John Tuthill
@tuthill.bsky.social
Neuroscientist at UW studying proprioception and motor control. Promoting the people and work in my lab (www.tuthill.casa). Also pursuing a snow fly side habit (www.snowflyproject.org).
Reposted by John Tuthill
I will be co-teaching a summer course at Allen Institute on connectomics education please apply. Travel support, new connectomics data sets and learning directly from the scientists who built these datasets. Details here: alleninstitute.org/events/incor...
Incorporating open connectomics data into teaching neuroscience
Learn to analyze open neuroscience data and introduce dry lab modules into your existing classes at the Incorporating Open Connectomics data into...
alleninstitute.org
November 24, 2025 at 1:53 AM
I will be co-teaching a summer course at Allen Institute on connectomics education please apply. Travel support, new connectomics data sets and learning directly from the scientists who built these datasets. Details here: alleninstitute.org/events/incor...
Reposted by John Tuthill
About that exclusive, "closed-to-press" MAHA summit last week with RFK and JD Vance: I got in.
Here's what I saw. 🧵 🧪
www.nature.com/articles/d41...
Here's what I saw. 🧵 🧪
www.nature.com/articles/d41...
November 21, 2025 at 5:01 PM
About that exclusive, "closed-to-press" MAHA summit last week with RFK and JD Vance: I got in.
Here's what I saw. 🧵 🧪
www.nature.com/articles/d41...
Here's what I saw. 🧵 🧪
www.nature.com/articles/d41...
Reposted by John Tuthill
SO HAPPY to share our new paper in @currentbiology.bsky.social! Using volumetric EM, we found daily shifts in synapses, vesicles, and mitochondria that accompany neuronal remodeling, linking structural plasticity to changes in how s-LNv neurons influence their targets
www.cell.com/current-biol...
www.cell.com/current-biol...
Daily ultrastructural remodeling of clock neurons
A cluster of Drosophila clock neurons remodel their axonal arbors daily. Using volumetric
electron microscopy at different times of day, Ispizua, Rodriguez-Caron, and colleagues
reveal ultrastructural...
www.cell.com
November 19, 2025 at 5:03 PM
SO HAPPY to share our new paper in @currentbiology.bsky.social! Using volumetric EM, we found daily shifts in synapses, vesicles, and mitochondria that accompany neuronal remodeling, linking structural plasticity to changes in how s-LNv neurons influence their targets
www.cell.com/current-biol...
www.cell.com/current-biol...
Reposted by John Tuthill
To study how animals understand the physical world (and the rules that govern its dynamics), @jinyao-y.bsky.social trains rats to play fetch with robots 🐀🤖🎾
To learn more, come to our poster Tuesday morning!
[Board W11] Rats learn and use intuitive physics knowledge to solve fetch tasks.
#SfN2025
To learn more, come to our poster Tuesday morning!
[Board W11] Rats learn and use intuitive physics knowledge to solve fetch tasks.
#SfN2025
November 18, 2025 at 1:16 AM
To study how animals understand the physical world (and the rules that govern its dynamics), @jinyao-y.bsky.social trains rats to play fetch with robots 🐀🤖🎾
To learn more, come to our poster Tuesday morning!
[Board W11] Rats learn and use intuitive physics knowledge to solve fetch tasks.
#SfN2025
To learn more, come to our poster Tuesday morning!
[Board W11] Rats learn and use intuitive physics knowledge to solve fetch tasks.
#SfN2025
Reposted by John Tuthill
A bad thing is unfolding at NIH this week: It looks like the Trump administration is trying to replace key civil servant scientific leaders, the Institute Directors, with political hires. These directors control the NIH budget, tens of billions.
A bit of a video explainer here: 1/ 🧪
A bit of a video explainer here: 1/ 🧪
November 13, 2025 at 10:31 PM
A bad thing is unfolding at NIH this week: It looks like the Trump administration is trying to replace key civil servant scientific leaders, the Institute Directors, with political hires. These directors control the NIH budget, tens of billions.
A bit of a video explainer here: 1/ 🧪
A bit of a video explainer here: 1/ 🧪
Reposted by John Tuthill
Confirmed this with an NIH source. At the moment, not aware of anyone else who has been placed on leave though.
According to a source, Jenna Norton, who led a letter criticizing Trump's decimation of the NIH (see below), has been placed on administrative leave. She's the first at NIH to be put on leave, joining EPA officials who criticized Trump policies.
www.pbs.org/newshour/nat...
www.pbs.org/newshour/nat...
