Vivien Horvath
@vivienhorvath.bsky.social
Postdoctoral fellow in the Molecular Neurogenetics lab at Lund University/Lund Stem Cell Center. Working on transposable elements, epigenetic regulation, aging and related brain disorders. 🧠🧬
Reposted by Vivien Horvath
Excited to share I’ve received a #SSMF #Consolidator grant!
📣 Recruiting a #postdoc to study #cancer #neuroscience #3Dgenomics #multiomics #singlecellomics
🔬How neural inputs shape #3Dgenome and #cellplasticity in #glioblastoma #GBM
Interested? Apply now 👇
rb.gy/m7xz7b
📣 Recruiting a #postdoc to study #cancer #neuroscience #3Dgenomics #multiomics #singlecellomics
🔬How neural inputs shape #3Dgenome and #cellplasticity in #glioblastoma #GBM
Interested? Apply now 👇
rb.gy/m7xz7b
Postdoctoral Researcher in "Cancer Neuroscience: the impact of neural activity on 3D genome organization and cellular plasticity in glioblastoma”
rb.gy
November 14, 2025 at 11:00 AM
Excited to share I’ve received a #SSMF #Consolidator grant!
📣 Recruiting a #postdoc to study #cancer #neuroscience #3Dgenomics #multiomics #singlecellomics
🔬How neural inputs shape #3Dgenome and #cellplasticity in #glioblastoma #GBM
Interested? Apply now 👇
rb.gy/m7xz7b
📣 Recruiting a #postdoc to study #cancer #neuroscience #3Dgenomics #multiomics #singlecellomics
🔬How neural inputs shape #3Dgenome and #cellplasticity in #glioblastoma #GBM
Interested? Apply now 👇
rb.gy/m7xz7b
Reposted by Vivien Horvath
#EMBOMobileGenome Session 4: Physiological impact 🧬 chaired by Josefa González
➡️ 'Transposon-mediated evolution of human immune gene regulation' AKA Stranger Genes 👁️🔦
presented by Edward Chuong (University of Colorado Boulder, USA) @edchuong.bsky.social @colorado.edu @gonzalezlabbcn.bsky.social
➡️ 'Transposon-mediated evolution of human immune gene regulation' AKA Stranger Genes 👁️🔦
presented by Edward Chuong (University of Colorado Boulder, USA) @edchuong.bsky.social @colorado.edu @gonzalezlabbcn.bsky.social
November 6, 2025 at 2:34 PM
#EMBOMobileGenome Session 4: Physiological impact 🧬 chaired by Josefa González
➡️ 'Transposon-mediated evolution of human immune gene regulation' AKA Stranger Genes 👁️🔦
presented by Edward Chuong (University of Colorado Boulder, USA) @edchuong.bsky.social @colorado.edu @gonzalezlabbcn.bsky.social
➡️ 'Transposon-mediated evolution of human immune gene regulation' AKA Stranger Genes 👁️🔦
presented by Edward Chuong (University of Colorado Boulder, USA) @edchuong.bsky.social @colorado.edu @gonzalezlabbcn.bsky.social
Reposted by Vivien Horvath
Updated version of our preprint on how SETDB1-mediated H3K9me3 controls the expression of L1 elements in human neural progenitor cells. The new analysis in this revised version supports a role for active DNA demethylation of L1s in the absence of H3K9me3.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Loss of SETDB1-mediated H3K9me3 in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons
Heterochromatin is characterised by an inaccessibility to the transcriptional machinery and is associated with the histone mark H3K9me3. However, studying the functional consequences of heterochromati...
www.biorxiv.org
November 5, 2025 at 9:29 PM
Updated version of our preprint on how SETDB1-mediated H3K9me3 controls the expression of L1 elements in human neural progenitor cells. The new analysis in this revised version supports a role for active DNA demethylation of L1s in the absence of H3K9me3.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
🧠 🌟 Im very happy and grateful for receiving the Starting Grant from the Swedish Research Council. This support will allow my lab at Umeå University to further understand the role of transposons in oligodendrocyte specific human brain ageing. Looking forward to the exciting research! 🧬 🧠
October 31, 2025 at 1:21 PM
🧠 🌟 Im very happy and grateful for receiving the Starting Grant from the Swedish Research Council. This support will allow my lab at Umeå University to further understand the role of transposons in oligodendrocyte specific human brain ageing. Looking forward to the exciting research! 🧬 🧠
Reposted by Vivien Horvath
'We hypothesize that CGIs, particularly those associated with housekeeping or developmentally important genes and which are evolutionarily older than tissue-specific genes (32, 34), have been maintained during evolution by escaping TE invasion.'
