Fuming Yang, Yicong Li, Hanspeter Pfister, Jeff W. Lichtman, Yaron Meirovitch
Towards 1000-fold Electron Microscopy Image Compression for Connectomics via VQ-VAE with Transformer Prior
https://arxiv.org/abs/2511.00231
Towards 1000-fold Electron Microscopy Image Compression for Connectomics via VQ-VAE with Transformer Prior
https://arxiv.org/abs/2511.00231
November 4, 2025 at 2:17 PM
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Fuming Yang, Yicong Li, Hanspeter Pfister, Jeff W. Lichtman, Yaron Meirovitch: Towards 1000-fold Electron Microscopy Image Compression for Connectomics via VQ-VAE with Transformer Prior https://arxiv.org/abs/2511.00231 https://arxiv.org/pdf/2511.00231 https://arxiv.org/html/2511.00231
November 4, 2025 at 6:30 AM
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Who is that playing trick-or-treat? That cheeky monster flashing its spook-tacular grin is actually a visual trick. Captured here are mouse brain cells using expansion microscopy. This approach has various applications, incl. tracing neurons for connectomics studies & also scaring the onlookers. 👻
October 31, 2025 at 7:00 AM
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Amazing work on interoception and connectomics going on in @micahgallen.com ‘s group. Thanks so much for sharing with us today, excited to see what’s coming up next! 🧠
Thrilled to be giving a talk at @lucinauddin.bsky.social's lab meeting in a few hours! Will cover what we've learned about interoception in recent years, and seek out some ideas for mapping the autonomic connectome!
October 28, 2025 at 2:41 AM
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Thank you so much @wellcometrust.bsky.social for supporting us to push the the limits of #X-ray #nanoimaging and #connectomics, and to make technology more broadly available to the scientific community! 🙏
ESRF scientist Alexandra Pacureanu is the recipient of the Wellcome Discovery Award, together with a team at the Francis Crick Institute, to develop X-ray nanoimaging technology to study the mechanisms of information processing in the neural circuits of olfaction.
www.esrf.fr/home/news/ge...
www.esrf.fr/home/news/ge...
October 27, 2025 at 5:39 PM
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🧠 When brain implants start to understand — not just record.
A landmark study in Nature Biomedical Engineering combines invasive neurophysiology, connectomics & AI to decode brain states across Parkinson’s, depression & epilepsy — paving the way for adaptive, closed-loop neurotherapies.
A landmark study in Nature Biomedical Engineering combines invasive neurophysiology, connectomics & AI to decode brain states across Parkinson’s, depression & epilepsy — paving the way for adaptive, closed-loop neurotherapies.
October 24, 2025 at 9:05 AM
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Join us Friday for our neuroscience seminar series!🧠
Dr. Forrest Collman, from the Allen Institute for Brain Science, will present: “Cortical Connectomics”
📅 Oct. 24, 2025
🕑 11am-12pm
📍 M112 DeBakey
Dr. Forrest Collman, from the Allen Institute for Brain Science, will present: “Cortical Connectomics”
📅 Oct. 24, 2025
🕑 11am-12pm
📍 M112 DeBakey
October 22, 2025 at 6:56 PM
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Journal club TODAY at 3 pm US Pacific Time: Functional Connectomics Reveals General Wiring Rule in Mouse Visual Cortex -- join at carboncopies.org/aspirational... #neuroscience #memorydecoding #aspirationalneuroscience #connectomics #mouse
October 21, 2025 at 5:23 PM
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There are still a few days left to apply for the San Juan Winter School on Connectomics and Brain Simulation!
Apply by October 24th! sjcabs.com
Apply by October 24th! sjcabs.com
Applications are now open for our course on connectomics & brain simulation.
Organizers: Sven Dorkenwald (MIT), Stefanie Hampel (UPR), Andrew Seeds (UPR), Sebastian Seung (Princeton), and Srini Turaga (Janelia).
Interested? Apply here ➜ sjcabs.com
Organizers: Sven Dorkenwald (MIT), Stefanie Hampel (UPR), Andrew Seeds (UPR), Sebastian Seung (Princeton), and Srini Turaga (Janelia).
Interested? Apply here ➜ sjcabs.com
San Juan Winter School on Connectomics and Brain Simulation
Two-week intensive course on connectomics and brain simulation in San Juan, Puerto Rico. December 29, 2025 - January 10, 2026.
sjcabs.com
October 20, 2025 at 9:47 PM
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Synapse Detection Efficiency in EM Drosophila Connectomics https://www.biorxiv.org/content/10.1101/2025.10.16.682869v1
October 19, 2025 at 11:15 AM
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Synapse Detection Efficiency in EM Drosophila Connectomics https://www.biorxiv.org/content/10.1101/2025.10.16.682869v1
October 19, 2025 at 11:15 AM
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🪰 166,000 neurons! The new blueprint of the fruit fly brain! The latest Drosophila connectome maps every neuron and synapse across brain and nerve cord. (Nicolas Hubacz)
🎥 Philip Hubbard/Alexandra Fragniere
📊 FlyEM Project Team, Cambridge C. G., Google Res.
#FruitFly #Neuroscience #Connectomics
🎥 Philip Hubbard/Alexandra Fragniere
📊 FlyEM Project Team, Cambridge C. G., Google Res.
