Zach Rosenthal
@zachrosenthal.bsky.social
👨⚕️ PGY4 psychiatry resident @ Penn Med, ⚡️🧠 neuroscientist postdoc and 🌈 🏔 human person. Previously WashU MSTP, Haverford College, and Scribbles Pre-school. Views my own.
WOW this is the honor of a lifetime, Vienna (Airport Conference Center) here I come!
August 6, 2025 at 1:52 AM
WOW this is the honor of a lifetime, Vienna (Airport Conference Center) here I come!
We then showed that CSD waves also occur in routine ECT treatments in human patients. This required a novel tool – bedside, non-invasive optical monitoring of brain hemodynamics – developed by our colleagues in the Penn Physics dept!
May 18, 2025 at 6:03 PM
We then showed that CSD waves also occur in routine ECT treatments in human patients. This required a novel tool – bedside, non-invasive optical monitoring of brain hemodynamics – developed by our colleagues in the Penn Physics dept!
Clinically, ECT stimulation parameters are known to modulate outcomes. Here, we found that electrode placement shapes where seizure is most intense and where CSD is triggered. Increasing pulse current and frequency increase seizure amplitude, which in turn predicts the likelihood of triggering CSD.
May 18, 2025 at 6:03 PM
Clinically, ECT stimulation parameters are known to modulate outcomes. Here, we found that electrode placement shapes where seizure is most intense and where CSD is triggered. Increasing pulse current and frequency increase seizure amplitude, which in turn predicts the likelihood of triggering CSD.
Why has this gone undetected for nearly 86 years? CSD wavefronts travel very slowly (millimeters per minute), such that when they are subjected to routine low frequency EEG filtering (our mainstay tool for brain monitoring during ECT), they’re rendered virtually invisible (right video panel).
May 18, 2025 at 6:03 PM
Why has this gone undetected for nearly 86 years? CSD wavefronts travel very slowly (millimeters per minute), such that when they are subjected to routine low frequency EEG filtering (our mainstay tool for brain monitoring during ECT), they’re rendered virtually invisible (right video panel).
In a mouse model, we observed that seizure is followed by a slow-traveling wave of maximal neural and hemodynamic activation followed by suppression, consistent with cortical spreading depolarization (CSD). Only high amplitude seizures cross the threshold of triggering this all-or-none event.
May 18, 2025 at 6:03 PM
In a mouse model, we observed that seizure is followed by a slow-traveling wave of maximal neural and hemodynamic activation followed by suppression, consistent with cortical spreading depolarization (CSD). Only high amplitude seizures cross the threshold of triggering this all-or-none event.
We then showed that CSD waves also occur in routine ECT treatments in human patients. This required a novel tool – bedside, non-invasive optical monitoring of brain hemodynamics – developed by our colleagues in the Penn Physics dept!
May 18, 2025 at 5:45 PM
We then showed that CSD waves also occur in routine ECT treatments in human patients. This required a novel tool – bedside, non-invasive optical monitoring of brain hemodynamics – developed by our colleagues in the Penn Physics dept!
Clinically, ECT stimulation parameters are known to modulate outcomes. Here, we found that electrode placement shapes where seizure is most intense and where CSD is triggered. Increasing pulse current and frequency increase seizure amplitude, which in turn predicts the likelihood of triggering CSD.
May 18, 2025 at 5:45 PM
Clinically, ECT stimulation parameters are known to modulate outcomes. Here, we found that electrode placement shapes where seizure is most intense and where CSD is triggered. Increasing pulse current and frequency increase seizure amplitude, which in turn predicts the likelihood of triggering CSD.
Why has this gone undetected for nearly 86 years? CSD wavefronts travel very slowly (millimeters per minute), such that when they are subjected to routine low frequency EEG filtering (our mainstay tool for brain monitoring during ECT), they’re rendered virtually invisible (right video panel).
May 18, 2025 at 5:45 PM
Why has this gone undetected for nearly 86 years? CSD wavefronts travel very slowly (millimeters per minute), such that when they are subjected to routine low frequency EEG filtering (our mainstay tool for brain monitoring during ECT), they’re rendered virtually invisible (right video panel).
In a mouse model, we observed that seizure is followed by a slow-traveling wave of maximal neural and hemodynamic activation followed by suppression, consistent with cortical spreading depolarization (CSD). Only high amplitude seizures cross the threshold of triggering this all-or-none event.
May 18, 2025 at 5:45 PM
In a mouse model, we observed that seizure is followed by a slow-traveling wave of maximal neural and hemodynamic activation followed by suppression, consistent with cortical spreading depolarization (CSD). Only high amplitude seizures cross the threshold of triggering this all-or-none event.
Come by poster 202 tonight at #ACNP2024 to talk about a new discovery about the neurobiology of ECT, and how we can optimize stimulation parameters to precisely modulate brain dynamics!
December 9, 2024 at 9:44 PM
Come by poster 202 tonight at #ACNP2024 to talk about a new discovery about the neurobiology of ECT, and how we can optimize stimulation parameters to precisely modulate brain dynamics!