NIH scientists publish letter criticizing Trump's deep cuts in public health research
The letter addresses the termination of 2,100 research grants valued at more than $12 billion and some of the human costs that have resulted, such as cutting off medication regimens to participants in...
www.pbs.org
November 13, 2025 at 9:10 PM
Confirmed this with an NIH source. At the moment, not aware of anyone else who has been placed on leave though.
Reposted by John Tuthill
Excited to share my most recent postdoctoral work in the Jeanne lab @yaleneuro.bsky.social !
“Sensory processing reformats odor coding around valence and dynamics”
www.biorxiv.org/content/10.1...
We ask: how is a sensory code transformed across multiple stages of processing to inform behavior?
“Sensory processing reformats odor coding around valence and dynamics”
www.biorxiv.org/content/10.1...
We ask: how is a sensory code transformed across multiple stages of processing to inform behavior?
Sensory processing reformats odor coding around valence and dynamics
Extracting relevant features of a complex sensory signal typically involves sequential processing through multiple brain regions. However, identifying the logic and mechanisms of these transformations...
www.biorxiv.org
November 9, 2025 at 12:58 PM
Excited to share my most recent postdoctoral work in the Jeanne lab @yaleneuro.bsky.social !
“Sensory processing reformats odor coding around valence and dynamics”
www.biorxiv.org/content/10.1...
We ask: how is a sensory code transformed across multiple stages of processing to inform behavior?
“Sensory processing reformats odor coding around valence and dynamics”
www.biorxiv.org/content/10.1...
We ask: how is a sensory code transformed across multiple stages of processing to inform behavior?
Reposted by John Tuthill
@runewberg.bsky.social congrats Rune and team! This looks really cool
Neural manifolds that orchestrate walking and stopping https://www.biorxiv.org/content/10.1101/2025.11.08.687367v1
November 9, 2025 at 1:26 PM
@runewberg.bsky.social congrats Rune and team! This looks really cool
Reposted by John Tuthill
Meet our 2025 cohort of Next Generation Leaders! For the next 3 years, they will network with other rising stars, participate in professional development, and share their ideas for future research directions.
November 4, 2025 at 4:25 PM
Meet our 2025 cohort of Next Generation Leaders! For the next 3 years, they will network with other rising stars, participate in professional development, and share their ideas for future research directions.
Reposted by John Tuthill
After 13 years in the US, I’ve made the difficult decision to leave. Having packed up everything and rethought about priorities, rather painstakingly, while I’m sad to leave the life I’ve made here, I’m also relieved that I won’t have to plan my life around immigration policies anymore.
October 31, 2025 at 4:08 AM
After 13 years in the US, I’ve made the difficult decision to leave. Having packed up everything and rethought about priorities, rather painstakingly, while I’m sad to leave the life I’ve made here, I’m also relieved that I won’t have to plan my life around immigration policies anymore.
Do flies feel pain?
Spooky new preprint from our lab on the cells and circuits that mediate nociceptive behaviors in adult Drosophila, led by graduate student (and newly minted PhD!) @jonesjes.bsky.social.
🪰⚡👻🎃
www.biorxiv.org/content/10.1...
Spooky new preprint from our lab on the cells and circuits that mediate nociceptive behaviors in adult Drosophila, led by graduate student (and newly minted PhD!) @jonesjes.bsky.social.
🪰⚡👻🎃
www.biorxiv.org/content/10.1...
October 29, 2025 at 6:56 PM
Do flies feel pain?
Spooky new preprint from our lab on the cells and circuits that mediate nociceptive behaviors in adult Drosophila, led by graduate student (and newly minted PhD!) @jonesjes.bsky.social.
🪰⚡👻🎃
www.biorxiv.org/content/10.1...
Spooky new preprint from our lab on the cells and circuits that mediate nociceptive behaviors in adult Drosophila, led by graduate student (and newly minted PhD!) @jonesjes.bsky.social.
🪰⚡👻🎃
www.biorxiv.org/content/10.1...
Reposted by John Tuthill
What a time to be alive
The songbird basal ganglia connectome https://www.biorxiv.org/content/10.1101/2025.10.25.684569v1
October 27, 2025 at 5:02 PM
What a time to be alive
Reposted by John Tuthill
How does life evolve to adapt to modern cities?
Out now in Science, my PhD work with @lindymcbr.bsky.social uncovers the ancient origin of the “London Underground mosquito” – one of the most iconic examples of urban adaptation.
