Xin Xiang
@xianglab.bsky.social
dynein, dynactin, Lis1, kinesin-1, Aspergillus nidulans as a genetic system. Opinions are my own.
My postdoctoral mentor N. Ronald Morris passed away on Nov. 20, 2025. He was 92. I am forever grateful to his mentorship and his visionary use of Aspergillus nidulans as a genetic system to explore fundamental questions in cell biology. www.hillsboroughfuneralhome.com/obituaries/D...
November 29, 2025 at 3:18 PM
My postdoctoral mentor N. Ronald Morris passed away on Nov. 20, 2025. He was 92. I am forever grateful to his mentorship and his visionary use of Aspergillus nidulans as a genetic system to explore fundamental questions in cell biology. www.hillsboroughfuneralhome.com/obituaries/D...
I had fun checking out the endomap site (endomap.hms.harvard.edu/network). Surprisingly, PRPF40A (pre-mRNA splicing, Huntingtin-interacting, Aspergillus homolog Prp40A involved in cytoplasmic dynein function) connects to axonemal dynein light intermediate chain polypeptide, which is interesting!
June 2, 2025 at 2:30 PM
I had fun checking out the endomap site (endomap.hms.harvard.edu/network). Surprisingly, PRPF40A (pre-mRNA splicing, Huntingtin-interacting, Aspergillus homolog Prp40A involved in cytoplasmic dynein function) connects to axonemal dynein light intermediate chain polypeptide, which is interesting!
www.dha.mil/News/2025/05...
Very proud of my colleague @pskcellbio.bsky.social and her lab for this important work on the clearance of misfolded GPI-anchor proteins out of the ER (supported by the NIH)!
journals.plos.org/plosbiology/...
Very proud of my colleague @pskcellbio.bsky.social and her lab for this important work on the clearance of misfolded GPI-anchor proteins out of the ER (supported by the NIH)!
journals.plos.org/plosbiology/...
www.dha.mil
May 24, 2025 at 1:16 PM
www.dha.mil/News/2025/05...
Very proud of my colleague @pskcellbio.bsky.social and her lab for this important work on the clearance of misfolded GPI-anchor proteins out of the ER (supported by the NIH)!
journals.plos.org/plosbiology/...
Very proud of my colleague @pskcellbio.bsky.social and her lab for this important work on the clearance of misfolded GPI-anchor proteins out of the ER (supported by the NIH)!
journals.plos.org/plosbiology/...
Reposted by Xin Xiang
Preprint from our lab is out! We identified a peroxisome-localized acyl-coA binding protein AcbdA - that regulates peroxisome movement. www.biorxiv.org/content/10.1.... Congratulations to members of my lab and the Christensen lab
@christensenlab.bsky.social www.biorxiv.org/content/10.1...
@christensenlab.bsky.social www.biorxiv.org/content/10.1...
Acyl-coA binding protein AcbdA regulates peroxisome hitchhiking on early endosomes
Motor-driven transport on microtubules is critical for distributing organelles throughout the cell. Most commonly, organelle movement is mediated by cargo adaptors, proteins on the surface of an organ...
www.biorxiv.org
April 24, 2025 at 6:50 PM
Preprint from our lab is out! We identified a peroxisome-localized acyl-coA binding protein AcbdA - that regulates peroxisome movement. www.biorxiv.org/content/10.1.... Congratulations to members of my lab and the Christensen lab
@christensenlab.bsky.social www.biorxiv.org/content/10.1...
@christensenlab.bsky.social www.biorxiv.org/content/10.1...
Beautiful work! Aside from the motor cooperation theme, this paper shows an insightful structure of the FHF complex (initially isolated by Wade Harper lab at Harvard. Xu et al 2008 MBoC). The structure contains FTS, the C-terminal part of Hook3 and FHIP1B. What a journey! Congrats to Abid Ali et al!
Great to see our story on dynein & kinesin co-dependence published www.nature.com/articles/s41..., and absolutely chuffed that it's made the front cover (thanks NSMB!). A brilliant News & Views too by Steven Markus www.nature.com/articles/s41.... Collab between @carter-lab.bsky.social & Straube lab🔬
April 27, 2025 at 11:30 AM
Beautiful work! Aside from the motor cooperation theme, this paper shows an insightful structure of the FHF complex (initially isolated by Wade Harper lab at Harvard. Xu et al 2008 MBoC). The structure contains FTS, the C-terminal part of Hook3 and FHIP1B. What a journey! Congrats to Abid Ali et al!
