#𝗠𝗶𝗰𝗿𝗼𝘀𝗰𝗼𝗽𝘆
December 1, 2025 at 7:18 PM
November 28, 2025 at 3:12 PM
The EMBO Practical Course "Hack your microscope" in Oeiras, PT, 20–25 Apr 2026 aims to innovate, democratize advanced #imaging technologies and shape the future of open-source #microscopy – Apply now!

Deadline: 12 Dec

https://meetings.embo.org/event/26-microscope
#EMBOmicroscope #EMBOevents 🧪
December 3, 2025 at 4:15 PM
Freaking wild videos - go watch all of them! I cannot decide which one I love more! Radler et al. "Dynamic protrusions mediate unique crawling motility in Asgard Archaea (Promethearchaeota)" Very creative live-microscopy work #testthymetagenomichypotheses
www.biorxiv.org/content/10.1...
December 3, 2025 at 3:41 AM
Lock-in-SIM, a new approach to reject background and minimize artefacts in structured illumination microscopy (SIM): www.nature.com/articles/s41...
Glad to see @esoubies.bsky.social's FlexSIM is the best opponent in side-by-side comparisons!
December 2, 2025 at 7:42 AM
December 1, 2025 at 3:33 PM
with MORE THAN 93% estimated efficacy. This means that in the years to come, people with high exposure risk for HIV might only need one or two shots per year to stay protected. Molecularly, the way 04_A06 clamps onto the virus, cryo-electron microscopy revealed. The long amino acid insertion on the
December 2, 2025 at 5:14 PM
4Pi-SIMFLUX is a single-molecule localization microscopy approach that achieves near-isotropic resolution. @yongdengzhang.bsky.social

www.nature.com/articles/s41...
4Pi-SIMFLUX: 4Pi single-molecule localization microscopy with structured illumination - Nature Methods
4Pi-SIMFLUX is a single-molecule localization microscopy approach that achieves a near-isotropic resolution below 10 nm in whole mammalian cells.
www.nature.com
December 3, 2025 at 3:55 PM
New preprint from the lab, and joint first authors @biomarkella.bsky.social and @stephenholmes.bsky.social!

Single-cell phenotypic analysis and multiplet detection through incorporation of microscopy data into cellenONE-based single-cell proteomic data analysis

www.biorxiv.org/content/10.6...
Single-cell phenotypic analysis and multiplet detection through incorporation of microscopy data into cellenONE-based single-cell proteomic data analysis
The reliability of single-cell proteomics (SCP) is intrinsically linked to the fidelity of cell isolation; however, the identification of co-isolated cells (doublets or multiplets) remains a persisten...
www.biorxiv.org
December 3, 2025 at 5:53 AM
#LatestIssue cover: Confocal #microscopy image showing DR5:3nucVenus expression in the inflorescence apical meristem of an Arabidopsis thaliana plt3 plt5 plt7 pin1-T600I mutant. Image courtesy of Kerstens and Willemsen.

📖 See @merijnkerstens.bsky.social & Willemsen et al.
doi.org/10.1111/nph....
December 4, 2025 at 1:03 PM
Holy cow, a completely 3D printed microscope, including lenses! (and that nearly a ‘ oh, by the way’ part of @gailmcconnell.bsky.social‘s opening talk on all sorts of advances in microscopy)

onlinelibrary.wiley.com/doi/10.1111/...
A 3D‐printed optical microscope for low‐cost histological imaging
3D printing has become a useful tool for fast, reproducible and accessible manufacturing of optical components and microscope hardware, but often is only used to part-build imaging setups or specimen...
onlinelibrary.wiley.com
December 3, 2025 at 11:19 AM
Como algumas pessoas tem dúvidas de como o processo de filmagem foi feito, segue aqui o artigo original do experimento que originou o vídeo

