Ming Tommy Tang
@tommytang.bsky.social
Director of bioinformatics at AstraZeneca. subscribe to my youtube channel @chatomics. On my way to helping 1 million people learn bioinformatics. Educator, Biotech, single cell. Also talks about leadership.
tommytang.bio.link
tommytang.bio.link
This morning, I had time.
Usually it's chaos—kids up at 8:30, barely time to grab bread and milk before the 8:50 school drop-off.
But today they woke at 7:20, so I made dumplings. Real breakfast. I even made soup: oil, salt, soy sauce, green onions.
Usually it's chaos—kids up at 8:30, barely time to grab bread and milk before the 8:50 school drop-off.
But today they woke at 7:20, so I made dumplings. Real breakfast. I even made soup: oil, salt, soy sauce, green onions.
November 19, 2025 at 2:00 AM
This morning, I had time.
Usually it's chaos—kids up at 8:30, barely time to grab bread and milk before the 8:50 school drop-off.
But today they woke at 7:20, so I made dumplings. Real breakfast. I even made soup: oil, salt, soy sauce, green onions.
Usually it's chaos—kids up at 8:30, barely time to grab bread and milk before the 8:50 school drop-off.
But today they woke at 7:20, so I made dumplings. Real breakfast. I even made soup: oil, salt, soy sauce, green onions.
it is more fragile than you think
November 19, 2025 at 1:24 AM
it is more fragile than you think
Comprehensive tumor-immune profiling reveals mediators of paradoxical immune sensitivity in sarcomatoid renal cell carcinoma www.cell.com/cancer-cell...
November 18, 2025 at 3:15 PM
Comprehensive tumor-immune profiling reveals mediators of paradoxical immune sensitivity in sarcomatoid renal cell carcinoma www.cell.com/cancer-cell...
🧵 RNA-seq Normalization: What You Need to Know
November 18, 2025 at 2:45 PM
🧵 RNA-seq Normalization: What You Need to Know
The Secret to Recreating Any Bioinformatics Figure (It’s easier than You Think). The other day, I was on Bioinformatics subReddit and saw someone ask how to generate the figure below
November 18, 2025 at 2:15 PM
The Secret to Recreating Any Bioinformatics Figure (It’s easier than You Think). The other day, I was on Bioinformatics subReddit and saw someone ask how to generate the figure below
cloudflare is down --> chatGPT/Claude is down --> you can not code without AI tools
You STILL need solid programming skills.
You STILL need solid programming skills.
November 18, 2025 at 1:33 PM
cloudflare is down --> chatGPT/Claude is down --> you can not code without AI tools
You STILL need solid programming skills.
You STILL need solid programming skills.
Friday night. VIP tickets to see Siqing Lu, one of China's most celebrated violinists, performing at Harvard.
November 18, 2025 at 2:00 AM
Friday night. VIP tickets to see Siqing Lu, one of China's most celebrated violinists, performing at Harvard.
Paneth-like transition drives resistance to dual targeting of KRAS and EGFR in colorectal cancer www.cell.com/cancer-cell...
November 17, 2025 at 3:15 PM
Paneth-like transition drives resistance to dual targeting of KRAS and EGFR in colorectal cancer www.cell.com/cancer-cell...
Want to master bioinformatics data visualization? Learn ggplot2! 🧵👇
November 17, 2025 at 2:45 PM
Want to master bioinformatics data visualization? Learn ggplot2! 🧵👇
Thread: Multi-omics sounds cool—until you actually try it. Here's are the nuances.
1/
You’ve got RNA-seq.
Methylation.
Proteomics.
Time to “integrate” the data.
But how? And why?
Let’s break it down.
1/
You’ve got RNA-seq.
Methylation.
Proteomics.
Time to “integrate” the data.
But how? And why?
Let’s break it down.
November 17, 2025 at 2:15 PM
Thread: Multi-omics sounds cool—until you actually try it. Here's are the nuances.
1/
You’ve got RNA-seq.
Methylation.
Proteomics.
Time to “integrate” the data.
But how? And why?
Let’s break it down.
1/
You’ve got RNA-seq.
Methylation.
Proteomics.
Time to “integrate” the data.
But how? And why?
Let’s break it down.
I thought my English was decent.
Not perfect, but good enough. I've been speaking it for years.
I communicate. I get things done.
Then I sat down with an English-speaking coach for two hours.
Not perfect, but good enough. I've been speaking it for years.
I communicate. I get things done.
Then I sat down with an English-speaking coach for two hours.
November 17, 2025 at 2:00 AM
I thought my English was decent.
Not perfect, but good enough. I've been speaking it for years.
I communicate. I get things done.
Then I sat down with an English-speaking coach for two hours.
Not perfect, but good enough. I've been speaking it for years.
I communicate. I get things done.
Then I sat down with an English-speaking coach for two hours.
Someone told me a real story: an AI team worked hard on a model to decipher the immune cell function.
Someone with biology background: what data did you use for the training?
Someone with biology background: what data did you use for the training?
November 17, 2025 at 12:22 AM
Someone told me a real story: an AI team worked hard on a model to decipher the immune cell function.
Someone with biology background: what data did you use for the training?
Someone with biology background: what data did you use for the training?
Toward a new standard: Sequential multi-agent neoadjuvant chemotherapy in resectable pancreatic cancer
www.cell.com/cancer-cell...
www.cell.com/cancer-cell...