Reposted by Xin Xiang
Our lab at the NIH (Bethesda, MD) is looking for postdoctoral fellows to join our team studying the molecular mechanisms of protein trafficking and their links to neurodevelopmental disorders starting on or after 10-1-2025. Send your application to [email protected]. Please share and repost!
April 13, 2025 at 4:37 PM
Our lab at the NIH (Bethesda, MD) is looking for postdoctoral fellows to join our team studying the molecular mechanisms of protein trafficking and their links to neurodevelopmental disorders starting on or after 10-1-2025. Send your application to [email protected]. Please share and repost!
Happy to share this short spotlight piece kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F... published online by @cp-trendscellbio.bsky.social
for an interesting paper about an unexpected mechanism behind Kinesin-1-mediated meiotic spindle positioning in C. elegans @cp-cellreports.bsky.social
for an interesting paper about an unexpected mechanism behind Kinesin-1-mediated meiotic spindle positioning in C. elegans @cp-cellreports.bsky.social
kwnsfk27.r.eu-west-1.awstrack.me
April 10, 2025 at 11:31 PM
Happy to share this short spotlight piece kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F... published online by @cp-trendscellbio.bsky.social
for an interesting paper about an unexpected mechanism behind Kinesin-1-mediated meiotic spindle positioning in C. elegans @cp-cellreports.bsky.social
for an interesting paper about an unexpected mechanism behind Kinesin-1-mediated meiotic spindle positioning in C. elegans @cp-cellreports.bsky.social
LC8 moonlighting (most likely) in channels. Nice work!
Check out our new publication "Dynein light chains 1 and 2 are auxiliary proteins of pH-sensitive Kir4.1 channels"
www.sciencedirect.com/science/arti...
A 🧵 1/n
www.sciencedirect.com/science/arti...
A 🧵 1/n
Dynein light chains 1 and 2 are auxiliary proteins of pH-sensitive Kir4.1 channels
Inward rectifier Kir4.1 potassium channels are abundantly expressed in cells that are important for electrolyte homeostasis. Dysregulation of Kir4.1 u…
www.sciencedirect.com
March 18, 2025 at 11:16 AM
LC8 moonlighting (most likely) in channels. Nice work!
An interesting read. Neil Gow just gave a fantastic talk at the #ecfg17 on fungal cell wall components- on mannose polymers that can either be a flag or a mask for different immune cells. The part on the malaria parasite is also fascinating.
I was j reviewed, along with other microbiologists. on how microbes disguise themselves from our immune systems. The article is out in The Scientist. www.the-scientist.com/the-art-of-m...
The Art of Microbial Disguise
On the battleground of the human body, microbes use every skill to mask, infiltrate, manipulate, and evade the immune radar.
www.the-scientist.com
March 9, 2025 at 12:20 PM
An interesting read. Neil Gow just gave a fantastic talk at the #ecfg17 on fungal cell wall components- on mannose polymers that can either be a flag or a mask for different immune cells. The part on the malaria parasite is also fascinating.
Reposted by Xin Xiang
Today in #journalclub, we looked at this fantastic new method from the @doudna-lab.bsky.social in Nature Biotechnology! They show how CRISPR–Csm enables single-molecule live-cell imaging of endogenous RNAs. Super cool!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
February 21, 2025 at 12:56 PM
Today in #journalclub, we looked at this fantastic new method from the @doudna-lab.bsky.social in Nature Biotechnology! They show how CRISPR–Csm enables single-molecule live-cell imaging of endogenous RNAs. Super cool!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Xin Xiang
our first serious attempt to understand F-actin (F standing for filamentous, among other things) in Aspergillus nidulans: www.biorxiv.org/content/10.1...
The actin module of endocytic internalization in Aspergillus nidulans: a critical role of the WISH/DIP/SPIN90 family protein Dip1
Using FPs fused with actin or its fiduciary probes Lifeact, Chromobody and Tractin, we studied, by time-resolved microscopy, the actin module of endocytosis in Aspergillus nidulans. F-actin probes eff...
www.biorxiv.org
February 16, 2025 at 7:58 PM
our first serious attempt to understand F-actin (F standing for filamentous, among other things) in Aspergillus nidulans: www.biorxiv.org/content/10.1...
Reposted by Xin Xiang
Reposted by Xin Xiang
I am excited for this opportunity to chair the Department of Biochemistry and Biophysics at Weill Cornell Medicine! news.weill.cornell.edu/news/2025/01...
Dr. Samara Reck-Peterson Named Chair of the Department of Biochemistry and Biophysics at Weill Cornell Medicine
The newly configured department marshals biochemists, biophysicists and experts in protein engineering and imaging to drive discoveries in the basic mechanisms of cell function.
news.weill.cornell.edu
January 31, 2025 at 11:38 PM
I am excited for this opportunity to chair the Department of Biochemistry and Biophysics at Weill Cornell Medicine! news.weill.cornell.edu/news/2025/01...