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Roles of transposable elements and DNA methylation in the formation of CpG islands and CpG-depleted regulatory elements | PNAS
The origins of CpG islands (CGIs) are not known. They are relatively short GC-rich
regions of DNA with a higher-than-expected occurrence of CpG din...
www.pnas.org
October 26, 2025 at 5:51 PM
'We hypothesize that CGIs, particularly those associated with housekeeping or developmentally important genes and which are evolutionarily older than tissue-specific genes (32, 34), have been maintained during evolution by escaping TE invasion.'
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
🌟Im happy to share that this winter I'll be starting my lab at the Wallenberg Center for Molecular Medicine at Umeå University! Excited to join the Department of Medical and Translational Biology as a Wallenberg Fellow and looking forward to new collaborations and cool transposon research 🤩 🧬
October 26, 2025 at 4:49 PM
🌟Im happy to share that this winter I'll be starting my lab at the Wallenberg Center for Molecular Medicine at Umeå University! Excited to join the Department of Medical and Translational Biology as a Wallenberg Fellow and looking forward to new collaborations and cool transposon research 🤩 🧬
Reposted by Vivien Horvath
📣 Our department is hiring an Assistant Professor in Evolutionary Cell and Molecular Biology to join the @weillinstitute.bsky.social PLS spread the word!
academicjobsonline.org/ajo/jobs/30607
academicjobsonline.org/ajo/jobs/30607
Cornell University, Molecular Biology & Genetics
Job #AJO30607, WDR-00055221 Assistant Professor, Molecular Biology & Genetics, Cornell University, Ithaca, New York, US
academicjobsonline.org
September 23, 2025 at 12:50 PM
📣 Our department is hiring an Assistant Professor in Evolutionary Cell and Molecular Biology to join the @weillinstitute.bsky.social PLS spread the word!
academicjobsonline.org/ajo/jobs/30607
academicjobsonline.org/ajo/jobs/30607
Very happy that I had the chance to contribute to this amazing work describing the role of transposable elements in Parkinson’s Disease. 🧠🧬
New preprint from my lab! We describe how transposable elements are activated in Parkinson’s disease, which is linked to an interferon response. We believe this study significantly advances our understanding of transposons and their role in human brains.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease
Parkinson's disease (PD) is a common age-related neurodegenerative disorder involving a neuroinflammatory response, the cause of which remains unclear. Transposable elements (TE) have been linked to i...
www.biorxiv.org
September 8, 2025 at 4:36 PM
Very happy that I had the chance to contribute to this amazing work describing the role of transposable elements in Parkinson’s Disease. 🧠🧬
Reposted by Vivien Horvath
New collaborative paper from our lab! We developed cell-type specific transcriptional ageing clocks using snRNA-seq data from human brain.
doi.org/10.1002/advs...
doi.org/10.1002/advs...
Human Brain Cell‐Type‐Specific Aging Clocks Based on Single‐Nuclei Transcriptomics
Muralidharan and colleagues develop cell-type-specific transcriptomic aging clocks using single-nucleus RNA sequencing of human post mortem prefrontal cortex samples. These clocks accurately predict ....
doi.org
August 29, 2025 at 6:04 PM
New collaborative paper from our lab! We developed cell-type specific transcriptional ageing clocks using snRNA-seq data from human brain.
doi.org/10.1002/advs...
doi.org/10.1002/advs...
Reposted by Vivien Horvath
Every so often, a paper lands at exactly the right moment. This one’s a gem. Can’t wait to try out this new strategy for delivering CRISPRoff chromatin-editing tools into our favorite cellular model system. Congrats to James K Nuñez and his team: www.nature.com/articles/s41...
Programmable epigenome editing by transient delivery of CRISPR epigenome editor ribonucleoproteins - Nature Communications
Epigenome editing programs gene silencing without inducing DNA breaks but challenges in delivery into human cells limit its broader use. Here, the authors present the RENDER platform, which uses virus...
www.nature.com
August 29, 2025 at 7:27 PM
Every so often, a paper lands at exactly the right moment. This one’s a gem. Can’t wait to try out this new strategy for delivering CRISPRoff chromatin-editing tools into our favorite cellular model system. Congrats to James K Nuñez and his team: www.nature.com/articles/s41...
Reposted by Vivien Horvath
New paper from our lab! We found that LINE-1 transposons contribute to early human brain development.
