Anniina Vihervaara
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viher.bsky.social
Anniina Vihervaara
@viher.bsky.social
1.3K followers 1.1K following 9 posts
Assistant Professor of Gene Technology, KTH & SciLifeLab, Stockholm. Transcription, method development, promoter and enhancer architecture. Mom of 2. 🧬🔬 🇫🇮🇸🇪🏳️‍🌈
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viher.bsky.social
Anniina Vihervaara @viher.bsky.social · Nov 21
Fascinated by molecular switches that transition cell states and coordinate transcription. Was a privilege to preview the Singer lab's latest in Molecular Cell, describing how the multitasker BRD4 transitions from a chromatin remodeler to a transcription activator. doi.org/10.1016/j.mo...
Schematic representation of JNK-mediated phosphorylation of BRD4, which converts BRD4 from a chromatin remodeller (1. at the left part of the figure) to an activator of RNA Polymerase II pause-release (2. at the early gene body). BRD4 is dephosphorylated by PP4 (3b.) The image is cropped from the Figure 1 of the linked article.
Reposted by Anniina Vihervaara
lindorfflarsen.bsky.social
Our review on machine learning methods to study sequence–ensemble–function relationships in disordered proteins is now out in COSB

authors.elsevier.com/sd/article/S...
Led by @sobuelow.bsky.social and Giulio Tesei
Figure from the paper illustrating sequence–ensemble–function relationships for disordered proteins. ML prediction (black) and design (orange) approaches are highlighted on the connecting arrows. Prediction of properties/functions from sequence (or vice versa, design) can include biophysics approaches via structural ensembles, or bioinformatics approaches via other hetero- geneous sources. The lower panels show examples of properties and functions of IDRs for predictions or design targets. ML, machine learning; IDRs, intrinsically disordered proteins and regions.
March 12, 2025 at 9:35 PM
Reposted by Anniina Vihervaara
ubadahsabbagh.com
NINDS just launched a $50K prize competition for early-career scientists championing research rigor beyond their normal duties. Do you organize workshops, journal clubs, or do work to try and shift culture? This could be you.
www.challenge.gov?challenge=ni...
Challenge.Gov
Challenge.Gov is the official GSA government website supporting prize challenges and prize competitions that are sponsored by the US federal government. Here federal agencies provide prize awards to ...
www.challenge.gov
January 9, 2025 at 12:07 AM
Reposted by Anniina Vihervaara
anshulkundaje.bsky.social
Very excited to announce that the single cell/nuc. RNA/ATAC/multi-ome resource from ENCODE4 is now officially public. This includes raw data, processed data, annotations and pseudobulk products. Covers many human & mouse tissues. 1/

www.encodeproject.org/single-cell/...
Single cell – ENCODEHomo sapiens clickable body map
www.encodeproject.org
January 7, 2025 at 9:29 PM
Reposted by Anniina Vihervaara
sheilateves.bsky.social
🎉Excited to share our new preprint on Biorxiv 🥳
We uncover how RNA Polymerase III (Pol3) dynamically regulates tRNA transcription during heat shock (HS) stress!
So what did we find? 🧵

www.biorxiv.org/content/10.1...
Dynamic regulation of RNA Polymerase III transcription in mouse embryonic stem cells during heat shock stress
Cells respond to many different types of stresses by overhauling gene expression patterns, both at the transcriptional and translational level. Under heat stress, global transcription and translation ...
www.biorxiv.org
November 30, 2024 at 5:21 PM
Reposted by Anniina Vihervaara
biologists.bsky.social
We are happy to report that our journals and community sites now have Bluesky accounts. Follow them at:
@dev-journal.bsky.social
@jcellsci.bsky.social
@jexpbiol.bsky.social
@dmmjournal.bsky.social
@biologyopen.bsky.social
@the-node.bsky.social
@prelights.bsky.social
@focalplane.bsky.social
November 25, 2024 at 2:44 PM
Reposted by Anniina Vihervaara
alexis-verger.cpesr.fr
Look who's here
@pnas.org ✔️
@science.org ✔️
@naturecellbiology.bsky.social ✔️
@natrevgenet.bsky.social ✔️
@naturebiotech.bsky.social ✔️
@naturemicrobiol.bsky.social ✔️
@naturechemistry.bsky.social ✔️
@genesdev.bsky.social ✔️
@cellchembiol.bsky.social ✔️
@genomeresearch.bsky.social ✔️
@jcellbiol.bsky.social ✔️
November 25, 2024 at 1:47 PM
Reposted by Anniina Vihervaara
jwietek.bsky.social
Hey @biorxivpreprint.bsky.social, I think you need to add another icon here 🦋
November 22, 2024 at 9:27 AM
viher.bsky.social
Fascinated by molecular switches that transition cell states and coordinate transcription. Was a privilege to preview the Singer lab's latest in Molecular Cell, describing how the multitasker BRD4 transitions from a chromatin remodeler to a transcription activator. doi.org/10.1016/j.mo...
Schematic representation of JNK-mediated phosphorylation of BRD4, which converts BRD4 from a chromatin remodeller (1. at the left part of the figure) to an activator of RNA Polymerase II pause-release (2. at the early gene body). BRD4 is dephosphorylated by PP4 (3b.) The image is cropped from the Figure 1 of the linked article.
November 21, 2024 at 5:34 PM