Unraveling the adsorption-limited hydrogen oxidation reaction at palladium surface via in situ electron microscopy www.pnas.org/doi/10.1073/...
December 2, 2025 at 11:48 AM
For an internal talk, I wanted an easy way to disprove the prevailing myth that expansion microscopy gels expand due to repulsion between charged polymer strands. I did a quick calculation of the supposed energy released during a standard experiment and it's equivalent to a small nuclear bomb...
December 1, 2025 at 9:29 PM
What, *Another* Microscope?
A second attempt at upgrading my compound microscope.
Read more: ajcarthropoda.blogspot.com/2025/12/what...
#equipment #microscopy
December 1, 2025 at 5:28 PM
*Fully funded PhD student positions available to discover what changes in 🧠 when we learn something new.*

You think virtual reality + laser scanning microscopy are cool? You like 💻 and 🐭? Come join us!

Apply either through
www.udel.edu/academics/co...
or
www.udel.edu/academics/co...
December 1, 2025 at 11:02 PM
Mid-week #mycorrhiza 🍄
Motivated by a seminar from @tomthirkell.bsky.social, I've delved back into my image archives of mycorrhizal fungi in random plant species. This beautifully bunchy fungal arbuscule in a buttercup root needed sharing!🔬🏵️
#mycosky #fungi #microscopy #outreach
December 3, 2025 at 11:00 AM
SPIN90 and #YanCao strike again! First NPF to only activate a subset of Arp2/3 iso-complexes to regulate lamellipodial actin & protrusion efficiency. Great collaboration with @romet-jegou-lab.bsky.social #ManosMavrakis polarized fluorescence microscopy rocks 🤘💥🎉
www.biorxiv.org/content/10.6...
SPIN90 modulates the architecture of lamellipodial actin in an ARPC5L dependent fashion.
When stimulated by nucleation-promoting factors such as WAVE, the Arp2/3 complex generates branched actin networks. In contrast, when activated by SPIN90, the Arp2/3 complex generates linear actin fil...
www.biorxiv.org
December 3, 2025 at 8:30 AM
December 3, 2025 at 9:20 AM
Forbidden Noodles for an early #FossilFriday. These are 1.3 (ish) billion year old fossil filaments exposed on a bedding plane and imaged via electron microscopy. Deets in Alt text. #Geology #Paleontology
December 2, 2025 at 11:59 PM
Early stage development mosquito larva
#microscopy #micrography #biology
November 30, 2025 at 3:33 AM
Your #microscopy cheat sheet: Magnification, numerical aperture, resolution, working distance, depth of field – explained clearly, in one place.
Most of us learned these in fragments. This carousel connects the dots.

💾 Save it. Share it with your lab.

Which term should we explain next?
December 3, 2025 at 8:15 AM
I'm on the job market. Including my graduate student days, here is my experience.

18 yrs of protein biochemistry
17 yrs of assay design
16 yrs of science writing
11 yrs of membrane proteins
11 yrs of eukaryotes
8 yrs of cryo-electron microscopy
7 yrs of X-ray crystallography
7 yrs of prokaryotes
December 2, 2025 at 8:19 PM
✨A gut feeling you’ll love this one 🐛 The anterior midgut of a Drosophila melanogaster 🪰larva puts on a confocal glow show! 🟢 Adult midgut progenitors 🔴 Actin 🔵 Nuclei 📸Image by Sapna Krishnakumar #FluorescenceFriday #Microscopy #DevBio
November 28, 2025 at 11:07 PM
#Diplonemids are among the most diverse & abundant #protists in the deep #ocean. This study localises >5,000 proteins of #Paradiplonema papillatum, revealing #organelle compartmentalisation, including a membrane coated with carbohydrate-degrading enzymes @plosbiology.org 🧪 plos.io/3XvmpIO
December 4, 2025 at 10:08 AM
Marie Hugenroth, Maria Bohnert @bohnertlab.bsky.social and colleagues interrogate the role of Pex31 in metabolic adaptation of the nucleus–vacuole junction.
journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
December 4, 2025 at 9:52 AM