🧵(1/n)
@science.org
www.science.org/doi/10.1126/science.ady4515
Out now in Science, my PhD work with @lindymcbr.bsky.social uncovers the ancient origin of the “London Underground mosquito” – one of the most iconic examples of urban adaptation.
🧵(1/n)
@science.org
www.science.org/doi/10.1126/science.ady4515
Ancient origin of an urban underground mosquito
Understanding how life is adapting to urban environments represents an important challenge in evolutionary biology. In this work, we investigate a widely cited example of urban adaptation, Culex pipie...
www.science.org
October 25, 2025 at 4:46 AM
How does life evolve to adapt to modern cities?
Out now in Science, my PhD work with @lindymcbr.bsky.social uncovers the ancient origin of the “London Underground mosquito” – one of the most iconic examples of urban adaptation.
🧵(1/n)
@science.org
www.science.org/doi/10.1126/science.ady4515
Out now in Science, my PhD work with @lindymcbr.bsky.social uncovers the ancient origin of the “London Underground mosquito” – one of the most iconic examples of urban adaptation.
🧵(1/n)
@science.org
www.science.org/doi/10.1126/science.ady4515
there is a special lounge in pape heaven reserved for authors who take the time to aggregate and plot out how species vary across a physical variable
October 24, 2025 at 5:29 PM
there is a special lounge in pape heaven reserved for authors who take the time to aggregate and plot out how species vary across a physical variable
Reposted by John Tuthill
🦎THREAD: We just published something wild in @asn-amnat.bsky.social - lizards missing entire limbs not only survive, but some appear to actually thrive in the wild?!
Let me tell you about the "three-legged pirate" lizards 🏴☠️
[Paper: www.journals.uchicago.edu/doi/10.1086/... ]
(1/n)
Let me tell you about the "three-legged pirate" lizards 🏴☠️
[Paper: www.journals.uchicago.edu/doi/10.1086/... ]
(1/n)
October 14, 2025 at 1:52 PM
🦎THREAD: We just published something wild in @asn-amnat.bsky.social - lizards missing entire limbs not only survive, but some appear to actually thrive in the wild?!
Let me tell you about the "three-legged pirate" lizards 🏴☠️
[Paper: www.journals.uchicago.edu/doi/10.1086/... ]
(1/n)
Let me tell you about the "three-legged pirate" lizards 🏴☠️
[Paper: www.journals.uchicago.edu/doi/10.1086/... ]
(1/n)
Reposted by John Tuthill
Excited to announce our new pre-print (www.biorxiv.org/cgi/content/...)!
This collaborative work (co-led by Adriane Otopalik and Gerry Rubin) examines how neuronal circuits regulate social behaviors, like courtship🫶 and aggression🥊, across sexes. #neuroscience #Drosophila #WomenInSTEM 🧪1/
This collaborative work (co-led by Adriane Otopalik and Gerry Rubin) examines how neuronal circuits regulate social behaviors, like courtship🫶 and aggression🥊, across sexes. #neuroscience #Drosophila #WomenInSTEM 🧪1/
October 23, 2025 at 12:44 PM
Excited to announce our new pre-print (www.biorxiv.org/cgi/content/...)!
This collaborative work (co-led by Adriane Otopalik and Gerry Rubin) examines how neuronal circuits regulate social behaviors, like courtship🫶 and aggression🥊, across sexes. #neuroscience #Drosophila #WomenInSTEM 🧪1/
This collaborative work (co-led by Adriane Otopalik and Gerry Rubin) examines how neuronal circuits regulate social behaviors, like courtship🫶 and aggression🥊, across sexes. #neuroscience #Drosophila #WomenInSTEM 🧪1/
Reposted by John Tuthill
The NIH institute director firing last Friday is very bad.
I made a video explainer about why.
Stay for last post, w link to @science.org story from @jocelynkaiser.bsky.social
1/4
🧪
I made a video explainer about why.
Stay for last post, w link to @science.org story from @jocelynkaiser.bsky.social
1/4
🧪
October 23, 2025 at 4:02 AM
The NIH institute director firing last Friday is very bad.
I made a video explainer about why.
Stay for last post, w link to @science.org story from @jocelynkaiser.bsky.social
1/4
🧪
I made a video explainer about why.
