Wendy Bickmore
@wbickmor.bsky.social
Scientist at University of Edinburgh. Director of MRC Human Genetics Unit but posting in my own capacity.
Excited to start working on this BBSRC sLola project to decode the semantic rules of large regulatory domains, led by @ferencmueller.bsky.social with colleagues from Birmingham, Manchester, Crick, MRC-LMS and EBI-ENSEMBL
institute-genetics-cancer.ed.ac.uk/decoding-the...
bsky.app/profile/fere...
institute-genetics-cancer.ed.ac.uk/decoding-the...
bsky.app/profile/fere...
November 18, 2025 at 4:15 PM
Excited to start working on this BBSRC sLola project to decode the semantic rules of large regulatory domains, led by @ferencmueller.bsky.social with colleagues from Birmingham, Manchester, Crick, MRC-LMS and EBI-ENSEMBL
institute-genetics-cancer.ed.ac.uk/decoding-the...
bsky.app/profile/fere...
institute-genetics-cancer.ed.ac.uk/decoding-the...
bsky.app/profile/fere...
Reposted by Wendy Bickmore
1. We start a major consortium programme funded by the sLoLa of BBSRC (shorturl.at/aUbnt) to decipher the semantic rules of enhancer arrangements driving regulator genes of development (shorturl.at/6qcjW).
shorturl.at
November 18, 2025 at 12:48 PM
1. We start a major consortium programme funded by the sLoLa of BBSRC (shorturl.at/aUbnt) to decipher the semantic rules of enhancer arrangements driving regulator genes of development (shorturl.at/6qcjW).
To advance our knowledge about the role of ecDNAs in cancer, it would be helpful if people could at least acknowledge that not everyone concludes that ecDNAs form "hubs" in the nucleus.
pubmed.ncbi.nlm.nih.gov/40972571/
pubmed.ncbi.nlm.nih.gov/41237767/
pubmed.ncbi.nlm.nih.gov/36476408/
pubmed.ncbi.nlm.nih.gov/40972571/
pubmed.ncbi.nlm.nih.gov/41237767/
pubmed.ncbi.nlm.nih.gov/36476408/
Extrachromosomal DNA associates with nuclear condensates and reorganizes chromatin structures to enhance oncogenic transcription - PubMed
Extrachromosomal, circular DNA (ecDNA) is a prevalent oncogenic alteration in cancer genomes, often associated with aggressive tumor behavior and poor patient outcome. While previous studies proposed a chromatin-based mobile enhancer model for ecDNA-driven oncogenesis, its precise mechanism and impa …
pubmed.ncbi.nlm.nih.gov
November 18, 2025 at 12:05 PM
To advance our knowledge about the role of ecDNAs in cancer, it would be helpful if people could at least acknowledge that not everyone concludes that ecDNAs form "hubs" in the nucleus.
pubmed.ncbi.nlm.nih.gov/40972571/
pubmed.ncbi.nlm.nih.gov/41237767/
pubmed.ncbi.nlm.nih.gov/36476408/
pubmed.ncbi.nlm.nih.gov/40972571/
pubmed.ncbi.nlm.nih.gov/41237767/
pubmed.ncbi.nlm.nih.gov/36476408/
I’m fascinated to try this. It’s such a relief to see the journey we are on that started with the launch of BioRxiv and that could liberate us from the most depressing aspect of science - “getting published”.
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
November 11, 2025 at 6:18 AM
I’m fascinated to try this. It’s such a relief to see the journey we are on that started with the launch of BioRxiv and that could liberate us from the most depressing aspect of science - “getting published”.
So excited to be funded by @erc.europa.eu to work with this extraordinarily talented group of scientists on the GeneMotors project - unravelling how SMC motors work, how they are regulated and how they regulate gene expression.
@ceesdekker.bsky.social @uoe-igc.bsky.social
@ceesdekker.bsky.social @uoe-igc.bsky.social
November 7, 2025 at 11:50 AM
So excited to be funded by @erc.europa.eu to work with this extraordinarily talented group of scientists on the GeneMotors project - unravelling how SMC motors work, how they are regulated and how they regulate gene expression.
