We apply IMC to biopsies from 65 MM patients, 6 SMM and 5 MGUS patients with an antibody panel focusing on immune, bone cells and metabolism. The dataset consists of roughly 1 million labeled cells including distance to the next bone surface for every image (soon on zenodo 10.5281/zenodo.17093203)

#kNOwMyeloma, while most individuals with myeloma are diagnosed at age >65 we know that individuals may have a myeloma precursor disease (SMM, MGUS) for decades before diagnosis. Earlier diagnosis, earlier treatment, better outcomes.
@imfmyeloma.bsky.social

Predicting Progression of Developing Myeloma in a High-Risk Screened Population (PROMISE) - www.promisestudy.org @PromiseStudy #NCT03689595 #mmsm #wmsm #precisionprevention US adults, age 40-75, qualify for a free screening: 1. African Americans and/or 2. 1st degree relative w/ MM, MGUS, SMM, WM

If you’ve been diagnosed with MGUS or SMM, be sure to keep all your healthcare appointments so if there are any changes to your health, you can act on them as quickly as possible... (3/4)

#MGUS (monoclonal gammopathy of undetermined significance), a condition detected through blood tests, may lead to smouldering multiple myeloma (SMM) and/or myeloma. Most people with MGUS don’t experience any symptoms, and treatment is not required... (1/4)

📅 Join the next webinar from the ASH Subcommittee on #PrecisionMedicine

Explore how single-cell tools are transforming hematologic disease research and clinical care with insights into MGUS, SMM, and AML.

Register now: bit.ly/40Ua03m

#HemeSky #BloodSky #Hematology #Leusm #MMsm

5/ Back to our alphabet 🍲 ⤵️

MGUS:
🔬No evidence of end-organ dysfunction
🔬SPEP w/ total M protein < 3 g/dL
🔬Bone marrow with < 10% plasma cells

SMM:
🔬No evidence of end-organ dysfunction
🔬SPEP w/ total M protein > 3 g/dL AND/OR
🔬Bone marrow w/ b/w 10-60% plasma cells

2/ Hungry? Time for some alphabet soup!

MGUS:
🔬Monoclonal Gammopathy of Undetermined Significance
🔬NO sxs attributed to monoclonal protein

SMM:
🔬Smoldering Multiple Myeloma
🔬NO sxs attributed to monoclonal protein

MM:
🦀 Multiple Myeloma
🦀 CRAB sxs

1/ 🚨 NEW #5Pearls: MGUS to Multiple Myeloma Diagnostics and Counseling

Monoclonal gammopathies:
🔬A spectrum of severity from MGUS to SMM to MM

🖥️: coreimpodcast.com/2025/01/22/mon…
Sponsor: Freed Medical

Congratulations to MSK's Dr. Urvi Shah for being awarded the @ash-hematology.bsky.social David M. Goldenberg Clinical Research Training Institute Award for her work on research that shows that a high-fiber, plant-based dietary intervention may delay progression #MGUS/#SMM to #MM.

#ASH24 #ASHKudos

Honorable mention #MajorPROsASH: PROs MGUS & SMM #ASH24
- worse anxiety, depression, fatigue, insomnia compared to general population
- anxiety much worse in MGUS (approaching severe!)
- pts want tx that prevent progression to MM
Need to align research priorities with pts. #mmsm

Characterizing Genomic Variants Defining a Plasma Cell Disorder Pt Cohort Using a Broad Next Generation Multi-Gene DNA Sequencing Panel [Dec 8, 2024] Ezell et al. - @UConn #ASH24 Abst 3314 ash.confex.com/ash/2024/web... #mmsm #wmsm n=158 PCD samples incl MGUS, SMM, MM, WM etc

Mostly the hashtag in this case, no way to add #smm and not contaminate the feed with all kinds of irrelevant content. But I’m in the let’s not have an intermediate group that just adds more confusion and patient stress. Hoping we eventually get to just #mgus and #myeloma needing treatment

Bluesky is proof we need to get rid of smoldering multiple myeloma, #SMM is a commonly used tag in social media and some other things I likely didn't want to see setting up the MyelomaSky feed. Time for accurate diagnosis to make it just #MGUS or #myeloma

Oh right, IMS might drive more myeloma peeps to this platform beyond a few others like @adamssperling.bsky.social, for finding myeloma content add the MyelomaSky feed, should pick up anything with myeloma, #myeloma, #mmsm, #smm, #mgus, and a few other tags

MyelomaSky as I like the bloodsky name you used. It should pick up posts with the following: multiple myeloma, myeloma, #myeloma, #mmsm, #smm, and #mgus. Did you add bloodsky to the regex also?

Thanks for sharing this, setup a feed for multiple myeloma content, myelomasky, will populate with posts containing: multiple myeloma, myeloma, #myeloma, #smm, #mgus, or #msmm