Stay for last post, w link to @science.org story from @jocelynkaiser.bsky.social
1/4
🧪
First snow fly of the season! From our star volunteer collector, Catherine, who was out in the Pasayten this weekend (Mt. Barney). It's rare to find them that far east of the Cascade Crest.
October 20, 2025 at 7:22 PM
First snow fly of the season! From our star volunteer collector, Catherine, who was out in the Pasayten this weekend (Mt. Barney). It's rare to find them that far east of the Cascade Crest.
Reposted by John Tuthill
New essay in @currentbiology.bsky.social special brain-body issue! Fly lab meets psychiatrist: how bodily signals shape cognition and mental health. Great collaboration with Albino Oliveira-Maia showing @champalimaudf.bsky.social discovery ↔️ clinic at its best. www.cell.com/current-biol...
From cognition in the body to the body in cognition
Carlos Ribeiro and Albino Oliveira-Maia propose how brain–body interactions may inform
the study of ‘higher’ cognitive functions such as learning and memory across model
systems.
www.cell.com
October 20, 2025 at 4:40 PM
New essay in @currentbiology.bsky.social special brain-body issue! Fly lab meets psychiatrist: how bodily signals shape cognition and mental health. Great collaboration with Albino Oliveira-Maia showing @champalimaudf.bsky.social discovery ↔️ clinic at its best. www.cell.com/current-biol...
Reposted by John Tuthill
Wow, nature is too cool! Structures on stinkbug hind legs that used to be interpreted as ears are actually chambers with fungi. The bugs coat their eggs in those fungi to protect them against parasitoid wasps. 🧪
Defensive fungal symbiosis on insect hindlegs | Science www.science.org/doi/10.1126/...
Defensive fungal symbiosis on insect hindlegs | Science www.science.org/doi/10.1126/...
Defensive fungal symbiosis on insect hindlegs
Dinidorid stinkbugs were reported to possess a conspicuous tympanal organ on female hindlegs. In this study, we show that this organ is specialized to retain microbial symbionts rather than to perceiv...
www.science.org
October 17, 2025 at 4:42 PM
Wow, nature is too cool! Structures on stinkbug hind legs that used to be interpreted as ears are actually chambers with fungi. The bugs coat their eggs in those fungi to protect them against parasitoid wasps. 🧪
Defensive fungal symbiosis on insect hindlegs | Science www.science.org/doi/10.1126/...
Defensive fungal symbiosis on insect hindlegs | Science www.science.org/doi/10.1126/...
Reposted by John Tuthill
If anyone on here knows how to ID polychaete larva, I’d love to work with you on getting to the species level on these worms I always find in Boston harbor. I could provide a ton of photos, if I knew what to image for an ID. I know they are spionid but that’s it. #sciart #microscopy #plankton
October 12, 2025 at 3:53 PM
If anyone on here knows how to ID polychaete larva, I’d love to work with you on getting to the species level on these worms I always find in Boston harbor. I could provide a ton of photos, if I knew what to image for an ID. I know they are spionid but that’s it. #sciart #microscopy #plankton
Reposted by John Tuthill
Lab’s 1st preprint!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵
Induction of menstruation in mice reveals the regulation of menstrual shedding
During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...
www.biorxiv.org
October 10, 2025 at 1:26 PM
Lab’s 1st preprint!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
Reposted by John Tuthill
Our department started a podcast to let people know about our research and the impact that it has on the public! Please have a listen and subscribe to the series! Also available on Apple podcast, Spotify, and Transistor, www.youtube.com/playlist?lis...
October 9, 2025 at 6:45 PM
Our department started a podcast to let people know about our research and the impact that it has on the public! Please have a listen and subscribe to the series! Also available on Apple podcast, Spotify, and Transistor, www.youtube.com/playlist?lis...
Reposted by John Tuthill
Today my @nytimes.com colleagues and I are launching a new series called Lost Science. We interview US scientists who can no longer discover something new about our world, thanks to this year‘s cuts. Here is my first interview with a scientist who studied bees and fires. Gift link: nyti.ms/3IWXbiE
nyti.ms
October 8, 2025 at 11:29 PM
Today my @nytimes.com colleagues and I are launching a new series called Lost Science. We interview US scientists who can no longer discover something new about our world, thanks to this year‘s cuts. Here is my first interview with a scientist who studied bees and fires. Gift link: nyti.ms/3IWXbiE
peak bloobs right now out in the glacier peak wilderness
October 7, 2025 at 10:35 PM
peak bloobs right now out in the glacier peak wilderness