MSD's confidence in its anti-TL1A drug tulisokibart in inflammatory diseases is made apparent by a decision to start trials in three new diseases.

A Fellow at St Catharine’s College has led extensive new research that looks set to overturn the established model about how one type of white blood cell regulates immune responses in tissues – what w...

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Background: Fatigue is a prevalent and debilitating symptom in many chronic conditions, including immune-mediated inflammatory diseases (IMIDs) and neurodegenerative diseases (NDDs). Fatigue often fluctuates significantly within and between days, yet traditional patient-reported outcomes (PROs) typically rely on recall periods of a week or more, potentially missing these short-term variations. The development of digital tools, such as electronic diaries (eDiaries), offers a unique opportunity to collect granular, real-time data. However, the #feasibility, adherence, and comparability of eDiary-based assessments to established PROs require further investigation. Objective: This study aimed to evaluate the #feasibility and acceptability of using a high-frequency eDiary to capture intra-day variability in fatigue and to compare eDiary data with scores obtained from the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F), a validated weekly recall PRO. Methods: Data were collected from 159 participants enrolled in the IDEA-FAST #feasibility Study; a four-week prospective observational study conducted at four European centres. Participants included individuals with NDDs (n=39), IMIDs (n=78), and healthy volunteers (HVs; n=42). Participants used an eDiary to report their physical and mental fatigue levels up to four times daily on a 7-point Likert scale (0 = low, 6 = high). Adherence was calculated as the proportion of completed eDiary entries relative to the total expected entries. Correlations between averaged eDiary scores and weekly FACIT-F scores were analysed. Results: Adherence to the eDiary protocol was 62% overall, varying by cohort, with the highest adherence (93%) observed in the primary Sjögren’s syndrome (PSS) cohort and the lowest adherence in Parkinson’s disease (PD) (43%) and Huntington’s Disease (HD) (44%) cohorts. The average adherence was 44% in the NDD cohorts and 74% in IMID cohorts. Fatigue levels showed clear diurnal variation, with significantly higher fatigue reported in the evening compared to the morning (p

The inflammatory condition affects approximately 30% of psoriasis patients

Researchers discovered that a specific haplotype on chromosome 21 is linked to five inflammatory diseases, offering insights into potential new treatments.