#FruitFly #Neuroscience #Connectomics
October 17, 2025 at 9:59 AM
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Barcode and image with PRISM! 🧠🌈🔬 Use AAVs to label neurons with thousands of unique combinations of protein epitope-tag barcodes for neuronal mapping and connectomics. Plasmids developed by @e11bio.bsky.social now online!
Addgene: E11 Bio PRISM Collection
Learn about PRISM, a set of molecular tools for high-throughput reconstruction of individual neurons in brain tissue developed by scientists at E11 Bio.
twp.ai
October 15, 2025 at 8:00 PM
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come for the multi-author thread, stay for the jaw-dropping connectomics effort
Excited to share our new #biorxivpreprint:
“Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1...
We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
“Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1...
We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
October 15, 2025 at 7:03 PM
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Excited to share more widely: I am starting the Dorkenwald Lab at MIT (McGovern Institute + BCS) in January 2026. We study the organizational principles of neuronal circuits using connectomics.
And we are hiring postdocs & tech associates! dorkenwaldlab.com/join
And we are hiring postdocs & tech associates! dorkenwaldlab.com/join
MIT’s McGovern Institute and Department of Brain and Cognitive Sciences welcome new faculty member Sven Dorkenwald - MIT McGovern Institute
The McGovern Institute and the Department of Brain and Cognitive Sciences are pleased to announce the appointment of Sven Dorkenwald as an assistant professor starting in January 2026. A trailblazer i...
mcgovern.mit.edu
October 15, 2025 at 4:57 PM
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Excited to share our new #biorxivpreprint:
“Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1...
We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
“Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1...
We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
October 15, 2025 at 4:17 PM
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💥New connectomics paper, now out in @braincomms.bsky.social
We show that indirect “multi-step” connectivity changes to the entorhinal cortex in #Alzheimers unfold along the major axes of 🧠 organization, aka the connectome gradients🌈
➡️ academic.oup.com/braincomms/a...
@sunnybrookhsc.bsky.social
We show that indirect “multi-step” connectivity changes to the entorhinal cortex in #Alzheimers unfold along the major axes of 🧠 organization, aka the connectome gradients🌈
➡️ academic.oup.com/braincomms/a...
@sunnybrookhsc.bsky.social
October 15, 2025 at 1:54 PM
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🏆 Brain Prize winner Larry Abbott speaks now at #ECNP2025!
🧠 “Neuroscience and neurology in the age of connectomics”
Don’t miss this Plenary Lecture on how #connectomics is reshaping our view of the brain.
#Neuroscience #BrainPrize Lundbeckfonden
🧠 “Neuroscience and neurology in the age of connectomics”
Don’t miss this Plenary Lecture on how #connectomics is reshaping our view of the brain.
#Neuroscience #BrainPrize Lundbeckfonden
October 14, 2025 at 8:58 AM
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Come and join The Brain Prize Lecture from Larry Abbott, US, at #ECNP2025. The 2024 prize co-recipient will present work on how connectomics advance our understanding of two neural systems, as well as its implications for neurology.
Details: www.ecnp.eu/congress2025...
#TheBrainPrize #neuroscience
Details: www.ecnp.eu/congress2025...
#TheBrainPrize #neuroscience
October 13, 2025 at 1:03 PM
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Neurophysiology and Connectomics: Decoding Brain Implants
In a groundbreaking study published in Nature Biomedical Engineering, researchers have unveiled a promising approach to understanding and decoding neural activity in patients with brain implants. This pioneering research, led by an…
In a groundbreaking study published in Nature Biomedical Engineering, researchers have unveiled a promising approach to understanding and decoding neural activity in patients with brain implants. This pioneering research, led by an…
Neurophysiology and Connectomics: Decoding Brain Implants
In a groundbreaking study published in Nature Biomedical Engineering, researchers have unveiled a promising approach to understanding and decoding neural activity in patients with brain implants. This pioneering research, led by an international team of scientists, explores the interface between invasive neurophysiology and whole-brain connectomics to create a detailed mapping of brain activity. This mapping has the potential to revolutionize how we perceive and treat neurological disorders.
scienmag.com
October 13, 2025 at 11:43 AM
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How does a simple brain wire itself for skilled action? Using connectomics, we tracked a 500-fold, non-random rise in cerebellar connections—revealing precise, input-driven wiring.
More in our preprint:
www.biorxiv.org/content/10.1...
More in our preprint:
www.biorxiv.org/content/10.1...
October 9, 2025 at 3:57 PM
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I’m super excited about what we can achieve using light microscopy for human connectomics and projectomics and would discuss with anyone interested!
October 8, 2025 at 1:33 AM
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There are so many facets of a connectomics pipeline to work on — histology, imaging, analysis, automation and more.
October 8, 2025 at 1:14 AM
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Our group at the Allen Institute is recruiting a technician and postdoc to work on light microscopy-based connectomics. Please DM me or share with anyone you think may be interested in this NIH BRAIN CONNECTS funded project.
October 8, 2025 at 12:28 AM
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It took more than a decade to trace the 130,000 connections in a fruit fly's brain. With the map in hand, researchers are turning to the next step in connectomics: building simulations.
By @ldattaro.bsky.social
#neuroskyence
www.thetransmitter.org/connectome/c...
By @ldattaro.bsky.social
#neuroskyence
www.thetransmitter.org/connectome/c...
Connectomics 2.0: Simulating the brain
With a complete fly connectome in hand, researchers are taking the next step to model how brain circuits fuel function.
www.thetransmitter.org
October 7, 2025 at 2:15 PM
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