Reposted by Xin Xiang
The deadline to attend the “Integrating cell and planetary scales to address climate resilience” EMBO meeting is Feb 1st! We are bringing together scientists, funders, and policy makers. Join us for this exciting meeting: meetings.embo.org/event/25-cli...
Integrating cell and planetary scales to address climate resilience
The climate crisis is a multiscale problem that requires transdisciplinary expertise for understanding and engineering climate resilience. Cells are the first responders of the biosphere and yet cell…
meetings.embo.org
January 20, 2025 at 5:04 PM
The deadline to attend the “Integrating cell and planetary scales to address climate resilience” EMBO meeting is Feb 1st! We are bringing together scientists, funders, and policy makers. Join us for this exciting meeting: meetings.embo.org/event/25-cli...
Reposted by Xin Xiang
Time to share our organelle proteome paper
out in @cellcellpress.bsky.social: doi.org/nzwz
We created a spatial map of human cells using organelle immunoprecipitation at scale.
Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/
1/3 🧪
out in @cellcellpress.bsky.social: doi.org/nzwz
We created a spatial map of human cells using organelle immunoprecipitation at scale.
Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/
1/3 🧪
January 14, 2025 at 4:03 PM
Time to share our organelle proteome paper
out in @cellcellpress.bsky.social: doi.org/nzwz
We created a spatial map of human cells using organelle immunoprecipitation at scale.
Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/
1/3 🧪
out in @cellcellpress.bsky.social: doi.org/nzwz
We created a spatial map of human cells using organelle immunoprecipitation at scale.
Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/
1/3 🧪
Reposted by Xin Xiang
I'm looking to database organelle dyes which work in fungi. Please comment if you can contribute w/ details.
We regularly see @mrccmm.bsky.social that some don't work in some fungi, but I just don't think it's been tested properly #Mycoscopy
I started this w/ Alex Lichius years ago, tip of the 🧊!
We regularly see @mrccmm.bsky.social that some don't work in some fungi, but I just don't think it's been tested properly #Mycoscopy
I started this w/ Alex Lichius years ago, tip of the 🧊!
January 3, 2025 at 11:28 AM
I'm looking to database organelle dyes which work in fungi. Please comment if you can contribute w/ details.
We regularly see @mrccmm.bsky.social that some don't work in some fungi, but I just don't think it's been tested properly #Mycoscopy
I started this w/ Alex Lichius years ago, tip of the 🧊!
We regularly see @mrccmm.bsky.social that some don't work in some fungi, but I just don't think it's been tested properly #Mycoscopy
I started this w/ Alex Lichius years ago, tip of the 🧊!
Reposted by Xin Xiang
Best way to start 2025! Thrilled to share our Nature paper about the structures of axonemal components from sperm flagella and from epithelial cilia of the oviduct and brain ventricles. Great collaboration with Tzviya Zeev-Ben-Mordehai and @alanbrownhms.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 1, 2025 at 5:20 PM
Best way to start 2025! Thrilled to share our Nature paper about the structures of axonemal components from sperm flagella and from epithelial cilia of the oviduct and brain ventricles. Great collaboration with Tzviya Zeev-Ben-Mordehai and @alanbrownhms.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Xin Xiang
This is an great opportunity. Andrew, his science, and his team are amazing!
Exciting 3-year postdoc opportunity with @carter-lab.bsky.social within a programme aimed at identifying the links between microtubule motors and axonal cargos.
Read more about the role here:
www.nature.com/naturecareer...
Apply by 30 DEC
#ScienceJobs #CambridgeJobs #PostdocJobs #GenomeEngineering
Read more about the role here:
www.nature.com/naturecareer...
Apply by 30 DEC
#ScienceJobs #CambridgeJobs #PostdocJobs #GenomeEngineering
December 12, 2024 at 3:30 PM
This is an great opportunity. Andrew, his science, and his team are amazing!
A very cool study revealing an important role of Fragile X messenger ribonucleoprotein (FMRP) in the local translation of a mitochondrial fission protein near its site of action. It really enhanced the understanding of the disease mechanism of Fragile X syndrome. Congratulations to all authors!
FMRP, MFF translation & mitochondrial fission in neurons ft. Adam Fenton, Ruchao Peng, @Charlie_R_Bond, @SHugelier, @melikel.bsky.social, @yiweichang.bsky.social, @erikaholzbaur.bsky.social & Thomas Jongens @BB_UPenn @penngenetics.bsky.social @cambupenn.bsky.social www.nature.com/articles/s41...
