the function of #histamine -1-receptors (H1Rs) on cortical astrocytes? @kiraposkanzer.bsky.social & co show that astrocytic H1R signaling modulates Ca2+ activity, extracellular adenosine & REM #sleep, revealing a key #astrocyte role in sleep-wake regulation @plosbiology.org 🧪 plos.io/4gRj9Ap