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development
Adami et al. demonstrate that evolutionarily young L1s are expressed in human pluripotent
stem cells and are dynamically regulated throughout neural differentiation. The study
examines the role of L1s...
www.cell.com
August 23, 2025 at 9:47 AM
New paper from our lab! We found that LINE-1 transposons contribute to early human brain development.
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
Reposted by Vivien Horvath
Reposted by Vivien Horvath
Very happy to share our protocols paper for CELLO-seq. This will make single cell long read RNA-seq more accessible and provides analysis guidelines. We hope this helps the #transposon #TEsky community and folks working on #singleCell isoform and allelic #gene expression. doi.org/10.1038/s415...
Long-read RNA sequencing of transposable elements from single cells using CELLO-seq - Nature Protocols
Single-cell long-read RNA sequencing enables the high-fidelity mapping of single-cell expression data from highly sequence-similar transposable elements to unique genomic loci by correcting errors fro...
doi.org
July 16, 2025 at 4:55 PM
Very happy to share our protocols paper for CELLO-seq. This will make single cell long read RNA-seq more accessible and provides analysis guidelines. We hope this helps the #transposon #TEsky community and folks working on #singleCell isoform and allelic #gene expression. doi.org/10.1038/s415...
Reposted by Vivien Horvath
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics
Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...
www.nature.com
July 9, 2025 at 10:05 AM
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Reposted by Vivien Horvath
We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease - Nature Reviews Molecular Cell Biology
Transposable elements (TEs) comprise nearly half of the human genome. This Review discusses transcriptional and post-transcriptional mechanisms that repress TE activity, how TEs escape this suppressio...
www.nature.com
June 30, 2025 at 1:12 PM
We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Vivien Horvath
🧬🌽 Happy Transposon Day! 🌽🧬
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
June 16, 2025 at 3:14 PM
🧬🌽 Happy Transposon Day! 🌽🧬
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
Reposted by Vivien Horvath
1/3 So pleased to have this latest installment of “the retrotransposon storm” submitted and on biorxiv. This work was driven by Shreevidya Korada, an amazing PhD student in Roger Sher’s lab, co-mentored by me. @mollygale.bsky.social was an awesome collaborator.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
LINE-1 replication in a mouse TDP-43 model of neurodegeneration marks motor cortex neurons for cell-intrinsic and non-cell autonomous programmed cell death.
A key pathological feature of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) is the loss of nuclear localization and the accumulation of cytoplasmic inclusions of hyperphosphory...
www.biorxiv.org
June 7, 2025 at 9:00 PM
1/3 So pleased to have this latest installment of “the retrotransposon storm” submitted and on biorxiv. This work was driven by Shreevidya Korada, an amazing PhD student in Roger Sher’s lab, co-mentored by me. @mollygale.bsky.social was an awesome collaborator.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Vivien Horvath
📣 New pre-print from the lab:
👉 “Gene regulatory networks linked to GABA signalling emerge as relevant for glioblastoma pathogenesis” #Glioblastoma #GB #GRNs #multiomics #GABA #CancerNeuroscience #ML #GBM
📝 Read the #BioRxiv here:
doi.org/10.1101/2025...
👉 “Gene regulatory networks linked to GABA signalling emerge as relevant for glioblastoma pathogenesis” #Glioblastoma #GB #GRNs #multiomics #GABA #CancerNeuroscience #ML #GBM
📝 Read the #BioRxiv here:
doi.org/10.1101/2025...
May 21, 2025 at 8:55 AM
📣 New pre-print from the lab:
👉 “Gene regulatory networks linked to GABA signalling emerge as relevant for glioblastoma pathogenesis” #Glioblastoma #GB #GRNs #multiomics #GABA #CancerNeuroscience #ML #GBM
📝 Read the #BioRxiv here:
doi.org/10.1101/2025...
👉 “Gene regulatory networks linked to GABA signalling emerge as relevant for glioblastoma pathogenesis” #Glioblastoma #GB #GRNs #multiomics #GABA #CancerNeuroscience #ML #GBM
📝 Read the #BioRxiv here:
doi.org/10.1101/2025...
Reposted by Vivien Horvath
Transposable elements are a major driver of intron gain in eukaryotes, and are capable of transmission between diverse species #HGT #evolution - www.pnas.org/doi/10.1073/...