December 12, 2024 at 11:42 PM
A very cool study revealing an important role of Fragile X messenger ribonucleoprotein (FMRP) in the local translation of a mitochondrial fission protein near its site of action. It really enhanced the understanding of the disease mechanism of Fragile X syndrome. Congratulations to all authors!
Reposted by Xin Xiang
My family don’t want me to mix my love of fungi with the decoration of the family Christmas tree. ….. But I’m allowed my own one! @mrccmm.bsky.social
December 11, 2024 at 8:52 PM
My family don’t want me to mix my love of fungi with the decoration of the family Christmas tree. ….. But I’m allowed my own one! @mrccmm.bsky.social
Reposted by Xin Xiang
We have a very cool (I know I am biased😁) project for a computational biologist (postdoc) interested in cancer evolution in collaboration with Nicky McGranahan’s lab! Perfect opportunity to expand your computational skills too!
👉 www.godinholab.com
RT please 🙏🙏🙏👍👍
👉 www.godinholab.com
RT please 🙏🙏🙏👍👍
Godinho Lab
www.godinholab.com
December 11, 2024 at 4:01 PM
We have a very cool (I know I am biased😁) project for a computational biologist (postdoc) interested in cancer evolution in collaboration with Nicky McGranahan’s lab! Perfect opportunity to expand your computational skills too!
👉 www.godinholab.com
RT please 🙏🙏🙏👍👍
👉 www.godinholab.com
RT please 🙏🙏🙏👍👍
Reposted by Xin Xiang
my first post in this network will be to honor Archibald Garrod, one of the forefathers (arguably the most ignored) of modern genetics.
December 9, 2024 at 7:30 AM
my first post in this network will be to honor Archibald Garrod, one of the forefathers (arguably the most ignored) of modern genetics.
Reposted by Xin Xiang
Excited to share the first published paper of my postdoc - a collaboration with Yildiz and Dumont groups led by Merve Aslan, on the fascinating dynein adaptor NuMA. Lots of super cool insights on how NuMA can activate dynein during mitosis. Thanks to @carter-lab.bsky.social for the support!
www.biorxiv.org
December 8, 2024 at 6:09 PM
Excited to share the first published paper of my postdoc - a collaboration with Yildiz and Dumont groups led by Merve Aslan, on the fascinating dynein adaptor NuMA. Lots of super cool insights on how NuMA can activate dynein during mitosis. Thanks to @carter-lab.bsky.social for the support!
Reposted by Xin Xiang
I’m so excited to organize the #Lysosomes Subgroup at @ASCBiology 2024 meeting on Sunday, Dec. 15 at 3:15pm, Room 33B.
Lysosomes naturally lend themselves to puns. So…Don’t be 𝒃𝒂𝒔𝒊𝒄. Join us for fresh, 𝒄𝒖𝒕𝒕𝒊𝒏𝒈-edge talks and puntastic times. It will 𝒆𝒂𝒕 𝒂𝒕 𝒚𝒐𝒖 if you miss it.
Lysosomes naturally lend themselves to puns. So…Don’t be 𝒃𝒂𝒔𝒊𝒄. Join us for fresh, 𝒄𝒖𝒕𝒕𝒊𝒏𝒈-edge talks and puntastic times. It will 𝒆𝒂𝒕 𝒂𝒕 𝒚𝒐𝒖 if you miss it.
December 5, 2024 at 12:14 AM
I’m so excited to organize the #Lysosomes Subgroup at @ASCBiology 2024 meeting on Sunday, Dec. 15 at 3:15pm, Room 33B.
Lysosomes naturally lend themselves to puns. So…Don’t be 𝒃𝒂𝒔𝒊𝒄. Join us for fresh, 𝒄𝒖𝒕𝒕𝒊𝒏𝒈-edge talks and puntastic times. It will 𝒆𝒂𝒕 𝒂𝒕 𝒚𝒐𝒖 if you miss it.
Lysosomes naturally lend themselves to puns. So…Don’t be 𝒃𝒂𝒔𝒊𝒄. Join us for fresh, 𝒄𝒖𝒕𝒕𝒊𝒏𝒈-edge talks and puntastic times. It will 𝒆𝒂𝒕 𝒂𝒕 𝒚𝒐𝒖 if you miss it.
Led by myosinactincrazy, this pack is on the way…. Simply ask the leader to add your name
December 4, 2024 at 9:49 AM
Led by myosinactincrazy, this pack is on the way…. Simply ask the leader to add your name