@ceesdekker.bsky.social @uoe-igc.bsky.social
@ceesdekker.bsky.social @uoe-igc.bsky.social
Reposted by Wendy Bickmore
It is with great sadness that we share the news of the death of our founder, colleague, mentor and friend, Professor Sir John Gurdon. His vision and dedication will continue to inspire generations of scientists.
🔗 www.gurdon.cam.ac.uk/nobel-laurea...
🔗 www.gurdon.cam.ac.uk/nobel-laurea...
October 8, 2025 at 1:15 PM
It is with great sadness that we share the news of the death of our founder, colleague, mentor and friend, Professor Sir John Gurdon. His vision and dedication will continue to inspire generations of scientists.
🔗 www.gurdon.cam.ac.uk/nobel-laurea...
🔗 www.gurdon.cam.ac.uk/nobel-laurea...
Reposted by Wendy Bickmore
We're all ready for #DoorsOpenDays2025 tomorrow and looking forward to showing off a snapshot of the work we do at the Institute 🔬🧬🥼🧪 🧫
@cmvm-edinburghuni.bsky.social
@cmvm-edinburghuni.bsky.social
September 26, 2025 at 8:54 AM
We're all ready for #DoorsOpenDays2025 tomorrow and looking forward to showing off a snapshot of the work we do at the Institute 🔬🧬🥼🧪 🧫
@cmvm-edinburghuni.bsky.social
@cmvm-edinburghuni.bsky.social
Reposted by Wendy Bickmore
Dan's latest song, for Stephen Colbert, Jimmy Kimmel, and all the comedians out there--
Dan Shore - Nothing Hurts Me More
YouTube video by danshoremusic
www.youtube.com
September 22, 2025 at 2:30 AM
Dan's latest song, for Stephen Colbert, Jimmy Kimmel, and all the comedians out there--
Honoured to be in Birmingham to mark Bryan Turner’s retirement- a gentleman and giant of epigenetics.
September 11, 2025 at 4:34 PM
Honoured to be in Birmingham to mark Bryan Turner’s retirement- a gentleman and giant of epigenetics.
Well, we survived our ERC Synergy interview. So exciting working with this great GeneMotors team of SMC experts @ceesdekker.bsky.social Benjamin Rowland, Leonid Mirny. Here's hoping we can continue working together for the next 6 years.
September 10, 2025 at 8:43 AM
Well, we survived our ERC Synergy interview. So exciting working with this great GeneMotors team of SMC experts @ceesdekker.bsky.social Benjamin Rowland, Leonid Mirny. Here's hoping we can continue working together for the next 6 years.
Reposted by Wendy Bickmore
September 8, 2025 at 2:02 PM
Working class women makes inadvertent mistake and resigns.
Posh bloke uses devious means to avoid paying income tax and stamp duty... and doesn't resign.
www.theguardian.com/politics/202...
Posh bloke uses devious means to avoid paying income tax and stamp duty... and doesn't resign.
www.theguardian.com/politics/202...
September 5, 2025 at 12:24 PM
Working class women makes inadvertent mistake and resigns.
Posh bloke uses devious means to avoid paying income tax and stamp duty... and doesn't resign.
www.theguardian.com/politics/202...
Posh bloke uses devious means to avoid paying income tax and stamp duty... and doesn't resign.
www.theguardian.com/politics/202...
Reposted by Wendy Bickmore
Our manuscript characterising tissue-specific consequences of tagged protein fusions in CRISPR-engineered mice is now online @PLOSGenetics. journals.plos.org/plosgenetics.... Thanks again to all coauthors, reviewers and editors for a smooth publication process. Brief summary below.
August 26, 2025 at 12:20 PM
Our manuscript characterising tissue-specific consequences of tagged protein fusions in CRISPR-engineered mice is now online @PLOSGenetics. journals.plos.org/plosgenetics.... Thanks again to all coauthors, reviewers and editors for a smooth publication process. Brief summary below.
Reposted by Wendy Bickmore
New paper out today in PLOS Comp Biol:
journals.plos.org/ploscompbiol...