Horizontal transmission of functionally diverse transposons is a major source of new introns | PNAS
Since the discovery of spliceosomal introns in eukaryotic genomes, the proximate molecular
and evolutionary processes that generate new introns hav...
www.pnas.org
May 26, 2025 at 5:03 AM
Transposable elements are a major driver of intron gain in eukaryotes, and are capable of transmission between diverse species #HGT #evolution - www.pnas.org/doi/10.1073/...
Great opportunity with a great lab and great PI in an amazing research environment. I highly recommend it!!🧠🧬
Come to Lund! We are looking for a postdoc to join the team. #transposons #epigenetics
April 18, 2025 at 7:11 PM
Great opportunity with a great lab and great PI in an amazing research environment. I highly recommend it!!🧠🧬
Reposted by Vivien Horvath
New preprint from our lab! Why is not everyone working on Transposons?
Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons
www.biorxiv.org/content/10.1...
Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons
www.biorxiv.org/content/10.1...
Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons
Heterochromatin is characterised by an inaccessibility to the transcriptional machinery and associated with the histone mark H3K9me3. Heterochromatin erosion is a hallmark of human ageing and H3K9me3 ...
www.biorxiv.org
March 29, 2025 at 10:05 AM
New preprint from our lab! Why is not everyone working on Transposons?
Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons
www.biorxiv.org/content/10.1...
Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons
www.biorxiv.org/content/10.1...
Reposted by Vivien Horvath
🔬👩🔬What sparked your interest in science?👨🔬🧫
For 10 years, #UniStemDay at Lund Stem Cell Center has invited students to step into the lab, meet scientists & explore science. This year, 200 joined us for hands-on experiments & career inspiration!
📖 Read more:
www.stemcellcenter.lu.se/article/unis...
For 10 years, #UniStemDay at Lund Stem Cell Center has invited students to step into the lab, meet scientists & explore science. This year, 200 joined us for hands-on experiments & career inspiration!
📖 Read more:
www.stemcellcenter.lu.se/article/unis...
UniStem Day 2025: A Decade of Inspiring Future Scientists in Lund
Lund University.
www.stemcellcenter.lu.se
March 21, 2025 at 2:41 PM
🔬👩🔬What sparked your interest in science?👨🔬🧫
For 10 years, #UniStemDay at Lund Stem Cell Center has invited students to step into the lab, meet scientists & explore science. This year, 200 joined us for hands-on experiments & career inspiration!
📖 Read more:
www.stemcellcenter.lu.se/article/unis...
For 10 years, #UniStemDay at Lund Stem Cell Center has invited students to step into the lab, meet scientists & explore science. This year, 200 joined us for hands-on experiments & career inspiration!
📖 Read more:
www.stemcellcenter.lu.se/article/unis...
Reposted by Vivien Horvath
DiMeLo-cito: a one-tube protocol for mapping protein-DNA interactions reveals CTCF bookmarking in mitosis https://www.biorxiv.org/content/10.1101/2025.03.11.642717v1
March 14, 2025 at 3:35 PM
DiMeLo-cito: a one-tube protocol for mapping protein-DNA interactions reveals CTCF bookmarking in mitosis https://www.biorxiv.org/content/10.1101/2025.03.11.642717v1
Reposted by Vivien Horvath
New preprint of my postdoc work! We found a novel group of zinc-finger proteins that rapidly evolved in a lineage-specific manner to repress regulatory activities of transposon-derived sequences through anchoring nucleosomes. #TEsky
biorxiv.org/content/10.110…
biorxiv.org/content/10.110…
March 10, 2025 at 8:49 AM
New preprint of my postdoc work! We found a novel group of zinc-finger proteins that rapidly evolved in a lineage-specific manner to repress regulatory activities of transposon-derived sequences through anchoring nucleosomes. #TEsky
biorxiv.org/content/10.110…
biorxiv.org/content/10.110…
Reposted by Vivien Horvath
Check out our latest preprint, where we cross-compared the molecular landscapes of immature neurons in the hippocampus in different mammalian species👨🐵🐷🐭, revealing specialized features in humans. www.biorxiv.org/content/10.1...
Comparative molecular landscapes of immature neurons in the mammalian dentate gyrus across species reveal special features in humans
Immature dentate granule cells (imGCs) arising from adult hippocampal neurogenesis contribute to plasticity, learning and memory, but their evolutionary changes across species and specialized features...
www.biorxiv.org
February 19, 2025 at 7:10 AM
Check out our latest preprint, where we cross-compared the molecular landscapes of immature neurons in the hippocampus in different mammalian species👨🐵🐷🐭, revealing specialized features in humans. www.biorxiv.org/content/10.1...