Yazan J. Meqbil
@yazmeq.bsky.social
Molecular Pharmacologist automating the intersections of HTS, molecular modeling, and molecular pharmacology | San Francisco Bay Area
Reposted by Yazan J. Meqbil
Reposted by Yazan J. Meqbil
#TobRegSky #PedSky #MedSky #addictionsci #neuroskyence #neurosci #policysky #polisky #painresearch 🧪🛟
We wrote this Neuroview to get the word out about the extremely exciting and important NIH funded work happening in the pain field and how it has the potential to really change pain treatment in the coming years www.cell.com/neuron/fullt... We did not imagine how rapidly things would be dismantled.
Human pain neuroscience and the next generation of pain therapeutics
The recent approval of suzetrigine for acute pain treatment highlights both the success
of targeting peripheral sensory neurons for pain management and the potential of developing
new pain therapies p...
www.cell.com
May 11, 2025 at 2:27 AM
Amazing indeed! This method tracks single molecules escaping nanoscale traps to reveal size, shape, and conformational states in solution. Hats off to the authors for an outstanding advancement.
An amazing new enabling technology. Measurements of molecular size and shape on a chip. Couldn't be prouder of our friend Madhavi Krishnan of @ox.ac.uk this was and is one among the must fun collaborations I ever had. www.science.org/doi/10.1126/...
Measurements of molecular size and shape on a chip
Size and shape are critical discriminators between molecular species and states. We describe a microchip-based high-throughput imaging approach offering rapid and precise determination of molecular pr...
www.science.org
May 10, 2025 at 2:25 AM
Amazing indeed! This method tracks single molecules escaping nanoscale traps to reveal size, shape, and conformational states in solution. Hats off to the authors for an outstanding advancement.
Reposted by Yazan J. Meqbil
The first paper from my PhD has been published!
Insights on Psychedelics: A Systematic Review of Therapeutic Effects
www.sciencedirect.com/science/arti...
Insights on Psychedelics: A Systematic Review of Therapeutic Effects
www.sciencedirect.com/science/arti...
Insights on psychedelics: A systematic review of therapeutic effects
Insight – a sudden change in understanding or perspective that feels true or reliable – is a common occurrence during psychedelic experiences, and oft…
www.sciencedirect.com
April 28, 2025 at 9:35 AM
The first paper from my PhD has been published!
Insights on Psychedelics: A Systematic Review of Therapeutic Effects
www.sciencedirect.com/science/arti...
Insights on Psychedelics: A Systematic Review of Therapeutic Effects
www.sciencedirect.com/science/arti...
Exciting news from our team here at Vilya! RFpeptides is an RFdiffusion-based DL pipeline for designing macrocyclic peptides. Exclusively licensed to Vilya🔥
It’s an exciting time to at the forefront of the macrocyclic peptide drug discovery space.
Preprint:
www.biorxiv.org/content/10.1...
It’s an exciting time to at the forefront of the macrocyclic peptide drug discovery space.
Preprint:
www.biorxiv.org/content/10.1...
November 21, 2024 at 7:39 PM
Exciting news from our team here at Vilya! RFpeptides is an RFdiffusion-based DL pipeline for designing macrocyclic peptides. Exclusively licensed to Vilya🔥
It’s an exciting time to at the forefront of the macrocyclic peptide drug discovery space.
Preprint:
www.biorxiv.org/content/10.1...
It’s an exciting time to at the forefront of the macrocyclic peptide drug discovery space.
Preprint:
www.biorxiv.org/content/10.1...
Congrats @tastelabhuji.bsky.social and team!
Sometimes a ligand can bind to two different sites at the same target — like in these interesting structures of the taste receptor TAS2R14 with gustducin by Peri et al.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A bitter anti-inflammatory drug binds at two distinct sites of a human bitter taste GPCR - Nature Communications
Bitter taste receptors (TAS2Rs) are a subfamily of G-protein coupled receptors (GPCRs). Here, the authors report a cryo-EM structure of the human TAS2R14 in complex with its signaling partner gustduci...
www.nature.com
November 21, 2024 at 12:26 AM
Congrats @tastelabhuji.bsky.social and team!
Another day, another excellent database.
I’ve been an avid and grateful user of GPCRdb, GPCRmd, and other databases, all of which keep getting better. I’m excited to try this one!
academic.oup.com/nar/advance-...
I’ve been an avid and grateful user of GPCRdb, GPCRmd, and other databases, all of which keep getting better. I’m excited to try this one!
academic.oup.com/nar/advance-...
PGxDB: an interactive web-platform for pharmacogenomics research
Abstract. Pharmacogenomics, the study of how an individual's genetic makeup influences their response to medications, is a rapidly evolving field with sign
academic.oup.com
November 21, 2024 at 12:25 AM
Another day, another excellent database.
I’ve been an avid and grateful user of GPCRdb, GPCRmd, and other databases, all of which keep getting better. I’m excited to try this one!
academic.oup.com/nar/advance-...
I’ve been an avid and grateful user of GPCRdb, GPCRmd, and other databases, all of which keep getting better. I’m excited to try this one!
academic.oup.com/nar/advance-...
Reposted by Yazan J. Meqbil
This is amazing! @shervinnia.bsky.social resurrected our cryoEM-papers bot. At it's peak we had over 12k followers on Twitter, but the bot became defunct by a silly Musk policy (and it all went downhill from there).
If you want to keep up with #cryoEM papers, follow:
cryoempapers.bsky.social
If you want to keep up with #cryoEM papers, follow:
cryoempapers.bsky.social
cryoEM papers (@cryoempapers.bsky.social)
Operated by @shervinnia.bsky.social and inspired by the now-defunct bot by Frédéric Poitevin and @gati.bsky.social. Suggestions welcome.
cryoempapers.bsky.social
November 20, 2024 at 3:54 PM
This is amazing! @shervinnia.bsky.social resurrected our cryoEM-papers bot. At it's peak we had over 12k followers on Twitter, but the bot became defunct by a silly Musk policy (and it all went downhill from there).
If you want to keep up with #cryoEM papers, follow:
cryoempapers.bsky.social
If you want to keep up with #cryoEM papers, follow:
cryoempapers.bsky.social
Another paper from the Van Rijn and Riley labs on natural product-derived agonists for the kappa opioid receptors.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Discovery of Potent Kappa Opioid Receptor Agonists Derived from Akuammicine
Akuammicine (1), an alkaloid isolated from Picralima nitida, is an agonist of the kappa opioid receptor (κOR). To establish structure–activity relationships (SARs) for this structurally unique κOR lig...
pubs.acs.org
November 20, 2024 at 5:37 PM
Another paper from the Van Rijn and Riley labs on natural product-derived agonists for the kappa opioid receptors.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Reposted by Yazan J. Meqbil
A first attempt to assemble GPCR aficionados here on 🦋 Let me know who I missed by replying below!
go.bsky.app/75ukb81
go.bsky.app/75ukb81
November 16, 2024 at 6:05 PM
A first attempt to assemble GPCR aficionados here on 🦋 Let me know who I missed by replying below!
go.bsky.app/75ukb81
go.bsky.app/75ukb81
It feels so good to be back! #sci-twitter was good but I hope #sci-sky will be better!
#science #gpcr #drugdiscovery
#science #gpcr #drugdiscovery
November 16, 2024 at 5:55 PM
It feels so good to be back! #sci-twitter was good but I hope #sci-sky will be better!
#science #gpcr #drugdiscovery
#science #gpcr #drugdiscovery