Intrinsically disordered regions make variant prediction deceptively easy for benign changes but very hard for pathogenic ones. Our work shows why current tools struggle here, and why disorder-aware approaches are needed.
journals.plos.org/ploscompbiol...
Intrinsically disordered regions make variant prediction deceptively easy for benign changes but very hard for pathogenic ones. Our work shows why current tools struggle here, and why disorder-aware approaches are needed.
Assessing variant effect predictors and disease mechanisms in intrinsically disordered proteins
Author summary Some parts of proteins, known as intrinsically disordered regions, do not fold into fixed shapes. Instead, they stay flexible and play key roles in controlling how cells work, often by ...
journals.plos.org
August 19, 2025 at 9:33 PM
New paper out today in PLOS Comp Biol:
journals.plos.org/ploscompbiol...
Intrinsically disordered regions make variant prediction deceptively easy for benign changes but very hard for pathogenic ones. Our work shows why current tools struggle here, and why disorder-aware approaches are needed.
journals.plos.org/ploscompbiol...
Intrinsically disordered regions make variant prediction deceptively easy for benign changes but very hard for pathogenic ones. Our work shows why current tools struggle here, and why disorder-aware approaches are needed.
GWAS to mechanism: when non-coding is coding. Beautiful insightful science from @gweykopf.bsky.social @simonbiddie.bsky.social Joe Marsh and many colleagues. @uoe-igc.bsky.social @cmvm-edinburghuni.bsky.social www.biorxiv.org/content/10.1...
July 28, 2025 at 9:50 AM
GWAS to mechanism: when non-coding is coding. Beautiful insightful science from @gweykopf.bsky.social @simonbiddie.bsky.social Joe Marsh and many colleagues. @uoe-igc.bsky.social @cmvm-edinburghuni.bsky.social www.biorxiv.org/content/10.1...
Great to see this published @genesdev.bsky.social. Evidence that enhancers can activate a bystander gene in an adjacent TAD, and that cohesin facilitates this. @uoe-igc.bsky.social.
pubmed.ncbi.nlm.nih.gov/40436628/
pubmed.ncbi.nlm.nih.gov/40436628/
May 30, 2025 at 2:13 PM
Great to see this published @genesdev.bsky.social. Evidence that enhancers can activate a bystander gene in an adjacent TAD, and that cohesin facilitates this. @uoe-igc.bsky.social.
pubmed.ncbi.nlm.nih.gov/40436628/
pubmed.ncbi.nlm.nih.gov/40436628/
Exquisite work. Well done to the whole team.
How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Conservation of regulatory elements with highly diverged sequences across large evolutionary distances
Nature Genetics - Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence...
rdcu.be
May 28, 2025 at 5:33 AM
Exquisite work. Well done to the whole team.
Reposted by Wendy Bickmore
Non-profit journals are on the critical list.
The cause: academics obsession with the Nature brand, coupled with the APC $ model.
Some will argue it doesn’t matter (“all as bad as each other”). But the fact is undeniable and it’s good guys who put money back into science like COB who are losing..
The cause: academics obsession with the Nature brand, coupled with the APC $ model.
Some will argue it doesn’t matter (“all as bad as each other”). But the fact is undeniable and it’s good guys who put money back into science like COB who are losing..
Thanks @mitodynamics.bsky.social for the fun interview and for saying it like it is:
“…JCS and other community journals are being crushed by the mega profit-making journals, which just seem to proliferate and spit out new journals by the day…we must all make an effort to move away from this…”
“…JCS and other community journals are being crushed by the mega profit-making journals, which just seem to proliferate and spit out new journals by the day…we must all make an effort to move away from this…”
In our Special Issue: Cell Biology of Mitochondria we interview Guest Editor Heidi McBride @mitodynamics.bsky.social Heidi discusses her career path, the past, present & future of #mitochondria research & her role as guest editor at JCS.
journals.biologists.com/jcs/article/...
#JCSMitoSI
journals.biologists.com/jcs/article/...