November 16, 2025 at 3:15 PM
Toward a new standard: Sequential multi-agent neoadjuvant chemotherapy in resectable pancreatic cancer
www.cell.com/cancer-cell...
www.cell.com/cancer-cell...
Making a heatmap is an essential skill for a bioinformatician. But you probably do not understand heatmap. 7 reading resources to understand heatmap! 🧵
November 16, 2025 at 2:45 PM
Making a heatmap is an essential skill for a bioinformatician. But you probably do not understand heatmap. 7 reading resources to understand heatmap! 🧵
1/ "How can I start learning bioinformatics?" As a former wet lab scientist, I hear this question a lot. Here's my journey—and lessons learned.
November 16, 2025 at 2:15 PM
1/ "How can I start learning bioinformatics?" As a former wet lab scientist, I hear this question a lot. Here's my journey—and lessons learned.
4:30 PM. Boston is dark. I'm sick, exhausted, an hour into my commute.
A podcast plays. I'll forget most of it.
But one line stuck: "Be a fountain, not a drain."
A podcast plays. I'll forget most of it.
But one line stuck: "Be a fountain, not a drain."
November 16, 2025 at 2:00 AM
4:30 PM. Boston is dark. I'm sick, exhausted, an hour into my commute.
A podcast plays. I'll forget most of it.
But one line stuck: "Be a fountain, not a drain."
A podcast plays. I'll forget most of it.
But one line stuck: "Be a fountain, not a drain."
I just published my weekly newsletter to >10K subscribers: The truth about AI coding for bioinformatics divingintogeneticsandgenomics.kit.com/posts/ai-po...
AI ported 6,000+ lines of Python in 8 hours. Here’s the catch
divingintogeneticsandgenomics.kit.com
November 15, 2025 at 3:41 PM
I just published my weekly newsletter to >10K subscribers: The truth about AI coding for bioinformatics divingintogeneticsandgenomics.kit.com/posts/ai-po...
Extrachromosomal DNA associates with nuclear condensates and reorganizes chromatin structures to enhance oncogenic transcription www.cell.com/cancer-cell...
November 15, 2025 at 3:15 PM
Extrachromosomal DNA associates with nuclear condensates and reorganizes chromatin structures to enhance oncogenic transcription www.cell.com/cancer-cell...
An introduction to Python for R users occasionaldivergences.com/posts/pytho...
November 15, 2025 at 2:45 PM
An introduction to Python for R users occasionaldivergences.com/posts/pytho...
1/ Exploratory Data Analysis (EDA) is the first step in any data analysis journey. When working with RNA-seq data, one of the most commonly used techniques is Principal Component Analysis (PCA). But what exactly is PCA, and why does it matter? Let’s break it down. 🧵👇
November 15, 2025 at 2:15 PM
1/ Exploratory Data Analysis (EDA) is the first step in any data analysis journey. When working with RNA-seq data, one of the most commonly used techniques is Principal Component Analysis (PCA). But what exactly is PCA, and why does it matter? Let’s break it down. 🧵👇
"Dad, my head hurts."
Boston's winter finally hit. And like clockwork, the seasonal domino effect began:
Boston's winter finally hit. And like clockwork, the seasonal domino effect began:
November 15, 2025 at 2:00 AM
"Dad, my head hurts."
Boston's winter finally hit. And like clockwork, the seasonal domino effect began:
Boston's winter finally hit. And like clockwork, the seasonal domino effect began:
8 Resources to study Transcription factor binding, enhancers and histone modification distribution
1. ENCODE www.encodeproject.org/
1. ENCODE www.encodeproject.org/
November 14, 2025 at 3:15 PM
8 Resources to study Transcription factor binding, enhancers and histone modification distribution
1. ENCODE www.encodeproject.org/
1. ENCODE www.encodeproject.org/
Two resources to learn bioinformatics yourself:
1. Path to a free self-taught education in Bioinformatics! github.com/ossu/bioinf...
#bioinformatics
1. Path to a free self-taught education in Bioinformatics! github.com/ossu/bioinf...
#bioinformatics
GitHub - ossu/bioinformatics: :microscope: Path to a free self-taught education in Bioinformatics!
:microscope: Path to a free self-taught education in Bioinformatics! - ossu/bioinformatics
github.com
November 14, 2025 at 2:45 PM
Two resources to learn bioinformatics yourself:
1. Path to a free self-taught education in Bioinformatics! github.com/ossu/bioinf...
#bioinformatics
1. Path to a free self-taught education in Bioinformatics! github.com/ossu/bioinf...
#bioinformatics
1/ You think RNA equals protein?
Not always.
If you're doing bioinformatics without understanding biology, you're flying blind. 🧵
Not always.
If you're doing bioinformatics without understanding biology, you're flying blind. 🧵
November 14, 2025 at 2:15 PM
1/ You think RNA equals protein?
Not always.
If you're doing bioinformatics without understanding biology, you're flying blind. 🧵
Not always.
If you're doing bioinformatics without understanding biology, you're flying blind. 🧵
"What did you say?" 👀
Phone rings while I'm driving home.
Phone rings while I'm driving home.
November 14, 2025 at 1:18 AM
"What did you say?" 👀
Phone rings while I'm driving home.
Phone rings while I'm driving home.