Yash Shukla
@yashshukla.bsky.social
Molecular biologist exploring protein translation & early development in C. elegans 🧬 | Ribosome profiling enthusiast | Investigating embryonic cell fate decisions @UT Austin | Cat dad 🐱
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#openforpostdoc
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#openforpostdoc
Post 5/5:
🔬 For fellow C. elegans researchers: Our dataset is at GSE281412 and I'm working on tools to make it more accessible.
Paper: cell.com/cell-reports/fulltext/S2211-1247(25)00549-2
#DevelopmentalBiology #CelegansResearch #Science
🔬 For fellow C. elegans researchers: Our dataset is at GSE281412 and I'm working on tools to make it more accessible.
Paper: cell.com/cell-reports/fulltext/S2211-1247(25)00549-2
#DevelopmentalBiology #CelegansResearch #Science
Landscape and regulation of mRNA translation in the early C. elegans embryo
Using ribosome profiling, Shukla et al. characterize dynamic translational regulation
of maternal mRNAs during the first four cell cycles of C. elegans development. Their
findings demonstrate how post...
cell.com
June 5, 2025 at 7:37 PM
Post 5/5:
🔬 For fellow C. elegans researchers: Our dataset is at GSE281412 and I'm working on tools to make it more accessible.
Paper: cell.com/cell-reports/fulltext/S2211-1247(25)00549-2
#DevelopmentalBiology #CelegansResearch #Science
🔬 For fellow C. elegans researchers: Our dataset is at GSE281412 and I'm working on tools to make it more accessible.
Paper: cell.com/cell-reports/fulltext/S2211-1247(25)00549-2
#DevelopmentalBiology #CelegansResearch #Science
Post 4/5:
This helps us understand one of biology's coolest tricks: how simple beginnings lead to complex, organized life forms through precise molecular choreography. 🪱➡️🐛
The timing and location of protein production is everything in early development.
This helps us understand one of biology's coolest tricks: how simple beginnings lead to complex, organized life forms through precise molecular choreography. 🪱➡️🐛
The timing and location of protein production is everything in early development.
June 5, 2025 at 7:37 PM
Post 4/5:
This helps us understand one of biology's coolest tricks: how simple beginnings lead to complex, organized life forms through precise molecular choreography. 🪱➡️🐛
The timing and location of protein production is everything in early development.
This helps us understand one of biology's coolest tricks: how simple beginnings lead to complex, organized life forms through precise molecular choreography. 🪱➡️🐛
The timing and location of protein production is everything in early development.
Post 3/5:
What we discovered:
Different developmental stages have distinct protein production "fingerprints"
Where mRNAs are located in the cell affects how efficiently proteins get made
A regulator called OMA-1 controls hundreds of maternal recipes simultaneously
What we discovered:
Different developmental stages have distinct protein production "fingerprints"
Where mRNAs are located in the cell affects how efficiently proteins get made
A regulator called OMA-1 controls hundreds of maternal recipes simultaneously
June 5, 2025 at 7:37 PM
Post 3/5:
What we discovered:
Different developmental stages have distinct protein production "fingerprints"
Where mRNAs are located in the cell affects how efficiently proteins get made
A regulator called OMA-1 controls hundreds of maternal recipes simultaneously
What we discovered:
Different developmental stages have distinct protein production "fingerprints"
Where mRNAs are located in the cell affects how efficiently proteins get made
A regulator called OMA-1 controls hundreds of maternal recipes simultaneously
Post 2/5:
We used ribosome profiling to watch protein-making during the first few cell divisions.
Think of it like watching cellular cooks (ribosomes) follow recipe cards (mRNAs) left by mom, while the master cookbook (DNA) stays closed. 🧬👩🍳
We used ribosome profiling to watch protein-making during the first few cell divisions.
Think of it like watching cellular cooks (ribosomes) follow recipe cards (mRNAs) left by mom, while the master cookbook (DNA) stays closed. 🧬👩🍳
June 5, 2025 at 7:37 PM
Post 2/5:
We used ribosome profiling to watch protein-making during the first few cell divisions.
Think of it like watching cellular cooks (ribosomes) follow recipe cards (mRNAs) left by mom, while the master cookbook (DNA) stays closed. 🧬👩🍳
We used ribosome profiling to watch protein-making during the first few cell divisions.
Think of it like watching cellular cooks (ribosomes) follow recipe cards (mRNAs) left by mom, while the master cookbook (DNA) stays closed. 🧬👩🍳
Awesome stuff! I use patchwork for most of my work. Was curious about the extra flexibility that your library provides
February 12, 2025 at 3:29 PM
Awesome stuff! I use patchwork for most of my work. Was curious about the extra flexibility that your library provides
Check out this pre-print to see what happens in germ- granules : www.biorxiv.org/content/10.1...
Landscape and regulation of new protein translation in the early C. elegans embryo
Translation of maternal mRNAs is crucial for early embryonic development. In C. elegans, cell fates become determined from the first division without new transcription, making this organism ideal for ...
www.biorxiv.org
December 23, 2024 at 11:29 PM
Check out this pre-print to see what happens in germ- granules : www.biorxiv.org/content/10.1...
"Using low-input ribosome profiling, we uncovered how cells control protein production in the first four cell divisions. Key finding: mRNA localization tightly links to translational efficiency, with OMA-1 emerging as a crucial player! 2/3"
December 19, 2024 at 12:27 AM
"Using low-input ribosome profiling, we uncovered how cells control protein production in the first four cell divisions. Key finding: mRNA localization tightly links to translational efficiency, with OMA-1 emerging as a crucial player! 2/3"