#JCSMitoSI
May 23, 2025 at 11:54 AM
Non-profit journals are on the critical list.
The cause: academics obsession with the Nature brand, coupled with the APC $ model.
Some will argue it doesn’t matter (“all as bad as each other”). But the fact is undeniable and it’s good guys who put money back into science like COB who are losing..
The cause: academics obsession with the Nature brand, coupled with the APC $ model.
Some will argue it doesn’t matter (“all as bad as each other”). But the fact is undeniable and it’s good guys who put money back into science like COB who are losing..
Reposted by Wendy Bickmore
Excited to share our new paper out today in @cp-molcell.bsky.social! We show that the H3K27M oncohistone rewires cPRC1, creating a unique dependency on CBX4/PCGF4-containing complexes, and also reveal a previously unknown function of CBX4. Highlights below (1/11).
May 21, 2025 at 4:13 PM
Excited to share our new paper out today in @cp-molcell.bsky.social! We show that the H3K27M oncohistone rewires cPRC1, creating a unique dependency on CBX4/PCGF4-containing complexes, and also reveal a previously unknown function of CBX4. Highlights below (1/11).
Reposted by Wendy Bickmore
“I certainly do not let myself be underpaid as many women do. There are people who write to me and think because I am a woman I will ask less than a man. This I never do. I know my profession and charge accordingly, as all women should do.” I love this 💞 www.theguardian.com/society/2025...
‘She changed the face of London’: statue to be unveiled of suffragist gardener
Fanny Wilkinson designed 75 parks in the capital, the first UK female landscape gardener to be paid for her work
www.theguardian.com
May 2, 2025 at 10:47 PM
“I certainly do not let myself be underpaid as many women do. There are people who write to me and think because I am a woman I will ask less than a man. This I never do. I know my profession and charge accordingly, as all women should do.” I love this 💞 www.theguardian.com/society/2025...
Reposted by Wendy Bickmore
Read more about this study by @jmarshlab.bsky.social 👇
April 30, 2025 at 2:40 PM
Read more about this study by @jmarshlab.bsky.social 👇
ZC3HC1 and TPR is not required for TPR localisation at the nuclear pore basket, and the two have different functions. wellcomeopenresearch.org/articles/10-...
April 14, 2025 at 10:07 AM
ZC3HC1 and TPR is not required for TPR localisation at the nuclear pore basket, and the two have different functions. wellcomeopenresearch.org/articles/10-...
Eric Green is a giant of the Human Genome Project. His legacy of discoveries, enhancing human knowledge and humanity, is engraved in the scientific literature and cannot be erased. Something these philistines who have seized power will never understand.
www.deiwatchlist.com/dossier/eric...
www.deiwatchlist.com/dossier/eric...
Eric Green - DEI Watch List
www.deiwatchlist.com
April 4, 2025 at 9:29 AM
Eric Green is a giant of the Human Genome Project. His legacy of discoveries, enhancing human knowledge and humanity, is engraved in the scientific literature and cannot be erased. Something these philistines who have seized power will never understand.
www.deiwatchlist.com/dossier/eric...
www.deiwatchlist.com/dossier/eric...
Reposted by Wendy Bickmore
OK, I'm not going to say a word about this.
Go ahead and list what's wrong with this study. We need a generation of reviewers to be confident expressing their concerns, just as we need researchers not to perform these wasteful and damaging studies in the first place.
www.nature.com/articles/s41...
Go ahead and list what's wrong with this study. We need a generation of reviewers to be confident expressing their concerns, just as we need researchers not to perform these wasteful and damaging studies in the first place.
www.nature.com/articles/s41...
March 22, 2025 at 2:31 PM
OK, I'm not going to say a word about this.
Go ahead and list what's wrong with this study. We need a generation of reviewers to be confident expressing their concerns, just as we need researchers not to perform these wasteful and damaging studies in the first place.
www.nature.com/articles/s41...
Go ahead and list what's wrong with this study. We need a generation of reviewers to be confident expressing their concerns, just as we need researchers not to perform these wasteful and damaging studies in the first place.
www.nature.com/articles/s41...