Demonstrated in rabbits, the 3-D printer might someday print bone grafts directly onto fractures, complete with antibiotics to ease healing.

Demonstrated in rabbits, the 3-D printer might someday print bone grafts directly onto fractures, complete with antibiotics to ease healing.

The field of 3D extrusion bioprinting has rapidly evolved, presenting significant advancements in tissue engineering applications. Traditionally, the development of printable hydrogel formulations has relied more on empirical approaches rather than rational design principles. However, to better mimic the dynamic and spatiotemporal nature of the extracellular matrix (ECM), novel bioinks with tunable properties and synthetic flexibility are being developed. Simultaneously, variations of extrusion bioprinting methods have been developed to improve the fabrication of sophisticated tissue patterns to emulate their in vivo counterparts. This review will provide a focused overview of recent advancements in bioink design and extrusion bioprinting technologies. By addressing the latest developments in these strategies, this review aims to offer insights into the future direction of extrusion bioprinting.

Researchers at Seoul National University of Science and Technology (SEOULTECH) have developed a Kombucha SCOBY (Symbiotic Culture of Bacteria and Yeast) bioink that could streamline in vivo tissue engineering....

The scarcity of human donor corneal graft tissue worldwide available for corneal transplantation nec

This work describes a protein-rich, low-cost, bioactive bioink, prepared by adding eggwhite powder to functionalize an established alginate-methylcellulose hydrogel blend and enhance its cellular res...

The research focuses on developing a bioink specifically tailored to replicate the softness of the hematopoietic niche within the bone marrow microenvironment to create a simplified and standardized model for in-depth investigation of hematological disorders. Printing human hematopoietic progenitors in the silk bioink has extended their lifespan and promoted their full functionality, enabling their differentiation into megakaryocytes, and significantly improving platelet generation ex vivo. Abstract Hematopoietic stem and progenitor cells (HSPCs) continuously generate platelets throughout one's life. Inherited Platelet Disorders affect ≈ 3 million individuals worldwide and are characterized by defects in platelet formation or function. A critical challenge in the identification of these diseases lies in the absence of models that facilitate the study of hematopoiesis ex vivo. Here, a silk fibroin-based bioink is developed and designed for 3D bioprinting. This bioink replicates a soft and biomimetic environment, enabling the controlled differentiation of HSPCs into platelets. The formulation consisting of silk fibroin, gelatin, and alginate is fine-tuned to obtain a viscoelastic, shear-thinning, thixotropic bioink with the remarkable ability to rapidly recover after bioprinting and provide structural integrity and mechanical stability over long-term culture. Optical transparency allowed for high-resolution imaging of platelet generation, while the incorporation of enzymatic sensors allowed quantitative analysis of glycolytic metabolism during differentiation that is represented through measurable color changes. Bioprinting patient samples revealed a decrease in metabolic activity and platelet production in Inherited Platelet Disorders. These discoveries are instrumental in establishing reference ranges for classification and automating the assessment of treatment responses. This model has far-reaching implications for application in the research of blood-related diseases, prioritizing drug development strategies, and tailoring personalized therapies.

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The bioprinted skin model is designed to serve as an alternative to animal testing for preclinical research. According to a scientific article published in the...

The scarcity of human donor corneal graft tissue worldwide available for corneal transplantation nec

The bioprinted skin model is designed to serve as an alternative to animal testing for preclinical research. According to a scientific article published in the Archives of Dermatological Research, the model developed by Mayo Clinic researchers combines CollPlant's plant-derived recombinant human collagen with distinct and essential human skin cell...

In a groundbreaking advance for food technology and pharmaceutical manufacturing, researchers at the University of Arkansas have unveiled a novel 3D-printable bioink derived from sorghum proteins. This innovation leverages the unique hydrophobic properties of sorghum—a drought-resilient grain known for its remarkable adaptability to diverse climatic conditions—to create highly stable and printable gels suitable for producing precise, structured edible and medicinal products.